ANTIOXIDANT AUTHORITY - THE YEARS OF RESEARCH IN EVERY DROP - Loreal
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FOR MEDICAL PROFESSIONAL USE ONLY THE ANTIOXIDANT AUTHORITY 30 Y EARS OF RESEARCH I N E V E RY D R OP EFFECTIVELY NEUTRALIZES free radical damage VISIBLY IMPROVES fine lines, wrinkles, and discoloration
THE SKINCEUTICALS
VITAMIN C DIFFERENCE
"Skin is naturally built for repair. When
bombarded by environmental assaults, skin
must focus on neutralizing oxidative damage,
limiting its capacity for reparative functions.
Daily use of pure vitamin C antioxidants,
when properly formulated to penetrate skin,
protect against damage, enhancing self-
repair to reduce signs of aging."
Sheldon Pinnell
M.D., Founding Scientist of SkinCeuticals
SKINCEUTICALS PROVIDES ADVANCED :
1
FORMULATION AND SYNERGIES
OF POTENT VITAMIN C
2
SCIENTIFIC AND CLINICAL
VALIDATION OF CLAIMS
3
INTEGRATION WITH
IN- OFFICE PROCEDURES
Dr. Pinnell’s research established
the paramaters for effective vitamin C
antioxidant delivery to skin, allowing
SkinCeuticals to pioneer the emergence
of cosmeceuticals.
FORMULATION AND SYNERGIES
OF POTENT VITAMIN C
FORMULATION AND SYNERGIES
With over 30 years of research, only SkinCeuticals vitamin C antioxidants have been shown to deliver enhanced
absorption and proven efficacy along three strict parameters.
60 0 PURE L-ASCORBIC
ACID
Topically delivered
l-ascorbic acid has
VITAMIN C (PMOL/MG)
40 0
PURE been shown to increase
L-A SCORB I C vitamin C levels in skin.
1 AC I D 20 0
0 CONTROL SKINCEUTICALS ASCORBYL MAGNESIUM
15% L-ASCORBIC ACID PALMITATE ASCORBYL
FORMULATION FORMULATION PHOSPHATE
FORMULATION
120 0 HIGH
CONCENTRATIONS
90 0
OF L-ASCORBIC ACID
ABSORPTION LEVELS
10–20% concentration
CONCENTRATION provides meaningful
1 0 -2 0 %
60 0
levels of vitamin C
in skin.
30 0
0 0 5 10 15 20 25 30
PERCENT VITAMIN C
120 0 FORMULATED AT AN
ACIDIC pH
90 0 Only pH levels below
VITAMIN C (PMOL/MG)
3.5 provide optimal
60 0 vitamin C delivery.
p H < 3. 5
30 0
40 0
0 CONTROL 2 2.5 3 3.5 4 4.5 5
PH LEVELS
Source: Douglas, D; Sheldon, P. (1992). Stable Ascobic Acid Compositions. US Patent: 5,140,043. Pinnell, S.R., et al (2001). Dermatol Surg 27: 137–142
FORMULATION AND SYNERGIES
POTENT VITAMIN C
FORMULATION AND SYNERGIES
In addition to strict formulation parameters for topical vitamin C, SkinCeuticals antioxidant
serums contain precise ingredient combinations proven to perform synergistically.
1
10
8x
8
ENVIRONMENTAL PROTECTION
EN VIRON MEN TA L
6 PROTECTION
C E Ferulic: The combination of vitamins C,
4 E, and of ferulic acid yields 8x skin’s natural
environmental protection (p≤0.05).
2
Phloretin CF and Phloretin CF Gel
match its environmental protection.
0 VEHICLE VITAMIN C VITAMIN E C+E C+E+
FERULIC ACID
C E FERULIC PHLORETIN CF
U.S. PATENT NO. U.S. PATENT NO.
7,179,841 9,248,082
Pinnell, S.R., et al (2005). Ferulic Acid Stabilizes a Solution of Vitamin C and E and Doubles its Photoprotection of Skin. J Invest Dermatol 125:826-832.
SCIENTIFIC AND CLINICAL VALIDATION
SCIENTIFIC AND CLINICAL
VALIDATION OF CLAIMS
SkinCeuticals has extensive in-vivo research demonstrating the benefits of topical application
of SkinCeuticals antioxidants to help protect against environmental aggressors.
40
PROTECTION FROM ERYTHEMA
C E FERULIC PROVIDES MORE THAN *Phloretin CF and Phloretin CF Gel provide
TWICE THE PROTECTION OF ITS MOST equally significant protection against
30
EFFICIENT COMPETITOR environmentally-induced inflammation
20
10
2 0
UNTREATED C E FERULIC COMPETITOR
A
COMPETITOR
B
COMPETITOR
C
COMPETITOR
D
COMPETITOR
E
COMPETITOR
F
COMPETITOR
G
Erythema is a marker of environmentally-induced free radical inflammation. SkinCeuticals
topical vitamin C formulation, C E Ferulic, provides superior protection against this damage
three times the minimum erythema doses (3x MED)
VISIBLE SUBSTANTIATION
UNTREATED C E FERULIC COMPETITOR A COMPETITOR B COMPETITOR C COMPETITOR D
Protocol: 23 subjects with five randomized test sites received application of test products
for four consecutive days, followed by UV-irradiation of 3x MED at 1x MED intervals.
Measurements were taken two hours after application. C E Ferulic was tested in two cells;
its weighted average is indicated in the quantitative data above. Competitors were seven
leading, global competitor formulations sold in the professional channel, that claim high
concentrations of vitamin C (between 10–20%).
COMPETITOR E COMPETITOR F COMPETITOR G
BIOLOGICAL SUBSTANTIATION
Erythema testing for inflammation is only one method of antioxidant testing. Comprehensive evaluation should
also include biomarker testing, indicating biological action, which is an additional predictor of antioxidant activity
in skin. This substantiation should be subject to peer-review for publication in scientific journals.
BIOMARKER SUBSTANTIATION IN PEER-REVIEWED PUBLICATIONS
SKINCEUTICALS SKINCEUTICALS COMPETITOR COMPETITOR COMPETITOR COMPETITOR COMPETITOR COMPETITOR COMPETITOR
C E FERULIC PHLORETIN CF A B C D E F G
Pinnell, S.R., et al (2005). J Invest Dermatol 125:826-832. Pinnell, S.R., et al (2008). J Am Acad Dermatol 59:418-425. Pinnell, S.R., et al (2008). J Cosmet Dermatol 7:290-297.
SCIENTIFIC AND CLINICAL VALIDATION
SCIENTIFIC AND CLINICAL
VALIDATION OF CLAIMS
C E FERULIC : REDUCTION OF THYMINE DIMERS
10 0 In-vivo, C E Ferulic significantly reduces
thymine dimer count versus vehicle (p≤0.05).
MEAN NO. THYMINE DIMERS
80
Caused by UVA radiation, thymine dimers
60
are DNA mutations.
2
40
Phloretin CF also shows significant results
20 on thymine dimers.
0
VEHICLE C E FERULIC
PHLORETIN CF: REDUCTION OF P53 INDUCTION
80 In-vivo, skin protected with Phloretin CF shows
significantly lower levels of p53 compared to
60
placebo (p≤0.05).
CELLS / MM SKIN
An increased expression of p53 indicates
40
damage to the skin.
20
C E Ferulic and Phloretin CF Gel also show
significant results on p53 induction.
0 PLACEBO PHLORETIN CF UNEXPOSED
(CONTROL)
C E FERULIC : REDUCTION OF INFRARED RADIATION A-INDUCED MMP-1 UPREGULATION
4 In-vivo, C E Ferulic significantly reduces the
upregulation of IR-A-induced MMP-1 by 62%
3 (p≤0.05).
MMP-1 / 185 RRNA
2 MMP-1 is the main collagen-degrading
enzyme in human skin.
1
0 UNIRRADIATED INFRARED A C E FERULIC
SCIENTIFIC AND CLINICAL VALIDATION
NEW DISCOVERY
SKINCEUTICALS C E FERULIC HELPS
REDUCE MARKERS OF DAMAGE INDUCED BY
A COMBINATION OF ATMOSPHERIC AGGRESSORS
Traditionally, the effects of atmospheric aggressors on skin have been tested individually. A new SkinCeuticals study
exposed skin explants to different combinations of ultraviolet light (UV), ozone (O3 ), and diesel engine exhaust
(DEE) that one would experience in a typical, urban environment.
This study demonstrates that the combination of these atmospheric aggressors increases levels of oxidative and
inflammatory markers, and decreases levels of key epidermal proteins required for healthy skin barrier function.
2 Topical treatment with C E Ferulic effectively helps prevent oxidative damage, inflammation, and skin protein
damage induced by combined aggressor exposure.
SCIENTIFIC AND CLINICAL VALIDATION
NEW DISCOVERY
SKINCEUTICALS C E FERULIC HELPS
REDUCE MARKERS OF DAMAGE INDUCED BY
A COMBINATION OF ATMOSPHERIC AGGRESSORS
C E FERULIC
HELPS PREVENT OXIDATIVE DAMAGE INDUCED BY COMBINED AGGRESSOR EXPOSURE - 4HNE
2
1.6
2
4HNE EXPRESSION
1.2
0.8
0.4
0
CONTROL C E FERULIC UV C E FERULIC UV C E FERULIC UV C E FERULIC UV C E FERULIC
+ + + + + + + +
CONTROL UV O3 UV DEE UV O3 UV
+ + + +
O3 DEE DEE O3
+
DEE
Exposure to aggressors can cause an increase in 4HNE, a biomarker of lipid peroxidation and protein oxidation. 4HNE
expression increased by 70% 24-hours after skin was exposed to the combination of UV, ozone, and diesel engine exhaust.
C E FERULIC
Helped to reduce 4HNE activation by 41% from the combination of all 3 aggressorss
*Statistically significant result vs. exposure to 3 aggressors alone, p < 0.05
CONTROL COMBINED AGGRESSOR C E FERULIC +
EXPOSURE COMBINED AGGRESSOR
The oxidative pathway 4HNE was EXPOSURE
activated when skin was exposed to When skin was exposed to the
the combination of UV + ozone + combination of UV + ozone + diesel
diesel engine exhaust, which can be engine exhaust, C E Ferulic helped
seen by the increase in fluorescence reduce 4HNE activation, which can
be seen by the lack of fluorescence
Reference: Ferrera, F. et al. (2020). Additive effect of combined pollutants to UV induced skin OxInflammation damage. Evaluating the protective topical application of a cosmeceutical mixture formulation.
Elsevier B.V. February 2020
SCIENTIFIC AND CLINICAL VALIDATION
NEW DISCOVERY
SKINCEUTICALS C E FERULIC HELPS
REDUCE MARKERS OF DAMAGE INDUCED BY
A COMBINATION OF ATMOSPHERIC AGGRESSORS
C E FERULIC
HELPS PREVENT INFLAMMATION INDUCED BY COMBINED AGGRESSOR EXPOSURE - NFkB
2
1.6
2
NFkB EXPRESSION
1.2
0.8
0.4
0
CONTROL C E FERULIC UV C E FERULIC UV C E FERULIC UV C E FERULIC UV C E FERULIC
+ + + + + + + +
CONTROL UV O3 UV DEE UV O3 UV
+ + + +
O3 DEE DEE O3
+
DEE
Exposure to aggressors can cause an increase in NFkB, a biomarker of skin inflammation. NFkB expression
increased by 97% 24-hours after skin was exposed to the combination of UV, ozone, and diesel engine exhaust.
C E FERULIC
Helped to reduce NFkB activation by 47% from the combination of all 3 aggressors
*Statistically significant result vs. exposure to 3 aggressors alone, p < 0.05
CONTROL COMBINED AGGRESSOR C E FERULIC +
EXPOSURE COMBINED AGGRESSOR
The inflammatory pathway EXPOSURE
NFkB was activated (stained When skin was exposed to the
green) when skin was exposed combination of UV + ozone +
to the combination of UV + diesel engine exhaust, C E Ferulic
ozone + diesel engine exhaust helped reduce NFkB activation
Reference: Ferrera, F. et al. (2020). Additive effect of combined pollutants to UV induced skin OxInflammation damage. Evaluating the protective topical application of a cosmeceutical mixture formulation.
Elsevier B.V. February 2020
SCIENTIFIC AND CLINICAL VALIDATION
NEW DISCOVERY
SKINCEUTICALS C E FERULIC HELPS
REDUCE MARKERS OF DAMAGE INDUCED BY
A COMBINATION OF ATMOSPHERIC AGGRESSORS
C E FERULIC
HELPS PREVENT SKIN PROTEIN DAMAGE INDUCED BY COMBINED AGGRESSOR EXPOSURE - FILAGGRIN
2
1.6
FILAGGRIN EXPRESSION
2 1.2
0.8
0.4
0
CONTROL C E FERULIC UV C E FERULIC UV C E FERULIC UV C E FERULIC UV C E FERULIC
+ + + + + + + +
CONTROL UV O3 UV DEE UV O3 UV
+ + + +
O3 DEE DEE O3
+
DEE
Exposure to aggressors can cause a decrease in filaggrin, a protein essential for skin barrier function. Filaggrin
expression decreased by 73% 24-hours after exposure to the combination of UV, ozone, and diesel engine exhaust.
C E FERULIC
Helped counteract 55% of filaggrin degradation from the combination of all 3 aggressors
*Statistically significant result vs. exposure to 3 aggressors alone, p < 0.05
CONTROL COMBINED AGGRESSOR C E FERULIC +
EXPOSURE COMBINED AGGRESSOR
Filaggrin expression decreased EXPOSURE
(stained red) when skin was exposed When skin was exposed to the
to the combination of UV + ozone + combination of UV + ozone +
diesel engine exhaust diesel engine exhaust, C E Ferulic
helped preserve filaggrin proteins
Reference: Ferrera, F. et al. (2020). Additive effect of combined pollutants to UV induced skin OxInflammation damage. Evaluating the protective topical application of a cosmeceutical mixture formulation.
Elsevier B.V. February 2020SCIENTIFIC AND CLINICAL VALIDATION
SKINCEUTICALS ANTIOXIDANTS HELP
REDUCE MARKERS OF OZONE POLLUTION-INDUCED
INFLAMMATION
HELPS PREVENT OZONE POLLUTION-INDUCED INFLAMMATION - NFkB
250 Exposure to ozone pollution can cause an
increase in markers of inflammation. This is
200
reflected by the activation of the NFkB pathway.
2
NFkB EXPRESSION
150 NFkB expression increased by 140% when skin
was exposed to 0.8 ppm ozone.
100
50
C E FERULIC
0 Helped to reduce NFkB activation by 28%
CONTROL OZONE C E FERULIC PHLORETIN CF
EXPOSURE + + PHLORETIN CF
OZONE OZONE
EXPOSURE EXPOSURE Helped to reduce NFkB activation by 47%
*Statistically significant result vs. ozone exposure alone, p < 0.0001
CONTROL OZONE EXPOSURE C E FERULIC + PHLORETIN CF +
The inflammation OZONE EXPOSURE OZONE EXPOSURE
pathway NFkB was When skin was When skin was
activated (stained exposed to 0.8 ppm exposed to 0.8 ppm
green) when skin was ozone, C E Ferulic ozone, Phloretin CF
exposed to 0.8 ppm helped reduce NFkB helped reduce NFkB
zone activation activation
Reference: Valacchi, G et al. Vitamin C Compound Mixtures Prevent Ozone-Induced Oxidative Damage in Human Keratinocytes as Initial Assessment of Pollution Protection. PLOS ONE DOI:10.1371/
journal.pone.0131097SCIENTIFIC AND CLINICAL VALIDATION
SKINCEUTICALS ANTIOXIDANTS HELP
REDUCE MARKERS OF OZONE POLLUTION-INDUCED
SKIN AGING
HELPS PREVENT AGAINST OZONE POLLUTION-INDUCED TYPE III COLLAGEN DEGRADATION
100 WHEN SKIN WAS EXPOSED TO 0.8 PPM OZONE
• Type III collagen decreased by an average of 60%
80
TYPE III COLLAGEN LEVELS
2
• Skin treated wtih C E Ferulic showed 35% less type
60 III collagen degradation
40 • Skin treated with Phloretin CF showed 95% less
type III collagen degradation
20
*Statistically significant result vs. ozone exposure alone, PCF pSCIENTIFIC AND CLINICAL VALIDATION
VISIBLE ANTI-AGING RESULTS
Along with extensive scientific testing, all SkinCeuticals vitamin C antioxidant
formulas are demonstrated to clinically improve skin aging.
C E FERULIC : REDUCTION IN COARSE WRINKLES, IMPROVED
SKIN FIRMNESS, AND A BRIGHTENED COMPLEXION
C E FERULIC: highly effective on
BASELINE
firmness, elasticity, and wrinkles
2 FINE LINES
FIRMNESS
ELASTICITY
WRINKLES
0 5 10 15 20 25 30 35 40
% IMPROVEMENT
Statistically significant (p≤0.05) Clinical results at week 52.
16 WEEKS
AVERAGE results
Protocol: 16-week clinical study conducted on 50 caucasian male and female subjects ages 40–60 years old (USA, 2013). Protocol: 52-week clinical study conducted on 50 female
For controlled results, subjects used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30 daily, and Emollience subjects ages 40–60 years old of all skin types (USA, 2011).
moisturizer as needed. For controlled results, subjects used SkinCeuticals Gentle
Cleanser and Ultimate UV Defense SPF 30 daily, and
Hydrating B5 Gel as needed.SCIENTIFIC AND CLINICAL VALIDATION
VISIBLE ANTI-AGING & ANTI – PIGMENTATION RESULTS
PHLORETIN CF: REDUCTION IN DISCOLORATION
AND UNEVEN SKIN TONE
PHLORETIN CF: highly effective
BASELINE
on skin tone, discoloration, and
skin radiance
2 FINE LINES
TONE
DISCOLORATION
WRINKLES
0 5 10 15 20 25 30 35 40
% IMPROVEMENT
Statistically significant (p≤0.05) Clinical results at week 24.
18 WEEKS
AVERAGE results
Protocol: 24-week clinical study conducted on 35 caucasian female subjects ages 35–65 years old (USA, 2008). Protocol: 24-week clinical study conducted on 35
For controlled results, subjects used SkinCeuticals Gentle Cleanser and a sunscreen daily. caucasian female subjects ages 35–65 years old (USA,
2008). For controlled results, subjects used SkinCeuticals
Gentle Cleanser and a sunscreen daily.SCIENTIFIC AND CLINICAL VALIDATION
VISIBLE ANTI-AGING RESULTS
AOX + EYE GEL : REDUCTION IN DARK CIRCLES
AND FINE LINES WHILE IMPROVING RADIANCE
BASELINE
2
8 WEEKS
AVERAGE results
Protocol: 12-week clinical study conducted on 40 male and female subjects 30-56 years old (USA, 2010).CE FERULIC + LASER
INTEGRATION WITH IN-OFFICE PROCEDURES
INTEGRATION WITH IN- OFFICE PROCEDURES
C E FERULIC: THE STANDARD FOR POST-LASER CARE
C E Ferulic is unique in its proof of safety and efficacy when used in conjunction with laser treatments.
Clinical trials
7 30+
Presentations
Published in 2017
Lasers Surgery
demonstrating efficacy globally and Medicine
and safety post-ablative -Waibel, et al.
and non-ablative laser.
3 1 INCREASES SERUM'S TOPICAL UPTAKE
A C C E L E R AT E D TO P I C A L U P TA K E
LOW-ENERGY NON-ABLATIVE FRACTIO NAL LASER INCREASES TOPICAL UPTAKE OF C E FERULIC
BY 17X 1
2 Laser + C E Ferulic
C U M U L AT I V E P E R M E AT I O N ( mg / cm 2)
17x
1.8 C E Ferulic alone
1.6
1.4
1.2
1
0.8
0.6
0.4
0.2
A C C E L E R A T E D T0O P I C A 5L U P T10A K E 15 20 25 30
TO P I C A L U P TA K E
T I M E ( hours)
2 Laser + C E Ferulic
17x
1.8 Laser + C E Ferulic C E Ferulic alone
17 xCLINICALLY PROVEN TO COMPLEMENT RESULTS + REDUCE DOWNTIME
1.6 C E Ferulic alone
2
1.4
1.2
POST NON-ABLATIVE LASER
1
0.8 IN- OFFICE POST-LASER APPLICATION OF PATIENT ASSESSMENT SHOWS INCREASED
0.6 C E FERULIC IS SAFE AND CLINICALLY PROVEN PATIENT SATISFACTION AFTER 1 AND 3
0.4
TO 2 : MONTHS IN 2 :
• Decrease post-laser erythema, edema, and heat • Dyschromia
0.2
sensation by 2 days
0 5 10 15 20 25 30 • Firmness
v
15 20 25 30
T I M E ( hours)
• Radiance
M E ( hours) • Overall appearance
References:
Elford, Erica Lee, et al. American Society for Laser Medicine and Surgery. Enhanced Skin Permeability of Topical Aqueous Antioxidant Serum following 1927nm Laser Treatment. 2013.
Brauer, Jeremy & Elford, Erica & Loncaric, Anya & Struck, Steven & Bedi, Vikramaditya & Geronemus, Roy. (2012). TREATMENT OF PHOTOAGED SKIN USING FRACTIONAL NON-ABLATIVE LASER IN
COMBINATION WITH TOPICAL ANTIOXIDANTS. Lasers in Surgery and Medicine. 44. 68-68.INTEGRATION WITH IN-OFFICE PROCEDURES
INTEGRATION WITH IN- OFFICE PROCEDURES
C E FERULIC: THE STANDARD FOR POST-LASER CARE
C E Ferulic is unique in its proof of safety and efficacy when used in conjunction with laser treatments.
3 CLINICALLY PROVEN TO ACCELERATE RECOVERY POST FRACTIONAL ABLATIVE LASER
C E FERULIC APPLIED IMMEDIATELY POST LASER AND REDUCTION OF SWELLING 4 DAYS POST TREATMENT
CONTINUED DAILY FOR SEVEN DAYS IS CLINICALLY
PROVEN TO3:
• Decrease post-laser erythema on days 3 and 5
3 • Decrease post-laser swelling on day 7
• Decrease post-laser downtime by 2 days
• Accelerate return to work and social activities at 5 days
vs. typical duration of 7-10 days
LASER + OCCLUSIVE OINTMENT LASER + C E FERULIC
Lasers in Surgery and Medicine
Laser-Assisted Delivery of Vitamin C, Vitamin E, and Ferulic
Acid Formula Serum Decreases Fractional Laser
Postoperative Recovery by Increased Beta Fibroblast
Growth Factor Expression
Jill S. Waibel, MD,1 Qing-Sheng Mi, MD, PhD,2 David Ozog, MD,3 Le Qu,4 Li Zhou, MD,2 Ashley Rudnick, BS,1
Firas Al-Niaimi, MSc, MRCP, EBDV,5 Julie Woodward, MD,6 Valerie Campos, MD,7 and Serge Mordon, PhD8
1
Miami Dermatology and Laser Institute, 7800 SW 87th Avenue, Suite B200, Miami, Florida 33173
2
Hesnry Ford Immunology Program, Departments of Dermatology and Internal Medicine, Henry Ford Hospital, 1 Ford
Place, Detroit, Michigan 48202
3
Henry Ford Immunology Program, Henry Ford Hospital, 3031 W Grand Blvd., Detroit, Michigan 48202
4
Henry Ford Immunology Program, Department of Dermatology, Henry Ford Hospital, 1 Ford Place, Detroit, Michigan
"Results from this study show trends of decreasing downtime 24–48 hours with ability of
48202
5
Sk:n Clinic, 144 Harley Street, London, UK
6
Duke University, 2351 Erwin Rd., Suite 3802, Durham, North Carolina 27705
7
Clı´nica Val
eria Campos, Jundiaı´, S~
ao Paulo, Brazil
8
INSERM U1189, INSERM, 1 Avenue Oscar Lambret, Lille, France
patients to return to work and social life more quickly."4
Background and Objective: Laser-assisted drug deliv- rapid wound healing. Lasers Surg. Med.
ery is an emerging technology to achieve greater penetra- 2015 Wiley Periodicals, Inc.
tion by existing topical medications to reach desired
targets in the tissue. The objective of this research Key words: drug delivery systems; wound healing
was to study whether laser-assisted delivery of Vitamin
C, E, and Ferulic immediately postoperatively of fractional
ablative laser could improve wound healing. Secondary INTRODUCTION
objectives were to evaluate the potential molecular Ablative fractional resurfacing has become a powerful
markers involved in this wound-healing process. tool for facial skin rejuvenation. In our busy society,
Study Design/Material and Methods: A double postoperative downtime is a major factor for patients when
blinded, prospective, single center, randomized split face considering esthetic procedures.
trial of Vitamin C, E, and Ferulic topical formula #740019 Fractional lasers were developed within the last decade
to decrease postoperative recovery time in fractional to treat rhytids [1,2]. Non-ablative fractional lasers were
ablative laser resurfacing for photo damage. Fifteen first discovered and only function to coagulate collagen. In
healthy men and women of ages 30–55 years were treated 2008, more robust fractional ablative lasers were intro-
- DR. JILL WAIBEL
with the Vitamin C, E, and Ferulic acid serum to one side of duced, which vaporize thin columns in the epidermis and
face and vehicle to the other side of face, within 2 minutes dermis in a fractional pattern. The depth of these zones
immediately after fractional ablative CO2 laser surgery is determined by the laser fluence. Because the wounds are
and daily during the healing process. Patients were so small (120–300 mm in diameter), there is a rapid healing
evaluated daily on days 1–7 using photographs, patient response with a unique molecular healing cascade and
questionnaires, and molecular evaluation. prolonged neocollagenesis [3]. These microscopic vertical
Results: Clinically, postoperative Vitamin C, E, and
Ferulic delivery resulted in decreased edema versus
vehicle on postoperative day 7 and decreased erythema
versus vehicle on postoperative days 3 and 5. Molecularly, Conflict of Interest Disclosures: All authors have completed
the expression of basic fibroblast growth factor (bFGF) was and submitted the ICMJE Form for Disclosure of Potential
Conflicts of Interest and none were reported.
significantly increased at day 5 on the lesion treated with Contract grant sponsor: Loreal/SkinCeuticals.
Vitamin C, E, and Ferulic acid serum compared to vehicle Correspondence to: Jill S. Waibel, MD, Miami Dermatology
control on the other side. and Laser Institute, 7800 SW 87th Avenue, Suite B200, Miami,
FL 33173.
Conclusion: This is first study to show that Vitamin C, E, E-mail: jwaibelmd@miamidermlaser.com
and Ferulic acid correlate with more rapid wound healing Accepted 9 November 2015
Published online in Wiley Online Library
post-fractional ablative laser. Elevated bFGF could be (wileyonlinelibrary.com).
involved in the Vitamin C, E, and Ferulic acid-induced DOI 10.1002/lsm.22448
2015 Wiley Periodicals, Inc.
Reference:
Waibel J.S., Mi Q.S. et al. (2015). Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor
expression., Laser in Surgery and Medicine, November 2015.INTEGRATION WITH IN-OFFICE PROCEDURES
WHICH ANTIOXIDANT FORMULA
IS RIGHT FOR YOUR PATIENT?
SkinCeuticals has developed a full menu of high-potency antioxidant formulas designed to provide
the most advanced protection from environmental damage for all skin types and concerns.
C E FERULIC®
N, D, C, S
AGIN G
3
DI S C OLOR AT I ON
PHLORETIN CF
N, O, C
SERUM 10
S E N S I T I ZE D
All skin types
AOX+ EYE GEL
N, O, D, C
E YE
RESVERATROL B E S KIN T Y P E S
NI GHT TI ME
N, D, C, S N : N ORMA L
O: OILY
D : DRY
C : C OMB IN ATION
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