CORPORATE REVIEW FY2018 - National Skin Centre

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CORPORATE REVIEW FY2018 - National Skin Centre
CORPORATE
REVIEW FY2018
CORPORATE REVIEW FY2018 - National Skin Centre
CONTENTS

01              02               04
Vision and      Board and Key    Director’s
Mission         Committees       Message

06              10               24
Patient Care    Advancing        Education
Ensuring        Research         Paving the
Continued       Excellence       Pathway
Excellence in   Innovation and   to Progress
Care Delivery   Technology

32              40
Our Staff,      Medical Staff
Our People      Listing
Fostering a
Conducive
Work
Community
for All
CORPORATE REVIEW FY2018 - National Skin Centre
VISION                         MISSION
Adding years of healthy life   • To be a centre of excellence in providing
                                  high-quality, safe and cost-effective
                                  dermatological care to the population
                               • To be a leading centre for education and
                                  training in dermatology
                               • To be a pivotal centre for clinical and
                                  translational research
                               In the setting of an innovative and nurturing
                               environment
CORPORATE REVIEW FY2018 - National Skin Centre
BOARD AND KEY
COMMITTEES 2018
 LEADERSHIP

                                    Mdm Kay Kuok
                                    Chairman, NSC Board
                                    Chairman, National
                                    Healthcare Group

              Prof Philip Choo
              Director, NSC Board
              GCEO, National
              Healthcare Group

                      02
CORPORATE REVIEW FY2018 - National Skin Centre
NATIONAL SKIN CENTRE

                                             MEDICAL STAFF COMMITTEE
                                             Standing (top left to right)        Absent from photo
                                             Adj Prof Steven Thng                Adj A/Prof Lim Yen Loo
                                             Deputy Head of                      Head of Subspeciality Division 2,
                                             Medical Education Division,         Senior Consultant
                                             Senior Consultant
                                                                                 Adj A/Prof Leow
                                             Adj A/Prof Chong                    Yung Hian
                                             Wei Sheng                           Head of Clinical
                                             Head of Subspecialty Division 1,    Governance and Quality,
                                             Senior Consultant                   Senior Consultant

                                             Adj A/Prof Tey                      Adj A/Prof Martin Chio
                                             Hong Liang                          Head of Department of Sexually
                                             Head of Research Division,          Transmitted Infections Control
                                             Senior Consultant                   (DSC) Clinic,
                                                                                 Senior Consultant
                                             Standing in front (left to right)
                                             A/Prof Chua Sze Hon                 Prof Leo Yee Sin
                                                                                 Executive Director, National
                                             Deputy Director & Head of
                                                                                 Centre of Infectious Diseases,
                                             Medical Education Division,
                                                                                 Senior Consultant
                                             Senior Consultant

                                             Ms Loo Swee Cheng                   A/Prof Tay Jam Chin
                                                                                 Department of
                                             General Manager, Ex-Officio
                                                                                 General Medicine,
                                             Prof Tan Suat Hoon                  Tan Tock Seng Hospital,
                                             Director,                           Senior Consultant
                                             Senior Consultant

MANAGEMENT COMMITTEE
Standing (from left to right)     Mrs Alice Chew
Mr Lee Sau Chuen                  Head of Medical Affairs
Laboratory Manager
                                  Seated (from left to right)
Mr Lawrence Quek                  Ms Loo Swee Cheng
Support Services Senior Manager
                                  General Manager
Ms Theresa Soon
Department of STI Control         Prof Tan Suat Hoon
(DSC) Manager                     Director

Mrs Tang Lee Foon                 Mr Koh Teck Chee
Head of Pharmacy                  Head of Human Resource

Ms Brenda Lim                     Mr Eric Goh
Head of Nursing                   Quality Manager

Mr Johnny Foo                     A/Prof Chua Sze Hon
                                  Deputy Director
Clinic Operations Manager

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CORPORATE REVIEW FY2018 - National Skin Centre
DIRECTOR’S
MESSAGE
             BREAKING
             NEW GROUND
             2     018 was a very special year for National
                   Skin Centre (NSC) as we celebrated our
                   30th Anniversary, a key milestone for us as
             the National Specialty Centre for Dermatology
             in Singapore since we opened our doors to
                                                                 Accessibility to dermatological care in
                                                                 the community has been increased, from
                                                                 right-siting patients through our General
                                                                 Practitioner (GP) partners and Tele-DERM at
                                                                 polyclinics, to public forums organised by NSC
             serve the public in November 1988. Behind           for raising more awareness on the importance
             our achievements as the national centre in          of good skin care. This will go a long way in
             providing clinical services for skin diseases,      fostering a culture of self-care through self-
             leading in education and research capabilities,     management of their condition, empowering
             it has been the dedication and passion of our       patients and their caregivers to take charge of
             people and staff that have made it possible,        their health within the community.
             many of whom have spent the greater part
             of their working lives from the Middle Road         As an extension of care, the Pharmacist
             Hospital to NSC. To chronicle the growth and        Eczema Clinic service was launched in
             development of Dermatology services as a            August 2018, providing adult patients
             specialty centre in Singapore, we launched          with stable mild eczema the option to be
             a commemorative book titled, Dermatology            referred to this clinic for step down care. This
             in Singapore, at the Singapore Health and           quality improvement initiative can improve
             Biomedical Congress in October 2018.                patient satisfaction with the interaction
                                                                 enhancing medication adherence. As part of
             As we prepare ourselves for a new and bigger        enhancing community care and continuing
             centre by 2022, the groundbreaking ceremony         professional nursing education, NSC’s nurses
             in April 2018 was graced by Senior Minister of      continue to trailblaze dermatological care
             State for Health Dr Amy Khor. It was a befitting    by training nurses, healthcare providers
             occasion to kick off our 30th Anniversary           and the Intermediate and Long-Term Care
             celebrations for the year as we announced the       Setting (ILTC) to increase capabilities in the
             exciting vision of a new medical facility, which    management of dermatological conditions
             will offer enhanced capacity and capabilities       within the community.
             for more comprehensive subspecialty services,
             as well as holistic care that is well-supported     One of NSC’s endeavours is to bring specialist
             by an efficient and seamless physical               care closer to the community, by upskilling
             infrastructure within the Health City @ Novena.     and training the primary care practitioners.
                                                                 Our primary care partners, Family Physicians
             Patients with complex skin diseases will            and GPs are important stakeholders critical
             benefit from NSC’s team-based clinical care,        to the management of skin conditions for
             comprising dermatologists, nurses and allied        the nation. In October 2018, NSC hosted
             health staff. The new NSC’s enhanced research       the Dermatology and Venereology Update
             and education facility will spearhead clinical      conference, providing updates on approaches
             innovations in dermatology and train more
                                                                 to clinical problems, future directions in
             dermatologists and healthcare professionals.
                                                                 dermatology and venereology to hone the
             The expanded facilities will make way for the
                                                                 expertise of dermatology specialists, trainees
             projected increment in medical student intake
                                                                 and GPs.
             from affiliated medical schools, namely Yong
             Loo Lin School of Medicine, National University     Research is key in driving care innovation
             Singapore, Lee Kong Chian School of Medicine,       through positive translational research
             Nanyang Technological University and Duke-          outcomes. The microneedles patch for keloids
             National University Singapore.                      is a transformative treatment procedure that

                                                   04
CORPORATE REVIEW FY2018 - National Skin Centre
NATIONAL SKIN CENTRE

“NSC will continue to break new ground towards providing
holistic dermatological care for our patients and bringing
skin knowledge to the community.”

will benefit patients with keloid conditions,
as suitable patients can opt for this painless
treatment in the comfort of their own homes.
Currently, NSC manages more than 5,000
keloid cases a year.
As a nod to care innovation, Tele-DERM,
the e-consultation platform clinched the
Excellence Award under the Cost Reduction
category in the Asian Hospital Management
Awards in Bangkok, Thailand. This accolade
is a testament to dermatological excellence
at NSC, and the achievement would not
have been possible without the invaluable        Professor
dedication of our staff.                         Tan Suat Hoon
In conjunction with our 30th Anniversary,        Director
community outreach efforts were increased
through a series of volunteering and
fundraising activities for the beneficiary,
Ang Mo Kio Family Service Centre (AMKFSC).
These included a health fair at Yio Chu Kang
Community Club in collaboration with NHGP
in April 2018, and a charity walk – Walk-
Together, held at Bishan-Ang Mo Kio Park in
September 2018 that was graced by Guest-
of-Honour, Speaker of Parliament Mr Tan
Chuan-Jin.
NSC will continue to break new ground
towards providing holistic dermatological care
for our patients and bringing skin knowledge
to the community. We look forward to more
partnerships with other healthcare providers
and community partners to raise awareness
on skin health, as well as early interventions
that reduce the risk of skin diseases.
I am grateful to all who have advanced
dermatological care over the last three
decades and we can only grow stronger as
NSC strides forward in the next lap to provide
high quality and safe care for the nation.
Together, we continue to pursue excellence
in dermatological care.

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CORPORATE REVIEW FY2018 - National Skin Centre
PATIENT CARE                                                     As Singapore’s healthcare
                                                               landscape evolves, ensuring
                                                                   the health of the nation
                                                                  requires care to be more
                                                              integrated and collaborative,
                                                                  expanding networks into
                                                                      the community. NSC
                                                                        continues to strive
                                                                         for dermatological
                                                                     excellence and value-
                                                                            add to patients’
                                                                        well-being through
                                                                             enhanced care
                                                                               delivery and
                                                                                innovation.

                  Patient Care at a Glance
Patient Attendances      Breakdown of Patient Attendances
(FY2018)                 — Top 10 Diseases Seen in 2018
                         DISEASE          FY2016    FY2017    FY2018
                         Dermatitis        18,775   18,039      15,846
                         Benign Skin
                                           7,322     6,804      6,393
                         Tumours
         New
                         Acne              5,786     5,433      4,623
       44,649            Viral Skin
                                           4,353     4,057      3,626
                         Infections
                         Pigmentary
         Total                             3,798     3,604      3,151
                         Disorders
     182,955             Hair Disorders
                         Urticaria
                                           3,020
                                           2,787
                                                     2,792
                                                     2,522
                                                                2,611
                                                                2,352
                         Fungal Skin
                                           2,586     2,442      2,078
        Repeat           Infections
                         Naevi             1,783     1,756      1,698
      138,306            Psoriasis         1,627     1,462      1,665

                         Total number of procedures
                         performed by nurses                 295,256

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CORPORATE REVIEW FY2018 - National Skin Centre
NATIONAL SKIN CENTRE

A Nod to Care Delivery Excellence
NSC’s Tele-Dermatology received regional
recognition at the Asian Hospital Management
Awards 2018 when our submission titled
“Tele-Dermatology Collaboration to Improve
Patients’ Care in Psychiatric Hospital” clinched
the Excellence Award in the Cost Reduction
category.
Piloted by NSC at Hougang Polyclinic in
2016, Tele-Dermatology is an e-consult
service that enables NHGP family doctors to
discuss dermatological cases and treatment
options with NSC specialists in a convenient
and prompt manner. The service has been
scaled up to the Institute of Mental Health,
allowing for the collaboration between
psychiatrists and dermatologists to provide
holistic care that complements mental and
dermatological care for psychiatric inpatients.
By reducing cost and waiting time for patients,      Members of the Tele-Dermatology team - Ngan Ai Khim, Medical Informatics
Tele-Dermatology benefits both the public            & Technology Office Manager; Johnny Foo, Clinic Operations Manager; Dr Pan
and medical sector with care integration at          Jiun Yit, Senior Consultant; Dr Heng Yee Kiat, Consultant; Prof Tan Suat Hoon,
system-level.                                        Director and Ang Li Li, Clinic Operations Assistant Manager.

                                                   Enhanced Capacity with
                                                   Dermatology Ward in New NCID
                                                   Facility
                                                   Patients who suffer from severe eczema,
                                                   psoriasis or immunoderm concerns may
                                                   need to be warded for inpatient care and
                                                   intensive topical therapy. This is especially
                                                   important for patients whose conditions
                                                   need to be controlled with initiation of
                                                   immunosuppressive therapy, biologic therapy
                                                   or require intensive skin treatment of wounds
                                                   by multidisciplinary dedicated teams.
                                                   The opening of the new dermatology
                                                   ward in the National Centre for Infectious
                                                   Diseases (NCID) marks the transition from the
                                                   dermatology ward in Communicable Disease
                                                   Centre’s (CDC) Ward 72, where inpatients
                                                   were previously hospitalised since NSC
                                                   started its operations in 1988.
                                                   In December 2018, we bade farewell to the
                                                   CDC ward and moved to NCID, located next
                                                   to Tan Tock Seng Hospital. With an increased
                                                   capacity of 20 beds, dermatology inpatients
                                                   can now receive higher levels of care and
                                                   improved facilities.

                                                          Medical staff attending to a patient at the
                                                         Dermatology Ward in the new NCID Facility.

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CORPORATE REVIEW FY2018 - National Skin Centre
Eczema Support Group
As part of public education, NSC’s Eczema        Senior Consultant and NSC nurses, along with
Public Forum organised by the Eczema Support     sharing sessions on various topics such as
Group saw a huge turnout and a significant       “Different Ways to Shower/Bathe”, “Secondary
increase in membership for the Eczema            Infections Affecting Eczema Skin” and “Habits
Support Group, with over 40 participants         that Sabotage Your Skin”.
signing up as new members.
Held at Raffles City Convention Centre on
27 October 2018, participants spent an
insightful afternoon learning more about
eczema, while new Eczema Support Group
members shared their stories on living with
the skin condition.
The Eczema Support Group also provided
ongoing support for members which included
educational talks and care management
tips by Dr Eugene Tan, Consultant, Dr Yew          Sister Wong Bee Yin, Senior Nurse Educator,
Yik Weng, Consultant, Dr Madeline Ho,              sharing on skin conditions.

Nurses in Community Care
As part of NSC’s ongoing efforts to enhance      Partnered the Singapore Nurses Association to
community care, NSC’s Nursing Department         support ongoing Toa Payoh West Community
continues to collaborate with community          Club-organised events:
partners on educating and equipping them         • Monthly outreach (January to May 2018)
with expertise for care continuity. NSC nurses      providing nail-cutting and skin education
also play an active role in public education,       services to seniors living in rental apartments
creating more awareness in the community on         at Toa Payoh West
the care and management of dermatological
conditions.                                      • Art painting and health screening for senior
                                                    citizens on 5 May 2018
Collaborations with Nursing Homes
                                                 NSC doctors and nurses supported the World
• Apex Harmony Lodge                             Psoriasis Day event on 28 October 2018 to
• Bright Hill Evergreen Home                     raise public awareness on Psoriasis.
• Institute of Mental Health (IMH)
• Lions Homes for the Elders (Bedok)
• Lions Homes for the Elders (Bishan)
• St Andrew’s Nursing Home

Transitional Care for Patients
Pharmacist Eczema Clinic
To provide more accessible care for the
convenience of patients, the Pharmacist
Eczema Clinic service was launched on
August 2018. Adult patients with stable mild
eczema who are ready for step down care
have an option to be seen at this clinic by
pharmacists, when assessed to be suitable by
the dermatologists.
Trained pharmacists are on hand to provide          NSC pharmacist providing counsel to patient.
clinic consultation to optimise disease
management through titration of topical          approach, pharmacists will play an impactful
corticosteroids, oral antihistamines and other   role in improving patient outcomes and
topical preparations. Through this team-based    enhancing medication adherence.
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NATIONAL SKIN CENTRE

                                                   and promote sexual health among patients.
                                                   The psychotherapist provides in-depth
                                                   counselling and therapy aimed at promoting
                                                   safe and healthy sexuality.
                                                   Counselling topics include:
                                                   • Relationship issues with partner
                                                   •C
                                                     oping with life stressors and transitions
                                                   • C oping after a Sexually Transmitted
                                                      Infection (STI) diagnosis
                                                   • Discussing risk-taking behaviours such as
                                                      drug use and unprotected sex
  Psychotherapy counselling session in progress.
                                                   • Exploring gender-specific sexual issues
Going Beyond Care                                  • Lesbian, Gay, Bisexual, Transgender and
                                                      Questioning (LGBTQ)-specific issues, etc.
The Department of STI Control launched
the Psychotherapy Counselling Services in          A few sessions with the psychotherapist can
July 2018, offering professional sexual health     help patients gain clarity and work through
counselling by a psychotherapist as part of        the issues that affect them. All sessions are
DSC’s ongoing efforts to expand services           fully non-judgmental and supportive.

Care Improvement for                               Using quality improvement tools from the
Patient Safety                                     CPIP, a team of pharmacists and pharmacy
                                                   technicians, as well as a doctor, reviewed
                                                   the process steps for dispensing and patient
                                                   administration, successfully implementing
                                                   interventions, which reduced the number
                                                   of Prednisolone-related dispensing and
                                                   administration errors to zero within six months.
                                                   Prednisolone, an oral corticosteroid, is typically
                                                   prescribed in a tapering/reducing regimen over
                                                   a few days or weeks, to prevent withdrawal
                                                   symptoms from abrupt discontinuation of the
                                                   drug. Prednisolone tapering dosing error is
  NSC Pharmacy Team.                               one of the most common medication errors
                                                   reported in pharmacy. This quality improvement
The Clinical Practice Improvement Programme        initiative demonstrates the commitment to
(CPIP) aims to enhance care and patient            care that underpins NSC’s interprofessional,
safety through active review of workflows.         multidisciplinary care delivery.

Nursing Care Transformation
The NSC Dermatological Nursing Competency          care practices to enhance patient skin
Framework serves as a training guide for           treatments and care. Nurse-led services in
nurses, to upgrade their skills and promote        Sexually Transmitted Infections (STI), Warts,
lifelong learning. Through this framework,         MMR Injections, Paediatric and Surgical
nurses are responsible for their individual        Reviews have also substituted the demand
skills upgrading and career planning to excel      for medical physicians to perform reviews of
as a professional dermatological nurse. NSC        stable patients, resulting in shorter waiting
nurses trained 1,086 Intermediate and Long-        time at clinics.
term Care (ILTC) nurses on dermatological

                                                          09
ADVANCING RESEARCH
EXCELLENCE                                                     As a pivotal centre for clinical
                                                                  and translational research,
                                                                      NSC strives to improve
                                                                   dermatological treatment
                                                                through advancing research
                                                                        and care innovation.

    Global Translational Impact                         on Adj A/Prof Tey Hong Liang,
    Dissolving Microneedles for the                     Senior Consultant. Adj A/Prof Tey,
    Treatment of Keloids                                together with researchers from NSC,
                                                        developed an innovative method
    Keloid scars can be unsightly, painful and          that uses dissolving microneedles
    itchy. A large keloid in the skin over a joint      — each about 100 times smaller than
    may even interfere with joint function. NSC         the needle used for conventional keloid
    patients with keloid scars, who are not able        injections — to administer the medication,
    to tolerate conventional treatment, now have        triamcinolone, onto the affected area without
    the option of a painless treatment. Under the       pain. The triamcinolone-embedded dissolving
    Transition Award funding from the Singapore         microneedle patch is a world-first.
    National Medical Research Council conferred
                                                        NSC manages more than 5,000 keloid cases
                                                        a year. Patients who wish to shrink their
                                                        keloid scars make monthly visits to NSC
                                                        for triamcinolone injections, which require
                                                        regular doses for the treatment to be effective.
                                                        However, this treatment is painful and deters
                                                        some patients, particularly children, who are
                                                        unable to withstand the pain of injections.
                                                        The novel dissolving microneedle patch now
                                                        addresses this unmet clinical need.
                                                        In the clinical trial, patients self-administered
                                                        the triamcinolone-embedded dissolving
      A photo of the microneedle patch containing       microneedle patch to one of their keloids
      triamcinolone, a type of steroid used to manage   daily over four weeks, with another keloid left
      keloids.                                          untreated to function as a control. Using a

                                             10
NATIONAL SKIN CENTRE

3D scanner to assess keloid volume, the team
found a significant reduction in the size of
keloids after treatment, with higher doses of
triamcinolone leading to greater reduction. The
study has been published in Dermatology and
Therapy, a Springer Nature journal.                                          Photo
Designed for one-time use, the dissolving
microneedle patch takes mere minutes to
apply and can be self-administered by patients
at home. This saves patients the time and
cost of travelling to NSC to undergo keloid
injections by the healthcare team. The self-
management nature of this treatment also
means that patients are able to treat their
keloid scars effectively and conveniently, even   Adj A/Prof Tey Hong Liang, Senior Consultant and Head of Research, NSC,
while overseas.                                   applying a microneedle patch on a patient.

Milestone Research Studies                        cells, and explain what triggers the ageing
                                                  process. Positive results and data have
2018 saw a plethora of research undertaken        been obtained, and future studies aim to
at NSC to improve care. The following are key     include additional variables to strengthen
research studies that can transform care for      these results. This study was funded by
dermatological conditions:                        A*STAR-NHG-NTU Skin Research Grant.
   he Social and Economic Burden of
  T                                                aman Confocal Microscopy and
                                                  R
  Atopic Dermatitis Among Children                High-Resolution Raster Scanning
  in Singapore — Establishing a                   Optoacoustic Mesoscopy in Patients
  Longitudinal Study Cohort                       with Atopic Dermatitis (Dr Yew Yik
  (Dr Yew Yik Weng and Team)                      Weng and Team)
  Funded by A*STAR-NHG-NTU Skin Research          This study is carried out to find out if
  Grant, this study aimed to measure the          two systems — the Raster-Scanning-
  burden that paediatric Atopic Dermatitis        Optoacoustic-Mesoscopy (RSOM) and
  (AD) places on patients and their families.     handheld confocal raman system — are
  Factors taken into account are the health-      useful in determining the chemical
  related quality of life (HRQoL), utilisation    changes in the skin of patients with
  of healthcare services, informal caregiving     Atopic Dermatitis (AD), and whether
  and the relevant out-of-pocket expenses.        that correlates well with skin physiology
  Findings of this study will provide better      measurements. The RSOM is a non-invasive
  insights into how the condition negatively      method of imaging that makes use of a
  affects the patient and caregiver, as well as   laser and detection system to create an
  a glimpse into the possible financial burden    image of the superficial blood vessels of
  imposed.                                        the skin. The confocal raman system is a
                                                  high-resolution imaging technique which
   he Role of Cellular Senescence
  T                                               can look non-invasively at the chemical
  in Age-Related Hair Depigmentation              compounds and distribution in the skin.
  (Dr Joyce Lee and Team)                         Success of this pilot study can pave the
  Senescent cells may contribute to the           way for characterising and managing AD,
  disease etiology of premature ageing            providing a deeper understanding of the
  syndromes such as Werner syndrome               condition in ways current dermatological
  or Hutchinson-Gilford Progeria as they          imaging techniques are unable to. This
  accumulate prematurely in afflicted tissues.    study is done in collaboration with
  This study is carried out to determine          Singapore Bioimaging Consortium (SBIC),
  how cell ageing impairs the functionality       Biomedical Sciences Institutes.
  (pigment production and transfer) of human
                                                       11
 alidation of an Algorithm that
                           V                                                mechanistic pathways and drug discovery
                           Automatically Segment and Calculate              for chronic inflammatory skin diseases.
                           the Area Affected by Vitiligo on the             NSC is supporting the efforts with clinical
                           Trunk of Patients for Assessment of              expertise and well-characterised cohorts
                           Extent of Disease and Response to                of patients with skin disorders. Moderate to
                           Treatment in Patients with Vitiligo (Dr          severe Atopic Dermatitis (AD) patients are
                           Anjali Jhingan and Team)                         recruited into the study to evaluate their
                           Current treatments available for vitiligo are    immunophenotypic profile in serum and
                           limited by intra-observer and inter-observer     skin biopsies. In addition, information on
                           variability. Funded by NHG Small Innovative      detailed AD clinical characteristics and skin
                           Grant (SIG), this study seeks to develop and     physiological measurements are collected
                           validate a scoring system using computer         in the study, and will go a long way for
                           image analysis of photographs from the           the development of possible enhanced
                           body trunk area to enable clinicians to          therapeutics.
                           standardise vitiligo severity and treatment
                           outcome measurements in an easy and               esearch Accolades
                                                                            R
                           reproducible manner. Subsequent findings         NSC doctors, along with a student, clinched
                           demonstrated efficiency of the automated         four awards in the scientific competition
                           scoring system, enabling a novel approach        at the Singapore Health & Biomedical
                           that is consistent and reliable. The algorithm   Congress 2018, graced by Mr Gan Kim
                           is an efficient tool in standardising severity   Yong, Minister for Health. Dr Kenneth Fong,
                           scoring for clinical practice.                   Senior Resident and team won Best Poster
                                                                            Award (Gold) for their work on assessing
                            ollaboration with International
                           C                                                how MMP14 may affect the pathogenesis
                           Research Partners                                of acne vulgaris. Dr Cao Taige, Senior
                           Scientists and clinicians from Singapore         Resident, clinched the Singapore Young
                           institutes, namely NSC, Skin Research            Investigator Award (Merit) for his study
                           Institute Singapore (SRIS) and A*STAR,           on the pathophysiology of itch in Atopic
                           are collaborating with C&C Research              Dermatitis.
                           Laboratories to research on new

Research Collaboration Agreement Ceremony.
Photo Credit: Agency for Science, Technology and Research.

                                                               12
NATIONAL SKIN CENTRE

     Award Category                      Name                          Title of study                             Results

  SHBC Best Poster Award —                                   Assessing the Role of MMP14 in the
                                       Dr Kenneth                                                                     GOLD
  Basic Science/Translational                                Pathogenesis of Acne Vulgaris Using
                                          Fong
  Research                                                       Sebocyte Organoid Models

  SHBC Singapore Young                                          Pathophysiology of Itch in Atopic
  Investigator Award                                            Dermatitis: A 3-Dimensional Study
                                       Dr Cao Taige                                                                  MERIT
  Basic Science/Translational                                     of IL-31 and its Receptors and
  Research                                                            Cutaneous Innervation

                                        Ms Claudia
                                                                                                                      BRONZE
                                       Koh Tze Min,         Serum Carcinoembryonic Antigen as a
  SHBC Student Award
                                      Adj A/Prof Tey            Clinical Marker in Hypohdrosis
                                       Hong Liang

                                      Dr Cao Taige,                                                                BEST LETTER
                                                            Anti-Pruritic Efficacies of Doxycycline                TO EDITOR
                                        Dr Eugene                                                                  2018
                                                            and Erythromycin in the Treatment of
  IJDVL International Award           Tan Sern Ting,
                                                            Acne Vulgaris: A Randomized Single-
                                      Adj A/Prof Tey
                                                                     Blinded Pilot Study
                                       Hong Liang

Research and Development
Immunology Lab
Project title: Prospective Study on Serum
Antibodies Against Target Antigens of
Bullous Autoimmune Diseases and Genetic
Susceptibility
Project period: 2017-2019
The objective of this project is to compare
current Indirect Immunofluorescence method
of testing patients with autoimmune blistering
diseases using an innovative biochip. The
biochip is potentially a more efficient method
and thus accelerates the diagnosis of such
patients.                                             NSC Laboratory staff at the Centre’s Clinical Laboratory.

                                                           13
Research Report                                           Research Studies
                           Only through research and innovation can NSC                  in 2018
                           push the frontiers of skin health by translating
                           scientific knowledge and research findings into
                           innovative solutions for patients.
                           In 2018, there were a total of 105 ongoing
                           research projects, including 21 new studies
                                                                                                      43%
                           initiated in the same year. Key milestones
                           included the introduction of a novel treatment
                           (Keloid Micro-dissolving Needles Patch) and
                           the commercialisation of our products by
                           partners to enhance care.                                33%
                                 Clinical Research                                                         14%
                                 Epidemiological

                                 Laboratory-based                                               10%
                                 Translational

Research Publications in FY2018
Preliminary Validation of the HS-QoL: A                                                      Journal of Cutaneous
                                                   Chelsea McLellan, Mia Sisic,
Quality-of-Life Measure for Hidradenitis                                                     Medicine and Surgery
                                                   Hazel Oon HB and Jerry Tan
Suppurativa                                                                                2018 Mar/Apr;22(2):142-146
                                                                                          Journal of the German Society
                                                  Kok Wai Leong, Tey Hong Liang
A Tale of Two “Half Tongues”                                                                     of Dermatology
                                                       and Lucinda Tan SY
                                                                                             2018 Apr;16(4):485-486
A Case Report of Granulomatous                     Kok Wai Leong, Hazel Oon HB             Singapore Medical Journal
Rosacea of the Face                                    and Giam Yoke Chin                    2018 Apr;59(4):228-229
Pemphigus Herpetiformis with
                                                   Evelyn Tay YX, Joyce Lee SS        Clinical and Experimental Dermatology
Autoantibodies to Desmocollins
                                                        and Lim Yen Loo                       2018 Apr;43(3):360-362
1, 2 and 3
Interstitial Granulomatous
                                                  Valencia Long CL, Tan Weisheng,   The American Journal of Dermatopathology
Variant of Scleromyxedema—
                                                 Joyce Lee SS and Steven Thng TG             2018 Apr;40(4):279-282
A Diagnostic Pitfall
                                                                                                  Springer Link
Metal Allergy in Asia                       Anthony Goon TJ, Chen J and Thyseen J
                                                                                               2018 Apr 14;515-520
                                                 Kok Wai Leong, Stephanie Ho GY     The American Journal of Dermatopathology
Multiple Papules on the Penis: Challenge
                                                       and Tee Shang-Ian                    2018 May;40(5):e62-e63
The Effectiveness of a Pharmacist-Led
                                                 Lee Shan Xian, Chong Wei Sheng,
Sun Protection Counselling Service:                                                       Annals Academy of Medicine
                                                  Lauw Xiu Ting, Tan Siew Kiang
Results from a Tertiary Dermatology                                                         2018 May;47(5):196-200
                                                        and Hazel Oon HB
Centre in Singapore
Clinical Characteristics and Management
of Patients with Rosacea in a Tertiary            Chong Kah Wai, Yew Yik Weng,         International Journal of Dermatology
Dermatology Center in Singapore from               Lai Yi Chun and Roy Chan                  2018 May;57(5):541-546
2009 to 2013
                                                   See Jo-Ann, Goh Chee Leok,
Optimising the Use of Topical Retinoids                                                      Journal of Dermatology
                                                  Hayashi Nobukazu, Suh Dae Hun
in Asian Acne Patients                                                                       2018 May;45(5):522-528
                                                        and Casintahan FA

                                                                  14
NATIONAL SKIN CENTRE

                                                    Sophie Nguyen, Chuah Sai Yee,
Atorvastatin in Combination with
                                                     Eric Fontas, Abdallah Khemis,                    JAMA Dermatology
Narrowband UV-B in Adult Patients with
                                                    Anjali Jhingan, Steven Thng TG                 2018 Jun 1;154(6):725-726
Active Vitiligo: A Randomized Clinical Trial
                                                         and Thierry Passeron
The Genetics of Chronic Itch: Gene              Nattkemper Leigh A, Tey Hong Liang,
Expression in the Skin of Patients with             Valdes-Rodriguez R, Helen Lee,            Journal of Investigative Dermatology
Atopic Dermatitis and Psoriasis with           Mollanazar Nicholas K, Albornoz Christian,          2018 Jun;138(6):1311-1317
Severe Itch                                     Sanders Kristen M and Yosipovitch Gil
                                                  Goh Chi Ching, Evrard Maximilien,
                                                    Chong Shu Zhen, Tan Yingrou,
The Impact of Ischemia-Reperfusion
                                                   Leonard Tan DL, Karen Teng WW,              European Journal of Immunology
Injuries on Skin Resident Murine
                                                 Weninger Wolfgang, Becker David L,                2018 Jun;48(6):1014-1019
Dendritic Cells
                                                 Tey Hong Liang, Newell Evan William,
                                                       Liu Bin and Ng Lai Guan
An Abstinence and Safer Sex Intervention
                                                     Junice Ng YS, Roy Chan KW,
for Adolescents Attending the Public                                                             Journal of Adolescent Health
                                                   Martin Chio TW, Raymond Lim BT,
Sexually Transmitted Infection Clinic in                                                           2018 Jun;62(6):737-746
                                                    David Koh and Wong Mee Lian
Singapore
                                                 Wang Dingyuan, Vanessa Chong CL,           American Journal of Clinical Dermatology
A Review on Pityriasis Rubra Pilaris
                                                 Chong Wei Sheng and Hazel Oon HB                   2018 Jun;19(3):377-390
Clinical Experience of Adalimumab in                                                             Indian Journal of Dermatology,
                                                   Mandy Chan WM, Hazel Oon HB
the Treatment of Psoriasis — A 10-Year                                                             Venereology and Leprology
                                                      and Chong Wei Sheng
Journey in a Tertiary Dermatology Centre                                                              2018;84(2):205-208
Disseminated Herpes Simplex Virus and                                                            Indian Journal of Dermatology,
Varicella Zoster Virus Co-Infection in an        Vanessa Lim ZY and Tey Hong Liang                 Venereology and Leprology
Immunocompetent Patient                                                                                2018;84(2):212-214
Classification of Non-Tumorous
                                               Liang Yunfeng, Sun Lei, Ser Wee, Lin Feng,
Skin Pigmentation Disorders Using                                                             Computers in Biology and Medicine
                                                     Steven Thng TG, Chen Qiping
Voting Based Probabilistic Linear                                                                  2018 Jun 5;99:123-132
                                                           and Lin Zhiping
Discriminant Analysis
Indeterminate Cell Histiocytosis in a
                                                    Chen Qiping, Joyce Lee SS,
Chinese Patient with Progressive and
                                                Michelle Liang WT, Michelle Chan MF,            Journal of Cutaneous Pathology
Extensive Nodular Lesions and Mixed
                                                   Ramon M. Pujol, Requena Luis                     2018 Jun;45(6):428-433
Indeterminate Cell and Macrophage-
                                                         and Tan Suat Hoon
Monocyte Lineage
The Association between Quality of Life
                                                  Ryan Chua RY, Jacqueline Cleator,                 Dermatological Nursing
and Self-Care in Singaporeans Living
                                                  Malcom Campbell and Brenda Lim                     2018 Jun;17(2):18-26
with Psoriasis
Automated Scoring of Vitiligo Using
Superpixel-Generated Computerized               Joseph Toh JH, Bhoi S, Virlynn Tan WD,
                                                                                                 British Journal of Dermatology
Digital Image Analysis of Clinical                  Chuah Sai Yee, Anjali Jhingan,
                                                                                                      2018 Jul;179(1):220-221
Photographs: A Novel and Consistent Way          Adams Kong WK and Steven Thng TG
to Score Vitiligo
Chronic Pruritus in the                               Cao Taige, Tey Hong Liang                      Dermatologic Clinics
Geriatric Population                                     and Yosipovitch Gil                         2018 Jul;36(3):199-211
Recalcitrant Psoriasiform Dermatosis
                                                      Emily Gan YP, Ng See Ket,                 Journal of Cutaneous Pathology
of the Face: Is It Related to Pityriasis
                                                   Goh Chee Leok and Joyce Lee SS                   2018 Jul;45(7):491-497
Rubra Pilaris?
                                                                                                    Hong Kong Journal of
Approach to Pigmented Skin
                                                            Giam Yoke Chin                        Dermatology & Venereology
Disorders in Children
                                                                                                       2018;26:113-121

                                                                15
Research publications in FY2018
Sebaceous Neoplasms with Rippled,
Labyrinthine/Sinusoidal, Petaloid, and            Wiedemeyer K, Kyrpychova L
Carcinoid-Like Patterns: A Study of 57         Isikci OT, Spagnolo DV, Kutzner H,
                                                                                                  The American Journal of
Cases Validating Their Occurrence as a         Rutten A, Fernandez-Figueras M,
                                                                                                     Dermatopathology
Morphological Spectrum and Showing             Denisjuk N, Suster S, Pavlovsky M,
                                                                                                   2018 Jul;40(7):479-485
No Significant Association with Muir-         Petersson F, Michal M, Joyce Lee SS,
Torre Syndrome or DNA Mismatch Repair                 Kerl K and Kazakov DV
Protein Deficiency
Delusion of Parasitosis:                       Su Peiqi, Teo Wan Lin, Pan Jiun Yit,                 Annals Academy of
A Descriptive Analysis of 88 Patients          Chan Keen Loong, Tey Hong Liang                      Medicine Singapore
at a Tertiary Skin Centre                             and Giam Yoke Chin                           2018 Jul;47(7):266-268
                                                                                                  Journal of Psoriasis and
                                                  Ashley Chen, Kristen M. Beck
Stigmatization in Psoriasis                                                                          Psoriatic Arthritis
                                                      and Eugene Tan ST
                                                                                                   2018 Jul;3(3):100-106
Anti-Pruritic Efficacies of Doxycycline
                                                  Cao Taige, Eugene Tan ST,                    Indian Journal of Dermatology,
and Erythromycin in the Treatment of
                                                Chan Yiong Huak, Gil Yosipovitch                 Venereology and Leprology
Acne Vulgaris: A Randomized Single-
                                                     and Tey Hong Liang                          2018 Jul-Aug;84(4):458-460
Blinded Pilot Study
A Mixed Methods Study of Non-
Occupational Post-Exposure Prophylaxis
                                                  Alvin Teo KJ, Tai Bee Choo,                            PLoS One
at an STI Clinic in Singapore: Five-Year
                                                Martin Chio TW and La Hanh Hao                    2018 Aug;13(8):e0202267
Retrospective Analysis and Providers’
Perspectives
Unusual Cutaneous Manifestation of               Agnes Chan WS, Joyce Lee SS,               Australasian Journal of Dermatology
Dermatomyositis                                  Ng See Ket and Hazel Oon HB                    2018 Aug;59(3):e228-e230
A Population-Based Cohort Study of
                                                  Kok Wai Leong, Yew Yik Weng               International Journal of Dermatology
Atopic Eczema Among Young Adult Males
                                                      and Steven Thng TG                           2018 Aug;57(8):e52-e54
in Singapore
Use of Silicone Gel to Enhance Skin
Wound Healing by Secondary Intention                    Angeline Yong AN                   Clinical and Experimental Dermatology
Following Tumour Excision on the Scalp                 and Goh Chee Leok                           2018 Aug;43(6):723-725
and Extremities
                                                Melissa Chan MH, Daryl Tan JA,                       Lancet Oncology
Blistering Langerhans Cell Histiocytosis
                                                Mark Koh JA and Lucinda Tan SY                      2018 Sep;19(9):e500
Nanostring Analysis of Skin Biopsies from    Tan Yingrou, Jackson Li LY, Bernett Lee
Patients with Henoch-Schönlein Purpura        TK, Josephine Lum, Dwi Pramono ZA,                Acta Dermato Venereologica
Reveals Genes Associated with Pathology       Evrard Maximilien, Poidinger Michael,              2018 Oct 10;98(9):896-897
and Heterogeneity in the Disease Process        Tey Hong Liang and Ng Lai Guan
                                             Tan Chee Hian, Kuan LY, Heng Yee Kiat
A Polymorphous Rash of an Uncommon                                                         Clinical and Experimental Dermatology
                                                  Pan Jiun Yit, Tee Shang Ian,
Blistering Disease                                                                                  2018 Oct;43(7):839-842
                                                   Lim Yen Loo and Tan LS
Methotrexate for the Treatment of
                                                    Stull CM, Tey Hong Liang                    Acta Dermato Venereologica
Recalcitrant Primary Localized Cutaneous
                                                       and Yosipovitch Gil                       2018 Oct 10;98(9):900-901
Amyloidosis: A Case Series
                                             Rayner Tan KJ, Christina Wong M, Mark
Chemsex Among Gay, Bisexual, and
                                             Chen I-Cheng, Chan Yin Ying, Muhamad
Other Men Who Have Sex with Men in                                                           International Journal of Drug Policy
                                            Alif Bin Ibrahim, Oliver Lim ZK, Martin Chio
Singapore and the Challenges Ahead:                                                                   2018 Nov;61:31-37
                                              TW, Wong Chen Seong, Roy Chan KW,
A Qualitative Study
                                              Lynette Chua J and Bryan Choong CH
A Retrospective Clinico-Pathological             Cheng Hui Mei, Chuah Sai Yee,
                                                                                            Australasian Journal of Dermatology
Study Comparing Lichen Planus                     Emily Gan YP, Anjali Jhingan
                                                                                                  2018 Nov;59(4):322-327
Pigmentosus with Ashy Dermatosis                     and Steven Thng TG

                                                                   16
NATIONAL SKIN CENTRE

Hydroa Vacciniforme-Like
Lymphoproliferative Disorder in an Elderly     Valencia Long CL, Michelle Liang WT        International Journal of Dermatology
Chinese Patient and a Literature Review of              and Tan Suat Hoon                       2018 Nov;57(11):1283-1292
Adult Cases
                                              Sulekha Kumari, Steven Thng TG, Navin          Acta Dermato Venereologica
Melanogenesis Inhibitors
                                               Kumar Verma and Hemant K. Gautam               2018 Nov 5;98(10):924-931
                                                   Yew Yik Weng, Zheng Qishi,
                                                                                                 Cochrane Database of
Topical Treatments for Eczema: A Network         Kok Wai Leong, Madeline Ho SL,
                                                                                                  Systematic Reviews
Meta-Analysis                                Jeremy Teoh, Yoko Wong KY, Shi Luming
                                                                                                   2018 Dec 4;12:1-27
                                                      and Edwin Chan SY
Can We End the Human
                                                                                               Ann Acad Med Singapore
Immunodeficiency Virus (HIV) in                            Roy Chan KW
                                                                                               2018 Dec;47(12):499-501
Singapore?
Psychological Profile of Patients                 Derek Lim SY, Anthony Bewley                 Ann Acad Med Singapore
with Psoriasis                                         and Hazel Oon HH                         2018 Dec;47(12):516-522
Sunburns and Sun-Protective Behaviors                                                                 Skinmed
                                                  Lai Yi Chun and Yew Yik Weng
After a Diagnosis of Melanoma                                                                  2018 Dec 21;16(6):379-383
                                                Hasan Erbil Abaci, Abigail Coffman,
Tissue Engineering of Human Hair                    Yanne Doucet, James Chen,
                                                                                                Nature Communications
Follicles Using a Biomimetic                      Joanna Jackow, Etienne Wang,
                                                                                                  2018 Dec 13;9:5301
Developmental Approach                              Guo Zongyou, Jung U. Shin,
                                             Colin A. Jahoda and Angela M. Christiano
Serum Carcinoembryonic Antigen as a             Claudia Koh TM, Douglas Leong Y           International Journal of Dermatology
Clinical Marker in Hypohidrosis                       and Tey Hong Liang                        2018 Dec;57(12):e162-e164
                                                Tan C, Yeo Chen Long D, Cao Taige,
Drug-Free Microneedles in the Treatment
                                             Virlynn Tan WD, Srivastava R, Yow Ai Ping,      British Journal of Dermatology
of Keloids: A Single-Blinded Intra-
                                               Tan Wei Ping, Damon Wong WK, Xu C                2018 Dec;179(6):1418-1419
Individual Controlled Clinical Trial
                                                        and Tey Hong Liang
                                               Mar Llamas-Velasco, Werner Kempf,
Multiple Eruptive Epithelioid
                                               Carlo Cota, M T Fernandez-Figueras,              The American Journal of
Hemangiomas: A Subset of Cutaneous
                                                  Joyce Lee SS, Gerardo Ferrara,                   Surgical Pathology
Cellular Epithelioid Hemangioma with
                                                Christian Sander, Philip E. Shapiro,              2019 Jan;43(1):26-34
Expression of FOS-B
                                                 Luis Requena and Heinz Kutzner
Impact of a Pharmacy-Led                           Cheng Hui Mei, Coni Liu WC,
                                                                                              Singapore Medical Journal
Smoking Cessation Clinic in a                   Germaine Chua, Liew Choon Fong,
                                                                                                 2019 Jan;60(1):31-33
Dermatology Centre                           Winnie Li, Winnie Choo and Hazel Oon HB
Acitretin-Altered Squamous Cell                    Koh Wei Liang, Hazel Oon HB                   Dermatologic Surgery
Carcinoma: A Pitfall in Diagnosis                      and Melissa Tan WP                        2019 Feb;45(2):311-313
Overexpression of CDC42SE1 in A431 Cells
                                             P Kalailingam, Tan Hui Bing, Pan Jiun Yit,                 Cells
Reduced Cell Proliferation by Inhibiting
                                                 Tan Suat Hoon and T Thanabalu                     2019 Feb;8(2):117
the Akt Pathway
A Systematic Review and Meta-Analysis of
                                                                                               Journal of the American
the Regional and Age-Related                     Yew Yik Weng, Thyssen Jacob P.
                                                                                               Academy of Dermatology
Differences in Atopic Dermatitis Clinical          and Silverberg Jonathan I.
                                                                                                2019 Feb;80(2):390-401
Characteristics
Idiopathic Generalized Exfoliative
Dermatitis and Association with                   Cheong Kah Wai, Yew Yik Weng                       Dermatology
Antihypertensive Drugs and Statins:                   and Tey Hong Liang                        2019 Feb;235(2):107-111
A Retrospective Case-Control Study

                                                               17
Research Grants
Research is the key to clinical innovation and advancement. Collaboration and support from partners catalyses
NSC’s translational research, bringing it closer from bench-to-bedside to improve patients’ lives.
In FY2018, the following new inter-institutional and national grants were accorded to NSC:

                                     Principle         Collaborating                                  Amount
 Project Title                                                             Name of Grant                             Grant Period
                                     Investigator      Institutes                                     Awarded

                                                                           Health for Life in
 Characterisation of Adult Atopic                                          Singapore-Early Disease
                                     Dr Yew            LKC School of                                                 2 Aug 2018 –
 Dermatitis in Singapore using a                                           Cohort (HELIOS-EDC)        $200,000
                                     Yik Weng          Medicine                                                      1 Aug 2021
 Longitudinal Case Cohort                                                  Studies Research Grant
                                                                           Award

                                                                           FY2018 NHG-
                                                                                                      $180,000
 Role of Macrophages in Human        Dr Etienne                            LKCMedicine Clinician-                    15 Feb 2019 –
                                                       SRIS                                           and 0.4FTE
 Hair Cycling and Alopecia           Wang                                  Scientist Career Scheme                   14 Feb 2022
                                                                                                      funding
                                                                           (CSCS)

                                                       A*STAR and          FY2018 NHG-                $9,000
 Role of Asporin in the Tumour
                                     Dr Wong           Kyoto University    LKCMedicine Clinician-     (Project)      1 Jul 2018 –
 Microenvironment of Basal Cell
                                     Yisheng           Graduate School     Scientist Preparatory      + $2,000       30 Jun 2019
 Carcinoma
                                                       of Medicine         Programme (CSPP)           (Training)

 Elucidation of Histopathologic
                                                       A*STAR and          FY2018 NHG-                $8,990
 and Immunopathologic
                                     Dr Cheng          Kyoto University    LKCMedicine Clinician-     (Project)      1 Jul 2018 –
 Differences between Intrinsic and
                                     Hui Mei           Graduate School     Scientist Preparatory      + $2,000       30 Jun 2020
 Extrinsic Atopic Dermatitis using
                                                       of Medicine         Programme (CSPP)           (Training)
 Multimodal Skin Imaging

 Testing the Efficacy of Yolk
 Lecithin Liposome-Based                                                   Skin Innovation Grant                     1 Oct 2018 –
                                     Dr Hazel Oon      A*STAR, IMB                                    $49,908
 Moisturizer in Alleviating Atopic                                         (SIG)                                     30 Sep 2020
 Dermatitis

 Three-Dimensional                   Adj A/Prof Tey                        NHIC Innovation to
                                                       A*STAR
 Representation of Skin Structure    Hong Liang                            Protect (I2P)

 Targeting of Melanocytes for
                                     Adj Prof
 Delivering Therapeutics Using                                             NHIC Innovation to
                                     Steven Thng       NTU
 Protein Nanocages Decorated                                               Protect (I2P)
                                     Tien Guan
 with Multiple Ligands

A*STAR: Agency for Science and Technology, SRIS: Skin Research Institute of Singapore, NTU: Nanyang Technological University, IMB:
Institute of Medical Biology and CGH: Changi General Hospital

                                                                     18
NATIONAL SKIN CENTRE

Highlights from the Lab

                       Quality Benchmarks
                       To improve quality standards at the Immunology Lab, NSC has subscribed to UK NEQAS
                       under the Mohs Procedure Pathology Programme, held six times a year. Submission of stained
                       Haematoxylin and Eosin frozen Mohs sections include specimens from cutaneous, mucosal,
                       cartilaginous and hair-bearing areas. Various quality standards are assessed, including the
                       presence of tumour within the specimen, and extent of margin clearance.

                       Improved Facilities and Equipment
                       T he Histopathology Lab acquired a new automated special stainer for the running of
                        histochemical stains. This has improved the quality of staining, contributed to a more efficient
                        workflow, and improved the overall quality of the dermatopathology service.

                       Education and Training
                       To provide educational and training opportunities to non-laboratory staff, NSC hosted
                       Micrographic Surgery practical attachments for nurses of NSC’s Advanced Dermatology
                       Nursing Course to harness knowledge on surgical techniques. Practical attachments to learn
                       techniques in skin scraping are also offered to staff from the Institute of Mental Health at the
                       clinical laboratory.

Laboratory Report
Summary of laboratory investigations (Microbiology, Histopathology, Immunology, Biochemistry, Haematology and
others) conducted:

                                  1 Apr 2016 – 31 Mar 2017     1 Apr 2017 – 31 Mar 2018     1 Apr 2018 – 31 Mar 2019

 TYPE OF INVESTIGATIONS                   FY2016                       FY2017                        FY2018

 MICROBIOLOGY                              40,818                       40,103                        39,433

 HISTOPATHOLOGY                           133,366                       136,584                      143,060

 IMMUNOLOGY                               130,274                       127,540                      127,952

 BIOCHEMISTRY                              69,365                       68,579                        69,798

 HAEMATOLOGY                              52,360                        47,967                        46,280

 OTHERS                                    1,983                         1,997                        2,230

 TOTAL                                    428,166                      422,770                       428,753

                                                        19
NATIONAL SKIN CENTRE

                                                                                NSC celebrated its 30th
                                                                                   year of public service                                         As an integrated hub, NSC will operate in an
                                                                                     in 2018, forging new                                        optimal environment that galvanises educators
                                                                             milestones to pave the way
                                                                              for further advancements                                         and students in learning, as well as supports and
                                                                                    and developments in                                       advances clinical research. It will be a place to engage
                                                                                         dermatology and                                    the community, whether in skin health promotion or
                                                                                   person-centred care.                                    for the community to be trained in self-care.
                                                                                                                                                                                                       - Professor Tan Suat Hoon,

                                               YEARS
                                               OF EXCELLENCE IN DERMATOLOGY
                                                                                                                                                                                                    Director, National Skin Centre

                                                                                                                                                                                              experience for patients with improved                 Dr Koh Poh Koon, Senior Minister of State for National Development and Trade and Industry, with CSR event helpers and performers.
                                                                                                                                                                                              dermatological treatments and wellness for
                                                                                                                                                                                              skin health.
                                                                                                                                                                                              By 2022, NSC will be able to provide seamless      Corporate Social Responsibility                         Walk-Together
                                                                                                                                                                                              access to specialised dermatological care          Activities with AMKFSC                                                                                            Charity Walk, held on
                                                                                                                                                                                              for more patients with a full spectrum of          Giving back to the community has been                                                                             22 September at
                                                                                                                                                                                              subspecialty expertise. The new 10-storey                                                                                                                            Bishan-Ang Mo Kio
                                                                                                                                                                                                                                                 a key focus at NSC over the years. In                                                                             Park, graced by Guest
                                                                                                                                                                                              building will see a 50% increase in clinic         conjunction with the 30th Anniversary, NSC                                                                        of Honour, Mr Tan
                                                                                                                                                                                              capacity, from 46 to 69 consultation rooms,        collaborated with Ang Mo Kio Family Service
                                                                      NSC Update in Dermatology &                                                                                             to meet the rising demand for outpatient
                                                                                                                                                                                                                                                                                                                                                                   Chuan-Jin, Speaker
                                                                      Venereology 2018                                                                                                                                                           Centre (AMKFSC), which was coincidentally                                                                         of Parliament, with
                                                                                                                                                                                              services. Patients with complex skin diseases      celebrating their 40th anniversary to give                                                                        proceeds going towards
                                                                      Organised every three years, the NSC Update                                                                             will also be able to benefit from the best         back to the community through a series of                                                                         AMKFSC Community
                                                                      in Dermatology and Venereology 2018 was                                                                                 clinical expertise, along with excellent nursing   volunteering and fundraising activities.                                                                          Services.
                                                                      held on 27 and 28 October at the Raffles         Mr Stephen Loh,          Groundbreaking Ceremony                       and allied health care.
                                                                      City Convention Centre. A key platform for       Representative and                                                                                                        Health Fair
                                                                                                                       Chief Development        A new chapter beckons for NSC with the        New facilities include a Day Treatment Centre,
                                                                      scientific updates and best clinical practices
                                                                                                                       Officer, Tan Tock Seng   groundbreaking ceremony for the new           which centralises diagnostic, monitoring                                                                   Food & Jumble Sale
                                                                      in dermatology, the conference received          Hospital; Prof Goh       building on 18 April 2018. Graced by Dr Amy   and treatment services, resulting in more
                                                                      more than 460 registrants from 23 countries.     Chee Leok, Senior                                                                                                                                                                                                                           NSC’s annual Food and
                                                                                                                                                Khor, Senior Minister of State for Health,    convenient access to care, especially for
                                                                      Participants were kept abreast of new            Consultant, NSC; A/                                                                                                                                                                                                                         Jumble Sale, organised
                                                                                                                                                the ceremony marked the redevelopment         elderly or less ambulant patients.
                                                                      approaches and therapeutics in managing          Prof Chua Sze Hon,                                                                                                                                                                                                                          by the Recreation Club,
                                                                                                                                                and expansion of the NSC building — a                                                                                                                                                                              with all proceeds raised
                                                                      patients with skin diseases.                     Deputy Director, NSC;
                                                                                                                       Prof Tan Suat Hoon,
                                                                                                                                                new milestone coinciding with NSC’s 30th                                                                                                                                                                           in support of AMKFSC.
                                                                      Covering a wide range of topics such as          Director, NSC and        Anniversary.
                                                                      Atopic Dermatitis, Psoriasis and Aesthetic       Dr Amy Khor, Senior
Prof Tan Suat          Commemorating Dermatology in                                                                                             The new centre will offer a more
Hoon, Director,                                                       Dermatology, the event’s panellists included     Minister of State
                       Singapore                                                                                       for Health.              seamless person-centred care
NSC, presenting                                                       medical luminaries such as Prof Dedee Murrell
the Dermatology in     In celebration of NSC’s achievements over      from Australia, Prof Keith Harding from the
Singapore book to      30 years, the Dermatology in Singapore (DiS)   United Kingdom, Prof Kenji Kabashima from
Mr Gan Kim Yong,       commemorative book was produced, which         Japan and NSC’s Adj Prof Steven Thng.
Minister for Health.   chronicled the development of dermatology                                                                                                                                                                                                                                                                                                   The public visiting the
                       in Singapore. It was presented to Mr Gan       Highlights include the inaugural Residents’                                                                                                                                  GOH Dr Koh Poh Koon, Senior Minister of                                                                         skin screening booth
                       Kim Yong, Minister for Health, at the 2018     Challenge Shield, which saw two teams of                                                                                                                                     State for National Development and Trade and                                                                    by NSC doctors and
                       Singapore Health & Biomedical Congress         junior doctors pitting their skills against                                                                                                                                  Industry, gracing the Health Fair at Yio Chu Kang                                                               nurses.
                       (SHBC), which had a record attendance of       each other and two symposia dedicated for                                                                                                                                    Community Club on 21 April 2018, organised by
                       more than 2,500 delegates from 10 countries    pharmacists and nurses, congruent with the                                                                                                                                   NSC in collaboration with NHGP.
                       with 638 submissions of abstracts. The         move towards team-based care for chronic
                                                                                                                                                                                                                                                 Event highlights included entertaining
                       DiS book highlighted the achievements of       skin diseases.
                                                                                                                                                                                                                                                 performances by COMNET seniors and Dr Ellie
                       pioneering forefathers in dermatology, and                                                                                                                                                                                Choi, Senior Resident, various educational
                       how dermatological care in NSC has evolved                                                                                                                                                                                booths and three tracks of health talks on
                       with the changing needs of the landscape                                                                                                                                                                                  chronic disease management, healthy skin
                       and community.                                                                                                                                                                                                            maintenance and healthcare tips.

                                                         20                                                                                                                                                                                                                                                      22
NATIONAL SKIN CENTRE                                                                                                                                                                                                                          NATIONAL SKIN CENTRE

                                                             Our Journey
                                                             NSC’s Dinner and Dance 2018, held on 30 June
                                                             2018 at Capella Singapore, commemorated 30
                                                                                                                 EDUCATION                                                      To continue providing high                                                                   NSC speakers imparting medical knowledge at
                                                                                                                                                                                                                                                                             the Aids Conference.
                                                             illustrious years of history and achievements.                                                                    standards of dermatological
                                                             Aptly themed “Our Journey”, the event saw                                                                       care, education is a key thrust
                                                             staff and guests dressed in their finest 80s,
                                                             90s, and millennium styles — a nod to the
                                                                                                                                                                                for continuity and renewal.                                                                 Singapore Aids Conference 2018
                                                             30th Anniversary.                                                                                                    With an eye on nurturing                                                                  Co-organised with Action for Aids (AfA) and
                                                                                                                                                                                     the next generation of                                                                 NCID, the 11th Singapore Aids Conference
                                                             Graced by Professor Philip Choo, Group CEO,                                                                                                                                                                    was held on 8 December 2018. This year’s
                                                             NHG, highlights of the festivities included                                                                                dermatologists and
                                                                                                                                                                                                                                                                            theme was “The Beginning of The End”, which
                                                             a cake cutting ceremony sang to a joyful                                                                                  staff, NSC continues                                                                 encompassed all aspects of HIV, addressing
                                                             rendition of “Happy Birthday”, a walk down                                                                                 to provide rigorous                                                                 issues in HIV care and response spectrum
Cake cutting ceremony at NSC’s Dinner and Dance 2018.        memory lane to reminisce key milestones,
                                                                                                                                                                                                  training to                                                               in the country. Dr Benson Yeo, Consultant,
                                                             and lively performances by NSC’s very own                                                                                                                                                                      presented the findings on the PrEP (Pre-
                                                             talented doctors and staff.                                                                                                      provide better                                                                Exposure Prophylaxis) in Singapore, while Dr
                                                                                                                                                                                              dermatological                                                                Ellen Chan, Consultant, introduced the hidden
                                                                                                                                                                                                 care for the                                                               populations for the HIV Blueprint in Singapore.
                                                                                                                                                                                                      nation.

                                                                                                                                                                                                                         World Psoriasis Day
                                                                                                                                                                                                                         NSC, together with the Psoriasis Association
                                                                                                                                                                                                                         of Singapore, organised the World Psoriasis
                                                                                                                                                                                                                         Day outreach event on 20 October 2018 at the
A toast to another great year at NSC.                          From Left: Ms Loo Swee Cheng, General Manager;                                                                                                            Bedok Central event hall with an attendance
                                                               Mrs Alice Chew, Head of Medical Affairs and Mrs
                                                                                                                                                                                                                         of more than 500 participants.
                                                               Tang Lee Foon, Head of Pharmacy.
                                                                                                                                                                       Eczema Public                                     Dr Colin Theng, NSC Visiting Consultant
                                                                                                                                                                       Forum 2018                                        and President of the Psoriasis Association
                                                                                                                                                                                                                         of Singapore, engaged the crowd with an
                                                                                                                                                                       Organised as part of a series of
                                                                                                                                                                                                                         informative talk on the condition, projecting
                                                                                                                                                                       events to commemorate NSC’s 30th
                                                                                                                                                                                                                         how new treatments can progressively
                                                                                                                                                                       Anniversary, the Eczema Public Forum
                                                                                                                                                                                                                         improve the lives of psoriasis patients.
                                                                                                                                                                       2018 saw a strong turnout of more than
                                                                                                                                                                       320 participants who learnt more about
                                                                                                                                                                       managing the condition and understanding
                                                                                                                                                                       the common misconceptions.
                                                                                                                                                                       The event also marked the launch of NSC’s
                                                                                                                                                                       first mobile application (app) on eczema
                                                                                                                      Attendees browsing through dermatology-related   management — Taggle Eczema. Jointly
                                                                                                                      books retailed at the Public Forum 2018.
                                                                                                                                                                       developed with the community health
                                                                                                                                                                       gaming platform, the Taggle app epitomises
                                                                                                                                                                       person-centred care, allowing patients to
                                                                                                                                                                       better manage their eczema. Available for                                                              Attendees engaging in activities at the World Psoriasis Day event.
                                                                                                                                                                       download, the app enables eczema patients
                                                                                                                                                                       to self-monitor their skin condition and obtain                                                      NSC nurses showed their support through
                                                                                                                                                                       daily updates and advice. Through an in-built                                                        activities such as first aid and skin care
                                                                                                                                                                       algorithm devised by NSC doctors, the app                                                            education, along with counselling services
                                                                                                                                                                       gives recommendations based on users’                                                                and balloon sculpting. The audience was
                                                                                                                                                                       uploaded data. The data also provides doctors                                                        treated to enthralling music and dance
                                                                                                                                                                       with insights on patient behaviour so that they                                                      performances, which included a rousing
                                                                                                                                                                       may adjust their medications where required.                                                         rendition of a popular musical by Dr Etienne
                                                                                                                                                                                                                           Community outreach at the World Psoriasis Day.   Wang, Consultant.
                                                                                                                      Dr Yew Yik Weng, Consultant, speaking at the
                                                                                                                      Public Forum 2018.
The NSC family in front of the existing NSC building.
                                                        23                                                                                                  24                                                                                                                     25
Continuing Professional                              Dermatology Bulletin
Education for Better Care                            NSC’s Dermatology Bulletin Vol 29, published
NSC GP Seminar 2018                                  in May 2018, covered the theme of STI. Titled
                                                     Focusing on Sexually Transmitted Infections,
NSC held its seminar for General Practitioners       the bulletin comprised of topics that included:
on 23 June 2018, with over 60 GPs and
staff in attendance. Focusing on Paediatric          • S TI Prevention & Control: Revisiting Principles,
Dermatology, the line-up of speakers included           Testing, New Ideas
Dr Madeline Ho, Senior Consultant and                • Molecular HPV Testing — A New Paradigm
Chairperson of the Seminar — Dr Suzanne                 in Cervical Cancer Screening
Cheng, Senior Consultant, Dr Lucinda Tan,            • Sexually Transmitted Infections in At-Risk
Consultant, Dr Su Peiqi, Consultant and Senior          Populations
Nurse Felicia Tan. The wide range of topics
covered included Approach to Itchy Skin              • The Evolution of Educational Materials at
Conditions in Childhood, Birthmarks as well as          the DSC Clinic
Talk and Demo on Wet Wraps, among others.            • S TIs and Adolescents
                                                     • Project Streetwalker & Project
                                                        Entertainment Workers
                                                     • Unusual Clinical Presentation of Secondary
                                                        Syphilis — A Report of Two Cases
                                                     • Self-Collected Rectal Swabs: Empowering
                                                        Asymptomatic Male Patients at the
                                                        DSC Clinic
                                                     • T he Human Papillomavirus Vaccines
                                                     Team-Based Learning for Derm GPs
                                                     Launched in October 2018, DSC embarked
                                                     on a team-based learning programme to
                                                     enhance continuing education for GPs with
                                                     minimal disruptions to clinic operations and
                                                     patient care process. The GPs, engaged
  Dr Suzanne Cheng, Senior Consultant, speaking at   through a series of briefings and case studies
  the GP Seminar 2018.
                                                     conducted by the multidisciplinary team at
                                                     DSC, can now better address STI conditions
                                                     in the community.

                                       26
NATIONAL SKIN CENTRE

SHBC Sexual Health Symposium                         least one year’s experience in the dermatology
In October 2018, DSC organised its inaugural         setting of an institution or hospital. A
Sexual Health Symposium at the Singapore             Phototherapy and Photodiagnostic Course
Health Biomedical Conference (SHBC). The             was also conducted from 17 to 25 September,
symposium, chaired by Adj A/Prof Martin              allowing participants to gain in-depth
Chio, Senior Consultant and Dr Benson                knowledge and skills on delivering safe and
Yeo, Consultant, aimed to equip healthcare           effective phototherapy treatment.
professionals in the community with knowledge
                                                     Four runs of dermatology nursing workshops
and latest developments in STIs.
                                                     and dermatological ward rounds were
The symposium included the following talks:          conducted for nurses at the Institute of Mental
                                                     Health to build knowledge capabilities and
• H PB’s Sexual Health Initiatives Among
                                                     skills in managing common skin conditions.
   Adolescents
• Efficacy of a Behavioural Intervention to         For the third consecutive year, NSC has had
   Reduce Sexual Risk in Adolescents                 the privilege of collaborating with the Alice
• Counselling LGBTQ and Individuals, Couples        Lee Centre for Nursing Studies, National
   and Families in a Community Setting               University of Singapore (NUS), to receive
                                                     second-year NUS nursing students for a
• Current STI/HIV Prevention Efforts in Female
                                                     one-day placement. A total of 251 students
   Sex Workers and Challenges for the Future
                                                     attended the programme this year, from 16
• Impact of Sexual Abuse on Sexual Behaviour        August to 15 November 2018. The programme,
   and STI: A Psychotherapeutic Approach             which was well-received by the nursing
• S ocio-Behavioural Approaches to HIV/             students, provided a platform for them to gain
   STI Research                                      insights into dermatology nursing, including
• An Update on HPV, Syphilis and its Myriad         hands-on sessions to learn the basics of
   Presentation                                      paring by practising on oranges.

Enhancing Nursing Care                               Pharmacy Symposium
As part of continuing professional nursing           The annual Pharmacy Symposium,
education in 2018, the Nursing Department            conducted on 27 October 2018, was part of
organised a series of courses and workshops for      the NSC Scientific Conference, Update in
nurses and healthcare providers in institutions      Dermatology & Venereology 2018. Themed
and the Intermediate and Long-Term Care              “Team-Based Care in Chronic Skin Diseases”,
Setting (ILTC), to build staff capabilities in the   the conference aimed to provide a better
management of dermatological conditions.             understanding on two chronic skin diseases,
                                                     psoriasis and eczema. The symposium also
Held from 14 May to 22 June, the Advanced            showcased NSC’s pharmacist-led eczema
Dermatology Nursing Course (Advanced DNC)            clinic, along with the optimisation of therapy
is a six-week course on holistic approaches to       for psoriasis patients through disease and
managing skin conditions for nurses with at          medication counselling.

                                                            27
Visiting Experts
Professor Thomas Luger

             Professor Thomas
             Luger, a Professor
             of Dermatology             NSC had the pleasure of hosting Prof Luger
             and Chairman of            during his week-long visit to Singapore from
             the Department             23 to 27 April. The centre’s facilities was a focal
             of Dermatology at          point of best practices sharing, especially the
             Munster University,        seamless functioning of the paperless system.
             Germany, is also           He shared that most hospitals in Germany
             the Director of            still rely heavily on paperwork, and the ones
             the Institute of           that have electronic systems are not yet as
             Cell Biology and           efficient as NSC.
  Immunobiology.
                                        Prof Luger commended the residents and
  A renowned expert on inflammatory     staff members for their keen interest and high
  and autoimmune diseases of the        standard of questions asked during lectures.
  skin, Prof Luger is also the former   Their knowledge and passionate spirit reflects
  Dean of the Medical Faculty of        the dermatologists’ motivation to give their
  Westphalian Wilhelms University       best in providing high quality dermatological
  and past President of the German      care for NSC patients.
  Society of Dermatology.

Professor Dedee Murrell

              Professor Dedee
              Murrell is the
              Chairman of the           It was NSC’s privilege to have Prof Dedee
              Department of             Murrell with us during her week-long visit
              Dermatology in St         from 22 to 28 October. NSC’s capabilities
              George Hospital,          as a world-renowned training institute, and
              Australia, and her        its collaboration with the Skin Research
              clinical expertise        Institution of Singapore (SRIS) featured
              lies in autoimmune        prominently in the knowledge exchange with
              blistering conditions     Prof Murrell. Clinicians had the opportunity
  and Epidermolysis Bullosa.            to learn from her expertise in autoimmune
  Prof Murrell first encountered        blistering conditions and Epidermolysis
  patients with Epidermolysis Bullosa   Bullosa through a series of thought-provoking
  — then a little-known rare disease    lectures.
  — during her training at a Centre     When asked about the future of dermatology,
  for blistering diseases in North      Prof Murrell was optimistic about artificial
  Carolina. Her rigorous laboratory     intelligence aiding doctors’ diagnoses and
  research has led to breakthroughs     improving clinical outcomes in the future.
  and enhancements of treatment         However, patient-doctor interaction is
  options.                              still needed to understand the social and
                                        psychological factors affecting each case,
                                        in order to provide the appropriate patient
                                        therapy with reassurance, understanding and
                                        encouragement.

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