Short Dental Implants ( 6 mm) to Rehabilitate Severe Mandibular Atrophy: A Systematic Review
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
Short Dental Implants (≤ 6 mm) to Rehabilitate Severe Mandibular Atrophy: A Systematic Review Paolo Carosi, DDS, MSc, PhD1/Claudia Lorenzi, DDS, PhD1/Mauro Laureti, MD, DDS2/ Nicola Ferrigno, DDS2/Claudio Arcuri, MD, DDS4 Purpose: This study aimed to assess the survival rate, marginal bone levels, and prosthetic success of short implants when placed in posterior areas of severely reabsorbed mandibles. Materials and Methods: A systematic review was performed of all randomized controlled trials with at least 10 patients with a control group where bone augmentations were performed that were published between January 2015 and February 2020. From 77 pertinent studies, 14 full-text publications were studied, and 6 studies fulfilled the inclusion criteria. Results: The implant survival rates of short dental implants ranged from 92% to 96.9% with a follow-up from 1 to 5 years, and the prosthetic success rate ranged from 90% to 100% during the same follow-up. The mean marginal bone level values of involved short implants ranged from –0.51 to –2.30 mm. Conclusion: The obtained data showed that short dental implants are a valid therapeutic choice to rehabilitate severe mandibular atrophy in the medium to long term. Int J Oral Maxillofac Implants 2021;36:30–37. doi: 10.11607/jomi.8510 Keywords: guided bone regeneration, mandibular atrophy, short dental implants, short implants T he rehabilitation of partially edentulous arches by means of dental implants is a well-accepted treat- ment. Currently, patients ask for an implant therapy in this zone. To prevent any nerve injury, several alter- native methods have been proposed, such as the lat- eralization of the inferior alveolar nerve,4 vertical ridge that is as minimally invasive and minimally morbid as augmentation (VRA),5 and guided bone regeneration possible. Expectations are increasing, but neverthe- (GBR). These techniques can be dangerous for the pa- less, many patients are reluctant to accept an implant tients because they are directly proportional to the sur- treatment, and they are especially apprehensive if a geon’s skills. In addition, these techniques can lead to bone augmentation procedure is required.1 The re- increased posttreatment morbidity, time, and costs for habilitation of the posterior region of the mandible the patients. Actually, earlier studies reported that the is always a hard-complexity case due to the course of lateralization of the inferior alveolar nerve could cause the inferior alveolar nerve.2 In most cases, bone verti- moderate postoperative morbidity.6 In the last years, cal height is enough to place a standard implant. Un- the use of short (≤ 6 mm) implants has been increasing fortunately, several alterations affect bone quality and by clinicians and has been investigated more by several quantity after tooth loss,3 and it is mandatory to avoid researchers.7–11 The definition of short implants is still any nerve damage when performing implant surgery not completely defined, and as a result, interpretation of the literature is complicated by several different defi- nitions. Strietzel and Reichart reported that all implants that have lengths less than or equal to 11 mm have to be considered short.12 On the other hand, Group 1 of 1Department of Chemical Science and Technologies, PhD in the 6th ITI Consensus Conference considered “short Materials for Health, Environment and Energy–Dentistry, Tor dental implants” to be all dental implants that are Vergata University of Rome, Rome, Italy. 2Department of Oral and Maxillo-Facial Sciences, “Sapienza,” ≤ 6 mm.13 Scientific evidence from several clinical stud- University of Rome, Rome, Italy. ies reported no statistically significant differences in 3Department of Clinical Sciences and Translational Medicine, survival rate and/or marginal bone loss (MBL) of short School of Dentistry, Tor Vergata University of Rome, Rome, Italy. dental implants compared with standard-length den- Correspondence to: Dr Paolo Carosi, Department of Chemical tal implants in augmented sites.14 In addition, the pos- Science and Technologies, Via della Ricerca Scientifica, 1, 00133 sible combination between short implants and GBR Rome, Italy. Email: carosipaolo29@gmail.com can result in a reduced complexity of the surgery.15 Furthermore, the use of short dental implants is often Submitted April 14, 2020; accepted June 16, 2020. ©2021 by Quintessence Publishing Co Inc. related to a nonfavorable prosthetic crown-to-implant 30 Volume 36, Number 1, 2021
Carosi et al (C/I) ratio. Garaicoa-Pazmiño et al16 demonstrated that Search Strategy an unfavorable C/I ratio is not connected to decreased The research involved electronic databases (MEDLINE, implant survival ratio and/or increased biologic com- Embase, and Cochrane Library). The following combi- plications. The aim of this study was to systematically nation of words was used: “short implant OR short im- review the literature concerning implant survival rates, plants OR extrashort implant OR extrashort implants marginal bone levels, and prosthetic success of short OR extra-short implant OR extra-short implants AND dental implants used for severe posterior mandibular mandible.” In addition, bibliographies of reviews were atrophy rehabilitation. analyzed and cross-checked. Selection Criteria and Data Extraction MATERIALS AND METHODS Two independent reviewers (P.C. and C.L.) performed a three-stage screening procedure of all the selected This study followed the Preferred Reporting Items for studies. Any possible disagreement was resolved by Systematic Review and Meta-Analyses (PRISMA) state- means of additional review. First of all, the titles were ment.17 The main question of the research was en- analyzed to eliminate studies that were not appropri- closed in PICO (Population, Intervention, Comparison, ate. Then, all the abstracts were analyzed, and only the Outcomes) format: “Do short implants (I) report the selected studies were involved in the full-text reading. same clinical outcomes (O) in the posterior edentulous mandible (P) as standard implants after bone augmen- Risk of Bias tation procedures (C)?” The inclusion and exclusion cri- The quality of the studies involved in the review was teria were defined by the authors before the start of the assessed by the reviewers (P.C. and C.L.) using the Co- study. The inclusion criteria were all randomized con- chrane Collaboration tool for assessing risk of bias for trolled trials (RCTs), based on human subjects, with at randomized trials. The potential risk of bias was classi- least 10 patients and 1 year of follow-up after prosthe- fied as low, high, or unclear. Any disagreement was dis- sis delivery and published in the English language. All cussed until it was resolved by consensus. trials were designed to evaluate clinical effectiveness of short implants to rehabilitate severe posterior man- dibular atrophy. All studies analyzed were published RESULTS between January 1, 2015, and February 29, 2020. The exclusion criteria were as follows: studies reporting Identified Articles the same data as following publications by the same The search resulted in 77 titles. After title and abstract authors, systematic reviews, commentaries and letters screening, a total of 14 potentially relevant studies were to the editor, case reports, in vitro studies, studies in identified. Four studies18–21 were excluded because animal models, and case series. Relevant systematic re- they reported a unitary statistical analysis of maxillary view papers, as well as the reference lists of all included and mandibular implant survival and MBL. Two stud- articles, were searched by hand to identify further pub- ies22,23 were excluded because the same data were re- lications. Full-text screening, study selection, and data ported in two other studies with longer follow-up. One extraction were performed in duplicate, and disagree- study24 was excluded because completely edentulous ments were resolved by consensus. mandibles were treated, another study25 was excluded due to lack of statistical data, and another study was ex- Types of Interventions cluded because standard-length implants were placed The analyzed studies were RCTs or split-mouth RCTs. without performing bone augmentation procedures26 The test group was treated with short dental implants, (Table 1). In the end, five studies were included in the and the control group was treated with bone augmen- qualitative analysis (Fig 1). tation procedures and regular dental implants in severe posterior mandibular atrophy. Included Studies The five studies that met the inclusion criteria are re- Outcome Measures ported in Table 2. The quality assessment is summa- The primary outcome investigated by this systematic rized in Table 3. All selected studies are RCTs published review was the implant survival rate of short dental between 2015 and 2020 and conducted in a university implants. The secondary outcomes were marginal environment. Three studies had only one treatment bone levels and prosthetic success rate. All the col- option that was accomplished on each patient in a lected and analyzed data were measured before inter- random way,8–10 and two studies had a split-mouth vention and at every yearly recall, for at least 1 year of design7,11 where both treatment modalities were per- follow-up. formed on each patient. A total of 167 short implants The International Journal of Oral & Maxillofacial Implants 31
Carosi et al Table 1 Excluded Studies and Reasons for Exclusion Studies Cause for exclusion Naenni et al (2018)18; Shah et al (2018)19; Statistical analysis is comprehensive and not divided by maxilla and mandible. Zadeh et al (2018)20; Felice et al (2016)21 Gastaldi et al (2018)22; Felice et al (2018)23 Patients or data reported in other included studies with longer follow-up. Guida et al (2019)24 Treatment on completely edentulous mandibles. Bernardi et al (2018)25 Lack of data. Rossi et al (2015)26 Bone augmentations were not performed to place standard-length dental implants. Implant Survival Rates Records identified through Additional records identified The overall short implant survival Identification database searching through other sources rates ranged from 92% to 96.9%, (n = 77) (n = 0) with a follow-up from 1 to 5 years in function. The standard-length dental implant groups had implant survival rates ranging from 84.8% to Records after duplicates removed 100% with a follow-up from 1 to 5 (n = 77) years. Esposito et al9 in 2019 report- ed an overall short implant survival Screening rate in atrophic mandibles of 96.9% after 5 years in function. Otherwise, Records screened the standard-length implant group (n = 77) had an overall implant survival rate of 93.5% after the same follow-up Records excluded period. Similar results are reported (n = 63) by Felice et al.10 The test short im- Eligibility plant group reported an overall im- Full-text articles assessed for eligibility (n = 14) plant survival rate of 95.1%, while the control group reported an over- Full-text articles excluded all implant survival rate of 93.6% with reasons after 5 years in function. Another (n = 9) study by Felice et al11 reported that Included Studies included in qualitative synthesis the short implant survival rate after (n = 5) 5 years in function was 94.1%, while the standard-length dental implant survival rate was 97.4% (Table 4). Fig 1 Search strategy flowchart. Marginal Bone Levels The MBL values were reported in (≤ 6 mm) were placed in 76 patients, while 176 standard implants with each study involved in this review > 6 mm length were placed in 76 patients. In four studies,8–11 implants for both implant groups. The mean were placed in the maxilla and in the mandible. Only results from the MBL values of the short implant mandibular implants were taken. Two studies7,8 had 1 year of follow-up, group between the studies ranged while the other four studies had 5 years of follow-up. Concerning dental from –0.51 to –2.30 mm. The mean implant length, the short implant group included implants of lengths of MBL values of the standard-length 4 to 6 mm with two studies reporting data on 4-mm implants7,8 and three implant groups between the studies studies9–11 reporting data on 5-mm implants. The control groups had ranged from –0.77 to –2.64 mm. a variety of implant lengths ranging from 8.5 to 15 mm. No immediate loading was performed in any of the studies. The prosthetic design was Prosthesis Success Rates assessed in order to splint multiple adjacent implants in five studies. Con- The studies involved in this system- cerning the retention of restorations, four studies8–11 reported combina- atic review reported high prosthesis tions between screw- or cement-retained restorations. The other study7 success rates. The values for the short included only cement-retained restorations. implant groups ranged from 90.9% 32 Volume 36, Number 1, 2021
Carosi et al Table 2 Main Characteristics of the Studies Control groups Short 1. C ontrol group implants Prosthetic Test groups patients total at 1. N o. of short Regular implants design 1. T est group patients baseline (male, implants total 1. N o. of regular implants total at 1. Short at baseline (male, female) at baseline baseline Implant implant female) 2. Age (mean, y) 2. No. of short 2. No. of regular implants total at last length (mm) group 2. Age (mean, y) 3. C ontrol group implants follow-up 1. Short 2. Regular Follow- 3. T est group patients patients total at total at last 3. Type of grafting 2. Regular implant up Study at last follow-up last follow-up follow-up 4. Healing period of grafted sites 3. Manufacturer group (mo) Rokn et al 1. 11 (2, 9) 1. 11 (2, 9) 1. 25 1. 22 1. 4 1. Splinted 12 (2018)7 2. 50.3 2. 50.3 2. 23 2. 20 2. 8–10 2. Splinted 3. 10 3. 10 3. Allograft mixed with autogenous 3. Straumann bone harvested from the external oblique ridge area 4. 6 months Bolle et al 1. 20 (7, 13) 1. 20 (12, 8) 1. 43 1. 46 1. 4 1. Splinted 12 (2018)8 2. 59.3 2. 63.25 2. 41 2. 39 2. 8 .5–10– 2. Splinted 3. 20 3. 19 3. Interposition of blocks of colla 11.5–13 genated cancellous equine bone 3. Global-D 4. 4 months Esposito 1. 20 (3, 17) 1. 20 (7, 13) 1. 32 1. 31 1. 5 1. Splinted 60 et al 2. 58.6 2. 52.8 2. 30 2. 28 2. 10–13 2. Splinted (2019)9 3. 17 3. 18 3.Interposition of blocks of colla 3. MegaGen genated cancellous equine bone. 4. 4 months Felice et al 1. 15 (4,11) 1. 15 (4,11) 1. 26 1. 30 1. 5 1. Splinted 60 (2019)10 2. 56 2. 56 2. 24 2. 29 2. 10–13 2. Splinted 3. 11 3. 11 3. Interposition of blocks of 3. MegaGen anorganic bovine bone 4. 4 months Felice et al 1. 10 (5, 5) 1. 10 (5,5) 1. 41 1. 47 1. 5 1. Splinted 60 (2019)11 2. 54.1 2. 54.1 2. 39 2. 44 2. 11.5–13–15 2. Splinted 3. 9 3. 9 3.Interposition of blocks of colla 3. No data genated cancellous equine bone 4. 3 months to 100%, while the values for standard-length implant the patients.4 In opposition, it is possible to use short groups ranged from 90% to 100%. dental implants with reduced length (≤ 6 mm) to over- come several surgery- and patient-centered issues.14 The main question about short dental implants is how long DISCUSSION they can survive once they are in function due to the re- duced bone-to-implant surface. To achieve the highest This study aimed to systematically review the literature level of evidence, only RCTs were included in the analysis regarding clinical outcomes of short dental implants in order to add more relief to the findings. Several RCTs in severe posterior mandibular atrophy rehabilitation. were conducted to better understand if short implant Severe mandibular atrophy rehabilitations are always survival rates can be compared with standard dental a difficult challenge for clinicians. Standard dental implants in augmented bone and if their use is justified implants (≥ 10 mm) are still the best choice when an as an alternative treatment approach. There were no sta- implant-supported rehabilitation needs to be planned. tistically significant differences between the test groups Unfortunately, sometimes several anatomical condi- and the control groups at 5 years of follow-up in all the tions such as reduced vertical bone heights at implant RCTs involved in this review. However, the main limita- sites (6 to 8 mm above the mandibular canals) prevent tion of these studies is that the longer follow-up is only at the chance to use standard dental implants. 5 years in function. These results are in accordance with The possibility to perform VRA or inferior alveolar the systematic review presented by Ravidà et al that re- nerve transposition is directly proportional to the sur- ported the survival rates of short dental implants in the geon’s skills, and often these techniques lead to aug- mandible as 99%, 98.5%, 98.1%, 97.3%, and 96.2% from mented posttreatment morbidity, time, and costs for years 1 to 5, respectively, validating the high survival rate The International Journal of Oral & Maxillofacial Implants 33
Carosi et al Table 3 Quality Assessment Blinding of Random participants Study sequence Allocation and (year) generation Note concealment Note personnel Note Rokn et al Low risk A randomization Low risk The allocation of each patient was sequentially High risk - The surgery treatment had to (2018)7 list was numbered and closed in an envelope. be known by the surgeon. created by an - It is in the rights of the independent patients to know how they investigator were treated. before all the surgeries. Bolle et al Low risk Randomization Low risk The allocation of each patient was sequentially High risk - The surgery treatment had to (2018)8 list was numbered and closed in an envelope. be known by the surgeon. generated by - It is in the rights of the one computer. patients to know how they were treated. Esposito et Low risk Randomization Low risk The allocation of each patient was sequentially High risk - The surgery treatment had to al (2019)9 list was numbered and closed in an envelope. be known by the surgeon. generated by - It is in the rights of the one computer. patients to know how they were treated. Felice et al Low risk Randomization Low risk The surgeon recorded one site of his choice High risk - The surgery treatment had to (2019)10 list was as site number 1 and the contralateral as site be known by the surgeon. generated by number 2. Sites numbered 1 of eligible patients - It is in the rights of the one computer. were randomized according to a split-mouth patients to know how they design. The information on how to treat were treated. site number 1 was enclosed in sequentially numbered, identical, opaque, sealed envelopes. Felice et al Low risk Randomization Low risk The surgeon recorded one site of his choice High risk - The surgery treatment had to (2019)11 list was as site number 1 and the contralateral as site be known by the surgeon. generated by number 2. Sites numbered 1 of eligible patients - It is in the rights of the one computer. were randomized according to a split-mouth patients to know how they design. The information on how to treat were treated. site number 1 was enclosed in sequentially numbered, identical, opaque, sealed envelopes. of short implants in the mandible.27 In another system- addition, a prospective study by Slotte et al in 201429 re- atic review, Papaspyridakos et al in 201828 showed how ported data from 1 to 5 years in function of short dental short dental implants (≤ 6 mm) had high survival rates implants. The short implant survival rate was 100% after when involved in posterior edentulous mandibular re- 1 year and 92.2% after 5 years in function. The survival habilitations. The mean survival rate reported after peri- rate of the dental implants depends on the quality and ods of 1 to 5 years in function was 96% for short implant quantity of peri-implant bone. The studies involved in test groups and 98% for standard-length control groups. this review reported similar MBL after 5 years in function The results from the RCTs by Esposito et al in 20199 and for test groups and for control groups. The test groups Felice et al in 201910 reported implant survival rates of showed minor values in terms of mean MBL compared short dental implant groups comparable to the surviv- with augmented control groups. The mean MBL values al rates of the control groups. The survival rate trends in test groups were 1.34 mm,10 1.43 mm,9 and 1.72 mm11 of both groups found in the two RCTs by Esposito et al at 5 years of follow-up. These values were slightly high- and Felice et al in the two systematic reviews27,28 dem- er compared with the ITI Consensus Statement that onstrate that short dental implants can be a valid treat- reported mean values ranging from +0.06 mm (bone ment option in severe posterior mandibular atrophy. In gain) to –1.22 mm. It is also notable that the mean MBL 34 Volume 36, Number 1, 2021
Carosi et al Free of Blinding of Incomplete another outcome outcome Selective source’s Overall assessment Note data Note reporting Note bias Note risk Low risk An independent Low risk Dropout Low risk All No The definitive prostheses were realized in order to Low risk operator evaluated outcomes splint the implants if two or more implants were the radiographies data were placed adjacent. and led the prosthetic published. follow-up. Low risk An independent Low risk Dropout Low risk All No The sample size was not calculated before the Low risk operator evaluated outcomes beginning of the study. The clinical examinations the radiographies data were were performed not knowing the group allocation, and led the prosthetic published. but the augmented sites could be identified follow-up. by means of length of the dental implants. The definitive prostheses were realized in order to splint the implants if two or more implants were placed adjacent. Low risk The clinical Unclear risk Dropout Low risk All No The sample size was not calculated before Unclear measurements outcomes the beginning of the study. It is not clear if the risk were made by data were dropped-out patients that authors can no longer three independent published. contact were involved in the statistical analysis as clinicians while successful cases. The clinical examinations were one independent performed not knowing the group allocation, but clinician made the augmented sites could be identified by means the radiographic of length of the dental implants. The definitive evaluation. prostheses were realized in order to splint the implants if two or more implants were placed adjacent. Low risk The clinical Unclear risk Dropout Low risk All No It is not clear if the dropped-out patients that Unclear measurements outcomes authors can no longer contact were involved in the risk were made by data were statistical analysis as successful cases. The clinical two independent published. examinations were performed not knowing the clinicians while one group allocation, but the augmented sites could be independent clinician identified by means of length of the dental implants made the statistical and the different radiolucency of bone. evaluation. Low risk The clinical measure Unclear risk Dropout Low risk All No It is not clear if the dropped-out patients that Unclear ments were made outcomes authors can no longer contact were involved in risk by six independent data were the statistical analysis as successful cases. The clinicians while published. definitive prostheses were realized in order to splint one independent the implants if two or more implants were placed dental student made adjacent. the radiographic evaluation. values of control groups of the studies included in this al,29 where the mean MBL was 0.44 mm after the first review were slightly higher compared with the mean year in function, 0.55 mm after 3 years in function, and MBL values reported in the ITI Consensus Statement.14 0.53 mm after 5 years in function. Rossi et al26 suggested The control augmented groups showed a mean MBL that this may have been due to the more apical shift in of 2.08 mm,9 2.10 mm,11 and 2.11 mm10 after 5 years in the biologic width during the first period of healing, and function. The Consensus Statement reported mean MBLs it provides marginal bone adaptation. It is mandatory to ranging from +0.02 mm (bone gain) to −1.54 mm.13 It is highlight that even if mean bone loss around short den- important to observe that the main bone remodeling tal implants seems to be minor compared with standard around short dental implants occurs during the first year dental implants, the loss of 2 mm of peri-implant bone after the prosthesis delivery. Two RCTs by Esposito et al9 height represents 30% (for 6-mm short implants) or 50% and Felice et al10 reported greater peri-implant bone re- (for 4-mm short implants) of the overall bone-to-implant absorption after 1, 3, and 5 years in function and mean contact area, whereas the same bone loss for standard MBLs of 0.94 mm, 1.33 mm, and 1.43 mm, and 1.05 mm, dental implants represents a maximum of 20% of the 1.25 mm, and 1.34 mm, respectively. The same state- overall bone-to-implant contact area. For this reason, it ment was reported in a prospective study by Slotte et is very important to involve the patients in a long-term The International Journal of Oral & Maxillofacial Implants 35
Carosi et al Table 4 Main Results from Selected Studies Short implant Regular implant Marginal Short implant group Regular implant survival rate survival rate bone loss complications group complications 1. Baseline 1. Baseline (mm) 1. P eri-implant mucositis 1. Peri-implant mucositis Prosthetic 2. Survived 2. Survived 1. Short 2. Temporary paresthesia 2. Temporary paresthesia success (in %) 3. Dropouts 3. Dropouts implant 3. Crown loosened 3. Crown loosened 1. Short implant 4. Failed 4. Failed 2. Regular 4. Chipping of definitive 4. Chipping of definitive 2. Regular Study 5. Percentage 5. Percentage implant crown crown implant Rokn et al (2018)7 1. 25 1. 22 1. 1.55 1. 0 1. 5 1. 100 1-year split-mouth 2. 23 2. 20 2. 1.97 2. 0 2. 3 2. 100 RCT 3. 2 3. 2 3. 0 3. 0 4. 0 4. 0 4. 0 4. 0 5. 92 5. 92 Bolle et al (2018)8 1. 43 1. 46 1. 0.51 1. 0 1. 1 1. 95 1-year RCT 2. 41 2. 39 2. 0.77 2. 0 2. 3 2. 95 3. 0 3. 6 3. 1 3. 0 4. 2 4. 1 4. 1 4. 0 5. 95.3 5. 84.8 Esposito et al 1. 32 1. 31 1. 1.43 1. 1 1. 1 1. 95 (2019)9 2. 30 2. 28 2. 2.08 2. 8 2. 14 2. 90 5-year RCT 3. 1 3. 1 3. 0 3. 0 4. 1 4. 2 4. 1 4. 0 5. 96.9 5. 93.5 Felice et al (2019)10 1. 26 1. 30 1. 1.72 1. 1 1. 0 1. 90.9 5-year split-mouth 2. 24 2. 29 2. 2.10 2. 3 2. 10 2. 100 RCT 3. 0 3. 0 3. 1 3. 0 4. 2 4. 1 4. 0 4. 0 5. 94.1 5. 96.6 Felice et al (2019)11 1. 41 1. 47 1. 1.34 1. 0 1. 5 1. 95 5-year RCT 2. 39 2. 44 2. 2.11 2. 0 2. 7 2. 91.4 3. 0 3. 0 3. 0 3. 0 4. 2 4. 3 4. 0 4. 0 5. 95.1 5. 93.6 professional oral-hygiene program in order to prevent complications7–11 when short dental implants are any peri-implant issues and to keep peri-implant tissues splinted. The ITI Consensus Report reminded that it healthy. is recommended to splint short dental implants and The use of short dental implants to rehabilitate the to avoid the risk of occlusal overload if the implant- posterior areas of the mandible is expected to deliver supported restorations involve a single missing molar prostheses with a nonfavorable C/I ratio due to the and/or the patient presents parafunctional habits. The loss of vertical height in the reabsorbed areas. A sys- occlusion should be assessed and modified as neces- tematic review16 and a retrospective study30 reported sary every maintenance visit.13 Even with the quality of that a nonfavorable C/I ratio seems to not have any ef- the included studies in this review, there is a risk of bias fect on bone-level changes. However, more studies are due to the small number of RCTs with a long follow- recommended to increase scientific evidence regard- up period. Consequently, it is mandatory to take care ing this topic. Moreover, it is important to focus on the when reading the results. prosthetic design. Some studies have hypothesized that splinting implants may lead to a better occlusal load distribution.31–33 Finite element analyses report- CONCLUSIONS ed that the occlusal load distribution on splinted im- plants allows the implant bodies to not be overloaded Within the limitations of this systematic review, it seems and distribution of less stress to the implant and the that short dental implants are a valid therapeutic choice peri-implant bone.32,34 Clinical evidence of this state- to rehabilitate severe mandibular atrophy in the medi- ment can be carried out from the studies involved um to long term. For further information, several RCTs in this review, whereas most of the authors reported comparing long-term survival rates of short and longer a high prosthetic success rate7–11 and few technical implants are required to collect new data. 36 Volume 36, Number 1, 2021
Carosi et al ACKNOWLEDGMENTS 16. Garaicoa-Pazmiño C, Suárez-López del Amo F, Monje A, et al. Influ- ence of crown/implant ratio on marginal bone loss: A systematic review. J Periodontol 2014;85:1214–1221. This study was not financially supported by any organizations. The 17. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred authors have no conflict of interest to declare. reporting items for systematic reviews and meta-analyses: The PRISMA statement. Plos Med 2009;6:e1000097. 18. Naenni N, Sahrmann P, Schmidlin PR, et al. Five-year survival of short single-tooth implants (6 mm): A randomized controlled clinical trial. J REFERENCES Dent Res 2018;97:887–892. 19. Shah SN, Chung J, Kim DM, Machtei EE. Can extra-short dental 1. Ferrigno N, Laureti M, Fanali S. Dental implants placement in con- implants serve as alternatives to bone augmentation? A preliminary junction with osteotome sinus floor elevation: A 12-year life-table longitudinal randomized controlled clinical trial. Quintessence Int analysis from a prospective study on 588 ITI implants. Clin Oral 2018;49:635–643. Implants Res 2006;17:194–205. 20. Zadeh HH, Guljé F, Palmer PJ, et al. Marginal bone level and survival 2. Neldam CA, Pinholt EM. State of the art of short dental implants: of short and standard-length implants after 3 years: An open multi- A systematic review of the literature. Clin Implant Dent Relat Res center randomized controlled clinical trial. Clin Oral Implants Res 2012;14:622–632. 2018;29:894–906. 3. Ozan O, Orhan K, Aksoy S, Icen M, Bilecenoglu B, Sakul BU. The 21. Felice P, Checchi L, Barausse C, et al. Posterior jaws rehabilitated with effect of removable partial dentures on alveolar bone resorption: partial prostheses supported by 4.0 × 4.0 mm or by longer implants: A retrospective study with cone-beam computed tomography. J One-year post-loading results from a multicenter randomised con- Prosthodontics 2013;22:42–48. trolled trial. Eur J Oral Implantol 2016;9:35–45. 4. Ferrigno N, Laureti M, Fanali S. Inferior alveolar nerve transposi- 22. Gastaldi G, Felice P, Pistilli V, Barausse C, Ippolito DR, Esposito M. tion in conjunction with implant placement. Int J Oral Maxillofac Posterior atrophic jaws rehabilitated with prostheses supported 2005;20:610–620. by 5 × 5 mm implants with a nanostructured calcium-incorporated 5. Elnayef B, Monje A, Gargallo-Albiol J, Galindo-Moreno P, Wang HL, titanium surface or by longer implants in augmented bone. 3-year Hernández-Alfaro F. Vertical Ridge augmentation in the atrophic results from a randomised controlled trial. Eur J Oral Implantol mandible: A systematic review and meta-analysis. Int J Oral Maxil- 2018;11:49–61. lofac Implants 2017;32:291–312. 23. Felice P, Barausse C, Pistilli V, Piattelli M, Ippolito DR, Esposito M. 6. Slotte C, Grønningsaeter A, Halmøy AM, et al. Four-millimeter Posterior atrophic jaws rehabilitated with prostheses supported by implants supporting fixed partial dental prostheses in the severely 6 mm long × 4 mm wide implants or by longer implants in augment- resorbed posterior mandible: Two-year results. Clin Implant Dent ed bone. 3-year post-loading results from a randomised controlled Relat Res 2012;14(suppl 1):e46–e58. trial. Eur J Oral Implantol 2018;11:175–187. 7. Rokn AR, Monzavi A, Panjnoush M, Hashemi HM, Kharazifard MJ, 24. Guida L, Annunziata M, Esposito U, Sirignano M, Torrisi P, Cecchinato Bitaraf T. Comparing 4-mm dental implants to longer implants D. 6-mm-short and 11-mm-long implants compared in the full-arch placed in augmented bones in the atrophic posterior mandibles: rehabilitation of the edentulous mandible: A 3-year multicenter One-year results of a randomized controlled trial. Clin Implant Dent randomised controlled trial. Clin Oral Implants Res 2020;31:64–73. Relat Res 2018;20:997–1002. 25. Bernardi S, Gatto R, Severino M, et al. Short versus longer implants in 8. Bolle C, Felice P, Barausse C, Pistilli V, Trullenque-Eriksson A, Esposito mandibular alveolar ridge augmented using osteogenic distraction: M. 4 mm long vs longer implants in augmented bone in posterior One-year follow-up of a randomized split-mouth trial. J Oral Implan- atrophic jaws: 1-year post-loading results from a multicentre ran- tol 2018;44:184–191. domised controlled trial. Eur J Oral Implantol 2018;11:31–47. 26. Rossi F, Botticelli D, Cesaretti G, De Santis E, Storelli S, Lang NP. Use 9. Esposito M, Barausse C, Pistilli R, et al. Posterior atrophic jaws reha- of short implants (6 mm) in a single-tooth replacement: A 5-year bilitated with prostheses supported by 5 × 5 mm implants with a follow-up prospective randomized controlled multicenter clinical nanostructured calcium-incorporated titanium surface or by longer study. Clin Oral Implants Res 2016;27:458–464. implants in augmented bone. Five-year results from a randomised 27. Ravidà A, Barootchi S, Askar H, Suárez-López Del Amo F, Tavelli L, controlled trial. Int J Oral Implantol (Berl) 2019;12:39–54. Wang HL. Long-term effectiveness of extra-short (≤ 6 mm) dental 10. Felice P, Pistilli R, Barausse C, Piattelli M, Buti J, Esposito M. implants: A systematic review. Int J Oral Maxillofac 2019;34:68–84. Posterior atrophic jaws rehabilitated with prostheses supported 28. Papaspyridakos P, De Souza A, Vazouras K, Gholami H, Pagni S, by 6-mm-long 4-mm-wide implants or by longer implants in Weber HP. Survival rates of short dental implants (≤ 6 mm) compared augmented bone. Five-year post-loading results from a within- with implants longer than 6 mm in posterior jaw areas: A meta- person randomised controlled trial. Int J Oral Implantol (Berl) analysis. Clin Oral Implants Res 2018;29(suppl 16):8–20. 2019;12:57–72. 29. Slotte C, Grønningsaeter A, Halmøy AM, et al. Four-millimeter-long 11. Felice P, Barausse C, Pistilli R, Ippolito DR, Esposito M. Five-year re- posterior-mandible implants: 5-year outcomes of a prospective multi- sults from a randomised controlled trial comparing prostheses sup- center study. Clin Implant Dent Relat Res 2015;17(suppl 2):e385–e395. ported by 5-mm long implants or by longer implants in augmented 30. Anitua E, Piñas L, Orive G. Retrospective study of short and extra-short bone in posterior atrophic edentulous jaws. Int J Oral Implantol (Berl) implants placed in posterior regions: Influence of crown-to-implant ra- 2019;12:25–37. tio on marginal bone loss. Clin Implant Dent Relat Res 2013;17:102–110. 12. Strietzel FP, Reichart PA. Oral rehabilitation using Camlog screw- 31. Yilmaz B, Seidt JD, McGlumphy EA, Clelland NL. Comparison of cylinder implants with a particle-blasted and acid-etched microstruc- strains for splinted and nonsplinted screw-retained prostheses on tured surface. Results from a prospective study with special consider- short implants. Int J Oral Maxillofac 2011;26:1176–1182. ation of short implants. Clin Oral Implants Res 2007;18:591–600. 32. Guichet DL, Yoshinobu D, Caputo AA. Effect of splinting and inter- 13. Jung RE, Al-Nawas B, Araujo M, et al. Group 1 ITI Consensus Report: proximal contact tightness on load transfer by implant restorations. J The influence of implant length and design and medications on Prosthet Dent 2002;87:528–535. clinical and patient-reported outcomes. Clin Oral Implants Res 33. Naert I, Koutsikakis G, Duyck J, Quirynen M, Jacobs R, 2018;29(suppl 16):69–77. van Steenberghe D. Biologic outcome of implant-supported restora- 14. Renouard F, Nisand D. Impact of implant length and diameter on tions in the treatment of partial edentulism. Part I: A longitudinal survival rates. Clin Oral Implants Res 2006;17(suppl 2):35–51. clinical evaluation. Clin Oral Implants Res 2002;13:381–389. 15. Nedir R, Bischof M, Briaux JM, Beyer S, Szmukler-Moncler S, Bernard 34. Bergkvist G, Simonsson K, Rydberg K, Johansson F, Dérand T. A finite JP. A 7-year life table analysis from a prospective study on ITI element analysis of stress distribution in bone tissue surrounding implants with special emphasis on the use of short implants. Results uncoupled or splinted dental implants. Clin Implant Dent Relat Res from a private practice. Clin Oral Implants Res 2004;15:150–157. 2008;10:40–46. The International Journal of Oral & Maxillofacial Implants 37
You can also read