COVID-19 Bulletin - 2nd July 2020 - Produced by the NHS Staff Library, Mid Yorkshire Hospitals NHS Trust - The Mid Yorkshire ...

COVID-19 Bulletin –
Official Guidance & Emerging Evidence

         2nd July 2020

 Produced by the NHS Staff Library,

 Mid Yorkshire Hospitals NHS Trust

      midyorks.library.pgh@nhs.net

Go To
Guidance
Statistics
Journals
Research & Reviews
Information Sources

Guidance
Department of Health and Social Care
   ● COVID-19: guidance for health professionals
Public Health England
   ● Coronavirus (COVID-19): guidance for health professionals and other organisations
   ● COVID-19: background information
     Information on COVID-19 including epidemiology, virology and clinical features
   ● National COVID-19 surveillance reports Updated weekly
   ● COVID-19: exceedances in Leicester
     A summary of the descriptive epidemiology of COVID-19 in Leicester following a
     preliminary investigation into COVID-19 exceedances during June 2020.
      Insufficient evidence for vitamin D preventing or treating ARTIs
       NICE and SACN have reviewed available evidence on vitamin D and the risk of acute
       respiratory tract infections (ARTIs) and COVID-19.

NHS England

   ● Specialty guides
     Guides for patient management during the coronavirus pandemic
   ● Coronavirus guidance for clinicians and NHS managers

NICE
   ● COVID-19 rapid evidence summary: vitamin D for COVID-19
   ● COVID-19 rapid guideline: rheumatological autoimmune, inflammatory and metabolic
     bone disorders UPDATED

Health Education England
   ● Coronavirus (COVID-19)

● e-Learning for Healthcare (e-LfH) : Coronavirus (COVID-19) e-learning programme
     The programme is freely available to colleagues working in the NHS, independent sector
     and social care.

      COVID-19 Pandemic Recovery Toolkit for NHS Trusts
       This toolkit is a collation of resources to support Trusts during the recovery phase of the
       COVID-19 pandemic. It includes sections on recovery planning, capacity and long-term
       impacts, workforce wellbeing, learning lessons, organisational resilience and innovation.

Statistics
   ● COVID-19: track coronavirus cases Department of Health and Social Care
   ● NHS test and trace statistics (England): weekly reports Department of Health and
     Social Care
   ● Number of coronavirus (COVID-19) cases and risk in the UK Department of Health and
     Social Care
   ● PHE data series on deaths in people with COVID-19: technical summary
     Summary of the PHE data series on deaths in people with COVID-19, outlining what the
     changes mean and how the data compare to other COVID-19 death data series. Public
     Health England
   ● Potential Coronavirus (COVID-19) symptoms reported through NHS Pathways and 111
     online NHS Digital

Journals
An NHS Athens account may be required for full text access, register here.

BMJ
      Diagnostic accuracy of serological tests for covid-19: systematic review and meta-
       analysis
       Higher quality clinical studies assessing the diagnostic accuracy of serological tests for
       covid-19 are urgently needed. Currently, available evidence does not support the
       continued use of existing point-of-care serological tests.
News
      Covid-19: Lopinavir-ritonavir does not benefit hospitalised patients, UK trial finds
      Covid-19: Four in 10 cases in Italian town that locked down early were asymptomatic

The Lancet
Research
   ● Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre,
     cross-sectional study
   ● The effect of frailty on survival in patients with COVID-19 (COPE): a multicentre,
     European, observational cohort study

Correspondence
   ● Pulmonary intravascular coagulopathy in COVID-19 pneumonia
   ● Early lessons from a second COVID-19 lockdown in Leicester, UK
Comment
   ● Endothelial cells orchestrate COVID-19 coagulopathy
   ● Applications of digital technology in COVID-19 pandemic planning and response
   ● Digital tools against COVID-19: taxonomy, ethical challenges, and navigation aid
   ● COVID-19 in children and young people

Nature
   ● A race to determine what drives COVID-19 severity
     Efforts are ongoing to find which human or viral factors underpin whether a person with
     COVID-19 will develop severe symptoms. Clinical evidence linked to two viral lineages
     now provides key insights into this enigma.
   ● A metabolic handbook for the COVID-19 pandemic
   ● COVID-19 severity correlates with airway epithelium–immune cell interactions
     identified by single-cell analysis
   ● A systematic review of pathological findings in COVID-19: a pathophysiological
     timeline and possible mechanisms of disease progression
   ● Coronavirus research updates
     Nature summarizes key papers as they appear
       26 June — Test frequency matters more than test sensitivity for stopping outbreaks

New England Journal of Medicine
Audio Interview
      A Covid-19–Related Syndrome in Children
Research
   ● Multisystem Inflammatory Syndrome in U.S. Children and Adolescents
Comment
      Accelerating Development of SARS-CoV-2 Vaccines

Nursing Standard
   ● Free Access to news and evidence-based resources relevant to the COVID-19 pandemic.

Publisher bundles FREE TO ACCESS
   ● Coronavirus (COVID-19): articles and resources Mark Allen Healthcare journals.
   ● Novel Coronavirus Information Center Elsevier
   ● Covid-19: Novel Coronavirus Content Free to Access Wiley Online Library

● SARS-CoV-2 and COVID-19 Springer Nature
    ● COVID-19: Novel Coronavirus Content Free to Access Taylor & Francis
    ● Access to OUP resources on COVID-19 Oxford University Press
--------------------------------------------------------------------------------------------------------------------------
Research & Reviews
Cochrane review
        Antibody tests for identification of current and past infection with SARS‐CoV‐2
MRC
        Report 29 - The impact of the COVID-19 epidemic on all-cause attendances to
         emergency departments in two large London hospitals: an observational study
Annals of Medicine and Surgery
        Haematological manifestations, mechanisms of thrombosis and anti-coagulation
         in COVID-19 disease: A review
BMC Medicine
        Ethnicity and COVID-19 infection: are the pieces of the puzzle falling into place?
Clinical Infectious Diseases
        Community Acquired Co-infection in COVID-19: A Retrospective Observational
         Experience
        SARS-CoV-2 infection in healthcare personnel with high-risk occupational exposure:
         evaluation of seven-day exclusion from work policy
        Investigating the sex differences in COVID-19: Another step forward, but many
         unanswered questions
Clinical Microbiology and Infection
        Bacterial and fungal coinfection among hospitalised patients with COVID-19: A
         retrospective cohort study in a UK secondary care setting
Diabetes & Metabolic Syndrome: Clinical Research & Reviews
        BMI and future risk for COVID-19 infection and death across sex, age and ethnicity:
         Preliminary findings from UK biobank
Emerging Microbes & Infections
        Risk factors associated with COVID-19 infection: a retrospective cohort study based on
         contacts tracing
Environmental Research
        Population-level COVID-19 mortality risk for non-elderly individuals overall and for
         non-elderly individuals without underlying diseases in pandemic epicenters

European Journal of Pharmacology
      Melatonin is a potential adjuvant to improve clinical outcomes in individuals with
       obesity and diabetes with coexistence of Covid-19
Infectious Disease Modelling
      Mathematical modeling and the transmission dynamics in predicting the Covid-19 -
       What next in combating the pandemic
Infection, Genetics and Evolution
      Characterizations of SARS-CoV-2 mutational profile, spike protein stability and viral
       transmission
International Journal of Epidemiology
      Comparisons between countries are essential for the control of COVID-19
International Journal of Infectious Diseases
      Case reports study of the first five patients COVID-19 treated with remdesivir in France
      Associations of Clinical Characteristics and Treatment Regimens with Viral RNA
       Shedding Duration in Patients with COVID-19
Journal of Antimicrobial Chemotherapy
      Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who
       recovered from COVID-19
The Journal of Applied Laboratory Medicine
      Screening the general population for SARS CoV-2 virus and COVID-19 antibodies: a
       counter-argument
Journal of Clinical Virology
      Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-
       CoV and lessons from the past
Journal of Infection
      Snapshot PCR Surveillance for SARS-CoV-2 in Hospital Staff in England
Journal of Neuroradiology
      Neuroimaging findings in COVID-19 and other coronavirus infections: a systematic
       review in 116 patients
Journal of Risk Research
      Bayesian network analysis of Covid-19 data reveals higher infection prevalence rates
       and lower fatality rates than widely reported
Medical Hypotheses
      Cross-immunity between respiratory coronaviruses may limit COVID-19 fatalities
      COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to
       mortality through its effect on SIRT1 activity

Pharmacological Research
        Edaravone: a potential treatment for the COVID-19-induced inflammatory syndrome?

Wiley Open Research Preprints
These are preprints and have not been peer reviewed. Data may be preliminary.
    ● Prospects of monoclonal antibodies in COVID-19 treatment: a systematic review
    ● Isolated, sudden, recoverable olfactory dysfunction: a pathognomonic sign of COVID-
      19
    ● Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting
      with nicotinamide?
    ● Severe Asthma in adults does not significantly affect the outcome of COVID-19
      disease: results from the Italian Severe Asthma Registry
    ● The hidden role of NLRP3 inflammasome in diabesity-related COVID-19 exacerbations:
      lessons for drug repurposing

COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Preprints are preliminary reports of work that have not been certified by peer review
Multiple reviews published daily.
--------------------------------------------------------------------------------------------------------------------------

Information Sources
BMJ Best Practice
    ● COVID-19
COVID-19 Evidence Alerts from McMaster PLUSTM
    ● Studies that have been reviewed for quality
    ● New studies currently under review
Critical Care Reviews
    ● Literature on SAR-CoV-2 published since the outbreak began in December 2019

Dynamed
    ● COVID-19 (Novel Coronavirus)
      Free temporary access available to COVID-19 resources only.
House of Commons Library
    ● Latest coronavirus (Covid-19) research and analysis from UK Parliament
Knowledge for Healthcare
    ● Links to information on COVID-19 from trusted sources

LitCovid
   ● LitCovid is a curated literature hub for tracking up-to-date scientific information about
     the 2019 novel Coronavirus
NIHR Innovation Observatory
Daily updates of clinical trials in the pipeline for potential Coronavirus (COVID-19) treatments
NIHR Policy Research Programme COVID-19 research
Projects have been funded through the Policy Research Programme's rapid COVID-19 funding
process, or are supported from existing funding to Policy Research Units where projects have
been adapted to address COVID-19
Oxford COVID-19 Evidence Service
Centre for Evidence-Based Medicine

      The ethics of COVID-19 treatment studies: too many are open, too few are double-
       masked
PHE Knowledge and Library Services team
Finding the evidence: Coronavirus
PHE Knowledge and Library Services team has produced this page to help those working on the
current coronavirus outbreak, embed evidence-informed decision-making in their daily
practice. Most of the resources are freely accessible but some may ask for an OpenAthens sign-
in.
The COVID-19 register provides details of PHE led studies that have taken place since February
2020. It includes only PHE led studies and not collaborative studies led by non-PHE
investigators.
The Strategy Unit
Analytical Collaboration for COVID-19
Five organisations are collaborating to provide analytical support to the health and care system
to help in the fight against COVID-19: the Health Foundation; King’s Fund; Nuffield Trust; and
two specialist NHS analytical teams, Imperial College Health Partners and the Strategy
Unit. The five organisations are working in a coordinated way to provide analysis and expertise
to support the NHS on COVID-19, using their expertise to focus on questions that the NHS may
lack the resources to look at, which may be more medium-term, cut across sectors, or benefit
from independent analysis.
Trip Database
Evidence and grey literature – updated daily
UpToDate
Clinical Effectiveness COVID-19 Resources Available to All
Free temporary access available to COVID-19 resources only. Registration required.

WHO Global Outbreak Alert and Response Network (GOARN)
       Rapid evidence reviews
       Clinical, mental health and nursing e-book collections from EBSCO
       Around 5,000 titles have temporarily been made available via NHS OpenAthens and include
       titles from Lippincott Williams & Wilkins, McGraw-Hill Education, Oxford University Press,
       Springer Publishing, Wolters Kluwer Health, Taylor and Francis, and Cambridge Scholars
       Publishing.
       The clinical collection is available here
       The nursing collection is available here
       The psychology collection is available here

Disclaimer:
While we make every possible effort to ensure that the information in this publication is accurate and
up to date at the time of publishing, we do not accept any responsibility for errors or omissions. Nor
do we accept any responsibility for loss or damage resulting from making use of this
information. Links to third party websites are provided for the convenience of users and we in no way
endorse the contents, views or information held on such sites.