Anxiety Disorders During The COVID- 19 Pandemic - Alyse Folino Ley D.O., FACN Child and Adolescent Psychiatry MSU Department of Psychiatry - MSU (SCS)
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
Anxiety Disorders During The COVID- 19 Pandemic Webmd Alyse Folino Ley D.O., FACN Child and Adolescent Psychiatry MSU Department of Psychiatry
• December 2019-cluster of cases SARs CoV-2 Hubei China • January 13, 2020-first case outside China • January 14, 2020-41 confirmed cases (WHO) • February 2, 2020 NY Times- “Medical workers transporting a coronavirus patient into an isolation ward in Fuyang, China, on Saturday. Experts fear a coronavirus pandemic, but its severity is uncertain.”-Donald G. McNeil Jr. Picture-Chinatopix, via Associated Press
Fear and Uncertainty During COVID-19 • 1/27/21 • Illness • 100million infected • Isolation worldwide • Death • 2 million have died • Economic worldwide • Academic • Jan 2021 “deadliest coronavirus month” • Domestic Violence 79,000 (CNN.com) • Child Abuse • US- • Elder Abuse • 25,152,433 cases • 419,827 deaths (COVID.CDC.gov)
Fear Anxiety Worry The fight or flight A feeling of being The cognitive response enabling out of control, component of reaction to clear and focused on future anxiety present danger potentially negative events-out of proportion to the context of life real situation that impairs functioning
Normal vs. Pathologic Anxiety • Anxiety can be adaptive • Signals imminent danger • Cues into important stimuli • Modifies Behavior • Social distance, wear mask, wash hands • Abnormal anxiety • Persistent, excessive, coupled with no objective threat of harm, or occurring at inappropriate times leading to ineffective or Tippi Hedren with daughter Melanie self-defeating behaviors Griffith and their pet lion -1971
Anxiety in Vulnerable Populations • Elderly • Children and Adolescents • Those with underlining psychiatric conditions • Homeless • Racial and Ethnic Minorities • Health Care Workers
Covid-19 and Underlying Mental Illness • COVID-19 may worsen underlying condition • Those with severe chronic conditions most at risk • Disruption of mental health services • Psychiatric • Therapy • Case management • Access to medicine • Social isolation • Costa et al (2020) • 60% of those who had a mental illness felt less connected since start of pandemic • Most concerned about worsening of their condition and running out of medication
Substance Use Disorders and COVID- 19 • Chronic stress may trigger relapse • Acute withdrawal due to disruption of markets • Benzos and alcohol-maybe fatal • Could lead to ingestion of toxic ethanol containing products • Opiates • Limited access to treatment • Medications • Acute Medical Detox • Therapy • Groups-AA • Rehabilitation services (Spagnolo 2020)
Children • Losses • Social contacts • 55 million children and teenagers cut off from school staff members • Extracurricular • Academic Changes • Transitions • Virtual, hybrid, in-person • Isolation • Friends • Missed Milestones • CDC –April 2020-October2020 • Mental health visits • Children 5-11 increased 24% (compared to 2019) • Children 12-17 increased 31% (compared to 2019) (Whitney, 2021)
College Students • Risk for psychiatric disorders • Onset of Depression, Anxiety and Psychosis • Risk for suicide • Altered school experience • Academic stress • 2020-Graduates • unemployment • United Nations Report • “Unless urgent action is taken, young people are likely to suffer severe and long-lasting impacts Plante. TulsaWorld 2020 of the pandemic.” (Menon, 2020)
COVID-19 and Suicide • Pandemic may exacerbate an existing crisis • The rate of suicide for individuals age 10-24 increased by 57.4% between 2007-2018 • CDC June 2020 • Survey of the impact of COVID-19 on mental health • ¼ of those age 18-24 seriously considered suicide over the last 30 days • Impulsivity risk factor in those under 24 (O’Connor, 2020)
Return to School? • Nevada Clark County • Virtual since March 2020 • 326,000 students • March 2020-Jan 2021 • 19 suicides vs.9 (2019) CNN.com
Older Adults • Isolation • Abuse • Self care • Fear • Unable/unwilling to seek medical care • Food restriction • Purpose and contribution • Higher rates of depression in older adults who experience • Anxiety • Loneliness • Isolation
COVID-19 and the Indigenous Community • Navajo Nation –173, 667 members • Strength comes from cultural connectedness • Multigenerational family homes, remote areas Utah, Az, NM) often no running water • DM, Obesity, CVD are common • In Dine’=The big cough • July 2020-7,320 tribal members diagnosed • Blamed for the 1993 Hanta Virus outbreak-decreases rates of seeking help • Historical trauma and discrimination increased rates of depression, anxiety, ptsd, ACEs, addiction and suicide • 70% report experiencing trauma (Levin, 2020)
COVID-19 and the Black Community • “Racism impacts health outcomes through close alignment with socioeconomic status in this country. It is a structural entity that operates on institutions and in interpersonal dynamics …” Morgan Medlock MD, MPH • Increased morbidity • Increased mortality • Health Disparity • Michigan -14% of the population is Black • 30% of COVID cases • 40% of deaths (D’Arrigo, 2020)
Med Students, Physicians and Residents • Fear of illness, death • Worry of spreading to loved ones • Burden of caring for the dying • Uncertainty • Fatigue • Loss of income • Lack of support • Initial support of health care hero's diminished • Non-believers • Health Care workers in NY (July 2020) • 57% reported acute distress • 48% reported depressive symptoms • 33% reported anxiety (Zilber 2020)
Neuropsychiatric Impact • To Be Determined…. • Impaired consciousness • Stroke • Cognitive disturbance • Fatigue • Psychiatric conditions • Survivors of 2003-2004 Hong Kong SARs Outbreak • 369 survivors-40% were diagnosed with a psychiatric condition 4 years after (Zilber, 2020)
Post COVID Infection and Psychiatric Disorders • Lancet November 2020- • De-identified data from 69.8 mill patients in 54 health care organizations • 62,354 diagnosed with COVID Jan 2020-Aug 2020 • Individuals with a psychiatric disorder were 65% more likely to be infected with COVID-19 • 1 in 5 COVID-19 patients are diagnosed with anxiety or depression within 3 months of testing positive for the virus • Increased medical attention • Stress of pandemic
When Does Anxiety Become a Psychiatric Condition?
Anxiety • The most common psychiatric disorders in children and adults • The most prevalent disorders • 25% lifetime prevalence • 14% point prevalence • Onset often in childhood • Children and Adolescents-6-18% depending on age • Children may not recognize that their anxiety is excessive or unreasonable • Decreased verbal abilities to express internal symptoms • Concrete thought in children under 11 • Frequent physical complaints • “stomach ache” “head ache” • Problems with attention, focus and concentration • School refusal • Parental anxiety poses a specific risk for anxiety disorders children (Lawrence 2019)
Risk Factors • Family history/genetic predisposition • Poor family support • Family discord • Dysfunctional parenting • Parent with untreated mental illness • Poor self-esteem/inadequate self image • Emotional dysregulation • Lack of social acceptance • Substance Abuse
Dimensions of Anxiety Subjective Behavioral Physiologic Tension Avoidance Muscle tension Apprehension Impaired speech and Increased HR Sense of impending motor coordination Dry mouth doom Performance deficits nausea Expectations of inability to cope
Consequences of Anxiety • Emotional • Fear and guilt • Cognitive • Impaired concentration and problem solving • Impaired academic and vocational achievement • Behavioral • Avoidance-school, social interaction • Self-medicating-substance abuse • Physiologic • Poor self care • Lowered immune response
Symptom Variation • Symptoms manifest differently at different ages • Cognitive development • Ability for abstract thought • Social functioning • Communication skills
Anxiety Disorders • Generalized Anxiety Disorder • Specific Phobia • Social Anxiety Disorder • Panic Disorder • Agoraphobia • Selective Mutism • Separation Anxiety
GAD • A. Excessive anxiety and worry • B. Difficult to control the worry • C. Anxiety and worry are associated • 1. restlessness or keyed up • 2. being easily fatigued • 3. difficulty concentrating • 4. irritability • 5. muscle tension • 6. sleep disturbance
Social Anxiety Disorder • A. Fear or anxiety about one or more social situations in which the individual is exposed scrutiny • Fear of embarrassment or humiliation • * in children must occur in peer settings and not just with adults • B. Fears that he/she will act in a way or show anxiety symptoms that will ne negatively evaluated (humiliating or embarrassing) • C. Social situation produces anxiety which may predispose to a panic attack • * in children -expressed as crying, tantrums, freezing or shrinking • D. Fear out of proportion to actual threat • E. Caused distress or impairment • F. Situations are avoided • * in children this feature may be absent
Specific Phobia A. Marked fear about a specific object or situation • * in children often expressed as crying, tantrums, freezing or shrinking • B. Phobic object or situation provokes immediate fear or anxiety • C. Feared object or situation is avoided or endured with intense fear • D. Causes distress or impairment
Panic Disorder • A. Recurrent unexpected panic attacks • Palpitations, pounding heart, increased HR, sweating, trembling or shaking, SOB, feeling of choking, chest pain or discomfort, nausea or abdominal distress, feeling dizzy or unsteady, derealization, fear of losing control or going crazy, fear of dying, paresthesias, chills or hot flashes • At least one of the attacks has been followed by • Persistent concern • Worry about the implications of the attack or its consequences • Significant change in behavior related to the attacks
Agoraphobia • A. Marked fear or anxiety about 2 (or more) • Public transportation, open spaces, enclosed spaces, crowds, outside of the home alone • B. The person fears or avoids these situations because of thoughts that escape might be difficult or help might not be available • C. Situation produces fear or anxiety • D. Avoidance
Separation Anxiety • Normal from 12 months-30 months and briefly in kindergarten and 1st grade • Typically begins during school age • Fear of harm to self or parents
Selective Mutism • A. Consistent failure to speak is specific social situations-at least one month • B. The disturbance interferes with educational or occupational achievement or with social communication
Obsessive Compulsive Disorder • A. obsessions or compulsions • Obsessions • Recurrent and persistent thoughts, impulses, or images that are intrusive and inappropriate and that cause marked anxiety or distress • Compulsions • Repetitive behaviors that the person feels driven to perform in response to an obsession or according to rules that must be applies rigidly • The behaviors or mental acts are aimed at preventing or reducing distress or preventing some dreaded event or situation
Posttraumatic Stress Disorder • Traumatic event • Intrusive Symptoms: event re-experienced • Negative Alterations in Cognition and mood • Avoidance of stimuli associated with the trauma and numbing of general responsiveness • Increased arousal
Treatment of Anxiety Disorders in Children and Adolescents • Therapy is first line • Cognitive Behavioral Therapy (CBT) • Specific Targeted Therapies (based in CBT) • PTSD-Trauma Focused CBT • Specific Phobia, -Systematic Desensitization • OCD-Exposure Response Prevention Therapy • Panic-Exposure Therapy
CBT Automatic Thoughts Emotional Behavioral Somatic Changes changes changes
Core Automatic Belief/Schema thoughts Emotional changes
Dysfunctional Functional Thoughts Thoughts Behavior Negative Behavior Positive Avoid Self-critical Confront Balanced Give up Biased Change Acknowledge Inappropriate Feelings Feelings Anxious Relaxed Depressed Calm Angry Happy
Cognitions Behavior Emotions Thought monitoring- Activity monitoring-identify Affective education- identification of automatic reinforcers distinguish between core thoughts beliefs and physical symptoms Identification of cognitive Goal planning Affective monitoring-rating distortions scales, rate intensity Thought evaluation- Target settings-practice Affective management- cognitive restructuring relaxation, anger management Development of new Graded exposure-response cognitive skills prevention Learn new skills-modeling, rehearsal
Response to CBT • Wolk et al-JAACAP 2015 • 7-19year follow-up study on adults who completed CBT as children • Chronic and enduring suicidal ideation is found in people who suffered from childhood anxiety that was not properly treated. • CBT has both short and long term benefits • Highlights the importance of early identification and evidence based treatments
Recommendations in Children and Teens • CBT recommended as first line • SSRIs in Children and Adolescents • Only medications supported by RCT • Studies: SAD, GAD, OCD, Soc Phobia • Equally efficacious • Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram • start low dose and titrate toward efficacy • No improved efficacy with SNRIs (Venlafaxine) • SSRIs are associated with more rapid greater improvement than SNRIs (Strawn et al 2018)
Child-Adolescent Anxiety Multimodal Study (CAMS) • Walkup et al. N Engl J Med 2008, 359: 2753-2766. • 488 children, ages 7-17 • Separation anxiety, GAD, Social phobia • Study Arms • 14 Sessions CBT • Sertraline (up to 200mg/day) • Combination • Placebo • Anxiety measured at baseline 4,8 and 12 weeks • Anxiety Disorders Interview Schedule for DSM-IV child • Establish diagnosis • Clinical Global Impression-Improvement Scale • Clinically meaningful improvement in anxiety • Pediatric Anxiety Rating Scale • Level of Anxiety 0-30; >13 moderate levels=anxiety disorder
Key Outcomes at 12 Weeks Walkup JT et al. N Engl J Med 2008;359:2753-2766
Conclusions • Compared with placebo, the 3 active therapies- CBT, Sertraline and combination are effective short term treatment of GAD, social phobia and separation anxiety. • Clinical Global Impression-12 weeks • Combo 80.7% (P
Scores on the Pediatric Anxiety Rating Scale during the 12-Week Study Figure 2. Scores on the Pediatric Anxiety Rating Scale during the 12-Week Study. Scores on the Pediatric Anxiety Rating Scale range from 0 to 30, with scores higher than 13 consistent with moderate levels of anxiety and a diagnosis of an anxiety disorder. The expected mean score is the mean of the sampling distribution of the mean. The I bars represent standard errors.
The Pediatric OCD Treatment Study POTS • A balanced, masked randomized controlled trial: • conducted in 3 academic centers in the United States • volunteer outpatient sample of 112 patients aged 7 through 17 years with a primary Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosis of OCD • Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) score of 16 or higher. • Recruited between September 1997 and December 2002. • INTERVENTIONS: • Random assignment to receive CBT alone, sertraline alone, combined CBT and sertraline, or pill placebo for 12 weeks. • MAIN OUTCOME MEASURES: • Change in CY-BOCS score over 12 weeks as rated by an independent evaluator masked to treatment status; rate of clinical remission defined as a CY-BOCS score less than or equal to 10.
POTS • RESULTS: • Ninety-seven of 112 patients (87%) completed the full 12 weeks of treatment. • Combined treatment also proved superior to CBT alone (P = .008) and to sertraline alone (P = .006), which did not differ from each other. • Clinical remission: • combined treatment was 53.6% (95% confidence interval [CI], 36%-70%); • CBT alone, 39.3% (95% CI, 24%-58%); • sertraline alone, 21.4% (95% CI, 10%-40%); • placebo, 3.6% (95% CI, 0%-19%). • The remission rate for combined treatment did not differ from that for CBT alone (P = .42) but did differ from sertraline alone (P = .03) and from placebo (P
Approach to Multiple School Transition • Multiple Transitions increase anxiety • School Refusal • Requires prompt attention regardless of the cause; the longer the child is out of school, the higher the likelihood of treatment resistance • Treatment: Behavioral • Limit setting • Eliminate secondary gain • Relaxation training • Exposure • Increasing lengths of time at school or virtual learning • Rewarding child for graduated success
When to Start Medications • Prolonged course • Limited response to therapy alone • Severely impaired functioning • Comorbid conditions
Treat Co-morbid Conditions • Anxiety disorder • OCD • Major Depressive Disorder • Trauma/PTSD • ADHD • Substance Use Disorder-cannabis • Psychosis • Rare 1/10,000 • Bipolar Disorder • Rare
Cannabis • Not helpful in psychiatric conditions • Amotivational Syndrome • THC (delta-9-tetrahydrocannabinol) content dramatically increasing • 1970s-less than 2% • 1990-3.74% • 2018-20-25% • Oil, wax, shatter, budder- extracts nearly pure THC • Daily use • 0.7% -8th graders • 3.4%-10th graders • 5.8%-12th graders • Risk of addiction 10%-equal to alcohol • Use before age 18 increases the risk of Cannabis Use Disorder by 4-7 times • Cannabis Use Disorder • 1.5% of Americans (NIDA 2018)
Cannabis Use in Adolescents and Risk • Gobbi et al (2019) • Neuroanatomic differences in regions with type 1 cannabinoid receptors • Decreased volume of hippocampus, amygdala, prefrontal cortex • The younger users of cannabis were at significantly higher risk of suicidal behavior • The younger the onset of use the higher the risk • Depression, anxiety, psychosis, academic and vocational functioning • Quitting cannabis by the end of adolescence did not protect people from most of the serious effects
Cannabis • Induces and exacerbates psychiatric conditions • Anxiety • Depression • Psychosis (induction of schizophrenia, cannabis induced psychosis) • Amotivational syndrome • Decreased concentration, working memory, processing speed and IQ • Paranoia • Hallucination • Panic • Increases risk of violence and aggression • Reduced school performance • Reduced life satisfaction • Impaired driving-10.3% of 12th graders drove after using in the past two weeks (NIDA-2018)
Treatment Approach • Therapy-CBT/IPT • Family involvement is essential with children/teens • Psychoeducation • Instruction on relapse prevention • Medication compliance • Recognizing symptoms of relapse • Avoiding precipitants • Sleep deprivation and substance abuse • School Accommodations • Remedial education or tutoring may be necessary • Medication determination
Starting/Monitoring SSRI • Review risk factors • Family history • Past attempts • Psychoeducation • Warning signs • Close monitoring • Worsening of symptoms • Activating symptoms • Risks, benefits, side effects and alternatives • Suicide risk assessment • Access to weapons
SSRIs • First line medications • SNRIs can also be used • Start low dose • Limit side effects • Limit anxiety • Increase compliance • Titrate toward efficacy while monitoring for side effects • Allow at least 6 weeks to establish efficacy • Continue 6-12 months once in remission
Medications • Medications: • SSRIs are first line • Fluoxetine (Prozac): FDA approved for the treatment of depression in children (>8) and adolescents (8-18 years) • Escitalopram (Lexapro) FDA approved in adolescents (12-17 years)--April 2010 • All SSRI medications (Fluoxetine, Paroxetine, Citalopram, Escitalopram, Sertaline and Fluvoxamine)-equal efficacy • SNRIs (venlafaxine, desvenlafaxine, duloxetine), Buproprion, Mirtazepine-do not improve efficacy but may increase SI • TCAs not more efficacious than placebo in children
Medications • Fluvoxamine (Luvox) • OCD>8 • Sertraline (Zoloft) • OCD 6-17 • Fluoxetine (Prozac), Paroxetine (Paxil) • OCD 7-17 • Clomipramine • OCD >10 • Imipramine • Nocturnal enuresis, depression and chronic pain >6
SSRI Side-effects •Nausea, diarrhea, constipation, increased anxiety with initiation, weight loss or gain, somnolence, insomnia •Very little risk with overdose •Serotonin syndrome
Black Box Warning • 2004 FDA warning: adolescents-age 24 increased suicidal ideation • Meta-analysis of SSRIs and depression in adolescents- 2400 participants • Increase in suicidal ideation • Depressed adolescents • 3.8 %(SSRI) vs. 2.1% (controls) • No completed suicides in any of the studies
Black Box Ripped from the Headlines •“FDA Links Drug to Being Suicidal”-New York Times- September 14, 2004 •“How Paxil Killed Our Son” -New York Post-September 19, 2004
Black Box Warning Unintended Consequences • Decline in suicide rate from 1990-2004 • 25% decrease SSRI prescription rate in 2004 • CDC-14% increase in suicide rates 5-19 year olds in 2004 compared to 2003
Research on BBW • Some conflicting evidence • Increased suicidal behaviors after 2004 • Meta-analysis-JAMA 2007 • US Food and Drug Administration-BMJ 2009 • Decreased suicidal behaviors after 2004 • Analysis FDA reports-Am J Psychiatry 2003, 2007
Research On BBW • FDA advisory associated with reduction in rates of diagnosis and treatment with no increase in treatment alternatives Am J Psych 2007 • Number of children and adolescents who were prescribed antidepressants significantly decreased. Shift in care from generalist to psychiatrists Arch Gen Psych 2007 • Children’s depression visits and visits with antidepressant declined after advisory Psych Serv 2011 • Suicide rate among adolescents rose in 2004, the year the warning went into effect, for the first time in 15 years BMJ 2014
Consensus • Same increase in SI not found in studies on anxiety disorders • Untreated depression is the most serious risk for suicide • FDA warning was not intended to discourage legitimate treatment • FDA warning was not intended to be a contraindication
Anxiety Disorders • Helpful • Cognitive Behavioral Therapy • Collaboration with school • IEP, 504, behavioral plan, counseling, tutoring, accommodations • • Psychoeducation for parents and caregivers • SSRIs/SNRIs • Safety plan • Remove all weapons from the home • Close monitoring • Involvement in positive peer- related activities
Not Recommended • Alternative “therapy” • No evidence base • Delays proper treatment of a life- threatening condition • EEG diagnosis by non-physicians • Cause/exacerbation of symptoms • Cannabis (THC), Alcohol, illicits • Expensive
Outcome • Early identification and treatment • Severity of illness • Co-morbid substance use disorder • Level of hopelessness • Family stressors
Resources for Children, Teens and Families • AACAP - https://www.aacap.org/coronavirus#families • Tips for transition back to school • How to Talk to Your Kids about Coronavirus - New York Times • 5 things to remember when talking to kids about the Coronavirus - Chicago Tribune • Just for Kids: A Comic Exploring the New Coronavirus • Comic: How To Turn Your Home Into A School Without Losing Your Sanity • The Clay Center for Young Healthy Minds - Self-Care for Resilience Resources • A Parent's Guide to COVID-19 - The Rush Cast Podcast • Tips to Keep Children Healthy While School’s Out • How to Explain the Coronavirus Pandemic to Young Children - Newsweek • Tips for Supporting Student Wellness During COVID-19 • I Have a Question About Coronavirus: Clear Answers for All Kids
Resources for HCP
Videos, Podcasts and Webinars CBT MGH- https://vimeo.com/398929603/0dcf0ba166 Webinar Series HMS: Regulating emotions and building resiliency in the face of pandemic Role of anxiety- https://vimeo.com/398662331/748f60ecce Slowing the brain- https://vimeo.com/398675016/b40bf3a0ba Charging up and staying connected- https://vimeo.com/400727093/254169fb7e Exploring thoughts- https://vimeo.com/401092639/094cc41127 How family members and friends can support COVID caregivers – HMS https://youtu.be/rcaYlDOQsHY Caring for yourself and others during COVID-19 pandemic: managing health care worker’s stress – Schwartz center for compassionate care • https://youtu.be/F4LU-EoAFew
Videos, Podcasts and Webinars Free 3-session video course on resiliency skills for healthcare providers MGH Resiliency and prevention program https://www.resilienceandprevention.com/healthcare-providers Clinical Self Care in the time of COVID- Mc Lean Hospital (available with Spanish & hindi subtitles) https://www.mcleanhospital.org/video/dr-blaise-aguirre-offers- covid-19-coping-tips-health-care-workers
BIPOC (Black, Indigenous and people of color) Self-guided resources The Safe Place: Free smartphone app focused on psychoeducation and self-care for minority mental health, geared towards the Black community Liberate: Free meditation app designed specifically for the BIPOC community and led by BIPOC teachers Racial Trauma Guide: Virtual guide on coping with racial stressors and being an ally, developed by the EMPOWER (Engaging Minorities in Prevention Outreach Wellness Education & Research) Lab https://www.psychology.uga.edu/racial-trauma-guide Black Emotional and Mental Health (BEAM) Toolkit & Resources https://www.beam.community/tool-kits-education
Resource: COVID Coach From: U.S. Department of Veterans Affairs Free app to support coping and resilience during the COVID-19 pandemic. Includes tools for tracking mood, managing stress, navigating caregiving, staying healthy and connected and connecting to further resources as needed
Resource: Mindshift CBT (app) Free interactive cognitive-behavioral tools to manage anxiety, develop more effective ways of thinking and take positive action Resource: Stop, Breathe & Think (app) Free app to help notice feelings and reactions, practice mindful breathing, and broaden perspectives via guided meditations
References Lawrence,PJ, Murayama, K, Creswell C, Systematic Review and Meta-analysis: Anxiety and Depressive Disorders in Offspring of Parents with Anxiety Disorders,. JAACAP. Jan 2019. 58(1) 46-60. Wolk, CB, Kendall PC, Beidas RS. Cognitive–behavioral Therapy for Child Anxiety Confers Long-term Protection from Suicidality. JAACAP. March 2015. 54 (3) 175-9. Strawn, JR, Mills, JA, Sauley, BA, Welge, JA. The Impact of Antidepressants Dose and Class on Treatment Response in Pediatric Anxiety Disorders: A Meta-analysis. JAACAP. April 2018. 57 (3). 235-244. Clayborne, ZM, Varin, M, Coleman, I. Systemic Review and Meta-analysis: Adolescent Depression and Long-term Psychosocial Outcomes. JAACAP. Jan 2019. 58 (1): 72-29. Gobbi, G., et al. Association of Cannabis Use in Adolescents and Risk of Depression, Anxiety and Suicidality in Young Adulthood. JAMA Psychiatry. 2019.; 76(4) 426-434. NIDA for Teens: What is Marijuana? May 2018. 1-15. https://teens.drugabuse.gov/drug-facts/marijuana Revised.
Brent, D. et al. Switching to another SSRI or Venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial. JAMA. 2008; 299(8): 901-913. Wiener and Dulcan. Textbook of Child and Adolescent Psychiatry. American Psychiatric Publishing. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders.5th Edition. Arlington, VA: American Psychiatric Association; Copyright 2013. Kaplan and Saddock’s: Synopsis of Psychiatry: 11th Edition. Lippincott Williams & Wilkins. Philadelphia, PA. 2014. Ana Luisa Pedrosa†, Letícia Bitencourt†, Ana Cláudia Fontoura Fróes, Maria Luíza Barreto Cazumbá, Ramon Gustavo Bernardino Campos, Stephanie Bruna Camilo Soares de Brito and Ana Cristina Simões e Silva* Emotional, Behavioral, and Psychological Impact of the COVID-19 Pandemic. Frontiers in Psychology. October 2020. Vol 11. 1-18. 10.3389/fpsyg.2020.566212 Reger, MA. et. al. Suicide Mortality and Coronavirus Disease 2019— A Perfect Storm? JAMA Psychiatry November 2020 Volume 77, Number 11 Primavera A. Spagnolo, M.D., Ph.D., Chiara Montemitro, M.D., Lorenzo Leggio, M.D., Ph.D. New Challenges in Addiction Medicine: COVID-19 Infection in Patients With Alcohol and Substance Use Disorders—The Perfect Storm. Am J Psychiatry 177:9, September 2020.805-807.
Sidhu, Shawn. COVID-19 Guidance to Help Our Patients and Ourselves Published Online:25 Mar 2020https://doi-org.proxy1.cl.msu.edu/10.1176/appi.pn.2020.4a23 COVID-19 Pandemic Is Taking MH Toll, Finds APA Poll Published Online: 24 Apr 2020https://doi-org.proxy1.cl.msu.edu/10.1176/appi.pn.2020.5a10 Mohammed J. Abbas, M.R.C.Psych., M.B.Ch.B., Golo Kronenberg, M.D., Martin McBride, M.B.Ch.B., B.Med.Sci.,Damodar Chari, M.B.B.S., D.P.M., Faisel Alam, M.B.B.S., M.Res., Elizabeta Mukaetova-Ladinska, Ph.D., M.R.C.Psych.,Mohammed Al-Uzri, M.D., F.R.C.Psych., Traolach Brugha, M.D., F.R.C.Psych. The Early Impact of the COVID-19 Pandemic on Acute Care Mental Health Services.ps.psychiatyonline.org Stone, M. et al. Risk of Suicidality in Clinical Trials of Antidepressants in Adults: Analysis of Proprietary Data Submitted to the US Food and Drug Administration. BMJ. 2009;339:b2880. Mark Costa, M.D., M.P.H., Anthony Pavlo, Ph.D., Graziela Reis, PMTIC, M.P.H., Katherine Ponte, J.D., M.B.A., Larry Davidson, Ph.D COVID-19 Concerns Among Persons With Mental Illness. Psychiatric Services 71:11, November 2020. Benjamin Rosen, M.D., F.R.C.P.C., Mary Preisman, M.D., F.R.C.P.C., Jonathan Hunter, M.D., F.R.C.P.C., Robert Maunder, M.D., F.R.C.P.C Applying Psychotherapeutic Principles to Bolster Resilience Among Health Care Workers During the COVID-19 Pandemic. Am J Psychother 73:4, 2020. 144- 148. Taquet M, Luciano S, Geddes J R, Harrison P J. Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA. Lancet Psychiatry 2020; published online Nov 9. https://doi.org/10.1016/S2215-0366(20)30462-4
An, G. Medical Student Experience in the Wake of COVID-19 Pandemic and Next Steps Published Online:16 Nov 2020 https://doi-org.proxy1.cl.msu.edu/10.1176/appi.pn.2020.11b30 Zilber, C. Psychological Stress May Not Be The Only Route of COVID-19’s Psychiatric Burden. Psychiatric News. Appi.pn.2020. Zilber, C. Physician Mental Health During COVID-19: A Call to Action Published Online:30 Oct 2020 https://doi-org.proxy1.cl.msu.edu/10.1176/appi.pn.2020.10b24 Zagorski, N. Psychological Stress May Not Be Only Route Of COVID-19’s Psychiatric Burden. Published Online:23 Jun 2020 https://doi-org.proxy1.cl.msu.edu/10.1176/appi.pn.2020.6b7 Elmaghraby, R. Serenity in the Midst of a Pandemic: Resident Toolkit for Responding to COVID-19 Published Online:10 Apr 2020 https://doi-org.proxy1.cl.msu.edu/10.1176/appi.pn.2020.4b29 Levin, A. Special Report: American Indians Face Special Hardships in Combating COVID-19 Pandemic Published Online:9 Jul 2020 https://doi-org.proxy1.cl.msu.edu/10.1176/appi.pn.2020.7b33 Yarbrough, E. Special Report: COVID-19 and the LGBTQ Community Published Online:27 Aug 2020 https://doi-org.proxy1.cl.msu.edu/10.1176/appi.pn.2020.9a18 O’Connor, K. Youth Suicide Rate Increases by Nearly 60% Published Online:7 Oct 2020 https://doi-org.proxy1.cl.msu.edu/10.1176/appi.pn.2020.10b13
Mark Costa, M.D., M.P.H., Anthony Pavlo, Ph.D., Graziela Reis, PMTIC, M.P.H., Katherine Ponte, J.D., M.B.A., Larry Davidson, Ph.D COVID-19 Concerns Among Persons With Mental Illness. Psychiatric Services 71:11, November 2020. Benjamin Rosen, M.D., F.R.C.P.C., Mary Preisman, M.D., F.R.C.P.C., Jonathan Hunter, M.D., F.R.C.P.C., Robert Maunder, M.D., F.R.C.P.C Applying Psychotherapeutic Principles to Bolster Resilience Among Health Care Workers During the COVID-19 Pandemic. Am J Psychother 73:4, 2020. 144-148. ZAGORSKI, Nick. Journal Digest: Seniors and Loneliness; Caripazine and Brain Development; Family and Bipolar Disorder; Alzheimer's and COVID-19 Published Online:6 Aug 2020https://doi-org.proxy1.cl.msu.edu/10.1176/appi.pn.2020.7b1 Whitney, E. and Vito Jose. Long-Term Impact of COVID-19 on Children, Adolescents Constitutes Public Health Emergency. Published Online:8 Jan 2021https://doi-org.proxy1.cl.msu.edu/10.1176/appi.pn.2021.1.37 ZAGORSKI, Nick. Journal Digest: Seniors and Loneliness; Caripazine and Brain Development; Family and Bipolar Disorder; Alzheimer's and COVID-19. Published Online:6 Aug 2020 https://doiorg.proxy1.cl.msu.edu/10.1176/appi.pn.2020.7b1 Whitney, E. and Vito Jose. Long-Term Impact of COVID-19 on Children, Adolescents Constitutes Public Health Emergency. Published Online:8 Jan 2021https://doi-org.proxy1.cl.msu.edu/10.1176/appi.pn.2021.1.37 COVID.CDC.gov
You can also read