Publication List Britta Engelhardt - April 2021
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Publication List Britta Engelhardt - April 2021
https://orcid.org/0000-0003-3059-9846
Original Acticles (*marks corresponding author if different to last author)
163. Derada Troletti, Claudio; Gaby Enzmann, Valerio Chiurchiù, Alwin Kamermans, Silvia M. Tietz, Paul C.
Norris, Neda Haghayegh Jahromi, Alessandro Leuti, Susanne M.A. van der Pol, Marijn Schouten, Charles
N. Serhan, Helga E. de Vries, Britta Engelhardt*, Gijs Kooij. 2021. Pro-resolving lipid mediator Lipoxin A4
attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome –
Cell Reports – in press-
162. Felix Baier, Tural Yarahmadov, Daniel Sánchez-Taltavull, Cristina Gómez Castellà, Fadi Jebbawi, Adrian
Keogh, Riccardo Tombolini, Adolfo Odriozola, Mariana Castro Dias, Urban Deutsch, Mikio Furuse, Britta
Engelhardt, Benoît Zuber, Alex Odermatt, Daniel Candinas, Deborah Stroka. 2021. Loss of claudin-3 leads
to altered hepatic metabolism, increased serum bile acids and impairment of hepatic proliferation. Cell
Mol Gastroenterol Hepatol – in press -
161. Castro Dias, Mariana; Adolfo Odriozola Quesada, Sasha Soldati, Fabio Bösch, Isabelle Gruber, Tobias
MIC Hildebrand, Derya Sönmez, Guillaume Witz, Jörg Piontek, Masuo Kondoh, Urban Deutsch, Benoît Zuber,
Britta Engelhardt. 2021.. Brain endothelial tricellular junctions as novel sites for T-cell diapedesis across
the blood-brain barrier. J Cell Sci- in press-
160. Reynoso-Moreno, Ines; Silvia Tietz, Erika Vallini, Britta Engelhardt, Jürg Gertsch, Andrea Chicca.. 2021.
Selective endocannabinoid reuptake inhibitor WOBE437 reduces disease progression in a mouse model
of multiple sclerosis. ACS Pharmacol Transl Sci –March 26, 2021;
https://doi.org/10.1021/acsptsci.0c00214
159. Ayer, Maxime; Olivier Burri, Romain Guiet, Arne Seitz, Elisa Kaba, Britta Engelhardt*, Harm-Anton Klok.
2021. Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T
Lymphocytes – Bioconjugate Chem – Feb 23. doi: 10.1021/acs.bioconjchem.1c00026.
158. Patricia Hamminger, Luca Marchetti, Teresa Preglej, Rene Platzer, Ci Zhu, Anton Kamnev, Ramona Rica,
MIC Valentina Stolz, Lisa Sandner, Marlis Alteneder, Elisa Kaba, Darina Waltenberger, Johannes Huppa,
Michael Trauner, Christoph Bock, Ruth Lyck, Jan Bauer, Loïc Dupré, Nicole Boucheron, Britta Engelhardt,
Wilfried Ellmeier. 2021. Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory
diseases. J Autoimmunity Feb 20;119:102610. doi: 10.1016/j.jaut.2021.102610.
157. Imeri, Faik; Bisera Stepanovska, Aleksandra Zivkovic, Stephanie Schwalm, Josef Pfeilschifter, Thomas
Homann, Burkhard Kleuser, Britta Engelhardt, Holger Stark, and Andrea Huwiler. 2021. Novel
compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective
in a mouse model of multiple sclerosis. Neuropharmacol. – 186 (2021) 108464
https://doi.org/10.1016/j.neuropharm.2021.108464
156. Maxime Ayer, Markus Schuster, Isabelle Gruber, Claudia Blatti, Elisa Kaba, Olivier Burri, Romain Guiet,
MIC Arne Seitz, Britta Engelhardt*, Harm-Anton Klok. 2021. T Cell-Mediated Transport of Polymer
Nanoparticles across the Blood-Brain Barrier. Advanced Healthcare Materials. 2001375- DOI:
10.1002/adhm.202001375
155. Hlushchuk Ruslan; David Haberthür, Petr Soukup, Sebastien F. Barré, Oleksiy-Zakhar Khoma, Neda
MIC Haghayegh Jahromi, Audrey Bouchet, Britta Engelhardt, Valentin Djonov. 2020. Innovative high-
resolution micro-CT of animal brain vasculature. Brain Struct Funct; doi.org/10.1007/s00429-020-02158-8
154. Hideaki Nishihara, Benjamin D. Gastfriend, Sasha Soldati, Sylvain Perriot, Amandine Mathias, Yasuteru
MIC Sano, Fumitaka Shimizu, Fabien Gosselet, Takashi Kanda, Sean P. Palecek, Renaud Du Pasquier, Eric V.
Shusta, Britta Engelhardt. 2020. Advancing human induced pluripotent stem cell-derived blood-brain
barrier models for studying immune cell interactions. FASEB J https://doi.org/10.1096/fj.202001507RR
153. Bisera Stepanovska, Aleksandra Zivkovic, Gaby Enzmann, Silvia Tietz, Thomas Homann, Burkhard Kleuser,Britta Engelhardt, Holger Stark, Andrea Huwiler. 2020. Morpholino analogues of fingolimod as novel and
selective S1P1 ligands with in vivo efficacy in a mouse model of experimental antigen-induced
encephalomyelitis. Int J Mol Sci 21, 6463; doi:10.3390/ijms21186463
152. Marjolein Heymans, Ricardo Figueiredo, Lucie Dehouck, David Francisco, Yasuteru Sano, Fumitaka
Shimizu, Takashi Kanda, Rémy Bruggmann, Britta Engelhardt, Peter Winter, Fabien Gosselet and Maxime
Culot. 2020. Contribution of brain pericytes in blood-brain barrier formation and maintenance: A
transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells.
FBCNS FBCNS 17, Article number: 48
151. David M. F. Francisco, Luca Marchetti, Sabela Rodríguez-Lorenzo, Eduardo Frias, Ricardo M. Figueiredo,
BtRAIN Network, Peter Winter, Ignacio Andres Romero, Helga E. de Vries, Britta Engelhardt*, Rémy
Bruggmann. 2020. Advancing brain barriers RNA sequencing: guidelines from experimental design to
publication. FBCNS 17, Article number: 51
150. Van Laethem, François; Ingrid Saba, Jinghua Lu, Abhisek Bhattacharya, Xuguang Tai, Terry I. Guinter,
Britta Engelhardt, Amala Alag, Mirelle Rojano, Jennifer M. Ashe, Ken-ichi Hanada, James C. Yang, Peter D.
Sun, Alfred Singer. 2020. Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-
Proteins and Their Selection in the Thymus. Front Immunol. 2020 Jun 16;11:1216. doi:
10.3389/fimmu.2020.01216. eCollection 2020.
149. Gericke C, A Mallone, B Engelhardt, RM Nitsch, MT Ferretti. 2020. Oligomeric human Aβ1-42 inhibits
antigen-presentation. Front. Immunol. 11:1029. doi: 10.3389/fimmu.2020.01029
148. Bruggisser Julia, Basma Tarek, Marianne Wyder, Philipp Müller, Christoph von Ballmoos, Guillaume Witz,
Gaby Enzmann, Urban Deutsch, Britta Engelhardt, Horst Posthaus.. 2020. Cell-specific targeting by
Clostridium perfringens β-toxin unraveled: the role of CD31 as the toxin receptor. Cell Host Microbe. 2020
May 29:S1931-3128(20)30254-7. doi: 10.1016/j.chom.2020.05.003. Online ahead of print
147. Li, Zhilin; Emilia A. Korhonen, Arianna Merlini, Judith Strauss, Eleonoora Wihuri, Harri Nurmi, Salli Antila,1
Urban Deutsch, Jennifer Paech, Britta Engelhardt, Sudhakar Chintharlapalli, Gou Young Koh, Alexander
Flügel, Kari Alitalo. 2020. Angiopoietin-2 blockade ameliorates neuroinflammation by inhibiting leukocyte
recruitment into the CNS. J Clin Invest. 2020 Apr 1;130(4):1977-1990
146. Nishihara H, Sasha Soldati, Adrien Mossu, Maria Rosito, Henriette Rudolph, William A. Muller, Daniela
Latorre, Federica Sallusto, Mireia Sospedra, Roland Martin, Hiroshi Ishikawa, Tobias Tenenbaum, Horst
Schroten, Fabien Gosselet, Britta Engelhardt. 2020. Human CD4+ T-cell subsets differ in their abilities to
cross endothelial and epithelial brain barriers in vitro. Fluids Barriers CNS. Volume 7, article 3
145. Haghayegh Jahromi N, Luca Marchetti, Federica Moalli, Donovan Duc, Camilla Basso, Heidi Tardent, Elisa
MIC Kaba, Urban Deutsch, Caroline Pot, Federica Sallusto, Jens V. Stein, Britta Engelhardt. 2020. Intercellular
adhesion molecule-1 (ICAM-1) and ICAM-2 differentially contribute to peripheral activation and CNS
entry of autoaggressive Th1 and Th17 cells in experimental autoimmune encephalomyelitis. Front.
Immunol. 10:3056. doi: 10.3389/fimmu.2019.03056. eCollection 2019
144. Vladymyrov Mykhailo, Neda Haghayegh Jahromi, Elisa Kaba, Britta Engelhardt, Akitaka Ariga. 2020.
MIC VivoFollow 2: Distortion free multiphoton intravital imaging. Frontiers in Physics- Medical Physics and
Imaging. 17 January 2020 | https://doi.org/10.3389/fphy.2019.00222
143. Thiele Lisa, Kirsten Guse, Silvia Tietz, Jana Remlinger, Seray Demir, Xiomara Pedreiturria, Robert Hoepner,
Anke Salmen, Maximilian Pistor, Timothy Turner, Britta Engelhardt, Dirk M. Hermann, Fred Lühder,
Stefan Wiese, Andrew Chan. 2020. Functional relevance of the multi drug transporter abcg2 on
teriflunomide therapy in an animal model of multiple sclerosis. J Neuroinflamm 17:9
doi.org/10.1186/s12974-019-1677-z
142. Hahn, Julia; Manina Günter, Juliane Schumacher, Kristin Bieber, Simone Pöschel, Monika Schütz, Britta
Engelhardt, Henrik Oster, Christian Sina, Tanja Lange, Stella E. Authenrieth. 2020. Sleep enhances
numbers and function of monocytes and improves bacterial infection outcome in mice. Brain Behavior
2Immunity. S0889-1591(19)30708-1. doi: 10.1016/j.bbi.2020.01.001.
141. Walter, Silke; Erich Gulbins, Ramona Halmer, Neda Haghayegh Jahromi, Katrin Anne Becker, Andrea
Schottek, Claudia Blatti, Laura Davies, Laura Schnoeder, Thomas Bertsch, Britta Engelhardt, Klaus
Fassbender. 2019. Pharmacological inhibition of acid sphingomyelinase ameliorates experimental
autoimmune encephalomyelitis. Neurosignals 27(S1):20-31. doi: 10.33594/000000183.
140. Wiatr, Marie; Carolin Stump-Guthier; Daniela Latorre; Stefanie Uhlig; Christel Weiss; Jorma Ilonen; Britta
Engelhardt; Hiroshi Ishikawa; Christian Schwerk; Horst Schroten; Tobias Tenenbaum, MD; Henriette
Rudolph. 2019. Distinct migratory pattern of naive and effector T cells across the blood-CSF barrier
following Echovirus 30 infection. J Neuroinflam 16(1):232. doi: 10.1186/s12974-019-1626-x
139. Gossarizza, A. et al., Britta Engelhardt (Coauthor of >200 alphabetically listed authors). 2019. Guidelines
for the use of flow cytometry and cell sorting in immunological studies. (second edition). Eur. J. Immunol.
2017. 47: 1584–1797
138. Castro Dias, Mariana; Caroline Coisne, Pascale Baden, Gaby Enzmann, Lillian Garrett, Lore Becker, Sabine
M. Hölter, German Mouse Clinic Consortium, Martin Hrabě de Angelis, Urban Deutsch, Britta Engelhardt.
2019. Claudin-12 is not required for blood-brain barrier tight junction function. Fluid Barriers CNS – Sep
12;16(1):30. doi: 10.1186/s12987-019-0150-9.
137. Garnier, Arnaud, Sophie Laffont, Laure Garnier, Elisa Kaba, Urban Deutsch, Britta Engelhardt, and Jean-
Charles Guéry. 2019. CD49d/CD29-integrin controls the migration of plasmacytoid dendritic cells across
the blood-brain barrier during neuroinflammation. Eur J Immunol, E pub Jul 18; doi:
10.1002/eji.201948086.
136. Wimmer, Isabella, Silvia Tietz, Hideaki Nishihara, Urban Deutsch, Federica Sallusto, Fabien Gosselet, Ruth
MIC Lyck, William A. Muller, Hans Lassmann, Britta Engelhardt. 2019. PECAM-1 stabilizes blood-brain barrier
integrity and favors paracellular T-cell diapedesis across the blood-brain barrier during
neuroinflammation. Front Immunol – 10:711. doi: 10.3389/fimmu.2019.00711
135. Tietz S and B. Engelhardt. 2019. Visualizing in vivo blood-brain barrier permeability and gelatinase
activity in brain sections of mice with experimental autoimmune encephalomyelitis. J Vis Exp (145),
e59249, doi:10.3791/59249
134. Enzmann Gaby, Roberto Adelfio, Aurélie Godel, Neda Haghayegh Jahromi, Silvia Tietz, Sabrina S.
Burgener, Urban Deutsch, Hartmut Wekerle, Charaf Benarafa , Britta Engelhardt. 2019. The genetic
background of mice influences the effects of cigarette smoke on onset and severity of experimental
autoimmune encephalomyelitis. Int J Mol Sci 20(6), 1433; https://doi.org/10.3390/ijms20061433 - 21
March 2019
133. Castro Dias, Mariana; Caroline Coisne, Ivana Lazarevic, Pascale Baden, Masaki Hata, Noriko Iwamoto,
David Miguel Ferreira Francisco, Michael Vanlandewijck, Liqun He, Felix A. Baier, Deborah Stroka, Rémy
Bruggmann, Ruth Lyck, Gaby Enzmann, Urban Deutsch, Christer Betsholtz, Mikio Furuse, Shoichiro
Tsukita and Britta Engelhardt. 2019. Claudin-3-deficient C57BL/6J mice display intact brain barriers. Sci
Reports Jan 18;9(1):203. doi: 10.1038/s41598-018-36731-3.
132. Adrien Mossu, Maria Rosito, Tejas Khire, Hung Li Chung, Hideaki Nishihara, Isabelle Gruber, Emma Luke,
Lucie Dehouck, Federica Sallusto, Fabien Gosselet, James McGrath, Britta Engelhardt. 2019. Rapid
Communication: A silicon nanomembrane platform for the visualization of immune cell trafficking across
the human blood-brain barrier under flow. J Cereb Blood Flow Metabol 39(3):395-410. doi:
10.1177/0271678X18820584. Epub 2018 Dec 19.
131. Silvia Tietz, Therese Périnat, Gretchen Greene, Gaby Enzmann, Urban Deutsch, Ralf Adams, Beat Imhof,
Michel Aurrand-Lions, Britta Engelhardt. 2018. Lack of Junctional Adhesion Molecule (JAM)-B
ameliorates experimental autoimmune encephalomyelitis. Brain Behavior Immunity Epub Jun 18. pii:
S0889-1591(18)30230-7. doi: 10.1016/j.bbi.2018.06.014.
3130. Evangelopoulos ME, Pistor M, Miclea A, Schrewe L, Briner M, Salmen A, Engelhardt B, Huwiler A, Chan A,
Hoepner R.. 2018. Frequency and clinical characteristics of Multiple Sclerosis rebounds after withdrawal
of Fingolimod. CNS Neurosci Ther 24:984-986. doi: 10.1111/cns.12992. Epub 2018 Jun 13.
129. Roth, S, V Singh, S Tiedt, L Schindler, G Huber, A Geerlof, D J Antoine, A Anfray, C Orset, M Gauberti, A
Fournier, L M Holdt, H Erlandsson Harris, B Engelhardt, M E. Bianchi, D Vivien, C Haffner, J Bernhagen, M
Dichgans, A Liesz. 2018. Brain-released alarmins and stress response synergize in accelerating
atherosclerosis progression after stroke. Sci Transl Med Vol. 10, Issue 432, eaao1313; DOI:
10.1126/scitranslmed.aao1313 – Cover Story (March 14th, 2018)
128. Enzmann, Gaby U, Sofia Pavlidou, Markus Vaas, Jan Klohs, Britta Engelhardt. 2018. ICAM-1null C57BL/6
mice are not protected from experimental ischemic stroke. Trans Stroke Res Epub February 4th, doi:
10.1007/s12975-018-0612-4
127. Pavlicek, David, Jörg Krebs, Simona Capossela, Allesandro Bertolo, Britta Engelhardt, Jüregen Pannek.
Jivko Stoyanov. 2017. Immunosenescence in persons with spinal cord injuury in relatin to urinary tract
infections – a cross-sectional study. Immunity and Ageing –14:22. doi: 10.1186/s12979-017-0103-6.
eCollection 2017.
126 Uster, Stephanie, Fernanda Matos Coelho, Daniel Aeberli, Jens V Stein, Wilhelm Hofstetter, Britta
Engelhardt*, Michael Seitz. 2017. TNF-a blockade mediates bone protection in antigen - induced arthritis
by reducing osteoclast precursor supply. Bone 107:56-65. doi: 10.1016/j.bone.2017.10.020.
125. Gossarizza, A. et al., Britta Engelhardt (Coauthor of 192 alphabetically listed authors). 2017. Guidelines
for the use of flow cytometry and cell sorting in immunological studies. Eur. J. Immunol. 2017. 47: 1584–
1797
124. Zaretsky Irina, Ofir Atrakchi, Roei Mazor, Liat Stoler-Barak, Adi Biram, Sara Feigelson, Alexander Gitlin,
Britta Engelhardt, Ziv Shulman. 2017. ICAMs support B cell interactions with T follicular helper cells and
promote clonal selection. J Exp Med 214(11):3435-3448. doi: 10.1084/jem.20171129. Epub 2017 Sep 22.
123. Mathias Amandine; Sylvain Perriot, Mathieu Canales, Coline Gaubicher, Claudia Blatti, Myriam Schluep,
Britta Engelhardt, and Renaud A. Du Pasquier. 2017. Impaired T cell migration to the central nervous
system under fingolimod and dimethyl fumarate. Neurology: Neuroimmunol & Neuroinflamm 4(6):e401.
doi: 10.1212/NXI.0000000000000401. eCollection 2017 Nov.
122. Llovera G, Benakis C, Enzmann G, Cai R, Arzberger T, Ghasemigharagoz A, Mao X, Malik R, Lazarevic I,
Liebscher S, Ertürk A, Meissner L, Vivien D, Haffner C, Plesnila N, Montaner J, Engelhardt B, Liesz A. 2017.
The choroid plexus is a key cerebral invasion route for T cells after stroke. Acta Neuropathol. 134(6):851-
868. doi: 10.1007/s00401-017-1758-y. Epub 2017 Jul 31.
121. Haghayegh Jahromi, Neda; Heidi Tardent, Gaby Enzmann, Urban Deutsch, Naoto Kawakami, Stefan
Bittner, Dietmar Vestweber, Frauke Zipp, Jens V. Stein, Britta Engelhardt. 2017. A novel cervical spinal
cord window preparation allows for two-photon imaging of T-cell interactions with the cervical spinal
cord microvasculature during experimental autoimmune encephalomyelitis. Front Immunol. 8:406. doi:
10.3389/fimmu.2017.00406
120. Lécuyer, Marc-André; Olivia Saint-Laurent, Lyne Bourbonnière, Sandra Larouche, Catherine Larochelle,
Laure Michel, Marc Charabati1, Michael Abadier2, Camille Pittet1, Ruth Lyck2, Britta Engelhardt,
Alexandre Prat.. 2017. The dual role of ALCAM in neuroinflammation and blood-brain barrier
homeostasis. Proc Natl Acad Sci (USA) Jan 24;114(4): E524-E533. doi: 10.1073/pnas.1614336114.
119. Lyck, Ruth; Marc-André Lécuyer, Michael Abadier, Christof B. Wyss, Christoph Matti, Maria Rosito, Gaby
Enzmann, Thomas Zeis, Laure Michel, Ana Garcia, Federica Sallusto, Fabien Gosselet, Urban Deutsch,
Joshua A. Weiner, Nicole Schaeren-Wiemers, Alexandre Prat, Britta Engelhardt. 2017. ALCAM (CD166) is
involved in extravasation of monocytes rather than T cells across the blood-brain barrier. J Cereb Blood
Flow Metab. 37(8):2894-2909. doi: 10.1177/0271678X16678639. Epub 2016 Nov 14.
4118. Vaas, Markus; Gaby Enzmann, Therese Perinat; Ulrich Siler, Janine Reichenbach,, Kai Licha, Anja Kipar,
Markus Rudin, Britta Engelhardt, Jan Klohs. 2016. Non-invasive near-infrared fluorescence imaging of the
neutrophil response in a mouse model of transient cerebral ischemia. J Cereb Blood Flow Metab. Epub
2016 Oct 27.
117. Fan, Zhichao; Sara McArdle, Alex Marki, Zbigniew Mikulski, Edgar Gutierrez, Britta Engelhardt, Urban
Deutsch, Mark Ginsberg, Alex Groisman, and Klaus Ley. 2016. Neutrophil recruitment limited by high
affinity bent beta2 integrin binding ligand in cis. Nature Comm Aug 31;7:12658.
116. Atangana, Etienne; Ulf C. Schneider, Kinga Blecharz, Salima Magrini, Josephin Wagner, Melina Nieminen-
Kelhä, Irina Kremenetskaia, Frank L. Heppner, Britta Engelhardt, Peter Vajkoczy. 2017. Intravascular
inflammation triggers intracerebral activated microglia and contributes to secondary brain injury after
experimental subarachnoid hemorrhage (eSAH). Transl Stroke Res. 2017 Apr;8(2):144-156. doi:
10.1007/s12975-016-0485-3. Epub 2016 Aug 1.
115. Tietz, Silvia M; Marcel Zwahlen, Neda Haghayegh Jahromi, Pascale Baden, Ivana Lazarevic, Gaby Enzmann
and Britta Engelhardt. 2016. Refined clinical scoring in comparative EAE studies does not enhance the
chance to observe statistically significant differences. Eur J Immunol 46: 2481-2483. Epub July 29
114. Rudolph H, Klopstein A, Gruber I, Blatti C, Lyck R, Engelhardt B. 2016. Post-arrest stalling rather than
crawling favors CD8+ over CD4+ T-cell migration across the blood-brain barrier under flow in vitro. Eur J
Immunol. 46:2187-203. Epub 2016 Jul 22 - Special: Cover story
113. Ferretti MT, Merlini M, Späni C, Gericke C, Schweizer N, Enzmann G, Engelhardt B, Kulic L, Suter T, Nitsch
RM. 2016. T-cell brain infiltration and immature antigen-presenting cells in transgenic models of
Alzheimer's disease-like cerebral amyloidosis. Brain Behav Immun. 2016 Feb 9. pii: S0889-1591(16)30030-
7.
112. Petrovich E, Feigelson SW, Stoler-Barak L, Hatzav M, Solomon A, Bar-Shai A, Ilan N, Li JP, Engelhardt B,
Vlodavsky I, Alon R. 2016. Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector
lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-
inflamed lungs. FASEB J. 2016 Jan 28. pii: fj.201500046.
111. Imeri Faik, Stephanie Schwalm, Ruth Lyck, Aleksandra Zivkovic, Holger Stark, Britta Engelhardt, Josef
Pfeilschifter, and Andrea Huwiler. 2016. Sphingosine kinase 2 deficient mice exhibit reduced
experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments.
Neuropharmacology. 2016 Jan 23;105:341-350.
110. Lazarevic I and B Engelhardt. 2016. Modeling immune functions of the mouse blood-cerebrospinal fluid
barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suitable to
study immune cell migration across this brain barrier. Fluids Barriers CNS. 2016 Jan 29;13(1):2.
109. Mundt Sarah, Michael Basler, Britta Engelhardt, Christopher J. Kirk, Marcus Groettrup. 2016. Inhibition
and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis. Eur J
Immunol 46(1):104-13. Epub 2015 Nov 2.
108. Martin-Blondel G, Pignolet B, Tietz S, Yshii L, Gebauer C, Perinat T, Van Weddingen I, Blatti C, Engelhardt
B*, Liblau R. 2015. Migration of encephalitogenic CD8 T cells into the central nervous system is
dependent on the α4β1-integrin. Eur J Immunol. 45(12):3302-12. Epub 2015 Oct 6. – Special: Inside cover
and highlight In this issue
107. Staat Christian, Caroline Coisne, Sebastian Dabrowski, Svetlana M. Stamatovic, Anuska, V. Andjelkovic,
Hartwig Wolburg, Britta Engelhardt and Ingolf E. Blasig. 2015. Mode of action of claudin peptidomimetics
in the transient opening of cellular tight junction barriers. Biomaterials 54: 9-20
106. Joshi A.U., C. Orset, B. Engelhardt, E. Baumgart-Vogt, T. Gerriets, D. Vivien, S.M. Kanse. 2015. Deficiency
of Factor VII Activating Protease (FSAP) alters the outcome of ischemic stroke in mice. Eur J Neurosci,
41(7):963-73. Epub Jan 23
5105. Eisele,P; M. Griebe, K. Szabo M.E. Wolf, A. Alonso,B. Engelhardt, M.G. Hennerici, A. Gass. 2015.
Investigation of leptomeningeal enhancement in MS – a post-contrast FLAIR MRI study. Neurology
84:770-775. Epub Jan23
104. Abadier Michael, Neda Haghayegh Jahromi, Ludmila Cardoso-Alves, Rémy Boscacci, Dietmar Vestweber,
Scott Barnum, Urban Deutsch, Britta Engelhardt* and Ruth Lyck. 2015. Cell surface levels of endothelial
ICAM-1 influence the transcellular or paracellular T cell diapedesis across the blood-brain barrier. Eur J
Immunol 45(4): 1043-58. Epub Jan 23- Special: Cover picture EJI 4/15
103. Steiner, Esther; Gaby U. Enzmann, Ruth Lyck, Shuo Lin, Markus A. Rüegg, Stephan Kröger and Britta
Engelhardt. 2014. The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse
brain endothelial cells by stabilizing adherens junctions. Cell Tissue Res 358(2):465-79. Epub Aug 9
102. Benoit Aubé, Sébastien A. Lévesque, Alexandre Paré, Émilie Chamma, Hania Kébir, Roser Gorina, Marc-
André Lécuyer, Jorge I. Alvarez, Yves De Koninck, Britta Engelhardt, Alexandre Prat, Daniel Côté, and
Steve Lacroix. 2014. Neutrophils mediate blood-spinal cord barrier disruption in demyelinating
neuroinflammatory diseases. J. Immunol. 193:2438-2454. Epub July 21
101. Imeri Faik, Daniel Fallegger, Alexandra Zivkovic; Stephanie Schwalm; Gaby Enzmann, Kira Blankenbach;
Dagmar Meyer zu Heringdorf; Thomas Homann; Burkhard Kleuser; Josef Pfeilschifter; Britta Engelhardt;
Holger Stark; Andrea Huwiler. 2014. Novel butterfly derivatives of FTY720 induce lymphopenia and
reduce symptoms of experimental autoimmune encephalomyelitis in mice. Neuropharmacology 85C:
314-327.
100. Cecchelli, R., Aday, S., Sevin, E., Almeida, C., Culot, M. , Dehouck, L., Coisne, C., Engelhardt, B., Langer, R.,
Dehouck, M.-P., Ferreira, L. 2014. A stable and reproducible human blood-brain barrier model derived
from stem cells. PLoS ONE, Jun 17;9(6):e99733.
99. Sathiyanadan Karthik, Caroline Coisne, Gaby Enzmann, Urban Deutsch and Britta Engelhardt. 2014. PSGL-
1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for
initiation of EAE. Eur J Immunol 44:2287-2294. Epub April 16
98. Minten, Carsten; Carsten Alt, Melanie Gentner, Elisabeth Frei, Urban Deutsch, Ruth Lyck, Nicole
Schaeren-Wiemers, Antal Rot, Britta Engelhardt. 2014. The Duffy antigen/receptor for chemokines
shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous
system inflammation. Brain - 137(Pt 5):1454-69. Epub Mar 12.
97. Gorina, Roser; Ruth Lyck, Dietmar Vestweber and Britta Engelhardt. 2014. β2-integrin-mediated crawling
on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the
inflamed blood-brain barrier. J Immunol.192: 324-37. Epub 2013 November 20
96. Moretti Federico A, Markus Moser, Ruth Lyck, Michael Abadier, Britta Engelhardt, Reinhard Fässler.
2013. Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells. Proc Nat
Acad Sci USA. 110: 17005-17010
95. Paolinelli Roberta, Monica Corada, Luca Ferrarini, Kavi Devraj, Cédric Artus, Cathrin Czupalla, Noemi
Rudini, Luigi Maddaluno, Elenna Papa, Britta Engelhardt, Pierre Olivier Couraud, Stefan Liebner and
Elisabetta Dejana. 2013. Wnt activation of immortalized brain endothelial cells as a tool for generating a
standardized model of blood brain barrier in vitro. PLoS ONE 8(8): e70233.
94. Coisne Caroline, Ruth Lyck and Britta Engelhardt. 2013. Live cell imaging techniques to study T cell
trafficking across the blood-brain barrier in vitro and in vivo. Fluids and Barriers of the CNS
10:7 doi:10.1186/2045-8118-10-7; 21 January 2013
93. Gaby Enzmann, Caroline Mysiorek, Roser Gorina, Yu-Jung Cheng, Sharang Ghavampour, Melanie-Jane
Hannocks, Vincent Prinz, Ulrich Dirnagl, Matthias Endres, Marco Prinz, Rudi Beschorner, Patrick N.
Harter, Michel Mittelbronn, Britta Engelhardt* and Lydia Sorokin. 2013. The neurovascular unit as a
selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury.
6Acta Neuropathologica 125(3): 395-412. Epub Dec 27 – Special: highlighted by Commentary
92. Wyss Lena, Julia Schäfer, Stefan Liebner, Michel Mittelbronn, Urban Deutsch, Gaby Enzmann, Ralf H.
Adams, Michel Aurrand-Lions, Karl H. Plate, Beat A. Imhof, Britta Engelhardt. 2012. Junctional adhesion
molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus. PLoSONE 7(9):e45619.
91. Steiner Esther, Gaby U. Enzmann, Shuo Lin, Sharang Ghavampour, Melanie-Jane Hannocks, Benoît Zuber,,
Markus A. Rüegg, Lydia Sorokin and Britta Engelhardt. 2012. Loss of astrocyte polarization upon transient
focal brain ischemia as a possible mechanism to counteract early edema formation. Glia 60(11):1646-59.
90. Kronstein R, Seebach J, Großklaus S, Minten C, Engelhardt B, Drab M, Liebner S, Arsenijevic Y, Abu Taha
A, Afanasieva T, Schnittler H-J. 2012. Caveolin-1 opens endothelial cell junctions by targeting catenins.
Cardiovasc Res 93:130-140
89. Pfeiffer F, Schäfer J, Lyck R, Makrides V, Brunner S, Schaeren-Wiemers N, Deutsch U and B Engelhardt.
2011. Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental
autoimmune encephalomyelitis. Acta Neuropathol 122: 601-614.
88. Lélu Karine, Sophie Laffont, Laurent Delpy, Pierre-Emmanuel Paulet, Therese Périnat, Stefan A. Tschanz,
Lucette Pelletier, Britta Engelhardt and Jean-Charles Guéry. 2011. Estrogen receptor a-signaling in T
lymphocytes is required for estradiol-mediated inhibition of Th1 and Th17 cell differentiation and
protection against EAE. J Immunol 187(5):2386-93.
87. Zattoni, Michela; Maria Luisa Mura, Francine Deprez, Reto Schwendener, Britta Engelhardt, Karl Frei, and
Jean-Marc Fritschy. 2011. Brain infiltration of leukocytes contributes to the pathophysiology of temporal
lobe epilepsy. J Neurosci 31, 4037-4050.
86. Döring, Axinia; Friederike Pfeiffer, Bénédicte Dehouck, Matthias Meier, Silke Tauber, Urban Deutsch and
Britta Engelhardt. 2011. TET-inducible expression of the a4b7-integrin ligand MAdCAM-1 on the blood-
brain barrier does not influence the immunopathogenesis of experimental autoimmune
encephalomyelitis. Eur J Immunol. 41:813-821.
85. Bill, Ruben; Axinia Döring, Urban Deutsch, Britta Engelhardt. 2011. PSGL-1 is dispensible for the
development of active experimental autoimmune encephalomyelitis in SJL/J mice. J Neuroimmunol.
232:207-8.
84. Lélu, Karine; Laurent Delpy, Virginie Robert, Eliane Foulon, Sophie Laffont, Lucette Pelletier, Britta
Engelhardt and Jean-Charles Guéry. 2010. Endogenous estrogens, through estrogen receptor a, constrain
autoimmune inflammation in female mice by limiting CD4+ T cell hohing to the CNS. Eur J Immunol.
40:3489-3498.
83. Steiner, Oliver; Caroline Coisne, Roméo Cecchelli, Rémy Boscacci, Urban Deutsch,
Britta Engelhardt* and Ruth Lyck. 2010. Endothelial ICAM-1 and ICAM-2 are essential for shear resistant
post-arrest T cell polarization and directed crawling on blood-brain barrier endothelium. J Immunol 185:
4846-4855. Special: Highlighted by „In this Issue“
82. Steiner, Oliver; Caroline Coisne, Britta Engelhardt*, Ruth Lyck. 2011. Comparing immortalized bEnd5 and
primary mouse brain microvascular endothelial cell as in vitro blood-brain barrier models to study T cell
extravasation. J Cereb Blood Flow Metab. 31:315-27. Epub 2010 Jul 7.
81. Pooja Jain, Caroline Coisne, Gaby Enzmann, Robert Rottapel and Britta Engelhardt. 2010. a4b1-integrins
mediate the recruitment of immature dendritic cells across the blood-brain barrier during experimental
autoimmune encephalomyelitis. J Immunol 184(12):7196-206
80. Boscacci RT, Pfeiffer F, Gollmer K, Sevilla AI, Martin AM, Soriano SF, Natale D, Henrickson S, von Andrian
UH, Fukui Y, Mellado M, Deutsch U, Engelhardt B*, Stein JV. 2010. Comprehensive analysis of lymph
node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1,
ICAM-2, and VCAM-1 in lymphocyte homing. Blood 116 (6):915-25. Special: Cover Picture Blood 116/6
779. Wolburg-Buchholz, Karen; Andreas F. Mack, Esther Steiner, Friederike Pfeiffer, Britta Engelhardt*,
Hartwig Wolburg. 2009. Loss of astrocyte polarity marks blood-brain barrier impairment during
experimental autoimmune encephalomyelitis. Acta Neuropathol. 118:219-33. Epub Jun17 Special: cover
picture Acta Neuropathol 118/2
78. Lyck, Ruth; Nadine Ruderisch, Anton Moll, Oliver Steiner, Clemens Cohen, Britta Engelhardt, Victoria
Makrides, Francois C. Verrey. 2009. The Blood Brain Barrier specific amino acid transporter and total
transcriptome is rapidly altered by culture. J Cereb Blood Flow Metab. 29:1491-502.
77. Rossy, Jérémie; Dominique Schlicht, Britta Engelhardt and Verena Niggli. 2009. Flotillins Interact with
PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently
accumulating in the uropod. PLoSONE 4: e5403
76. Caroline Coisne, Wenxian Mao and Britta Engelhardt.. 2009. CUTTING EDGE: Natalizumab blocks
adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of
multiple sclerosis. J. Immunol. 182:5909-5913
75. Woodfin, A., Mathieu-Benoit Voisin, Beat Imhof, Elisabetta Dejana, Britta Engelhardt, and Sussan
Nourshargh. 2009. Endothelial cell activation leads to neutrophil transmigration as supported by the
sequential roles of ICAM-2, JAM-A and PECAM-1. Blood 113:6246-657.
74. Andrea Reboldi, Caroline Coisne, Dirk Baumjohann, Federica Benvenuto, Sergio Lira,
Antonio Uccelli, Antonio Lanzavecchia, Britta Engelhardt and Federica Sallusto. 2009. Initiation of EAE by
chemokine receptor CCR6–dependent entry of TH-17 cells into the CNS through the choroid plexus.
Nature Immunol 10(5):514-23
73. Bauer, M., Cord Brakebusch, Caroline Coisne, Michael Sixt, Hartmut Wekerle, Britta Engelhardt, Reinhard
Fässler. 2009. b1 integrins differentially control extravasation of inflammatory cell subsets into the CNS
during autoimmunity. Proc Natl Acad Sci (USA) –106:1920-1925
72. Linker, Ralf A., Fred Lühder, Karl-Josef Kallen, De-Hyung Lee, Britta Engelhardt, Stefan Rose-John and Ralf
Gold. 2008. IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain-
barrier. J Neuroimmunol. 205:64-72. Epub 2008 Oct 23
71. Nottebaum, Astrid F., Giuseppe Cagna, Mark Winderlich, Alexander C. Gamp, Ruth Linnepe, Christian
Polaschegg, Kristina Filippova, Ruth Lyck, Britta Engelhardt, Olena Kamenyeva, Gabriele M. Bixel, Stefan
Butz and Dietmar Vestweber. 2008. VE-PTP maintains the endothelial barrier via plakoglobin and
becomes dissociated from VE-cadherin by leukocytes and by VEGF. J Exp Med. 205: 2929-2945.
70. Schrage A., K.Wechsung, K. Neumann, B. Engelhardt, M. Zeitz, A. Hamann, K. Klugewitz. 2008. Enhanced
T cell transmigration across murine liver sinusoidal endothelium is mediated by transcytosis and surface
presention of chemokines. Hepatol 48:1262-72
69. Uboldi, C., Axinia Döring, Carsten Alt, Pila Estess, Mark Siegelman, Britta Engelhardt. 2008.L-Selectin-
deficient SJL and C57BL/6 mice are not resistant to experimental autoimmune encephalomyelitis. Eur J
Immunol 38: 2156-67
68. Pfeiffer, F., Varsha Kumar, Stefan Butz, Dietmar Verstweber, Beat A. Imhof, Jens V. Stein, Britta
Engelhardt. 2008. Distinct molecular composition of blood and lymphatic vascular endothelial cell
junctions establishes specific functional barriers within the peripheral lymph node. Eur J Immunol. 38:
2142-55. Special: Cover picture EJI 8/08
67. Kraus J, Voigt K, Schuller AM, Scholz M, Kim KS, Schilling M, Schäbitz W, Oschmann P, Engelhardt B. 2008.
Interferon-{beta} stabilizes barrier characteristics of the blood-brain barrier in four different species in
vitro. Mult Scler. 14:843-52. Epub 2008 May 27.
66. Sellner, J., Isabell Greeve, Oliver Findling, Christian P. Kamm, Carsten Minten, Britta Engelhardt, Denis
8Grandgirard, Stephen L. Leib, Heinrich P. Mattle. 2008. Effect of interferon-beta and atorvastatin on
Th1/Th2 cytokines in multiple sclerosis. Neurochem Int. 53:17-21. Epub 2008 Apr 20.
65. Deutsch, U., Thorsten M Schlaeger; Bénédicte Dehouck; Axinia Doering; Silke Tauber;
Werner Risau; Britta Engelhardt. 2008. Inducible endothelial cell specific gene expression in transgenic
mouse embryos and adult mice. Exp Cell Res. 314(6):1202-16.
64. Döring, A., M. Wild, D. Vestweber, U. Deutsch and B. Engelhardt. 2007. E- and P-selectin are not
required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice.
J. Immunol. 179: 8470-8479.
63. Klotz, L., Linda Diehl, Indra Dani, Harald Neumann, Nanette von Oppen, Andreas Dolf, Elmar Endl,
Thomas Klockgether, Britta Engelhardt, Percy Knolle. 2007. Brain endothelial PPARγ controls
inflammation-induced CD4+ T cell adhesion and transmigration in vitro. J. Neuroimmunol. 190:34-43.
Epub Aug23 rd
62. Wethmar, K., Y. Helmus, K. Lühn, C. Johnes, A. Laskowska, G. Varga, S. Grabbe, R. Lyck, B. Engelhardt,
M.G. Bixel, S. Butz, K. Loser, S. Beissert, U. Ipe, D. Vestweber, M. Wild. 2006. Migration of immature
mouse dendritic cells across resting endothelium is mediated by ICAM-2 but independent of b2-integrins
and murine DC-SIGN homologs. Eur J Immunol. 36: 2781-2794
61. Hochmeister S, Grundtner R, Bauer J, Engelhardt B, Lyck R, Gordon G, Korosec T, Kutzelnigg A, Berger JJ,
Bradl M, Bittner RE, Lassmann H. 2006. Dysferlin is a new marker for leaky brain blood vessels in multiple
sclerosis. J Neuropathol Exp Neurol;65(9):855-65.
60. Walter, S., A. Doering, M. Letiembre, Y. Liu, W. Hao, R. Diem, C. Bernreuther, M. Glatzel, B. Engelhardt,
K. Fassbender. 2006. The LPS receptor, CD14 in experimental autoimmune encephalomyelitis and
multiple sclerosis. Cell. Physiol. Biochem. 17: 167-172.
59. Schulz, M. and B. Engelhardt. 2005. The circumventricular organs participate in the immunopathogenesis
of experimental autoimmune encephalomyelitis. Cerebrospinal Fluid Res. 2: 8 Epub 2005 Sep 30
58. Tzima, E., M. Irani-Tehrani, W. B. Kiosses, E. Dejana, D. A. Schultz, B. Engelhardt, G. Cao, H. DeLisser. M.
A. Schwartz. 2005. Identification of a mechanosensory complex required for endothelial cell
responsiveness to shear stress. Nature 437: 426-431
57. Engelhardt, B.*, B. Kempe , S. Merfeld-Clauss, M. Laschinger, B. Furie, M. K. Wild, D. Vestweber . 2005.
PSGL-1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and
C57Bl6 mice. J. Immunol. 175: 1267-1275.
56. Semmrich, M., A. Smith, C. Feterowski, S. Beer, B. Engelhardt, D. H. Busch, B. Bartsch, M. Laschinger, N.
Hogg, K. Pfeffer. B. Holzmann. 2005. Importance of integrin LFA-1 deactivation for the generation of
immune responses. J Exp Med 201: 1987-98. Epub 2005 Jun 13.
55. Wolburg, H., K. Wolburg-Buchholz, B. Engelhardt*. 2005. Diapedesis of mononuclear cells across cerebral
venules during experimental autoimmune encephalomyelitis leaves tight junctions intact. Acta
Neuropathol. 109: 181-190. Epub Nov 10,2004.
54. Alt, C., K. Duvefelt, B. Franzén, Y. Yang, B. Engelhardt. 2005. Gene and protein expression profiling of the
microvascular compartment in experimental autoimmune encephalomyelitis in C57Bl/6 and SJL mice.
Brain Pathol. 15: 1- 16.
53. Rothermel, T. A., B. Engelhardt, N. Sheibani. 2005. Polyoma Virus Middle-T-Transformed PECAM-1
deficient mouse brain endothelail cells proliferate rapidly in culture and form hemangiomas in mice. J.
Cellular Physiol. 202: 230-239. Epub: Jun 22, 2004
952. Chatzimanolis, N., J. Kraus, R. Bauer, B. Engelhardt, T. Bregenzer, B. S. Kuehne, J. Tofighi, C. Laske,
E. Stolz, F. Blaes, K. Voigt, H. Traupe, M. Kaps, P. Oschmann. 2004. CD45RA+ ICAM-3+ lymphocytes in
interferon- beta 1b-treated and -untreated patients with relapsing-remitting multiple sclerosis. Acta
Neurol Scand. 110: 377-385.
51. Bixel, G., S. Kloep, S. Butz, B. Petri, B. Engelhardt, D. Vestweber. 2004. Mouse CD99 participates in T cell
recruitment into inflamed skin. Blood, 104: 3205-3213. Epub 2004Jul 27.
50. Kraus, J., A. K. Ling, S. Hamm, K. Voigt, P. Oschmann, B. Engelhardt. 2004. Interferon- stabilizes blood-
brain barrier characteristics of cerebral endothelial cells in vitro. Ann. Neurol. 56: 192-205.
49. Kraus, J., R. Bauer, N. Chatzimanolis, B.Engelhardt, J. Tofighi, T. Bregenzer, B. S. Kuehne, E. Stolz, F. Blaes,
K. Morgen, H. Traupe, M. Kaps, P. Oschmann. 2004. Interferon-beta1 b leads to a short-term increase of
soluble but long-term stabilisation of cell surface bound adhesion molecules in MS. J. Neurol. 251: 464-
472.
48. Hamm, S., B. Dehouck, J. Kraus, K. Wolburg-Buchholz, H. Wolburg, W. Risau†, R. Cecchelli, B. Engelhardt
*, M.-P. Dehouck. 2004. Astrocyte mediated modulation of blood-brain barrier permeability does not
correlate with a loss of tight junction proteins from the cellular contacts. Cell Tiss Res. 315:157-66;
Epub2003Nov13.
47. Lyck, R., Y. Reiss, N. Gerwin, J. Greenwood, P. Adamson, B. Engelhardt. 2003. T cell interaction with
ICAM-1/ICAM-2-double-deficient brain endothelium in vitro: The cytoplasmic tail of endothelial ICAM-1 is
necessary for transendothelial migration of T cells. Blood,102:3675-3683. Epub 2003 Jul 31.
46. Greenwood, J., C. L. Amos, C. E. Walters, P.-O. Couraud, R. Lyck, B. Engelhardt, P. Adamson. 2003.
Intracellular domain of brain endothelial ICAM-1 is essential for T-lymphocyte-mediated signalling and
migration. J. Immunol. 171: 2099-2108.
45. Franzen, B., C. Jonsson, B. Engelhardt, J. Ottervald, M. Wickman, Y. Yang, I. Schuppe-Koistinen. 2003.
Gene and protein expression profiling of human cerebral endothelial cells activated with tumor necrosis
factor-a. Mol Brain Res. 115: 130-146.
44. Gratzinger D., S. Canosa, B. Engelhardt, J. A. Madri. 2003. Platelet endothelial cell adhesion molecule-1
modulates endothelial cell motility through the small G protein Rho. FASEB J. 17:1458-1469
43. Vajkoczy, P., S. Blum, M. Lamparter, R. Mailhammer, R. Erber, B. Engelhardt, D. Vestweber, A.K.
Hatzopoulos. 2003. Multistep nature of microvascular recruitment of ex vivo expanded embryonic
endothelial progenitor cells during tumor angiogenesis. J Exp. Med. 197:1755-1765.
42. Wolburg, H., K. Wolburg-Buchholz, J. Kraus, G. Rascher-Eggstein, S. Liebner, S. Hamm, F. Duffner, E.-H.
Grote, W. Risau†, B. Engelhardt..2003. Localization of claudin-3 in tight junctions of the blood-brain
barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma
multiforme. Acta Neuropathol. 105: 586-592
41. Kreuter, J., P. Ramge, V. Petrov, S. Hamm, S. E. Gelperina. B. Engelhardt, R. Alyautdin, H. Von Briesen, D.
J. Begley. 2003. Direct evidence that Polysorbate 80-coated poly(butylcyanoacrylate) nanoparticles
deliver drugs to the CNS via specific mechanisms requiring prior bidning of drug to the nanoparticles.
Pharm. Res. 20: 409-416
40. Laschinger, M., P. Vajkoczy, B. Engelhardt. 2002. Encephalitogenic T cells use LFA-1 for transendothelial
migration but not during capture and initial adhesion strengthening in healthy spinal cord microvessels in
vivo. Eur. J. Immmunol. 32:3598-3606.
39. Unger, R.E., J.B. Oltrogge, H. von Briesen, B. Engelhardt, U. Woelki, W. Schlote, R. Lorenz, H. Bratzke, C.J.
Kirkpatrick. 2002. Isolation and molecular characterization of brain microvascular endothelial cells from
10human brain tumors. In Vitro Cell Dev Biol Anim. 38:273-281.
38. Fassbender, K., S. Walter, E. Gulbins, M. Rieschel, M. Herten, T. Bertsch, M. Hennerici, B. Engelhardt.
2002. Glycosylation processing inhibition by castanospermine prevents experimental autoimmune
encephalomyelitis by interference in Il-2 receptor signal transduction. J Neuroimmunol. 132:1-10.
37. Alt, C., M. Laschinger, B. Engelhardt. 2002. Functional expression of the lymphoid chemokines CCL19
(ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their possible involvement in lymphocyte
recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur. J.
Immunol. 32: 2133-2144.
36. Nasdala, I., K. Wolburg-Buchholz, K., H. Wolburg, A. Kuhn, K. Ebnet, G. Brachtendorf, U. Samulowitz, B.
Kuster, B. Engelhardt, D. Vestweber, S. Butz. 2002. A transmembrane tight junction protein selectively
expressed on endothelial cells and platelets. J Biol. Chem. 277:16294-16303.
35. Graesser, D., A. Solowiej, M. Bruckner, E. Osterweil, A. Juedes, S. Davis, N. Ruddle, B. Engelhardt, and J.
A. Madri. 2002. Changes in vascular permeability and early onset of experimental autoimmune
encephalomyelitis in PECAM-1 (CD31) deficient mice. J. Clin. Invest. 109: 383-392.
34. Kraus, J., B. S. Kuehne, J. Tofighi, P. Frielinghaus, E. Stolz, F. Blaes, C. Laske, B. Engelhardt, H. Traupe, M.
Kaps, P. Oschmann. 2002. Serum cytokine levels do not correlate with disease activity and severity
assessed by brain MRI in multiple sclerosis. Acta Neurol. Scan. 105: 300-308.
33. Kraus J., B. Engelhardt, N. Chatzmanolis, R. Bauer, J. Tofighi, B. S. Kuehne, C. Laske, E. Stolz, P.
Frielinghaus, C. Schaefer, F. Blaes, H. Traupe, M. Kaps, P. Oschman. 2002. Cell surface bound and soluble
adhesion molecules in CSF and blood in multiple sclerosis: Correlation with MRI-measures of subclinical
disease severity and activity. J. Neuroimmunol. 122: 175-185.
32. Kraus J., B. Engelhardt, B. S. Kuehne, C. Laske, E. Stolz, F. Blaes, H. Traupe, M. Kaps, P. Oschman. 2001.
Soluble and cell surface bound adhesion molecules in blood and cerebrospinal fluid as diagnostic markers
and parameters for disease activity, disease severity and treatment efficacy in patients with multiple
sclerosis. J. Lab. Med. 25: 548-556.
31. Vajkoczy, P., M. Laschinger, B. Engelhardt. 2001. a4-integrin mediates G-protein independent capture of
encephalitogenic T cell blasts on endothelial VCAM-1 in spinal cord white matter microvessels. J Clin
Invest. 8: 557-565.
30. Wolburg, H., K. Wolburg-Buchholz, S. Liebner, B. Engelhardt. 2001. OSP/claudin-11, claudin-1 and
claudin-2 are present in tight junctions of choroid plexus epithelium of the mouse. Neurosci Letters 307:
77-80.
29. Sixt, M., B. Engelhardt, F. Pausch, R. Hallmann, O. Wendler, L.M. Sorokin. 2001. Endothelial Cell Laminin
Isoforms, Laminin 8 and 10, Play Decisive Roles in T-Cell Recruitment Across the Blood-Brain-Barrier in
Experimental Autoimmune Encephalomyelitis (EAE). J Cell Biol. 153: 933-945. Special: Cover Picture J
Cell Biol 153/5
28. Wong, C. W. Y., G. Wiedle, C. Ballestrem, M. Bruckner, B. Engelhardt, S. Etteldorf, R. H. Gisler, B. A.
Imhof. 2000. PECAM-1/CD31 trans-homophilic binding at the intercellular junctions is independent of its
cytoplasmic domain; evidence for heterophilic interaction with integrin avb3 in cis. Mol Biol. Cell 11:
3109-3121
27. Kraus, J., P. Oschmann, B. Engelhardt, E.Stolz, B. S. Kuehne, C. Laske, C. Schaefer, H. Traupe, M. Kaps.
2000. CD45RA(+) ICAM-3(+) lymphocytes in cerebrospinal fluid and blood as markers of disease activity in
patients with multiple sclerosis. Acta Neurol. Scand. 102: 326-332.
26. Klingler, C., U. Kniesel, S.D. Bamforth, H. Wolburg, B. Engelhardt*, W. Risau†. 2000. Disruption of
epithelial tight junctions is prevented by cyclic nucleotide-dependent protein kinase inhibitors.
Histochem. Cell. Biol.113: 349-361
1125. Lee, H. J., B. Engelhardt, J. Lesley, U. Bickel, W. Pardridge. 2000. Targeting rat anti-mouse transferrin
receptor monoclonal antibodies through the blood-brain barrier in the mouse. J. Pharmacol. Exp. Ther.
292: 1048-1052
24. Kraus, J., P. Oschmann, B. Engelhardt, R. Bauer, A. Kern, H. Traupe., W. Dorndorf. 2000. Soluble and cell
surface ICAM-3 in blood and cerebrospinal fluid of patients with multiple sclerosis: influence of
methylprednisolone treatment and relevance as markers for disease activity. Acta Neurol. Scand. 101:
135-139.
23. Laschinger, M., B. Engelhardt. 2000. Interaction of a4-integrin with VCAM-1 is involved in adhesion of
encephalitogenic T cells blasts to brain endothelium but not in their transendothelial migration in vitro. J.
Neuroimmunol. 102:32-43
22. Reiss, Y., B. Engelhardt. 1999. T-cell interaction with ICAM-1 deficient endothelium in vitro:
Transendothelial migration of different T cell populations is mediated by endothelial ICAM-1 and ICAM-2.
Int. Immunol. 11:1527-1539
21. Boss, B., G. Neeck, B. Engelhardt, W. Riedel. 1999. Influence of corticosteroids on neutrophils,
lymphocytes, their subsets, and T-cell activitymarkers in patients with active rheumatoid arthritis,
compared to healthy controls. Ann. N Y Acad. Sci. 22: 198-200.
20. Bamforth, S. D., U. Kniesel, H. Wolburg, B. Engelhardt*,W. Risau†.1999. A dominant mutant of occludin
disrupts tight junction structure and function. J. Cell. Sci.112: 1879-1888
19. Wolburg, K., H. Gerhardt, M. Schulz, H. Wolburg, B. Engelhardt. 1999. Ultrastructural localization of
adhesion molecules in the healthy and inflamed choroid plexus of the mouse. Cell Tiss. Res. 296: 259-269
18. Gerwin, N., J.-A. Gonzalo, C. Loyd, A. J. Coyle, Y. Reiss, N. Banu, B. Wang, H. Xu, H. Avraham, B.
Engelhardt, T. Springer, J. C. Guiterrez-Ramos. 1999. Prolonged eosinophil accumulation in allergic lung
interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. Immunity 10: 9-19.
17. Engelhardt, B.*, M. Laschinger, M. Schulz, U. Samulowitz, D. Vestweber, G. Hoch. 1998. The development
of experimental autoimmune encephalomyelitis in the mouse requires a4 -integrin but not a4b7 -
integrin. J. Clin. Invest. 102: 2096-2105.
16. Reiss, Y. G. Hoch, U. Deutsch and B. Engelhardt. 1998. T cell interaction with ICAM-1 deficient
endothelium in vitro: Requisite role for ICAM-1 and ICAM-2 in transendothelial migration of T cells. Eur. J.
Immunol. 28: 3086-3099.
15. Kraus, J., P. Oschmann, B. Engelhardt, C. Schiel, C. Hornig, R. Bauer, A. Kern, H. Traupe, W. Dorndorf.
1998. Soluble and cell surface ICAM-1 in blood and cerebrospinal fluid as markers for disease activity in
multiple sclerosis. Acta Neurol. Scand. 98:102-109
14. Kissel, K., S. Hamm, M. Schulz, A. Vecchi, C. Garlanda, B. Engelhardt. 1998. Immunohistochemical
localization of the murine transferrin-receptor (TfR) on blood-tissue barriers using a novel anti-TfR
monoclonal antibody. Histochem. Cell Biol. 110(1):63-72
13. Engelhardt, B.*, M.-T. Martin-Simonet, L. S. Rott, E. C. Butcher, S. Michie. 1998. Adhesion molecule
phenotype of T lymphocytes in the inflamed CNS. J. Neuroimmunol. 84: 92-104
12. Engelhardt, B.*, D. Vestweber, R. Hallmann, M. Schulz. 1997. E- and P-selectin are not involved in the
recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune
encephalomyelitis. Blood 90: 4459-4472.
11. Neumann, B., B. Engelhardt, H. Wagner, B. Holzmann. 1997. Induction of acute inflammatory lung injury
by staphylococcal enterotoxin B. J Immunol. 158: 1862-1871
1210. Röhnelt, R.K., G. Hoch, Y. Reiß, B. Engelhardt. 1997. Immunosurveillance modelled in vitro: Naive and
memory T cells spontaneously migrate across unstimulated microvascular endothelium. Int. Immunol. 9:
435-450
9. Steffen, B. J., G. Breier, E. C. Butcher, M. Schulz, B. Engelhardt. 1996. ICAM-1, VCAM-1 and MAdCAM-1
are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in
vitro. Am. J. Pathol. 148: 1819-1838.
8. Engelhardt, B.*, F.K. Conley, P. J. Kilshaw, E.C. Butcher. 1995. Lymphocytes infiltrating the central
nervous system during inflammation display a distinctive phenotype and bind to VCAM-1 but not to
MAdCAM-1. Int. Immunol. 7: 481-491.
7. Engelhardt, B.*, H. Görlach, W. Risau, H. Wekerle. 1994. Lysis of rat brain microvascular endothelial cells
is mediated by resting but not activated MBP-specific CD4+ T cell lines. J. Neuroimmunol. 55:69-80.
6. Honda, S., J. J. Campbell, D. P. Andrew, B. Engelhardt, B. A. Butcher, R. A. Warnock, R. D. Ye, E. C.
Butcher. 1994. Ligand induced activation of alpha4beta1 integrin in lympohocytes transfected with the
N-formyl peptide receptor. J. Immunol. 152: 4026-4035.
5. Steffen, B.J., E.C. Butcher, B. Engelhardt. 1994. Evidence for involvement of ICAM-1 and VCAM-1 in
lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis (EAE) in the
central nervous system (CNS) in the SJL/J mouse. Am. J. Pathol. 145: 189-201.
4. Engelhardt, B.*, F.K. Conley, E.C. Butcher. 1994. Cell adhesion molecules on vessels during inflammation
in the mouse central nervous system (CNS). J. Neuroimmunol. 51:199-208.
3. Linington, C., B. Engelhardt, G. Kapocs, H. Lassmann. 1992. Induction of persistently demyelinated
lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating
antibody. J. Neuroimmunol. 40:219-224.
2. Risau, W., B. Engelhardt, H. Wekerle. 1990. Immune function of the blood-brain barrier: Incomplete
presentation of protein (auto)-antigens by rat brain microvascular endothelium in vitro. J. Cell Biol.
110:1757-1766.
1. Engelhardt, B., T. Diamantstein, H. Wekerle. 1989. Immunotherapy of experimental autoimmune
encephalomyelitis (EAE): Differential effect of anti-Il-2 receptor antibody therapy on actively induced and
T-line mediated EAE of the Lewis rat. J. Autoimmun. 2:61-73.
Reviews
Marchetti L and B Engelhardt. 2020. Immune cell trafficking across the blood-brain barrier in the
absence and presence of neuroinflammation. Vasc Biol –March 20, DOI: https://doi.org/10.1530/VB-
19-0033
50. Castro Dias, Mariana; Josephine A. Mapunda; Mykhailo Vladymyrov; Britta Engelhardt. 2019.
Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers. Int J Mol Sci
20(21), 5372; https://doi.org/10.3390/ijms20215372
46. Enzmann, G, S Kargaran, B. Engelhardt. 2018. Ischemia – reperfusion injury in stroke: Impact of the
brain barriers and brain immune privilege on neutrophil function. Ther Adv Neurol Dis - Aug 27;
11:1756286418794184. doi: 10.1177/1756286418794184. eCollection 2018.
45. Ghersi-Egea JF, Strazielle N, Catala M, Silva-Vargas V, Doetsch F, Engelhardt B. 2018. Molecular
anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease. Acta
Neuropathol. 135(3):337-361.
44. Engelhardt B, P Vajkoczy, RO Weller. Movers and shapers of immuneprivilege of the CNS. 2017.
13Nature Immunol 18(2):123-131.
43. Engelhardt B, Carare RO, Bechmann I, Flügel A, Laman JD, Weller RO. Vascular, glial, and lymphatic
immune gateways of the central nervous system. 2016. Acta Neuropathol. 132:317-38. Epub Aug 13
42. Martin, Roland; Mireia Sospedra; Maria Rosito and Britta Engelhardt. 2016. Current multiple sclerosis
treatments have improved our understanding of MS autoimmune pathogenesis. Eur J Immunol
46(9):2078-90 -Epub Jul 28.
41. Lopes Pinheiro, Melissa A; Gijs Kooij; Mark Mizee; Alwin Kamermans; Gaby Enzmann; Ruth Lyck;
Markus Schwaninger; Britta Engelhardt; Elga de Vries, PhD. 2016. Immune cell trafficking across the
barriers of the central nervous system in multiple sclerosis and stroke. Biochim Biophys Acta. 2016
Mar;1862(3):461-71.
40. Wälchli, T, Andrian Wacker, Karl Frei, Simon P. Hoerstrup, Martin E. Schwab, Holger Gerhardt and
Britta Engelhardt. 2015. Wiring the vascular network with neural cues – a CNS perspective. Neuron
87:271-296.
39. Tietz, Silvia and Britta Engelhardt. 2015. Brain Barriers: Crosstalk between complex tight junctions
and adherens junctions. J Cell Biol 209: 493-506
38. Engelhardt, Britta and Stefan Liebner. 2014. Novel insights into the development and maintenance of
the blood-brain barrier. Cell Tiss Res 355:687-99.
37. Leslie L. Muldoon, Jorge I. Alvarez, David J. Begley, Ruben J. Boado, Gregory J. del Zoppo, Nancy D.
Doolittle, Britta Engelhardt, John M. Hallenbeck, Russell R. Lonser, John R. Ohlfest, Alexandre Prat,
Maurizio Scarpa, Richard J. Smeyne, Lester R. Drewes, Edward A. Neuwelt. 2013. Immunological
privilege in the central nervous system and the blood-brain barrier. J Cereb Blood Flow Metab 33
(1):13-21.
36. Engelhardt Britta and Richard M Ransohoff. 2012. Capture Crawl Cross: The T cell code to breach the
blood-brain barriers. Trends Immunol 33(12):579-89.
35. Ransohoff RM, Engelhardt B. 2012. The anatomical and cellular basis of immune surveillance in the
central nervous system. Nature Rev Immunol. 12: 623-35.
34. Lyck R and B Engelhardt. 2012. Going against the tide - how encephalitogenic T cells breach the
blood-brain barrier. J Vasc Res 49: 497-509.
33.
Sallusto Federica, Daniela Impellizzieri, Camilla Basso, Alice Laroni,
Antonio Uccelli, Antonio Lanzavecchia, and Britta Engelhardt. 2012. T cell trafficking in the central
nervous system. Immunological Rev 248: 216-27.
32. Coisne C. and Britta Engelhardt. 2011. Tight Junctions in Brain Barriers during CNS Inflammation. Forum
Issue of Antioxidants & Redox Signaling on Tight Junctions and Tissue Barriers. Eds. Ingolf Blasig and
Reiner Haseloff. 15(5):1285-303. Epub Feb 2011
31. Engelhardt, Britta and C. Coisne. 2011. Fluids and barriers of the CNS establish immune privilege by
confining immune surveillance to a two-walled castle moat surrounding the CNS castle. Fluids Barriers
CNS. Jan 18;8(1):4.
30. Greenwood, J., S.J. Heasman, J.I. Alvarez, A. Prat, R. Lyck and B. Engelhardt. 2011. Leukocyte-
endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to
the brain. Neuropathol Appl Neurobiol 37(1):24-39.
29. Engelhardt , B. 2010. T cell migration into the CNS during health and disease: Different molecular
keys allow access to different CNS compartments. Clinical Exp Neuroimmunol. 1:79-93
1428. Engelhardt, B. and L. Sorokin. 2009. The blood-brain and the blood-cerebrospinal fluid barriers:
Function and Dysfunction. Immunopathology of the CNS. Seminars in Immunopathol. Eds. L. Kappos
and R. Hohlfeld. Vol. 31, 497-511. Epub 2009 Sept 25th
27. Dodelet-Devillers, A., Romain Cayrol, Jack van Horssen, Arsalan S. Haqqani, Helga E. de Vries, Britta
Engelhardt, John Greenwood and Alexandre Prat. 2009. Functions of lipid raft membrane
microdomains at the blood-brain barrier. J Mol Med 87(8):765-74. Epub 2009 May 30.
26. Owens, T., I. Bechmann. B. Engelhardt. 2008. Perivascular Spaces and the 2 steps to
neuroinflammation. J Neuropathol Exp Neurol. 67 Epub 2008 Nov 14.
25. Engelhardt, B. 2008. Immune cell entry into the central nervous system: involvement of adhesion
molecules and chemokines. J Neurol Sci 274:23-6. Epub 2008 Jun 24
24. Engelhardt, B. 2008. The blood-central nervous system barriers actively control immune cell entry
into the central nervous system. Curr Pharm Des. 14: 1555-1565.
23. Engelhardt, B. 2008. Adhesion and signalling molecules controlling the extravasation of leukocytes
across the endothelium. Transf Med Hemother. 35: 73-75.
22. Endres, M., B. Engelhardt, Jari Koistinaho, Olle Lindvall, Stephen Meairs, Jay P. Mohr, Anna Planas,
Nancy Rothwell, Markus Schwaninger, Martin E. Schwab, Denis Vivien, Tadeusz Wieloch, Ulrich
Dirnagl. 2008. Improving outcome after stroke: Overcoming the translational roadblock. Cerebrovasc
Dis. 25:268-278
21. Edward Neuwelt, N. Joan Abbott, Lauren Abrey, William A. Banks, Brian Blakley, Thomas Davis, Britta
Engelhardt, Paula Grammas, Maiken Nedergaard, John Nutt, William Pardridge, Gary A. Rosenburg,
Quentin Smith, Lester Drewes. 2008. Strategies to advance translational research into brain barriers.
Lancet Neurol. 7: 84-96.
20. Engelhardt, B and L. Kappos. 2008. Natalizumab: Targeting a4-integrins in multiple sclerosis.
Neurodegenerative Diseases, Special issue: Therapeutic Antibodies in MS. Eds. N.Goebels and B.
Becher. Karger AG, Basel Vol. 5, pp 16 - 22
19. Coisne, C., R. Lyck, B. Engelhardt. 2007. Therapeutic targeting of leukocyte trafficking across the
blood-brain barrier. Inflamm. Allerg Drug Targ. 6: 210-222
18. Engelhardt B. 2006. Regulation of immune cell entry into the central nervous system. Cell
communication in Nervous and Immune System. Eds. E. D. Gundelfinger, C. I. Seidenbecher, B.
Schraven. Series: "Results and Problems in Cell Differentiation". Springer, Berlin, pp 259-280
17. Meairs S, Wahlgren N, Dirnagl U, Lindvall O, Rothwell P, Baron JC, Hossmann K, Engelhardt B, Ferro J,
McCulloch J, Kaste M, Endres M, Koistinaho J, Planas A, Vivien D, Dijkhuizen R, Czlonkowska A, Hagen
A, Evans A, De Libero G, Nagy Z, Rastenyte D, Reess J, Davalos A, Lenzi GL, Amarenco P, Hennerici M.
2006. Stroke Research Priorities for the Next Decade - A Representative View of the European
Scientific Community. Summary of Stroke Research Workshop, Brussels, October 25, 2005.
Cerebrovasc Dis;22(2-3):75-82
16. Engelhardt, B. 2006. Molecular mechanisms involved in T cell migration across the blood brain
barrier. J Neur Transm 113:477-485.
15. Engelhardt, B. 2006. Immune cell migration across the blood-brain barrier: molecular mechanisms
and therapeutic targeting. Future Neurol. 1, 47-56.
14. Engelhardt, B., R. M. Ransohoff. 2005. The ins and outs of T lymphocyte trafficking to the central
nervous system: Anatomic sites and molecular mechanisms. Trends Immunol. 26(9):485-95.
13. Engelhardt, B. and H. Wolburg. 2004. Transendothelial migration of leukocytes: through the front
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