2nd International Congress of the World Association for Stress Related and Anxiety Disorders
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www.wasad2019.org 2nd International Congress of the World Association for Stress Related and Anxiety Disorders in conjunction with the Collaborative Research Center SFB TRR 58, Fear, Anxiety, Anxiety Disorders (funded by the DFG) Stress, Anxiety and Mental Health 03-05 October 2019 Würzburg, Germany Final Program
Congress Information Congress Venue Julius-Maximilians-Universität Würzburg Building Z6 Hubland Süd (Zentrales Hörsaal- u. Seminargebäude) Am Hubland 97074 Würzburg, Germany Host Organization World Association for Stress Related and Anxiety Disorders (WASAD) Schwanenhof 4, 97070 Würzburg, Germany Phone: +49 (0) 931 – 207 90248; Fax: + 49 (0) 931 – 207 90246 info@wasad.de Affiliate Organizer SFB-TRR 58 Fear, Anxiety, Anxiety Disorders Institut für Physiologie I, Robert-Koch-Straße 27, 48149 Münster, Germany Congress Presidents Prof. Dr. H. C. Pape, Germany; Prof. Dr. A. J. Fallgatter, Germany Local Organizing Committee Chairs: M. Gamer and P. Riederer, Germany J. Deckert, Germany; M. Gamer, Germany; P. Pauli, Germany; P. Riederer, Germany; M. Romanos, Germany Scientific Committee Chairs: H. C. Pape and A. J. Fallgatter, Germany Scientific Committee WASAD E. Binder, Germany, A.J. Fallgatter, Germany, J. Fayyad(†), Beirut, C. Jacob, Germany, J. Li, China, H. Ozawa, Japan, A. Reif, Germany, T. Renner, Germany, P. Riederer, Germany, E. Seifritz, Switzerland, S. Walitza, Switzerland Scientific Committee SFB-TRR 58 C. Büchel, Germany, U. Dannlowski, Germany, K. Domschke, Germany, J. Haaker, Germany, C. Heim, Germany, M. Gamer, Germany, K. Jüngling, Germany, H.C. Pape, Germany, P. Pauli, Germany 2
Congress Information Session formats Keynote Lectures Keynote lectures of 60 minutes will be given by a distinguished and renowned expert and will be devoted to a specific topic of major interest. Symposia These sessions of 90 minutes will focus on a particular topic and present the very latest data related to it. The symposia will include four speakers who present their research followed by discussion. These sessions will combine presentations by invited speakers and the best submitted papers accepted for the congress by the scientific committees. Posters Authors present their latest research findings or ongoing research as posters. Industry Sponsored Sessions Industry sponsored sessions of 60 minutes are organized by the industry in consultation with the scientific committee. Information for speakers: We kindly ask all speakers to come to their assigned room 15 minutes before the session starts. Please have your presentation ready in MS Powerpoint format on a USB stick. Please do not bring your own laptop. Someone will be available to assist you with uploading your presentation. Information for poster presenters: We kindly ask all poster presenters to mount their poster on Thursday, October 3rd, 13.15 - 17.00 or on Friday, October 4th, 08.15 - 11.00. Assistance and mounting material (poster strips) are available. Please see detailed program (p. 10) for the time you are requested to be present at your poster. The posters can remain on display until Saturday, October 5th, 18.30 (removal by the author is possible on Saturday afternoon), and will be removed by the organizers afterwards. Three posters will be selected for a WASAD Poster Award (Award Ceremony during Closing Session). Rooms: HS 0.001, HS 0.002 - ground floor SR 1.012, SR 1.003 - 1st floor CME points: The scientific program of the congress is certified by the Bayerische Landesärztekammer (BLÄK) with 22 CME points. Certificates can be obtained at the registration desk. Please note that only presenting authors are stated in the program due to space restrictions. All authors will be named in the printed abstracts. 3
Program overview Thursday HS 0.001 HS 0.002 SR 1.012 SR 1.003 Oct 3rd 14.00- Opening ceremony, 14.30 Welcome addresses New insights into Clinical perspectives Imaging of stress- 15.00- (dys-) regulation of in the treatment of induced brain 16.30 fear and anxiety in anxiety disorders functional changes rodents (GAF-Symposium) 17.00- Keynote lecture by 18.00 Rachel Yehuda 18.00- Welcome reception at the congress venue 20.00 Friday HS 0.001 HS 0.002 SR 1.012 SR 1.003 Oct 4th 09.00- Keynote lecture by 10.00 Mathias Schmidt Mapping mechanisms of gene 10.30- How anxiety Stress resilience and x environment 12.00 modulates attention vulnerability interaction in stress - from endophenotype to disease 12.15- Industry symposium 13.15 13.30- Keynote lecture by 14.30 Martin Paulus 15.30-16.30: 14.30- Poster session WASAD General 17.00 Assembly Anxiety Disorders - 17.00- Prediction, Stress and dementia SGAD Symposium 18.30 prevention and personalized therapy 4
Program overview Saturday HS 0.001 HS 0.002 SR 1.012 SR 1.003 Oct 5th 09.00- Keynote lecture by 10.00 Brenda Penninx Clinical targets for Temperament, gene Individual stress related and 10.30- and nutrition in differences in fear anxiety disorders in 12.00 anxiety and related and anxiety children and disorders adolescents 12.15- Meeting of SFB TRR Industry symposium 13.15 58 members 13.30- Keynote lecture by 14.30 Thomas Kash (Maternal) Stress Anxiety, depression 15.00- Neural dynamics of and its and cognition in 16.30 aversive learning consequences: from brain and heart animals to humans Telemedicine and Anxiety: genetics, Adult ADHD and 17.00- mobile assessment in social interactions stress: cause or 18.30 stress related and therapy consequence? disorders 18.45- Closing ceremony 19.00 5
Welcome address Dear colleagues, The World Association for Stress-Related and Anxiety Disorders (WASAD) aims to promote basic research and to foster effective and safe treatments and prevention strategies for mental illnesses related to abundant stress and anxiety. Such illnesses include depression, panic disorders, social anxiety disorders, specific phobias or separation anxiety disorders, PTSD, ADHD, sleep disorders and others. These are the most prevalent mental disorders and they are definitely related to increased levels of stress and associated with immense health care costs and a high burden of disease. According to large population-based surveys, roughly one third of the population is affected by an anxiety disorder during their lifetime. Substantial underrecognition and undertreatment of these disorders have been shown and recent efforts underline the importance of resilience. Untreated, stress related and anxiety disorders frequently follow a chronic course, and they are highly comorbid with other mental disorders, in particular with affective and substance abuse disorders. While research on pathophysiological mechanisms as well as diagnosis and treatment made substantial progress during the last years, translation into clinical practice is still lacking behind. At this joint conference, WASAD and the "SFB-TRR 58, Fear, Anxiety, Anxiety Disorders” offer a total of 23 scientific sessions addressing those problems and provide a forum for scientists, clinicians, practicing physicians, psychotherapists, PostDocs and PhDs, students and other health care professionals to exchange knowledge and experiences in the fields of basic and clinical research and to transfer this information into successful clinical applications for the benefit of our patients. In this sense, we wish you all a fruitful and stimulating conference! Yours sincerely, Prof. Dr. Peter Riederer Prof. Dr. Andreas J. Fallgatter Prof. Dr. Hans-Christian Pape President WASAD Vice-President WASAD Coordinator SFB-TRR 58 and Congress President and Congress President 6
Scientific Program – Thursday, October 3rd 14.00 - 14.30 | Opening Ceremony HS 0.002 Welcome Addresses Alfred Forchel, President, University of Würzburg Matthias Frosch, Dean, Faculty of Medicine, University of Würzburg Andreas Fallgatter, Congress President Hans Christian Pape, Congress President Peter Riederer, President WASAD 15.00 - 16.30 | Parallel Sessions HS 0.001 SFB Symposium | New insights into (dys-) regulation of fear and anxiety in rodents Chair: Andreas Draguhn, Heidelberg, and Hans-Christian Pape, Münster Studying neural mechanisms of stress vulnerability and 15.00 Gal Richter-Levin resilience in an animal model of PTSD Brainstem circuits mediating behavioral and autonomic 15.20 Philip Tovote defensive states Novel vistas on Neuropeptide S-mediated fear regulation from 15.40 Kay Jüngling a humanized mouse model Encoding of social information by subpopulations of amygdala 16.00 M. S. Fustiñana neurons HS 0.002 WASAD Symposium | Clinical perspectives in the treatment of anxiety disorders (Symposium of the GAF) Chair: Katharina Domschke, Freiburg, and Peter Zwanzger, Wasserburg D-cycloserine (DCS) adjunct treatment in combination with 15.00 Andreas Ströhle cognitive behavioral therapy (CBT) 15.20 Miriam Schiele Prevention of anxiety disorders Non-invasive brain-stimulation and its impact on extinction 15.40 Martin Herrmann learning 16.00 Julia Diemer Virtual reality as a new tool for the treatment of anxiety 7
Scientific Program – Thursday, October 3rd SR 1.012 WASAD Symposium | Imaging of stress-induced brain functional changes Chair: Martin Walter, Jena, and Andreas J. Fallgatter, Tübingen Marie-José van 15.00 Imaging stress effects in depression and anxiety Tol 15.20 Martin Walter Imaging of stress-induced brain functional changes Neuroimaging results from the Leiden Family Lab study on Janna Marie Bas- 15.40 Social Anxiety Disorder: a multiplex, multigenerational Hoogendam endophenotype study Temporal unpredictability increases BNST and Amygdala 16.00 Niklas Siminski activity during threat processing 17.00 - 18.00 | Keynote Lecture HS 0.001 Chair: Elisabeth Binder, Munich Rachel Yehuda, New York Intergenerational effects of trauma 18.00 - 20.00 | Welcome Reception Ground floor 8
Scientific Program – Friday, October 4th 9.00 - 10.00 | Keynote Lecture HS 0.001 Chair: Norbert Sachser, Münster Mathias Schmidt, Munich Ramping up stress resilience: Genetic and environmental factors 10.30 - 12.00 | Parallel Sessions HS 0.001 SFB Symposium | How anxiety modulates attention Chair: Herta Flor, Heidelberg, and Matthias Gamer, Würzburg How to conceptualize, measure, and modify anxiety-related 10.30 Ernst Koster attentional bias Fear and anxiety in the visual brain - Differential visuocortical 10.50 Matthias Wieser processing of predictable and unpredictable threat Space, time and anxiety: Survival decisions along defensive 11.10 Dean Mobbs circuits Fear generalization of implicit conditioned facial features – 11.30 Kati Roesmann Behavioral and magnetoencephalographic correlates HS 0.002 WASAD Symposium | Stress resilience and vulnerability Chair: Annamaria Cattaneo, London, and Marco A. Riva, Milano Annamaria Role of miRNA19 in the mechanisms associated with stress 10.30 Cattaneo vulnerability and stress resilience Molecular signatures of prenatal stress exposure and 10.50 Marco A. Riva relevance for the susceptibility and resilience to mental illness Stress reactivity in individuals with high vs low interoceptive 11.10 Hina Ghafoor accuracy Long-term effectiveness of prolonged exposure for adolescents 11.30 Soraya Seedat with PTSD using a task-shifted intervention: Randomised controlled trial with supportive counselling as a comparator 9
Scientific Program – Friday, October 4th SR 1.003 WASAD Symposium | Mapping mechanisms of gene x environment interaction in stress - from endophenotype to disease Chair: Elisabeth Binder, Munich, and Thora Halldorsdottir, Reykjavik Neurobiology of self-regulation: Longitudinal influence of Thora 10.30 FKBP5 early life stress on emotional and cognitive Halldorsdottir development in childhood A polygenic score of molecular sensitivity to GR-stimulation 10.50 Immanuel Elbau maps to stress related changes of the brains hemodynamic response function Charlotte Interactions between FKBP5 variation and environmental 11.10 Piechaczek stressors in adolescent major depression Posttraumatic stress disorder in a war-exposed sample from Alma Džubur 11.30 Balkan countries: The impact of (epi-) genetic variation on Kulenović disease susceptibility and the severity of symptoms 12.15 - 13.15 | Industry Sponsored Session SR 1.012 13.30 - 14.30 | Keynote Lecture HS 0.001 Chair: Paul Pauli, Würzburg Martin Paulus, Tulsa Computational models of anxiety 14.30 - 17.00 | Poster Session Open areas on 1st and 2nd floor List of posters: see pages 19-23 Posters with even numbers are to be presented between 14.30 and 15.45, posters with odd numbers are to be presented between 15.45 and 17.00. 10
Scientific Program – Friday, October 4th 17.00 - 18.30 | Parallel Sessions HS 0.001 SFB Symposium | Anxiety Disorders – Prediction, prevention and personalized therapy Chair: Andreas Papassotiropoulos, Basel, and Katharina Domschke, Freiburg Vijaya Separation anxiety grows up: an overview of separation 17.00 Manicavasagar anxiety in adults 17.20 Marcel Romanos Developmental fear generalization Katharina 17.40 Epigenetics of anxiety Domschke Genetic variability of GLRB impact cognitive behavioral 18.00 Heike Weber therapy response in panic disorder HS 0.002 WASAD Symposium | Stress and dementia Chair: Peter Riederer, Würzburg, and Frank Jessen, Cologne 17.00 Frank Jessen The role of stress in the development of dementia Early life stress and its programming effects and lasting 17.20 Paul J. Lucassen consequences Stress and neuroinflammation as possible mediators of acute 17.40 Ana Babić Perhoč cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer’s disease 18.00 Thomas Polak Anxiety in old age – data of the Vogel study 11
Scientific Program – Friday, October 4th SR 1.003 WASAD Symposium | Symposium of the SGAD (Schweizerische Gesellschaft für Angst und Depression) Chair: Erich Seifritz, Zurich, and Susanne Walitza, Zurich 17.00 Birgit Kleim Predictors of stress resilience The effect of psychosocial and craving-induced stress on social 17.20 Boris Quednow cognition and decision-making in cocaine users: a longitudinal approach The relationship between sleep and brain plasticity and its 17.40 Reto Huber relevance for psychiatric disorders Preclinical view on the mechanism of antidepressant activity of 18.00 Hans Kalkmann eicosapentaenoic acid 12
Scientific Program – Saturday, October 5th 9.00 - 10.00 | Keynote Lecture HS 0.001 Chair: Marcel Romanos, Würzburg Brenda Penninx, Amsterdam Towards reducing the public health impact of anxiety disorders 10.30 - 12.00 | Parallel Sessions HS 0.001 SFB Symposium | Individual differences in fear and anxiety Chair: Tina Lonsdorf, Hamburg, and Ulrike Lüken, Berlin Isaac R. Galatzer- Hacking behavior to understand brain based disorders: the role 10.30 Levy of computation to re-define clinical phenotypes Using individual differences to construct machine learning 10.50 Kevin Hilbert based models for single-subject classification and prediction in anxiety and related disorders Theranostic markers for personalized therapy of spider phobia: 11.10 Elisabeth Leehr Methods of a bicentric external cross-validation machine learning approach Do individual patterns of attentional exploration predict 11.30 Mario Reutter differences in fear generalization? 13
Scientific Program – Saturday, October 5th HS 0.002 WASAD Symposium | Temperament, gene and nutrition in anxiety and related disorders Chair: Hiroki Ozawa, Nagasaki, and Takeshi Inoue, Tokyo 10.30 Ken Yonezawa Relationship between omega-3 fatty acid and mental disorder Yoshirou Gene-based rare variants association test implicates PLA2G4E 10.50 Morimoto as a risk gene for panic disorder Temperaments, child abuse and stressful events in anxiety and 11.10 Takeshi Inoue related disorders Gene polymorphisms are associated with treatment-resistant 11.30 Jie Li depression in Han Chinese SR 1.012 WASAD Symposium | Clinical targets for stress related and anxiety disorders in children and adolescents Chair: Susanne Walitza, Zurich, and Lizbeth Utens, Amsterdam The link between the genetic risk load, anxiety and stress in 10.30 Edna Grünblatt individuals at clinical high risk for psychosis Anxiety in children with somatic conditions: outcome of CBT 10.50 Lizbeth Utens and EMDR for the clinical targets IBD and congenital heart disease Potential DNA methylation and miRNA markers for 11.10 Ulrike Schmidt posttraumatic stress disorder (PTSD) Madlena 11.30 Psychological risk factors of gifted adolescents Arakelyan 12.15 - 13.15 | Industry Sponsored Session HS 0.002 14
Scientific Program – Saturday, October 5th 13.30 - 14.30 | Keynote Lecture HS 0.001 Chair: Christian Büchel, Hamburg Thomas Kash, Chapel Hill The role of the extended amygdala in alcohol-drinking driven alterations in threat response 15.00 - 16.30 | Parallel Sessions HS 0.001 SFB Symposium | Neural dynamics of aversive learning Chair: Marta Andreatta, Würzburg, and Jan Haaker, Hamburg 15.00 Andreas Olsson Social learning and decision making under threat Dissociable influences of anxiety on pain and arousal during 15.20 Lauren Atlas aversive reversal learning Influencing and modulating factors of aggression and 15.40 Ute Habel impulsivity 16.00 Christian Büchel Neural mechanisms of fear generalization HS 0.002 WASAD Symposium | (Maternal) Stress and its consequences: from animals to humans Chair: Birgit Derntl, Tübingen, and Andreas J. Fallgatter, Tübingen 15.00 Liisa Galea Stress effects in postpartal depression Stress and its consequences on cognition and emotion in 15.20 Birgit Derntl women and men Psychological outcomes after pediatric hospitalization: the role 15.40 Maya Meentken of trauma type Truth lies in the hair: Prenatal hair steroids predict postpartum 16.00 Thorsten Mikoteit depression 15
Scientific Program – Saturday, October 5th SR 1.012 WASAD Symposium | Anxiety, depression and cognition in brain and heart Chair: Jürgen Deckert, Würzburg, and Stefan Frantz, Würzburg Investigating the brain-heart connection: the Depression 15.00 Andreas Menke Associated Cardiac Failure (DACFAIL) Study A web-based intervention for improving psychosocial distress 15.20 Stefan M. Schulz in heart failure patients with an implantable cardioverter defibrillator Sarah Kittel- Anxiety, depression and heart function – The genetic 15.40 Schneider connection 16.00 Anna Frey Cognition matters in patients with chronic heart failure 17.00 - 18.30 | Parallel Sessions HS 0.001 WASAD Symposium | Telemedicine and mobile assessment in stress related disorders Chair: Tobias J. Renner, Tübingen, and Gudmundur Skarphedinsson, Reykjavik 17.00 Karsten Hollmann E-health interventions in pediatric OCD Gudmundur Developing and implementing iCBT for pediatric obsessive- 17.20 Skarphedinsson compulsive disorder in Iceland An online based stress management intervention for patients 17.40 Sonja Kleih with Parkinson’s disease Clinical, behavioral and magnetoencephalographic correlates 18.00 Kati Roesmann of fear generalization before and after virtual reality exposure therapy in spider phobia 16
Scientific Program – Saturday, October 5th HS 0.002 WASAD Symposium | Anxiety: genetics, social interactions and therapy Chair: Grit Hein, Würzburg, and Manuel Mattheisen, Würzburg Manuel OCD genetics: updates from the Danish OCD and Tourette’s 17.00 Mattheisen study and the Psychiatric Genomics Consortium 17.20 Angelika Erhardt Genetics and epigenetics of panic disorder 17.40 Grit Hein Social buffering of anxiety Expectancy violation as mechanism of change in exposure- 18.00 André Pittig based cognitive-behavioural therapy SR 1.012 WASAD Symposium | Adult ADHD and stress: cause or consequence? Chair: Christian Jacob, Esslingen, and Gara Arteaga Henríquez, Barcelona Gara Arteaga 17.00 Cortisol awakening response and ADHD Henríquez 17.20 Corina Greven ADHD and stress-reducing psychotherapy 17.40 Francisco Esteves Attention, eating disorders and body dissatisfaction Sarah 18.00 Chronic stress and quality of life in adult ADHD Kittel-Schneider 18.45 - 19.00 | Closing Ceremony HS 0.002 Awards Ceremony for poster awards Closing remarks Peter Riederer, Germany 17
Speakers Keynote speakers Kay Jüngling, Münster Thomas Kash, Chapel Hill Hans Kalkmann, Basel Martin Paulus, Tulsa Sarah Kittel-Schneider, Würzburg Brenda Penninx, Amsterdam Sonja Kleih, Würzburg Mathias Schmidt, Munich Birgit Kleim, Zurich Rachel Yehuda, New York Ernst Koster, Ghent Elisabeth Leehr, Münster Jie Li, Tianjin Speakers in plenary symposia Paul J. Lucassen, Amsterdam (listed in alphabetical order) Vijaya Manicavasagar, Sydney Madlena Arakelyan, Yerevan Manuel Mattheisen, Würzburg Lauren Atlas, Bethesda Maya Meentken, Rotterdam Ana Babić Perhoč, Zagreb Andreas Menke, Würzburg Janna Marie Bas-Hoogendam, Leiden Thorsten Mikoteit, Solothurn Christian Büchel, Hamburg Dean Mobbs, Pasadena Annamaria Cattaneo, London Yoshirou Morimoto, Nagasaki Birgit Derntl, Tübingen Andreas Olsson, Stockholm Julia Diemer, Wasserburg Charlotte Piechaczek, Munich Katharina Domschke, Freiburg Andre Pittig, Würzburg Alma Džubur Kulenović, Sarajevo Thomas Polak, Würzburg Immanuel Elbau, Munich Boris Quednow, Zurich Angelika Erhardt, Munich Gal Richter-Levin, Haifa Francisco Esteves, Östersund Mario Reutter, Würzburg Anna Frey, Würzburg Marco Riva, Milano M. S. Fustiñana, Basel Marcel Romanos, Würzburg Liisa Galea, Vancouver Kati Roesmann, Münster Isaac R. Galatzer-Levy, New York Miriam Schiele, Freiburg Hina Ghafoor, Würzburg Ulrike Schmidt, Göttingen Corina Greven, Nijmegen Stefan M. Schulz, Würzburg Edna Grünblatt, Zurich Soraya Seedat, Stellenbosch Ute Habel, Aachen Niklas Siminski, Würzburg Thora Halldorsdottir, Reykjavik Gudmundur Skarphedinsson, Reykjavik Grit Hein, Würzburg Andreas Ströhle, Berlin Gara Arteaga Henríquez, Barcelona Marie-José van Tol, Utrecht Martin Hermann, Würzburg Philip Tovote, Würzburg Kevin Hilbert, Berlin Lizbeth Utens, Amsterdam Karsten Hollmann, Tübingen Martin Walter, Jena Reto Huber, Zurich Heike Weber, Würzburg Takeshi Inoue, Tokyo Matthias Wieser, Rotterdam Frank Jessen, Cologne Ken Yonezawa, Nagasaki 18
Posters Poster Session | Friday, October 4th, 14.30 - 17.00 Posters with even numbers are to be presented between 14.30 and 15.45, posters with odd numbers are to be presented between 15.45 and 17.00. Group A Serotonergic system of the anterodorsal BNST is involved 1 Hessel, Margarita Münster in phasic and sustained fear in freely behaving mice Krakenberg, Effect of serotonin transporter deficiency on the cognitive 2 Münster Viktoria judgment bias of mice Towards highly specific genetic manipulation of the mouse Remmers, cannabinoid CB1 receptor using CRISPR/Cas9: cell-type 3 Mainz Floortje selective and region-specific CB1 knockout in the adult brain and generation of a CB1 point-mutation mouse line 4 Kästner, Niklas Münster Brain serotonin deficiency affects female aggression Impact of Brain-Derived Neurotrophic Factor on synaptic 5 Fiedler, Dominik Münster transmission and plasticity in the oval nucleus of Bed Nucleus of the Stria Terminalis OCD and neurodegeneration in SPRED2-deficient mice is 6 Hepbasli, Denis Würzburg associated with brain ventricle enlargement and ultrasonic vocalization changes Local deletion of Y2 receptors in BNSTav mediates 7 Jamil, Sara Münster extinction and return of remote fear memory Altered expression of genes related to the vasopressin and Hamann, 8 Würzburg oxytocin brain systems: A study with 5-HTT deficient mice Catharina after experiencing prenatal stress Stress-induced epigenetic programming in serotonin 9 Zöller, Johanna Würzburg transporter deficient mice: Epigenetic editing – a strategy to cope with anxiety A human relevant polymorphism in the Neuropeptide-S 10 Goedecke, Lena Münster receptor (NPSR1 I107N) alters receptor signaling and fear- related behavior in mice Cortes Cortes, Neuroanatomical tracing of glutamatergic brainstem 11 Würzburg Orlando Jose circuits for behavioral and autonomic defense responses Signoret-Genest, Brainstem circuits for cardiac interoception and control of 12 Würzburg Jérémy defensive states Impact of the human neuropeptide-S receptor 13 Jüngling, Kay Münster polymorphism (I107N) on fear and anxiety in mice 19
Posters Group B Brno, Czech Life-long effects of extreme stress on brain structures – a 14 Fňašková, Monika Republic holocaust survivor MRI study Temporal dynamics of threat processing: Modulation of 15 Sperl, Matthias Marburg event-related potential components during a sequential- set fear acquisition paradigm Anxiety sensitivity as a modulator of fear generalization in 16 Vietz, Melanie Würzburg healthy adults Berking, Ann- 17 Würzburg The role of DNA methyltransferases in anxiety disorders Cathrine The TGFB-Inducible Early Growth Response Protein 2 18 Kollert, Leonie Würzburg (TIEG2) gene as a new candidate in the etiology of panic disorder? Deep learning can increase the reliability, objectivity, 19 Segebarth, Dennis Würzburg reproducibility and transparency in image data analysis Reward prediction error signaling during reinforcement 20 Becker, Michael Münster learning in social anxiety disorder is altered by social observation Nieratschker, Investigation of MORC1 DNA methylation as biomarker of 21 Tübingen Vanessa early life stress and depressive symptoms Fear generalization in children and adolescents: a cross- 22 Slyschak, Anna Würzburg sectional study across ages Investigating attentional mechanisms during the 23 Stegmann, Yannik Würzburg interaction of phasic fear and sustained anxiety Klinke, Distal stress induction facilitates fear memory 24 Würzburg Christopher M. consolidation Nx4 effect on stress-induced changes in EEG frequency 25 Krylova, Marina Tübingen powers Magnetoencephalographic correlates of fear 26 Wessing, Ida Münster generalization in adolescence Early negative attentional bias in persons with high 27 Riepl, Korbinian Würzburg depressive symptoms during a facial oddball task Muehlhan, Dose-dependent effects of cortisol on functional large- 28 Hamburg Markus scale connectivity of the visual cortex Association between rs734194 genetic variant of nerve Yerevan, 29 Avetyan, Diana growth factor receptor (NGFR) and peripheral telomere Armenia length with posttraumatic stress disorder Freezing of gaze supports action preparation under threat 30 Rösler, Lara Würzburg imminence 20
Posters Adenosine A1 receptor availability in healthy human 31 Hohoff, Christa Münster brains: Modulation by interacting adenosinergic gene variants and sleep habit in anxiety-related brain regions 32 Weber, Heike Würzburg Allelic variation in PPID predisposes to anxiety disorders Ridderbusch, Stability and reliability of the delayed extinction fMRI- 33 Marburg Isabelle Caroline paradigm of the multicentric trial PROTECT-AD Leimeister, 34 Würzburg Subsequent memory effects in threat and safety learning Franziska Modulation of pain by social stress - the role of positive and 35 Schneider, Sarah Würzburg negative feedback Reducing Generalization of Conditioned Fear: comparison 36 Herzog, Katharina Würzburg of a fear-specific discrimination training with fear- unrelated control tasks Merscher, Alma- Freezing of gaze in conditions that require distributed 37 Würzburg Sophia attention 38 Zillig, Anna-Lena Würzburg The influence of learned safety on pain perception Temporal dynamics of costly avoidance in newly acquired 39 Boschet, Juliane Würzburg fears Context conditioning and extinction in virtual reality: 40 Winkler, Markus Würzburg effects on self-report in anxiety patients Habitual and goal-directed avoidance behavior: 41 Glück, Valentina Marburg associations with trait anxiety Zurich, Associations between the genetic burden, anxiety and 42 Smigielski, Lukasz Switzerland stress in the at-risk state for psychosis Sleep quality and salivary biomarkers: A pilot study connecting the cortisol awakening response and the dim 43 Dubberke, Anne Trier light melatonin onset with an overnight polygraphy assessment 21
Posters Group C Single or multiple dose applications of Silexan do not 44 Klement, Stephan Karlsruhe impair fitness to drive – results from a placebo-controlled crossover trial Repeated stress leads to enhanced cortisol stress response 45 Asbrand, Julia Freiburg in child social anxiety disorder but this effect can be prevented with CBT Kreifelts, The neural correlates of face-voice-integration in social 46 Tübingen Benjamin anxiety disorder Associations between resting state connectivity, symptom 47 Seeger, Fabian Würzburg severity and within-session extinction in the treatment of spider phobia Schwarzmeier, Brain-morphometric predictors of within-session 48 Würzburg Hanna extinction during behavioral exposure in spider phobia Work tandems of psychiatry and anxiety self-help: Can 49 Goede, Wolfgang Munich research and society benefit from the collaboration of academic experts and experience experts? Sarajevo, Bosnia and Combination of aripiprazole and clozapine in first episode 50 Hasanagic, Senad Herze- of psychosis and metabolic syndrome: report of five cases govina Baumgartner, Zurich, Inter-informant agreement of the Children’s Depression 51 Noemi Switzerland Rating Scale Revised in depressed children and adolescents Excitatory transcranial direct current stimulation of the Junghöfer, 52 Münster anterior ventromedial prefrontal cortex reveals add-on Markus effects for the therapy of Major Depressive Disorder (MDD) The comparative analysis of cognitive function and Tianjin, 53 Li, Pan neuropsychiatric behavior between Alzheimer's disease China and frontotemporal dementia patients Scherf-Clavel, How smoking cigarettes affects the serum concentrations 54 Würzburg Maike of escitalopram Scherf-Clavel, Baseline HPA axis activity predict improvement in HPA axis 55 Würzburg Maike function during antidepressant treatment Paris, 56 Lellouch, Laurent Vocal markers of pre-operative anxiety: a pilot study France Zurich, Häberling, Anxious depression as a clinically relevant subtype of 57 Switzer- Isabelle pediatric major depressive disorder land 58 Herrmann, Martin Würzburg Non-invasive brain stimulation augments fear extinction Association of pain relief for chronic musculoskeletal pain after interdisciplinary multimodal pain treatment (IMPT) 59 Breisinger, Sarah Würzburg with serum concentrations of antidepressant drugs in a real-life analysis Tianjin, The prevalence, risk factors of burnout in Chinese 60 Li, Shen China preschool teachers 22
Posters Heart rate variability associated with suicidality in 61 Sauter, Amelie Würzburg depressed patients Tianjin, Suicide rates changing in China and suicide prevention in 62 Li, Jie China Tianjin 63 Genetic variability of GLRB impact cognitive Weber, Heike Würzburg behavioral therapy response in panic disorder Transcranial ultrasound neuromodulation as a new potential intervention for affective disorders - Recent 64 Ziebell, Philipp Würzburg findings and ideas for the future from a differential psychology perspective Pfaffinger, Development and test of a new scale for the measurement 65 Munich Katharina F. of digital anxiety 66 Hellmuth, Anna Würzburg SGK1 signaling predict response in major depression Jakarta, 67 Andri, Andri Somatic Symptoms in Depression: Indonesian Perspective Indonesia Microdeletion syndrome 22q11.2 – Clinical and Molecular 68 Hock, Anja Würzburg Characterization of a High-Risk Cohort Treatment overview of mentally ill patients at Bugando Mwanza, 69 Wambura, Matiko Medical Centre in Mwanza, Tanzania with a focus on PTSD, Tanzania Depression and Anxiety Stellen- bosch, Childhood trauma and hippocampal subfield volumes in 70 du Plessis, Stéfan South first-episode schizophrenia and healthy controls Africa Three poster award winners – one from each group, in order to represent the entire spectrum of topics – will be selected by the award committee: R. Blum, Würzburg; A. Fallgatter, Tübingen; J. Haaker, Hamburg; M. Herrmann, Würzburg; C. Jacob, Esslingen; S. Kittel-Schneider, Würzburg; T. Lonsdorf, Hamburg; U. Lüken, Berlin; A. Ströhle, Berlin 23
General Information Registration and Organizer of the Industrial Exhibition & Sponsoring INTERPLAN Congress, Meeting & Event Management AG Project Management: Jasmin Greger Landsberger Strasse 155 80687 Munich, Germany Phone +49 (0) 89 54 82 34 62 Fax +49 (0) 89 54 82 34 62 wasad@interplan.de Opening Hours of the registration counter 3 October 2019: 10.00 – 18.30 4 October 2019: 08.00 – 19.00 5 October 2019: 08.00 – 19.00 The registration desk is open for registration and assistance during the above mentioned opening hours. Onsite registration is possible at the registration counter. Registration fees can be paid in cash or via credit card. Registration for single days is not possible. Registration Fees Regular Registration Fee: € 390 Student Fee*: € 70 SFB Members/GAF Members**: € 180 *Only valid for full time students who have not finished their studies yet before the congress starts. A valid/current student ID copy or letter from advisor is required. **Validity of membership will be checked Name Badge Please wear your name badge for the entire duration of the congress. It serves as your entrance ticket. Opening Hours of the industrial exhibition 3 October 2019: 13.30 – 18.00 4 October 2019: 08.30 – 18.30 5 October 2019: 08.30 – 17.00 24
General Information Catering: Coffee, cold drinks, snacks, and a light lunch are available in the catering area on the 2nd floor. Changes of schedule at short notice: In case of necessary changes of schedule at short notice (cancellation or time changes of single talks or sessions, change of speaker), the registration fee cannot be refunded. WiFi: Free WiFi is available at the congress site either via “eduroam” (if set up by your home university) or via “BayernWLAN” (free WIFI, no password necessary). Data Protection Interplan handles all personal data according to the laws of the EU-Data Protection Regulation (EU-GDPR) and the Federal Data Protection Act (BDSG New). For your booking within the above mentioned congress the collecting, saving and processing of your personal data is imperative. This is done solely as a means of the organization and completion of the event. We will collect your data on behalf of the World Association for Stress Related and Anxiety Disorders e.V. (WASAD), Schwanenhof 4, 97070 Würzburg, Germany. Your data will only be passed onto a third party who is directly involved with the running of the Congress and when the organizational procedure makes this necessary (operator, hotel). The registration to this congress is not possible if we do not get this. For a complete overview of the applicable privacy policy, see the following Link: https://www.interplan.de/en/data-protection.php#datasec 25
General Information Congress Venue: Zentrales Hörsaal- und Seminargebäude Z6, Am Hubland, 97074 Würzburg Map data © OpenStreetMap contributors Bus from Würzburg Hauptbahnhof (main station): Line 114 – direction “Hubland” – to stop „Hubland/Mensa“ Line 214 – direction “FHWS” – to stop „Hubland/Mensa “ Bus from Sanderring (stop „Sanderglacisstraße“): Line 10 – direction “Sprachenzentrum/Campus Nord” – to stop „Hubland/Mensa“ Taxi dispatch Würzburg: Phone +49 931 19410 26
About WASAD Society Profile The World Association for Stress-related and Anxiety Disorders, WASAD, is an independent non- profit organization founded in 2016 by leaders of clinical and translational science. Board: President: Prof. Dr. P. Riederer, Würzburg Vice-President: Prof. Dr. A. Fallgatter, Tübingen Secretary: Prof. Dr. T. Renner, Tübingen Treasurer: Prof. Dr. C. Jacob, Esslingen WASAD has set itself the goal: To promote basic research on stress-related and anxiety disorders To ensure effective and safe drug treatment and prevention strategies for these mental illnesses To make the interdisciplinary scientific findings suitable for clinical and psychological institutions and their representatives To offer the right framework for clinicians and practicing physicians, psychotherapists, physicians and psychotherapists in training, students and health care professionals in order to exchange knowledge and experiences in the fields of clinical and basic research, stress, stress-related and anxiety disorders To make recommendations to current therapy-relevant topics To promote international contacts in this field 27
Sponsors The support of the following sponsors and exhibitors is gratefully acknowledged: 28
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Industry Sponsored Sessions Friday, 12.15 - 13.15 | Industry Sponsored Session SR 1.012 Heel Symposium | Imaging All the data – what can and what can’t we get from pharmacological and other interventional brain imaging studies on stress and anxiety? Chair: Martin Walter, Jena Rupert Chances and limitation for Multimodal MRI and PET imaging 12.15 Lanzenberger studies on pharmacological mechanisms Resting state and task fMRI insights on mechanisms of 12.35 Martin Walter mediation and complex therapeutics Limitations and lessons learned from brain imaging studies – 12.55 Steven Williams implications for studies of stress and anxiety Saturday, 12.15 - 13.15 | Industry Sponsored Session HS 0.002 Janssen Symposium | Depression and Suicidality - from Neurobiology to clinical practice Chair: Martin Walter, Jena, and Claus Normann, Freiburg 12.15 Claus Normann Depression 12.45 Martin Walter Suicidality 31
Sponsors Industrial Exhibition Exhibitor Booth Number Akademische Buchhandlung Knodt 5 daacro-Contract Research & Saliva Lab Trier 2 Heel GmbH 6 Janssen 4 neuraxpharm Arzneimittel GmbH 3 Recordati Pharma GmbH, Ulm 1 Schwabe Pharma Deutschland 7 32
Sponsors Disclosure As organizer of the industrial exhibition, Interplan AG is obliged to disclose all sums received by sponsors and exhibitors in order to comply with the regulations of the Bayerische Landesärztekammer (BLÄK). For the industry partners mentioned below, we are herewith informing about their overall support within the framework of the WASAD Congress 2019*. Company Total Amount daacro-Contract Research & Saliva Lab Trier 1.000,00 € Heel GmbH 16.000,00 € Janssen 15.000,00 € neuraxpharm Arzneimittel GmbH 1.500,00 € Recordati Pharma GmbH, Ulm 1.000,00 € Schwabe Pharma Deutschland 1.000,00 € *at the time of printing Furthermore, WASAD wishes to acknowledge the support of XXXLutz KG Springer Nature VENT e.V. Dr. med. Edda Neele Stiftung 33
Sponsors 34
For your notes 35
www.wasad2019.org
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