SYNC NEUROMODULATION SYMPOSIUM 2020 NOVEL TREATMENTS FOR THE 21ST CENTURY: THE RISE OF THE BRAIN COMPUTER INTERFACE
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SyNC Neuromodulation Symposium 2020 Novel Treatments for the 21st Century: The Rise of the Brain Computer Interface and Neuromodulation of Incontinence Date: 25th November 8am-5pm Australian Eastern Daylight Time (afternoon/evening US EST 24th November) Meeting Location: Function Room 277, Sydney Knowledge Hub, Level 2, Merewether Building H04 University of Sydney Teleconference attendance via Zoom is encouraged. To Register: Go to http://www.joedusseldorp.com/sync-2020 Please register by 19 November to attend the Sydney venue in person Hosted by: Dr Joseph Dusseldorp Professor Alistair McEwan Plastic and Reconstructive Surgeon Ainsworth Chair of Technology and Royal Australasian College of Surgeons Innovation Concord Clinical School Cerebral Palsy Alliance Faculty of Medicine and Health School of Electrical and Information University of Sydney Engineering SyNC Neuromodulation Symposium 2020
University of Sydney About the Symposium The goals of this SyNC symposium are to highlight advances in neuromodulation, lessons learned and challenges for the future. Researchers and Clinicians from Australia and internationally will have the opportunity to interact directly with families in what we hope will be another highly productive meeting. The Sydney Neurobionics Collaboration was founded in 2018 to address the need for communication between clinicians and biomedical engineers. Our goal is to leverage rapid technological advances to improve outcomes in neuromotor dysfunctions such as spasticity, incontinence and non-verbal communication. Our last meeting was extremely productive, leading to the initiation of the Liberty Trial and UnlockCP, an industry collaboration under the MRFF to explore: Electrical Stimulation of the dorsal columns of the spinal cord with spinal cord stimulation reduces the reflex hyperactivity and reduces muscle tone present in spasticity. Find out more: The Liberty Trial: https://tinyurl.com/y3d22lon The Grant: https://tinyurl.com/y43lkyat The Research Paper: https://tinyurl.com/y3alv7xg Born out of the University of Sydney, SyNC has developed a broad network of institutes and entities, including: • The Cerebral Palsy Alliance • Saluda Medical, Sydney • Bionics Queensland • Ingenuity Electronics, Sydney • The ANZAC Research Institute • Cochlear, Sydney • Harvard University, Boston • Synchron Medical, New York • Inventia Life Sciences, Sydney SyNC Neuromodulation Symposium 2020
• Global Surgical Innovations, Sydney We are pleased to welcome another group of clinicians, researchers and medical technology developers to the 2020 SyNC Neuromodulation Symposium, including: SyNC Neuromodulation Symposium 2020
Symposium Program Note relevant time zones: AEDT – Australian Eastern Daylight Time (Sydney) QT – Queensland Time EST – Eastern Time (USA) Session 1: Brain Computer Interfaces (BCI): Updates from the Cutting Edge Chair: Alistair McEwan, SyNC Founder 08:00 – 10:10 AEDT (07:00 – 09.10 QT) (16:00 – 18:10 EST) Time 8:00 Joe Dusseldorp, Alistair McEwan, Convenors Welcome 8:10 Mariska Vansteensel, Utrecht Brain Centre Utrecht NeuroProsthesis: Implantable ECoG-based BCI for Home Use 8:40 Leigh Hochberg, Brown University Update on the BrainGate Trial 9:10 Panel Discussion - Morning Tea: 9:40 – 10:10 - 10:10 Gil Rind, Synchron Medical Stentrode: The Australian Deep Brain Interface Session 2: Living with Communication Challenges in Cerebral Palsy Chair: Pete Horsley, Remarkable 10:40 – 12:00 AEDT (09:40 – 11:00 QT) (18:40 – 20:00 EST) Time 10:40 Lived Experience and Family Panel Discussion - Lunch: 12:00 – 13:00 - SyNC Neuromodulation Symposium 2020
Session 3: Deep Brain and Spinal Cord Neuromodulation for Movement Disorders Chair: Joe Dusseldorp, SyNC Founder 13:00 – 14:40 AEDT (12:00 – 13:40 QT) (21:00 – 23:00 EST) Time 13:00 David Borton, Brown University Responsive Neuromodulation of Spinal Cord Injuries 13:20 Hugh McDermott, Bionics Institute Feedback Control for Deep Brain Stimulation for Motor Disorders 13:40 Simon Paget, Children’s Hospital Westmead The Liberty Trial: Testing Spinal Cord Stimulation for Lower Limb Spasticity in Cerebral Palsy 14:00 John Parker, Saluda Medical The Unlock CP Project 14:20 Panel Discussion - Afternoon tea: 14:40 – 15:00 - Session 4: Sacral Nerve Neuromodulation for Incontinence: Challenges for the Future Chair: Joe Dusseldorp, SyNC Founder 15:00 – 17:00 AEDT (14:00 – 16:00 QT) (23:00 – 01:00 EST) Time 15:00 Pejman Pak Lived Experience Perspective 15:20 Amanda Chung, North Shore Private Sacral Nerve Neuromodulation for urinary Hospital incontinence in adults 15:40 Danielle Delaney, North Shore Private Sacral Nerve Neuromodulation for urinary Hospital incontinence in children 16:00 Margaret Schnitzler, North Shore Private Sacral Nerve Neuromodulation for Faecal Hospital Incontinence 16:20 Gerrit Gmel, Closed Loop Medical Close Loop Neuromodulation of the Sacral Nerve 16:40 Panel Discussion SyNC Neuromodulation Symposium 2020
Attendance Information Teleconference attendance via Zoom is encouraged. To Register: Go to http://www.joedusseldorp.com/sync-2020 Please register by 19 November if you are attending the Sydney location in person Venue logistics Function Room 277, Sydney Knowledge Hub, Level 2, Merewether Building H04 University of Sydney How to find the building: https://cce.sydney.edu.au/site/233 The link below explains parking options at Sydney University’s Camperdown campus. Parking is very limited, so it is recommended that you consider public transport, taxi or Uber. If you have any difficulty locating the venue, please contact Dr Dusseldorp on 0411 022 644. Refreshments and lunch will be provided for those on site. Wifi will be available at the venue, with details provided on arrival. https://sydney.edu.au/campus-life/getting-to-campus/parking.html SyNC Neuromodulation Symposium 2020
Profiles of Speakers, Chairs and Convenors Mariska Vansteensel Mariska Vansteensel obtained her PhD in the field of Neurophysiology in 2006 at Leiden University Medical Center, the Netherlands. In 2007, she moved to the BCI lab of Nick Ramsey and she is Assistant Professor at UMC Utrecht. Her main research goal is to use the wealth of neuroscientific knowledge directly for the benefit of people with disease or disability. She currently coordinates research on implantable ECoG-based Brain Computer Interfaces (BCIs) and conducts research within the Utrecht NeuroProsthesis project, which aims to implement and validate implantable communication-BCIs for home use. In addition, she is the principal investigator of several projects related to clinical implementation of BCIs and paediatric neuroscience. http://neuroprosthesis.eu Leigh Hochberg Leigh Hochberg is Professor of Engineering at Brown University and a vascular and critical care neurologist at Massachusetts General Hospital (MGH), where he also directs the Center for Neurotechnology and Neurorecovery. His research focuses on the translation of neurophysiology and computational neuroscience discoveries into devices to restore function for patients with neurologic disease or injury. As Principal Investigator and lead Clinical Investigator of the BrainGate Neural Interface team, he is focused on developing and testing practical, ground-breaking brain-computer interface devices to restore communication, mobility and independence to people affected by neurologic disease, paralysis, or limb loss. https://www.massgeneral.org/neurology/doctors/17357/Leigh-Hochberg https://www.braingate.org/about-braingate/ Gil Rind Gil Rind is the Director of Neuromodulation at the pioneering neurotech company, Synchron Inc., which recently published a first-in-human study demonstrating successful use of the Stentrode™ brain-computer interface (BCI), or neuroprosthesis. Specifically, the study shows the Stentrode’s ability to enable patients with severe paralysis to resume daily tasks, including texting, emailing, shopping and banking online, through direct thought, and without the need for open brain surgery. The study is the first to demonstrate that a BCI implanted via the patient’s blood vessels is able to restore the transmission of brain impulses out of the body, and did so wirelessly. Gil received his Bachelor of Engineering, Mechanical and Biomedical, from McGill University in 2009. He has been involved in the development of the Stentrode device for almost 4 years. https://www.linkedin.com/in/gil-rind-b165603b/ SyNC Neuromodulation Symposium 2020
Peter Horsley Pete Horsley is the founder of Remarkable, a division of Cerebral Palsy Alliance. Remarkable is a tech accelerator with a mission to harness the power of technological innovation for driving inclusion of people with disability. Pete has more than 10 years’ experience in the not for profit sector in youth, corporate engagement, social impact and innovation, and he is building an ecosystem of innovators and innovative companies working together to solve the toughest problems in disability. https://remarkable.org.au/about-us/ Allan McCay Allan McCay teaches at the University of Sydney Foundation Program and also at the University of Sydney Law School, where he is an Adjunct Lecturer. He holds a PhD from the University of Sydney Law School and is interested in behavioural genetics, neuroscience, neurotechnology, and the criminal law. He has a particular interest in ethical issues emerging from artificial intelligence. Allan has co-authored two books: Free Will and the Law: New Perspectives, published by Routledge, and Neurointerventions and the Law: Regulating Human Mental Capacity, is published by Oxford University Press. His work can also be found in many journals and media. https://www.linkedin.com/in/allan-mccay-81b285185/ David Borton David Borton is an Assistant Professor of Engineering at Brown University School of Engineering and the Brown Institute for Brain Science. He is also part of the BrainGate team. David currently focuses on engineering new tools for wireless neural recording and stimulation in order to untangle neuromotor disease states, and more generally to understand how these states are dynamically represented in the brain and spinal cord. Using these tools, he explores how motor processing in the brain evolves during long-term, naturalistic recording. David received his Bachelors degree in Biomedical Engineering from Washington University in St. Louis in 2006, his doctorate in Biomedical Engineering from Brown University in 2012, and performed his post-doctoral training at the Ecole Polytechnique in Lausanne Switzerland (EPFL) under a Marie Curie International Fellowship. In 2015, Prof. Borton received the DARPA Young Faculty Award. https://www.braingate.org/team/david-borton-ph-d/ SyNC Neuromodulation Symposium 2020
Hugh McDermott Professor Hugh McDermott is the Chief Technology Officer of the Bionics Institute and Chief Science Officer of a start-up company, Deep Brain Stimulation Technologies Pty Ltd. He also holds honorary appointments as a Professorial Fellow at The University of Melbourne. Hugh is an inventor on over 25 patent families. Several of his inventions have been successfully implemented in commercial products available worldwide. Hugh has contributed to the design, development, and evaluation of neurostimulation devices, particularly cochlear implants and biomedical signal-processing systems, for over 35 years. In the past 10 years his work has extended into the fields of prosthetic vision and brain stimulation. The latter research aims to treat conditions such as movement disorders, including Parkinson’s disease, by electric stimulation of selected brain targets. https://www.bionicsinstitute.org/FAQs/prof-hugh-mcdermott Simon Paget Simon Paget is a Paediatric Rehabilitation Medicine Physician and the Head of the Cerebral Palsy and Movement Disorders Service at Kids Rehab, the Children's Hospital at Westmead. He is passionate about improving healthcare delivery through clinical innovation and research, and leads a team dedicated to improving outcomes for children with cerebral palsy and their families. https://www.linkedin.com/in/simon-paget-16618270/ John Parker John Parker is the founder and CEO of Saluda Medical. The company is commercialising research from Australia's Information Communications Technology Centre of Excellence (NICTA). John founded the Implant Systems team at NICTA that developed the closed loop feedback technology. He has over 20 years of experience in medical devices, including 13 years at Cochlear Limited, where he served in the role of Chief Technology Officer and Executive Member of the Board of Directors. https://www.afr.com/brand/boss/true-leaders-game-changers-2017-john-parker-saluda- medical-20170919-gykkaj Amanda Chung Amanda Chung completed her medical degree at the University of New South Wales in 2007, Master of Surgery (MS) at the University of Sydney in 2012, and a Fellowship of the Society of Genitourinary Reconstructive Surgeons (Eastern Virginia Medical School, Norfolk VA, USA) in 2017. She combines her clinical work with research and is currently undertaking a PhD through the University of Sydney. Her research topic is “Detrusor ultrastructural studies in geriatric lower urinary tract dysfunction: correlation of features and development of a standardised protocol. Dr Amanda Chung joined Sydney Urological Associates in 2018 and operates at a number of Sydney hospitals. https://urologist.net.au/profile/dr-amanda-chung-2/ SyNC Neuromodulation Symposium 2020
Danielle Delaney Danielle Delaney completed her medical training at the University of Sydney and the Northern Clinical School (Royal North Shore Hospital) and her formal Urology training in Victoria. She has since opened a private practice offering services to both adults and children. Danielle has a special interest in functional urology and is passionate about optimising bladder function from birth to death. At Sydney Children’s Hospital, Randwick, she has improved management of continence issues for children and adolescents. She has been involved in two international clinical trials for Overactive Bladder (OAB) in adolescents and neurogenic bladder in children and adolescents. Danielle often works as a proctor instructing urological colleagues on subspecialised procedures such as sacral neuromodulation for urinary incontinence. https://www.drdanielledelaney.com.au Margaret Schnitzler Associate Professor Margaret Schnitzler is a specialist colorectal surgeon. She trained in surgery at Royal North Shore Hospital and obtained further specialist training in colorectal surgery at the Ferguson Clinic in Michigan, USA and the University of Toronto, Canada. She completed her PhD on molecular genetics of colorectal cancer at the University of Sydney Her main clinical interests are in familial colorectal cancer, anorectal conditions, faecal incontinence and pelvic floor disorders. A/Prof Schnitzler has a teaching appointment at the University of Sydney and is Sub-Dean for Surgery and Academic Coordinator for Surgery at the Northern Clinical School, University of Sydney. https://northernsydneycolorectal.com.au/our-doctors/dr-margaret-schnitzler Gerrit Gmel Gerrit Gmel is the Project Leader at Closed Loop Medical. Completing a PhD in 2016 with a crossover project between engineering and neuroscience, Gerrit applied his deep passion for unravelling the mechanisms of action of neuromodulation to a wide range of applications including spinal cord stimulation, sacral nerve stimulation, and deep brain stimulation. He manages the clinical research efforts at Closed Loop Medical, running basic science experiments, first-in-human trials, and larger safety and performance studies. He is interested in all aspects of neuromodulation, from the basic neuroscience to product development to the commercial aspects of bringing new products to market. https://www.linkedin.com/in/gerrit-gmel-phd-15a93149/ SyNC Neuromodulation Symposium 2020
Symposium Convenors Joe Dusseldorp Joe Dusseldorp is a Plastic and Reconstructive surgeon with a special focus on cutting-edge facial reconstructive and facial nerve reanimation surgery. His research is focused on solving some of the difficult problems in plastic surgery, particularly, malformations of the ear, facial palsy, cerebral palsy, and peripheral neuropathy in diabetic feet. Among other roles, he is currently the Co-ordinating Principal Investigator with Saluda Medical for the Liberty Trial, a world-first clinical trial seeking to find an “outside-the-box” solution for the physical disability affecting children with cerebral palsy. He is a Clinical Senior Lecturer at University of Sydney, co-founder of the Sydney Neurobionics Collaboration (SyNC), and he provides reconstructive plastic surgery services from his own practice and at numerous Sydney hospitals. https://www.joedusseldorp.com/about-dr-joe-dusseldorp Alistair McEwan Alistair McEwan is currently Ainsworth Chair of Technology and Innovation within the Sydney University School of Electrical and Information Engineering, conducting research into bioelectronics, the electrical and optical properties of tissue, and disabilities such as cerebral palsy. His research focuses on using signal processing, electronics and modelling to understand the effects of the impedance of tissue as a biomarker in neurology, cardiology, musculoskeletal tissue and the effect on neuromodulation, and he works closely with clinicians from a number of Sydney hospitals. He is co-founder of the Sydney Neurobionics Collaboration (SyNC). https://sydney.edu.au/engineering/people/alistair.mcewan.php Notes SyNC Neuromodulation Symposium 2020
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