2021 Queensland Clinical Sciences Symposium - Building Bridges and Breaking Boundaries
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2021 Queensland Clinical Sciences Symposium Building Bridges and Breaking Boundaries Saturday 20 March 2021 Translational Research Institute, Brisbane
About the Academy The Australian Academy of Health and Medical Sciences is the impartial, authoritative, cross-sector voice of health and medical science in Australia. We are an independent, interdisciplinary body of 426 Fellows – elected by their peers for their distinguished achievements and exceptional contributions to health and medical science in Australia. Collectively, they are a representative and independent voice, through which we engage with the community, industry and governments. The Academy is uniquely positioned to convene cross-sector stakeholders from across Australia to address the most pressing health challenges facing society. We focus on the development of future generations of health and medical researchers, on providing independent advice to government and others on issues relating to evidence based medical practice and medical researchers, and on providing a forum for discussion on progress in medical research with an emphasis on translation of research into practice. The Academy is registered with the Australian Charities and Not-for-profits Commission (ACNC) and is endorsed as a deductible gift recipient. www.aahms.org @MedSciAcademy @AAHMS_Health
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM WELCOME Welcome to Life as a Clinician Scientist Why consider life as a clinician scientist? Clinician scientists possess an invaluable skillset that allows them to solve clinical questions and provide deep scientific insights into human biology. Today we showcase the many pathways that can lead you to this exciting and rewarding career, which leads to a lifetime of challenge and discovery. Clinical work and science are a unique combination that allow you to work with patients and take your insights from the bedside to answer fundamental scientific questions. In 2021, you cannot go it alone. Collaborating with scientists from many disciplines is both fun and inspiring. Health and medical research can take you down surprising paths towards areas you would never have expected. A career in research can be tough, but the often lengthy journey is rich, varied and fulfilling. The Australian Academy of Health and Medical Sciences exists to advance health and medical research in Australia and its translation into benefits for all, by fostering leadership within our sector, providing expert advice to decision makers, and engaging patients and the public. One of our key objectives is to grow and mentor Australia’s future generations of health and medical researchers, and today’s symposium is aiming to do just that. We are honoured that nationally and internationally recognised clinician scientists from Queensland and beyond have kindly agreed to share their wisdom and expertise today. We are grateful for the generous support of our sponsors. Our platinum sponsors are The University of Queensland's Faculty of Medicine, Griffith University Menzies Health Institute and the Translational Research Institute. Our gold sponsor is QIMR Berghofer and our silver sponsor is the Queensland Brain Institute-The University of Queensland. This event would not be possible without their support. Funding for this event has been provided by the Australian Government. The views expressed at the event do not necessarily reflect the views of the Australian Government. We encourage you to join the twitter conversation using #LACS2021 and @AAHMS_Health and we hope you enjoy the symposium! Symposium Convenors Professor Isaac Maisah Catherine Chloe David Whiteman Carmichael Joarder Lawton Yap Chair Co-Chair We need your feedback to continue providing these type of events. Please complete a short survey at bit.ly/QCSS-2021-survey
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM “You have three careers in a day – a doctor, a scientist and a teacher” Laureate Professor Ingrid Scheffer AO FRS FAA PresAHMS President, Australian Academy of Health and Medical Sciences Chair of Paediatric Neurology Research, The University of Melbourne and Florey Institute of Neuroscience and Mental Health 4 Australian Academy of Health and Medical Sciences
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM PROGRAM SATURDAY 20 MARCH 2021 8.15 am Registration SESSION 1 Building Bridges 9.00 am Professor David Whiteman Welcome to the 2021 Queensland AM FAHMS and Isaac Carmichael Clinical Sciences Symposium 9.15 am Professor Claire Wainwright From genetics to the pharmaceutical market for AM FAHMS cystic fibrosis therapies 9.40 am Distinguished Professor Dietmar Interdisciplinary collaboration in surgery - W. Hutmacher FAHMS and engineering the world's first 3D bone implant Dr Michael Wagels 10.20 am Morning tea 10.50 am Professor Bala Venkatesh FAHMS Building capacity and culture in translational intensive care research 11.15 am Professor Tammy Hoffmann The ‘other’ type of translational research OAM FAHMS 11.40 am Panel Discussion Building a career in translational research Chair: Professor David Whiteman AM FAHMS 12.20 pm Lunch SESSION 2 Breaking Boundaries 1.20 pm Emeritus Professor Stem cells as models for brain diseases and drug Alan Mackay-Sim discovery 1.50 pm A/Prof Clair Sullivan Digital health to improve health outcomes 2.15 pm Dr Eamonn Eeles Ageing. Challenges, opportunities and innovations 2.40 pm Afternoon tea 3.10 pm Panel Discussion Building a career in translational research – Chair: Professor David Whiteman perspectives across career stages AM FAHMS A/Prof David Cavallucci Dr Cameron Snell (hepato-pancreatico-biliary surgery) (pathology) Dr Michelle Roets Dr Monica Ng (anaesthetics) (renal medicine) 4.00 pm Event close Australian Academy of Health and Medical Sciences 5
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM SPEAKERS Professor David Whiteman AM FAHMS Medical Epidemiologist and Deputy Director, QIMR Berghofer Professor David Whiteman is a medical epidemiologist with a special interest in the causes, control and prevention of cancer. He received his medical degree from the University of Queensland in 1991, and his PhD in cancer epidemiology in 1997. Professor Whiteman has an international reputation for research into melanoma and skin cancer, and the public health aspects of cancer control. He has more than 350 peer-reviewed research publications, an H-index of 72 and has been awarded more than $50 million in competitive research grants as Chief Investigator. In addition to his research activities, he is Deputy Director of QIMR Berghofer, a Fellow of the Australian Academy of Health and Medical Sciences, a Fellow of the Australasian Faculty of Public Health Medicine, and Honorary Fellow of the Skin Cancer College of Australasia. In 2019, he was made a Member of the Order of Australia for his services to cancer epidemiology. Professor Claire Wainwright AM FAHMS SMO Respiratory & Sleep Medicine, Co-Lead Cystic Fibrosis Services, Children's Health Queensland Professor Claire Wainwright is a paediatric respiratory physician and Co-Lead for cystic fibrosis (CF) services at the Queensland Children’s Hospital in Brisbane which manages around 450 children with CF across Queensland and northern NSW. She is a Professor of Paediatrics and Child Health at the University of Queensland and her research interests include clinical trials, development of lung disease in CF, airway microbiology, and patient reported outcomes in CF. 6 Australian Academy of Health and Medical Sciences
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM SPEAKERS Distinguished Professor Dietmar W. Hutmacher FAHMS Director, ARC ITTC in Additive Biomanufacturing;Director, Centre in Transformative Biomimetics in Bioengineering, Queensland University of Technology Distinguished Professor Hutmacher is a biomedical engineer, an educator, an inventor, and a creator of new intellectual property opportunities. He is committed to fostering transformative research and pedagogical innovation as well as programs that create an entrepreneurial mindset amongst faculty and students. He directs the Centre for Regenerative Medicine and the ARC Training Centre in Additive Biomanufacturing at QUT, an interdisciplinary team of researchers including engineers, cell biologists, polymer chemists, clinicians, and veterinary surgeons. Professor Hutmacher is an internationally recognized leader in the fields of biomaterials, tissue engineering and regenerative medicine with expertise in commercialization. He has translated a bone tissue engineering concept from the laboratory through to clinical application involving in vitro experiments, preclinical studies and ultimately clinical trials. His recent research efforts have resulted in traditional scientific/academic outputs as well as pivotal commercialisation outcomes. His pre-eminent international standing and impact on cross-disciplinary fields are illustrated by his ranking as an highly cited researcher. Dr Michael Wagels Deputy Director, Department of Plastic and Reconstructive Surgery, Princess Alexandra Hospital; Senior Lecturer, The University of Queensland Michael Wagels is Deputy Director of the Department of Plastic and Reconstructive Surgery at the Princess Alexandra Hospital with a conjoined academic appointment as Senior Lecturer at the University of Queensland. He completed a BMedSci undergraduate research degree in 1999 and an MBBS undergraduate medical degree in the same year. He completed his FRACS in Plastic and Reconstructive Surgery in 2012 and was awarded a PhD by the University of Queensland in 2014. His theses evaluated amputation in severe lower limb trauma and the behaviour of auto-transplanted muscle for traumatic lower limb injuries. Michael has a special interest in complex lower limb reconstruction, hand and wrist surgery, reanimation of the upper limb and head and neck reconstructive surgery. He is also interested in the translational aspects of tissue engineering for complex reconstructive defects. In 2019 he was appointed Director of the Australian Centre for Complex Integrated Surgical Solutions. This organisation is based at the Translational Research Institute and is dedicated to making clinically applied digital innovations accessible to clinicians and the patients that they treat. Australian Academy of Health and Medical Sciences 7
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM SPEAKERS Professor Bala Venkatesh FAHMS Director of Intensive Care, Wesley Hospital; Professor of Intensive Care Medicine, The University of Queensland and the University of New South Wales; Professorial Fellow at the George Institute for Global Health, Sydney Australia Professor Bala Venkatesh is Director of Intensive Care at the Wesley Hospital, Pre-Eminent specialist in Intensive Care Medicine at the Princess Alexandra Hospital, Brisbane, Professor of Intensive Care Medicine at the University of Queensland, and at the University of New South Wales, and Professorial Fellow at the George Institute for Global Health, Sydney Australia. He is currently the Chair of the QLD Statewide Sepsis Steering Committee. He has completed Fellowship training in Internal Medicine, Anaesthesia and Intensive Care Medicine. He then undertook a research degree from the University of Birmingham, UK which led to the award of an MD. He pioneered the development of a continuous blood gas monitoring system which reached clinical application. He served as the President for the College of Intensive Care Medicine of Australia and New Zealand between 2014-2016. He is the Principal Investigator of the NHMRC funded multi-center international ADRENAL trial which is largest septic shock trial to date. This was published in the New England Journal of Medicine. He is currently supervising 4 PhD students. He has been involved in 4 major RCTs of sepsis. His research interests include glucocorticoid physiology in critical illness including the development of the idea of the "sick euadrenal state", sepsis and vitamin D in critical illness. He has published more than 200 papers, and 40 book chapters. He is currently running 4 COVID-19 trials in India. Professor Tammy Hoffmann OAM FAHMS Professor of Clinical Epidemiology & NHMRC Senior Research Fellow, Institute for Evidence-Based Health Care, Bond University Tammy is Professor of Clinical Epidemiology and NHMRC Senior Research Fellow at the Institute for Evidence- Based Health Care, Bond University, and a Fellow of the Australian Academy of Health and Medical Sciences. Tammy’s research spans many aspects of shared decision making, evidence-based practice, and maximising the translation of evidence to assist clinicians, patients, and the public to make informed health decisions. She is also Co-Director of the Australasian Equator Centre, which is an international initiative that seeks to improve the reliability and value of published health research literature by promoting transparent and accurate reporting and wider use of robust reporting guidelines. Tammy has over 250 publications, including many articles in leading journals such as JAMA, BMJ, JAMA Internal Medicine, PLOS Medicine, and BMC Medicine. Tammy has been involved in the development of a number of reporting guidelines including the 2020 PRISMA statement and led the development of the TIDieR (Template for Intervention Description and Replication) checklist and guide. 8 Australian Academy of Health and Medical Sciences
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM SPEAKERS Emeritus Professor Alan Mackay-Sim Neuroscientist and Stem Cell Scientist, Griffith University; 2017 Australian of the Year 2017 Australian of the Year, Professor Alan Mackay-Sim is a neuroscientist and stem cell scientist. A global authority on the human sense of smell, Alan uses his knowledge of regeneration of olfactory sensory neurons to move from the lab to the clinic. In preclinical work Alan and his team showed that transplantation of nasal cells (“olfactory ensheathing cells”) could restore motor function after spinal cord injury. He then led the world’s first Phase I clinical trial demonstrating the safety of this procedure in human paraplegia. This research is continuing at Griffith University’s Spinal Injury Project, with a Phase II trial planned in the near future. Professor Mackay-Sim has developed a unique “NeuroBank”, neural stem cells from the nose from 300 patients and controls used to understand the biological bases of brain diseases and for drug discovery. In Hereditary Spastic Paraplegia, a rare neurodegenerative condition, patient stem cells have led to a potential new therapy being taken to Phase I/II trial. Associate Professor Clair Sullivan Head, UQ Digital Health Network; Consultant Endocrinologist and Medical Informatician Associate Professor Clair Sullivan graduated with Honours in Medicine from UQ and a Research Doctorate in Medicine from the University of Leeds. She is a fellow of both the Royal Australasian College of Physicians and the Australian College of Health Informatics. She has been appointed Associate Professor of Medicine in Clinical Informatics at the University of QLD and is Adjunct Professor, Faculty of Health, Queensland University of Technology. She is widely published in clinical informatics and serves on several national advisory boards for digital health. Clair is currently the Head of The University of Queensland's Digital Health Network. Australian Academy of Health and Medical Sciences 9
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM SPEAKERS Dr Eamonn Eeles Consultant Physician and Geriatrician, The Prince Charles Hospital Dr Eeles is a consultant physician and geriatrician and a keen researcher in the field of dementia and delirium. Dr Eeles is research council chair at TPCH, Head of research IMS, Statewide advisor to the Queensland Brain Institute, member of Statewide Dementia Network and Australasian Delirium Association committees. Associate Professor David Cavallucci Hepato-Pancreatico-Biliary Surgical Oncologist; Senior Lecturer, The University of Queensland Associate Professor David Cavallucci is an Hepato-pancreatico-biliary surgical oncologist. He is a graduate of the two-year ANZHPBA post-fellowship program in HPB surgery as well as the surgical oncology and abdominal transplantation Fellowship at the University of Toronto. He has a special interest in minimally invasive pancreatic and liver surgery with a broad experience of laparoscopic surgery and developing robotic surgery. Outside of oncology, he manages benign biliary disease including the laparoscopic management of bile duct stones and the surgical management of acute and chronic pancreatitis. Having completed a Masters degree in Biostatistics, he has published on the use of Propensity Scores and novel weighting techniques in observational surgical research. He is active in teaching and maintains a strong interest in clinical and translational research. A/Prof Cavallucci is President of the ANZHPBA, and active on the Education and Training committee of the IHPBA and the HPB Journal Editorial board.
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM SPEAKERS Dr Michelle Roets Consultant Anaesthetist & Lead, Intraoperative Cell Salvage Service, Royal Brisbane and Women’s Hospital Dr Michelle Roets is a consultant anaesthetist, lead of the intraoperative cell salvage (ICS) service at the Royal Brisbane and Women’s Hospital (RBWH) and is currently a PhD student with the University of Queensland (UQ), studying the cost and immunological benefits of ICS. She did her undergraduate medical training at the University of Pretoria (South Africa), completed a fellowship in Anaesthesia, Intensive care and Pain Medicine at the Royal College of Anaesthetists of Ireland, a Master’s degree in Clinical Research Administration with the Walden University (Baltimore, Maryland, USA) and a fellowship with the Australian and New Zealand College of Anaesthetists (Australia). She was involved in the first implementation of ICS in Obstetric Anaesthesia in Ireland, co-author of the “Guidance for the Provision of ICS” documents with the National Blood Authority in Australia (2014), ICS chapters in the Australasian Anaesthesia textbook (2017 & 2019) and invited presenter (21 national and two international conferences). Dr Cameron Snell Medical Director, Mater Pathology; Anatomical Pathologist and Honorary Senior Lecturer, The University of Queensland Dr. Cameron Snell is the Medical Director at Mater Pathology in Brisbane. He has a strong interest in translational cancer research and completed his DPhil “Mitochondrial Modulators of hypoxia related pathways in tumours” in 2014 at the Nuffield Department of Clinical Laboratory Sciences, University of Oxford. He leads the Breast and Lung tumour streams at the Mater Hospital Brisbane and has established the Mater-IHBI Breast Cancer Biobank. Dr. Snell holds academic appointments at the Mater Research Institute, University of Queensland and is an Adjunct Associate Professor at the Queensland University of Technology. Australian Academy of Health and Medical Sciences 11
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM SPEAKERS Dr Monica Ng Renal Advanced Trainee, Princess Alexandra Hospital; Post-doctoral Researcher, Conjoint Kidney Research Laboratory; Adjunct Research Fellow, Institute of Molecular Biosciences Dr Monica Ng is a renal advanced trainee at Princess Alexandra Hospital, Postdoctoral researcher at the Conjoint Kidney Research Laboratory and Adjunct Research Fellow at Institute of Molecular Biosciences. She completed medical school with first class honours at the University Queensland in 2014 and completed her PhD in blood transfusion and vascular modelling in 2019. Her postdoctoral research involves using molecular methods such as flow cytometry and spatial transcriptomics; as well as large data analyses to improve the diagnosis and treatment of glomerulonephritides. Monica has presented her research in various international journals and conferences; and acts as an invited peer reviewer for journals such as Medicine, BMJ Open, BMJ Case Reports and BMC Nephrology. Monica also participates in teaching activities and is a Lecturer at Faculty of Medicine, University of Queensland. In her spare time, Monica enjoys hiking and kayaking. 12 Australian Academy of Health and Medical Sciences
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM PLATINUM SPONSORS For more than a century, The University of Queensland (UQ) has maintained a global reputation for delivering knowledge leadership for a better world. The most prestigious and widely recognised rankings of world universities consistently place UQ among the world’s top universities. UQ has also won more national teaching awards than any other Australian university. This commitment to quality teaching empowers our 53,600 current students, who study across UQ’s three campuses, to create positive change for society. Our research has global impact, delivered by an interdisciplinary research community of more than 1500 researchers at our six faculties, eight research institutes and more than 100 research centres. The Faculty of Medicine The University of Queensland’s Faculty of Medicine is an internationally recognised provider of world-class education and research. The Faculty of Medicine offers Australia’s largest medical degree program for graduates and school-leavers. Undergraduate and postgraduate programs are available in the disciplines of Medicine, Health Sciences, E-Health, Mental Health, Biomedical Sciences and Public Health. The Faculty possesses enormous strengths spanning research, teaching, industry engagement and clinical practice in disciplines ranging from the basic sciences, biomedical research and development, to clinical trials and public health. The Menzies Health Institute Queensland (MHIQ) undertakes research across the lifecycle to identify key factors that influence health. From this, we develop and test strategies to improve health and wellbeing for individuals, families and communities. With more than 580 of the world’s leading biomedical scientists, clinical researchers and research candidates, Griffith’s MHIQ continues to achieve remarkable outcomes. Four overarching programs—Disability and Rehabilitation, the Economic, Policy and Innovation Centre for Health Systems (EPIC Health Systems), Healthcare Practice and Survivorship, and Infectious Diseases and Immunology—encapsulate our research strengths and align with local and national health priorities. Underpinning the work of these programs is a focus on innovation, data science, research translation and meaningful clinical and community partnerships. The Translational Research Institute (TRI) is an Australian-first initiative of ‘bench to bedside’ medical research. TRI’s unique model combines clinical and translational research to advance progress from laboratory discovery to application in the community. The work is driven by the needs of patients with research focused on cancer, dermatology, gastroenterology, immunology, genomics and trauma. Located in Brisbane, Queensland at the Princess Alexandra Hospital, TRI is one of few institutes worldwide where new biopharmaceuticals and biotech treatments can be researched, discovered, manufactured, and clinically tested in one location. Created by its founding partners: The University of Queensland, Queensland University of Technology, Mater Research and Queensland Health, TRI is now the base for a powerhouse of over 1,000 clinicians, researchers and support staff working together with patients to solve health challenges faster and more efficiently. Australian Academy of Health and Medical Sciences 13
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM GOLD SPONSOR QIMR Berghofer Medical Research Institute is a world-leading translational research institute where research develops from the laboratory bench through to the patient’s bedside. With almost 900 scientists, students and support staff, and more than 50 state-of-the-art laboratories, QIMR Berghofer is one of Australia’s largest and most successful institutes. For over 70 years, QIMR Berghofer has led advances in the understanding, prevention, control, diagnosis and treatment of disease. Today, in collaboration with research institutions, governments and industry throughout the world, QIMR Berghofer focuses on cancer, infectious diseases, chronic disorders and mental health, and has developed impressive capability in genomics across these programs. 14 Australian Academy of Health and Medical Sciences
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM Notes Australian Academy of Health and Medical Sciences 15
2021 QUEENSLAND CLINICAL SCIENCES SYMPOSIUM Australian Academy of Health and Medical Sciences 411 Vulture Street, PO Box 6114, Woolloongabba, QLD 4102 Woolloongabba, QLD 4102 Australia Australia www.aahms.org | info@aahms.org | T: +61 (0) 7 3102 7220 AAHMSABN: Annual55 167 124 Meeting 0672019 | October 16 Australian Academy of Health and Medical Sciences Australian Academy of Health and Medical Sciences 16
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