Short Dental Implants ( 6 mm) to Rehabilitate Severe Mandibular Atrophy: A Systematic Review

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Short Dental Implants (≤ 6 mm) to Rehabilitate
               Severe Mandibular Atrophy: A Systematic Review
                    Paolo Carosi, DDS, MSc, PhD1/Claudia Lorenzi, DDS, PhD1/Mauro Laureti, MD, DDS2/
                                     Nicola Ferrigno, DDS2/Claudio Arcuri, MD, DDS4

   Purpose: This study aimed to assess the survival rate, marginal bone levels, and prosthetic success of short implants
   when placed in posterior areas of severely reabsorbed mandibles. Materials and Methods: A systematic review was
   performed of all randomized controlled trials with at least 10 patients with a control group where bone augmentations
   were performed that were published between January 2015 and February 2020. From 77 pertinent studies, 14 full-text
   publications were studied, and 6 studies fulfilled the inclusion criteria. Results: The implant survival rates of short dental
   implants ranged from 92% to 96.9% with a follow-up from 1 to 5 years, and the prosthetic success rate ranged from
   90% to 100% during the same follow-up. The mean marginal bone level values of involved short implants ranged from
   –0.51 to –2.30 mm. Conclusion: The obtained data showed that short dental implants are a valid therapeutic choice
   to rehabilitate severe mandibular atrophy in the medium to long term. Int J Oral Maxillofac Implants 2021;36:30–37. doi:
   10.11607/jomi.8510

   Keywords: guided bone regeneration, mandibular atrophy, short dental implants, short implants

T   he rehabilitation of partially edentulous arches by
    means of dental implants is a well-accepted treat-
ment. Currently, patients ask for an implant therapy
                                                                     in this zone. To prevent any nerve injury, several alter-
                                                                     native methods have been proposed, such as the lat-
                                                                     eralization of the inferior alveolar nerve,4 vertical ridge
that is as minimally invasive and minimally morbid as                augmentation (VRA),5 and guided bone regeneration
possible. Expectations are increasing, but neverthe-                 (GBR). These techniques can be dangerous for the pa-
less, many patients are reluctant to accept an implant               tients because they are directly proportional to the sur-
treatment, and they are especially apprehensive if a                 geon’s skills. In addition, these techniques can lead to
bone augmentation procedure is required.1 The re-                    increased posttreatment morbidity, time, and costs for
habilitation of the posterior region of the mandible                 the patients. Actually, earlier studies reported that the
is always a hard-complexity case due to the course of                lateralization of the inferior alveolar nerve could cause
the inferior alveolar nerve.2 In most cases, bone verti-             moderate postoperative morbidity.6 In the last years,
cal height is enough to place a standard implant. Un-                the use of short (≤ 6 mm) implants has been increasing
fortunately, several alterations affect bone quality and             by clinicians and has been investigated more by several
quantity after tooth loss,3 and it is mandatory to avoid             researchers.7–11 The definition of short implants is still
any nerve damage when performing implant surgery                     not completely defined, and as a result, interpretation
                                                                     of the literature is complicated by several different defi-
                                                                     nitions. Strietzel and Reichart reported that all implants
                                                                     that have lengths less than or equal to 11 mm have to
                                                                     be considered short.12 On the other hand, Group 1 of
1Department    of Chemical Science and Technologies, PhD in          the 6th ITI Consensus Conference considered “short
 Materials for Health, Environment and Energy–Dentistry, Tor
                                                                     dental implants” to be all dental implants that are
 Vergata University of Rome, Rome, Italy.
2Department of Oral and Maxillo-Facial Sciences, “Sapienza,”         ≤ 6 mm.13 Scientific evidence from several clinical stud-
 University of Rome, Rome, Italy.                                    ies reported no statistically significant differences in
3Department of Clinical Sciences and Translational Medicine,
                                                                     survival rate and/or marginal bone loss (MBL) of short
 School of Dentistry, Tor Vergata University of Rome, Rome, Italy.   dental implants compared with standard-length den-
Correspondence to: Dr Paolo Carosi, Department of Chemical           tal implants in augmented sites.14 In addition, the pos-
Science and Technologies, Via della Ricerca Scientifica, 1, 00133    sible combination between short implants and GBR
Rome, Italy. Email: carosipaolo29@gmail.com                          can result in a reduced complexity of the surgery.15
                                                                     Furthermore, the use of short dental implants is often
Submitted April 14, 2020; accepted June 16, 2020.
©2021 by Quintessence Publishing Co Inc.                            related to a nonfavorable prosthetic crown-to-implant

30 Volume 36, Number 1, 2021
Carosi et al

(C/I) ratio. Garaicoa-Pazmiño et al16 demonstrated that       Search Strategy
an unfavorable C/I ratio is not connected to decreased        The research involved electronic databases (MEDLINE,
implant survival ratio and/or increased biologic com-         Embase, and Cochrane Library). The following combi-
plications. The aim of this study was to systematically       nation of words was used: “short implant OR short im-
review the literature concerning implant survival rates,      plants OR extrashort implant OR extrashort implants
marginal bone levels, and prosthetic success of short         OR extra-short implant OR extra-short implants AND
dental implants used for severe posterior mandibular          mandible.” In addition, bibliographies of reviews were
atrophy rehabilitation.                                       analyzed and cross-checked.

                                                              Selection Criteria and Data Extraction
MATERIALS AND METHODS                                         Two independent reviewers (P.C. and C.L.) performed
                                                              a three-stage screening procedure of all the selected
This study followed the Preferred Reporting Items for         studies. Any possible disagreement was resolved by
Systematic Review and Meta-Analyses (PRISMA) state-           means of additional review. First of all, the titles were
ment.17 The main question of the research was en-             analyzed to eliminate studies that were not appropri-
closed in PICO (Population, Intervention, Comparison,         ate. Then, all the abstracts were analyzed, and only the
Outcomes) format: “Do short implants (I) report the           selected studies were involved in the full-text reading.
same clinical outcomes (O) in the posterior edentulous
mandible (P) as standard implants after bone augmen-          Risk of Bias
tation procedures (C)?” The inclusion and exclusion cri-      The quality of the studies involved in the review was
teria were defined by the authors before the start of the     assessed by the reviewers (P.C. and C.L.) using the Co-
study. The inclusion criteria were all randomized con-        chrane Collaboration tool for assessing risk of bias for
trolled trials (RCTs), based on human subjects, with at       randomized trials. The potential risk of bias was classi-
least 10 patients and 1 year of follow-up after prosthe-      fied as low, high, or unclear. Any disagreement was dis-
sis delivery and published in the English language. All       cussed until it was resolved by consensus.
trials were designed to evaluate clinical effectiveness
of short implants to rehabilitate severe posterior man-
dibular atrophy. All studies analyzed were published          RESULTS
between January 1, 2015, and February 29, 2020. The
exclusion criteria were as follows: studies reporting         Identified Articles
the same data as following publications by the same           The search resulted in 77 titles. After title and abstract
authors, systematic reviews, commentaries and letters         screening, a total of 14 potentially relevant studies were
to the editor, case reports, in vitro studies, studies in     identified. Four studies18–21 were excluded because
animal models, and case series. Relevant systematic re-       they reported a unitary statistical analysis of maxillary
view papers, as well as the reference lists of all included   and mandibular implant survival and MBL. Two stud-
articles, were searched by hand to identify further pub-      ies22,23 were excluded because the same data were re-
lications. Full-text screening, study selection, and data     ported in two other studies with longer follow-up. One
extraction were performed in duplicate, and disagree-         study24 was excluded because completely edentulous
ments were resolved by consensus.                             mandibles were treated, another study25 was excluded
                                                              due to lack of statistical data, and another study was ex-
Types of Interventions                                        cluded because standard-length implants were placed
The analyzed studies were RCTs or split-mouth RCTs.           without performing bone augmentation procedures26
The test group was treated with short dental implants,        (Table 1). In the end, five studies were included in the
and the control group was treated with bone augmen-           qualitative analysis (Fig 1).
tation procedures and regular dental implants in severe
posterior mandibular atrophy.                                 Included Studies
                                                              The five studies that met the inclusion criteria are re-
Outcome Measures                                              ported in Table 2. The quality assessment is summa-
The primary outcome investigated by this systematic           rized in Table 3. All selected studies are RCTs published
review was the implant survival rate of short dental          between 2015 and 2020 and conducted in a university
implants. The secondary outcomes were marginal                environment. Three studies had only one treatment
bone levels and prosthetic success rate. All the col-         option that was accomplished on each patient in a
lected and analyzed data were measured before inter-          random way,8–10 and two studies had a split-mouth
vention and at every yearly recall, for at least 1 year of    design7,11 where both treatment modalities were per-
follow-up.                                                    formed on each patient. A total of 167 short implants

                                                                  The International Journal of Oral & Maxillofacial Implants 31
Carosi et al

 Table 1 Excluded Studies and Reasons for Exclusion
 Studies                                                                                                Cause for exclusion
 Naenni et al (2018)18; Shah et al (2018)19;                    Statistical analysis is comprehensive and not divided by maxilla and mandible.
 Zadeh et al (2018)20; Felice et al (2016)21
 Gastaldi et al (2018)22; Felice et al (2018)23                 Patients or data reported in other included studies with longer follow-up.
 Guida et al (2019)24                                           Treatment on completely edentulous mandibles.
 Bernardi et al (2018)25                                        Lack of data.
 Rossi et al (2015)26                                           Bone augmentations were not performed to place standard-length dental implants.

                                                                                                                Implant Survival Rates
                     Records identified through              Additional records identified                      The overall short implant survival
    Identification

                        database searching                     through other sources                            rates ranged from 92% to 96.9%,
                              (n = 77)                                  (n = 0)                                 with a follow-up from 1 to 5 years
                                                                                                                in function. The standard-length
                                                                                                                dental implant groups had implant
                                                                                                                survival rates ranging from 84.8% to
                                     Records after duplicates removed                                           100% with a follow-up from 1 to 5
                                                  (n = 77)                                                      years. Esposito et al9 in 2019 report-
                                                                                                                ed an overall short implant survival
    Screening

                                                                                                                rate in atrophic mandibles of 96.9%
                                                                                                                after 5 years in function. Otherwise,
                                             Records screened
                                                                                                                the standard-length implant group
                                                 (n = 77)                                                       had an overall implant survival rate
                                                                                                                of 93.5% after the same follow-up
                                                                                    Records excluded            period. Similar results are reported
                                                                                        (n = 63)
                                                                                                                by Felice et al.10 The test short im-
    Eligibility

                                                                                                                plant group reported an overall im-
                                  Full-text articles assessed for eligibility
                                                   (n = 14)                                                     plant survival rate of 95.1%, while
                                                                                                                the control group reported an over-
                                                                                Full-text articles excluded     all implant survival rate of 93.6%
                                                                                       with reasons             after 5 years in function. Another
                                                                                           (n = 9)
                                                                                                                study by Felice et al11 reported that
    Included

                                  Studies included in qualitative synthesis                                     the short implant survival rate after
                                                  (n = 5)                                                       5 years in function was 94.1%, while
                                                                                                                the standard-length dental implant
                                                                                                                survival rate was 97.4% (Table 4).

Fig 1   Search strategy flowchart.                                                                              Marginal Bone Levels
                                                                                                                The MBL values were reported in
(≤ 6 mm) were placed in 76 patients, while 176 standard implants with                                           each study involved in this review
> 6 mm length were placed in 76 patients. In four studies,8–11 implants                                         for both implant groups. The mean
were placed in the maxilla and in the mandible. Only results from the                                           MBL values of the short implant
mandibular implants were taken. Two studies7,8 had 1 year of follow-up,                                         group between the studies ranged
while the other four studies had 5 years of follow-up. Concerning dental                                        from –0.51 to –2.30 mm. The mean
implant length, the short implant group included implants of lengths of                                         MBL values of the standard-length
4 to 6 mm with two studies reporting data on 4-mm implants7,8 and three                                         implant groups between the studies
studies9–11 reporting data on 5-mm implants. The control groups had                                             ranged from –0.77 to –2.64 mm.
a variety of implant lengths ranging from 8.5 to 15 mm. No immediate
loading was performed in any of the studies. The prosthetic design was                                          Prosthesis Success Rates
assessed in order to splint multiple adjacent implants in five studies. Con-                                    The studies involved in this system-
cerning the retention of restorations, four studies8–11 reported combina-                                       atic review reported high prosthesis
tions between screw- or cement-retained restorations. The other study7                                          success rates. The values for the short
included only cement-retained restorations.                                                                     implant groups ranged from 90.9%

32 Volume 36, Number 1, 2021
Carosi et al

Table 2 Main Characteristics of the Studies
                                        Control groups             Short
                                       1. C
                                           ontrol group         implants                                                                        Prosthetic
                      Test groups         patients total at   1. N
                                                                  o. of short              Regular implants                                       design
               1. T est group patients baseline (male,          implants total   1. N
                                                                                      o. of regular implants total at                          1. Short
                  at baseline (male,      female)                at baseline         baseline                                   Implant             implant
                  female)              2. Age (mean, y)       2. No. of short    2. No. of regular implants total at last   length (mm)           group
               2. Age (mean, y)        3. C
                                           ontrol group          implants            follow-up                               1. Short          2. Regular      Follow-
               3. T est group patients patients total at         total at last   3. Type of grafting                         2. Regular            implant        up
Study              at last follow-up      last follow-up          follow-up       4. Healing period of grafted sites         3. Manufacturer       group         (mo)
Rokn et al         1. 11 (2, 9)             1. 11 (2, 9)           1. 25          1. 22                                1. 4                     1. Splinted        12
(2018)7            2. 50.3                  2. 50.3                2. 23          2. 20                                2. 8–10                  2. Splinted
                   3. 10                    3. 10                                 3. Allograft mixed with autogenous 3. Straumann
                                                                                      bone harvested from the external
                                                                                      oblique ridge area
                                                                                  4. 6 months
Bolle et al        1. 20 (7, 13)            1. 20 (12, 8)          1. 43          1. 46                                 1. 4                    1. Splinted        12
(2018)8            2. 59.3                  2. 63.25               2. 41          2. 39                                 2. 8
                                                                                                                            .5–10–             2. Splinted
                   3. 20                    3. 19                                 3. Interposition of blocks of colla­    11.5–13
                                                                                      genated cancellous equine bone 3. Global-D
                                                                                  4. 4 months
Esposito           1. 20 (3, 17)            1. 20 (7, 13)          1. 32          1. 31                                1. 5                     1. Splinted        60
et al              2. 58.6                  2. 52.8                2. 30          2. 28                                2. 10–13                 2. Splinted
(2019)9            3. 17                    3. 18                                 3.Interposition of blocks of colla­ 3. MegaGen
                                                                                    genated cancellous equine bone.
                                                                                  4. 4 months
Felice et al       1. 15 (4,11)             1. 15 (4,11)           1. 26          1. 30                                       1. 5              1. Splinted        60
(2019)10           2. 56                    2. 56                  2. 24          2. 29                                       2. 10–13          2. Splinted
                   3. 11                    3. 11                                 3. Interposition of blocks of              3. MegaGen
                                                                                      anorganic bovine bone
                                                                                  4. 4 months
Felice et al       1. 10 (5, 5)             1. 10 (5,5)            1. 41          1. 47                                1. 5                     1. Splinted        60
(2019)11           2. 54.1                  2. 54.1                2. 39          2. 44                                2. 11.5–13–15            2. Splinted
                   3. 9                     3. 9                                  3.Interposition of blocks of colla­ 3. No data
                                                                                    genated cancellous equine bone
                                                                                  4. 3 months

to 100%, while the values for standard-length implant                                    the patients.4 In opposition, it is possible to use short
groups ranged from 90% to 100%.                                                          dental implants with reduced length (≤ 6 mm) to over-
                                                                                         come several surgery- and patient-centered issues.14 The
                                                                                         main question about short dental implants is how long
DISCUSSION                                                                               they can survive once they are in function due to the re-
                                                                                         duced bone-to-implant surface. To achieve the highest
This study aimed to systematically review the literature                                 level of evidence, only RCTs were included in the analysis
regarding clinical outcomes of short dental implants                                     in order to add more relief to the findings. Several RCTs
in severe posterior mandibular atrophy rehabilitation.                                   were conducted to better understand if short implant
Severe mandibular atrophy rehabilitations are always                                     survival rates can be compared with standard dental
a difficult challenge for clinicians. Standard dental                                    implants in augmented bone and if their use is justified
implants (≥ 10 mm) are still the best choice when an                                     as an alternative treatment approach. There were no sta-
implant-supported rehabilitation needs to be planned.                                    tistically significant differences between the test groups
Unfortunately, sometimes several anatomical condi-                                       and the control groups at 5 years of follow-up in all the
tions such as reduced vertical bone heights at implant                                   RCTs involved in this review. However, the main limita-
sites (6 to 8 mm above the mandibular canals) prevent                                    tion of these studies is that the longer follow-up is only at
the chance to use standard dental implants.                                              5 years in function. These results are in accordance with
   The possibility to perform VRA or inferior alveolar                                   the systematic review presented by Ravidà et al that re-
nerve transposition is directly proportional to the sur-                                 ported the survival rates of short dental implants in the
geon’s skills, and often these techniques lead to aug-                                   mandible as 99%, 98.5%, 98.1%, 97.3%, and 96.2% from
mented posttreatment morbidity, time, and costs for                                      years 1 to 5, respectively, validating the high survival rate

                                                                                               The International Journal of Oral & Maxillofacial Implants 33
Carosi et al

 Table 3 Quality Assessment
                                                                                                              Blinding of
                 Random                                                                                       participants
Study           sequence                       Allocation                                                         and
(year)         generation        Note         concealment                        Note                          personnel                  Note
Rokn et al      Low risk    A randomization     Low risk    The allocation of each patient was sequentially    High risk     - The surgery treatment had to
(2018)7                     list was                        numbered and closed in an envelope.                                 be known by the surgeon.
                            created by an                                                                                    - It is in the rights of the
                            independent                                                                                         patients to know how they
                            investigator                                                                                        were treated.
                            before all the
                            surgeries.
Bolle et al     Low risk    Randomization       Low risk    The allocation of each patient was sequentially    High risk     - The surgery treatment had to
(2018)8                     list was                        numbered and closed in an envelope.                                 be known by the surgeon.
                            generated by                                                                                     - It is in the rights of the
                            one computer.                                                                                       patients to know how they
                                                                                                                                were treated.

Esposito et     Low risk    Randomization       Low risk    The allocation of each patient was sequentially    High risk     - The surgery treatment had to
al (2019)9                  list was                        numbered and closed in an envelope.                                 be known by the surgeon.
                            generated by                                                                                     - It is in the rights of the
                            one computer.                                                                                       patients to know how they
                                                                                                                                were treated.

Felice et al    Low risk    Randomization       Low risk    The surgeon recorded one site of his choice        High risk     - The surgery treatment had to
(2019)10                    list was                        as site number 1 and the contralateral as site                      be known by the surgeon.
                            generated by                    number 2. Sites numbered 1 of eligible patients                  - It is in the rights of the
                            one computer.                   were randomized according to a split-mouth                          patients to know how they
                                                            design. The information on how to treat                             were treated.
                                                            site number 1 was enclosed in sequentially
                                                            numbered, identical, opaque, sealed envelopes.

Felice et al    Low risk    Randomization       Low risk    The surgeon recorded one site of his choice        High risk     - The surgery treatment had to
(2019)11                    list was                        as site number 1 and the contralateral as site                      be known by the surgeon.
                            generated by                    number 2. Sites numbered 1 of eligible patients                  - It is in the rights of the
                            one computer.                   were randomized according to a split-mouth                          patients to know how they
                                                            design. The information on how to treat                             were treated.
                                                            site number 1 was enclosed in sequentially
                                                            numbered, identical, opaque, sealed envelopes.

of short implants in the mandible.27 In another system-                        addition, a prospective study by Slotte et al in 201429 re-
atic review, Papaspyridakos et al in 201828 showed how                         ported data from 1 to 5 years in function of short dental
short dental implants (≤ 6 mm) had high survival rates                         implants. The short implant survival rate was 100% after
when involved in posterior edentulous mandibular re-                           1 year and 92.2% after 5 years in function. The survival
habilitations. The mean survival rate reported after peri-                     rate of the dental implants depends on the quality and
ods of 1 to 5 years in function was 96% for short implant                      quantity of peri-implant bone. The studies involved in
test groups and 98% for standard-length control groups.                        this review reported similar MBL after 5 years in function
The results from the RCTs by Esposito et al in 20199 and                       for test groups and for control groups. The test groups
Felice et al in 201910 reported implant survival rates of                      showed minor values in terms of mean MBL compared
short dental implant groups comparable to the surviv-                          with augmented control groups. The mean MBL values
al rates of the control groups. The survival rate trends                       in test groups were 1.34 mm,10 1.43 mm,9 and 1.72 mm11
of both groups found in the two RCTs by Esposito et al                         at 5 years of follow-up. These values were slightly high-
and Felice et al in the two systematic reviews27,28 dem-                       er compared with the ITI Consensus Statement that
onstrate that short dental implants can be a valid treat-                      reported mean values ranging from +0.06 mm (bone
ment option in severe posterior mandibular atrophy. In                         gain) to –1.22 mm. It is also notable that the mean MBL

34 Volume 36, Number 1, 2021
Carosi et al

                                                                                        Free of
Blinding of                            Incomplete                                      another
 outcome                                outcome               Selective                source’s                                                           Overall
assessment            Note                data       Note     reporting     Note         bias                             Note                             risk

 Low risk     An independent            Low risk    Dropout   Low risk    All            No       The definitive prostheses were realized in order to    Low risk
              operator evaluated                                          outcomes                splint the implants if two or more implants were
              the radiographies                                           data were               placed adjacent.
              and led the prosthetic                                      published.
              follow-up.

 Low risk     An independent            Low risk    Dropout   Low risk    All            No       The sample size was not calculated before the          Low risk
              operator evaluated                                          outcomes                beginning of the study. The clinical examinations
              the radiographies                                           data were               were performed not knowing the group allocation,
              and led the prosthetic                                      published.              but the augmented sites could be identified
              follow-up.                                                                          by means of length of the dental implants. The
                                                                                                  definitive prostheses were realized in order to splint
                                                                                                  the implants if two or more implants were placed
                                                                                                  adjacent.
 Low risk     The clinical             Unclear risk Dropout   Low risk    All            No       The sample size was not calculated before              Unclear
              measurements                                                outcomes                the beginning of the study. It is not clear if the     risk
              were made by                                                data were               dropped-out patients that authors can no longer
              three independent                                           published.              contact were involved in the statistical analysis as
              clinicians while                                                                    successful cases. The clinical examinations were
              one independent                                                                     performed not knowing the group allocation, but
              clinician made                                                                      the augmented sites could be identified by means
              the radiographic                                                                    of length of the dental implants. The definitive
              evaluation.                                                                         prostheses were realized in order to splint the
                                                                                                  implants if two or more implants were placed
                                                                                                  adjacent.
 Low risk     The clinical             Unclear risk Dropout   Low risk    All            No       It is not clear if the dropped-out patients that       Unclear
              measurements                                                outcomes                authors can no longer contact were involved in the risk
              were made by                                                data were               statistical analysis as successful cases. The clinical
              two independent                                             published.              examinations were performed not knowing the
              clinicians while one                                                                group allocation, but the augmented sites could be
              independent clinician                                                               identified by means of length of the dental implants
              made the statistical                                                                and the different radiolucency of bone.
              evaluation.
 Low risk     The clinical measure­    Unclear risk Dropout   Low risk    All            No       It is not clear if the dropped-out patients that       Unclear
              ments were made                                             outcomes                authors can no longer contact were involved in         risk
              by six independent                                          data were               the statistical analysis as successful cases. The
              clinicians while                                            published.              definitive prostheses were realized in order to splint
              one independent                                                                     the implants if two or more implants were placed
              dental student made                                                                 adjacent.
              the radiographic
              evaluation.

values of control groups of the studies included in this                         al,29 where the mean MBL was 0.44 mm after the first
review were slightly higher compared with the mean                               year in function, 0.55 mm after 3 years in function, and
MBL values reported in the ITI Consensus Statement.14                            0.53 mm after 5 years in function. Rossi et al26 suggested
The control augmented groups showed a mean MBL                                   that this may have been due to the more apical shift in
of 2.08 mm,9 2.10 mm,11 and 2.11 mm10 after 5 years in                           the biologic width during the first period of healing, and
function. The Consensus Statement reported mean MBLs                             it provides marginal bone adaptation. It is mandatory to
ranging from +0.02 mm (bone gain) to −1.54 mm.13 It is                           highlight that even if mean bone loss around short den-
important to observe that the main bone remodeling                               tal implants seems to be minor compared with standard
around short dental implants occurs during the first year                        dental implants, the loss of 2 mm of peri-implant bone
after the prosthesis delivery. Two RCTs by Esposito et al9                       height represents 30% (for 6-mm short implants) or 50%
and Felice et al10 reported greater peri-implant bone re-                        (for 4-mm short implants) of the overall bone-to-implant
absorption after 1, 3, and 5 years in function and mean                          contact area, whereas the same bone loss for standard
MBLs of 0.94 mm, 1.33 mm, and 1.43 mm, and 1.05 mm,                              dental implants represents a maximum of 20% of the
1.25 mm, and 1.34 mm, respectively. The same state-                              overall bone-to-implant contact area. For this reason, it
ment was reported in a prospective study by Slotte et                            is very important to involve the patients in a long-term

                                                                                       The International Journal of Oral & Maxillofacial Implants 35
Carosi et al

 Table 4 Main Results from Selected Studies
                         Short implant    Regular implant   Marginal        Short implant group           Regular implant
                          survival rate    survival rate    bone loss         complications             group complications
                          1. Baseline     1. Baseline         (mm)         1. P
                                                                               eri-implant mucositis   1. Peri-implant mucositis      Prosthetic
                          2. Survived     2. Survived       1. Short      2. Temporary paresthesia    2. Temporary paresthesia     success (in %)
                          3. Dropouts     3. Dropouts           implant    3. Crown loosened            3. Crown loosened            1. Short implant
                          4. Failed       4. Failed         2. Regular    4. Chipping of definitive   4. Chipping of definitive   2. Regular
 Study                    5. Percentage   5. Percentage         implant        crown                        crown                        implant
 Rokn et al (2018)7         1. 25            1. 22           1. 1.55              1. 0                            1. 5                   1. 100
 1-year split-mouth         2. 23            2. 20           2. 1.97              2. 0                            2. 3                   2. 100
 RCT                        3. 2             3. 2                                 3. 0                            3. 0
                            4. 0             4. 0                                 4. 0                            4. 0
                            5. 92            5. 92

 Bolle et al (2018)8        1. 43            1. 46           1. 0.51              1. 0                            1. 1                   1. 95
 1-year RCT                 2. 41            2. 39           2. 0.77              2. 0                            2. 3                   2. 95
                            3. 0             3. 6                                 3. 1                            3. 0
                            4. 2             4. 1                                 4. 1                            4. 0
                            5. 95.3          5. 84.8
 Esposito et al             1. 32            1. 31           1. 1.43              1. 1                            1. 1                   1. 95
 (2019)9                    2. 30            2. 28           2. 2.08              2. 8                            2. 14                  2. 90
 5-year RCT                 3. 1             3. 1                                 3. 0                            3. 0
                            4. 1             4. 2                                 4. 1                            4. 0
                            5. 96.9          5. 93.5
 Felice et al (2019)10      1. 26            1. 30           1. 1.72              1. 1                            1. 0                   1. 90.9
 5-year split-mouth         2. 24            2. 29           2. 2.10              2. 3                            2. 10                  2. 100
 RCT                        3. 0             3. 0                                 3. 1                            3. 0
                            4. 2             4. 1                                 4. 0                            4. 0
                            5. 94.1          5. 96.6
 Felice et al (2019)11      1. 41            1. 47           1. 1.34              1. 0                            1. 5                   1. 95
 5-year RCT                 2. 39            2. 44           2. 2.11              2. 0                            2. 7                   2. 91.4
                            3. 0             3. 0                                 3. 0                            3. 0
                            4. 2             4. 3                                 4. 0                            4. 0
                            5. 95.1          5. 93.6

professional oral-hygiene program in order to prevent                     complications7–11 when short dental implants are
any peri-implant issues and to keep peri-implant tissues                  splinted. The ITI Consensus Report reminded that it
healthy.                                                                  is recommended to splint short dental implants and
   The use of short dental implants to rehabilitate the                   to avoid the risk of occlusal overload if the implant-
posterior areas of the mandible is expected to deliver                    supported restorations involve a single missing molar
prostheses with a nonfavorable C/I ratio due to the                       and/or the patient presents parafunctional habits. The
loss of vertical height in the reabsorbed areas. A sys-                   occlusion should be assessed and modified as neces-
tematic review16 and a retrospective study30 reported                     sary every maintenance visit.13 Even with the quality of
that a nonfavorable C/I ratio seems to not have any ef-                   the included studies in this review, there is a risk of bias
fect on bone-level changes. However, more studies are                     due to the small number of RCTs with a long follow-
recommended to increase scientific evidence regard-                       up period. Consequently, it is mandatory to take care
ing this topic. Moreover, it is important to focus on the                 when reading the results.
prosthetic design. Some studies have hypothesized
that splinting implants may lead to a better occlusal
load distribution.31–33 Finite element analyses report-                   CONCLUSIONS
ed that the occlusal load distribution on splinted im-
plants allows the implant bodies to not be overloaded                     Within the limitations of this systematic review, it seems
and distribution of less stress to the implant and the                    that short dental implants are a valid therapeutic choice
peri-implant bone.32,34 Clinical evidence of this state-                  to rehabilitate severe mandibular atrophy in the medi-
ment can be carried out from the studies involved                         um to long term. For further information, several RCTs
in this review, whereas most of the authors reported                      comparing long-term survival rates of short and longer
a high prosthetic success rate7–11 and few technical                      implants are required to collect new data.

36 Volume 36, Number 1, 2021
Carosi et al

ACKNOWLEDGMENTS                                                                  16. Garaicoa-Pazmiño C, Suárez-López del Amo F, Monje A, et al. Influ-
                                                                                     ence of crown/implant ratio on marginal bone loss: A systematic
                                                                                     review. J Periodontol 2014;85:1214–1221.
This study was not financially supported by any organizations. The               17. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred
authors have no conflict of interest to declare.                                     reporting items for systematic reviews and meta-analyses: The
                                                                                     PRISMA statement. Plos Med 2009;6:e1000097.
                                                                                 18. Naenni N, Sahrmann P, Schmidlin PR, et al. Five-year survival of short
                                                                                     single-tooth implants (6 mm): A randomized controlled clinical trial. J
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                                                                                      The International Journal of Oral & Maxillofacial Implants 37
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