40 Jahre Brustkrebsforschung auf höchstem Niveau - GABG-GBG 40 years of high level BREAST Cancer Research Made in Germany
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40 Jahre Brustkrebsforschung auf höchstem Niveau
GABG-GBG 40 years of high level BREAST Cancer Research
Made in Germany
Prof. Dr. Sibylle Loibl
Chair of the German Breast Group
Centre of Haematology and Oncology
History and Milestones of the German Breast Group
1981: Foundation of GABG e.V. 2003: Foundation of GBG 2008: Expansion in 2015: Biobank 2.0
Forschungs GmbH translational research
Today the living founders of the GBG Modernization of biobank with
are honorary members of the group by Prof. von Minckwitz more than 40,000 samples
Group renamed as German Breast Surgical study (INSEMA)
Group (GBG)
2005: Biomaterial bank at the Dept. of
Pathology of the Charité Biobank in Marburg
1990s: Further
studies and new
2005: Start of the first post- 2011: Central pathology
regulations
neoadjuvant study (NATAN)
1981 1980s 1990s 2002 2003 2004 2005 2006 2008 2011 2014 2015 2017 2019 2021
2014: First global study
2002: Launch of neoadjuvant 2006: Establishment Penelope-B: launch of first
study GeparTrio MedCODES® global registration study with
patients from 4 continents
2,358 participants sponsored by GBG
First large scale study sponsored 2019: ONCOBIOME
by GBG 2004: First international GBG study in 2011: Responsify
1980s: Initial studies and expansion metastatic breast cancer (TBP) and ARO EU-framework program
criteria First EU-framework program H2020 with both partners
Merger of GABG with the study group of the
under scientific leadership of
Bundesministerium für Forschung und
GBG (Prof. Loibl and Prof.
2018: 50,000th patient
Technologie (BMFT)
Denkert)
Studienpatienten
60000
50000
40000
30000
20000
10000
0
1980 1985 1990 1995 2000 2005 2010 2015 2020
Der Vorstand der GABG
GABG I
GABG III
GABG III-B
tamoxifen (2 years)
R 6 x CMF
+ tamoxifen (2 years)
6 x CMF → tamoxifen (2 years)*
R 6 x FEC → tamoxifen (2 years)*
* in ER/PgR positive disease only GABG III-C
GABG IV
ZEBRA Studie – die erste internationale Kooperation
ER +ve x N=1189
ER -ve x
N=304
Kaplan-Meier DFS: ER-ve Overall x N=1614
1.0
Zoladex 0.8 1.0 1.25
0.9
Proportion alive and free of disease
CMF
0.8 Zoladex Region of equivalents CMF
0.7
better better
0.6 Interaction test, p=0.0016
0.5
0.4
0.3
0.2
0.1
0.0
0 1 2 3 4 5 6 7 8 9 10
Disease-free survival (years)
Wo war die GABG 2001
Studientreffen 2000 der GABG
Studienleitkommission
Neoadjuvante Therapie - die Anfänge
GEPARDO
JCO 1999, JCO 2001
The German
JCO 2005, JCO 2001
JNCI 2008, JNCI 2008, JCO 2013 GeparD
JCO 2010; JCO 2010; Ann Oncol 2013
NEJM 2012; Lancet Oncol 2012; Ann Oncol 2013
Lancet Onc 2014; Annals Oncol 2019
Lancet Onc 2016; J Clin Oncol 2019
>15000 Eur J Cancer 2019; SABCS 2019
Annals Oncol 2019; ASCO 2021
patients Annals Oncol 2020
since 1998 SABCS 2019Bei der BIG 2003
2003 in St. Gallen
GBG 2006
Internationales Parket
2014
2015
SABCS 2019-Impressionen GBG Beteiligung
GBG Subboards 2020 & AGO-B Board 2020
Neoadjuvant Operativ
Blohmer, Denkert, Fasching, Hanusch, Ataseven, Blohmer, Denkert, Gerber,
Huober, Jackisch, Link, Loibl, Rhiem, Golatta, Hahn, Heil, Krug, Kühn, Loibl
Schneeweiss, Solbach, Untch
Adjuvant Translationale Forschung (TraFo)
Vielen Dank an alle für die
Loibl, Marmé, Möbus, Reimer, Stickeler,
Reinisch, Janni, Schmatloch, Schmidt,
Denkert, Fasching, Karn, Loibl, Marmé,
Müller, Schem, Stickeler, van
Sinn, Untch GUTE ZUSAMMENARBEIT Mackelenbergh
Palliativ
Decker, Denkert, Loibl, Lübbe, AGO-B
Mundhenke, Müller, Schmidt, Thill Fasching, Fehm, Jackisch, Janni, Kühn,
Lück, Möbus, Müller, Rack, Schmidt,
Schneeweiss, Stickeler, Thomssen,
Untch u.a.Collaborators and network
Network Cooperation partners
Cooperating study groups and universities
Cooperating laboratories
Grupo Espanol de
Investigacion del
Cancer de Mama
Alliance for Clinical
Trials in Oncology
Latin American
Cooperative
Oncology GroupAcknowledgements
External Partners GBG
GBG Subboard Members
GBG Team
Michael Untch
Peter Fasching
Carsten Denkert
Cooperating partners
Paul Jank
Wolfgang Schmidt
GBG
Rita Schmutzler Valentina Nekljudova
Kerstin Rhiem Bärbel Felder
Eric Hahnen Karsten WeberGrüße aus Frankfurt
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