PANDEMIC - N 08 ISSUE - Know Science
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21st PANDEMIC CENTURY PANDEMOS ISSUE N°08 Published Published on on August September 2020, Toronto, 2020, Toronto, CA www.knowscience.org/pandemos-news/ CA www.knowscience.org/pandemos-news/
WHO ARE WE? As part of the University of Toronto’s @PANDEMOSNEWS COVID-19 engagement project, Pandemos is a team of undergrad students from across Canada and America in an initiative aimed at combating untrue information regarding the COVID-19 pandemic. We have two main PANDEMOS goals - distribute true information on a reg- ular basis and answer public questions. Pri- marily, we provide people with the latest ac- HTTPS://KNOWSCIENCE. curate information on the pandemic, spread ORG/PANDEMOS-HOME/ of the virus, control methods, impacts on life, advances in the academic field and var- ious news stories through our Social media, upcoming website, and our newsletter. Our second goal is to provide a platform from which we can connect the public to experts. This is in the form of a Public Q&A portion of our social media, website and newsletter. The public sends in questions and we reply with answers verified by our team of subject matter experts via our social media/website/ newsletter outlets. Disclaimer: The views and information presented in this newsletter, the Pandemos website or Pandemos associated social media is not intended to be medical advice. We aim simply to disperse information as it becomes available in today’s ever-changing situation. 01
CONTENTS 03 Meet The Team 05 Meet The Sponsors 06 Authored Article 09 Academic Research 13 News Update 16 Statistics and Trends 22 Questions and Answers 02
MEET THE TEAM Chirag hana Chopra sharifi PROJ EC T LE A D E R R E S E A RCH E R U N I V E RS I T Y O F TO RO N TO ‘ 22 U N I V E RS I T Y O F TO RO N TO ‘ 2 3 LI FE SCI E N CE S LI FE SCI E N CE S Chinmayi tanin Balusu khorrami taj E D I TO R R E S E A RCH E R CO LU M B I A U N I V E RS I T Y ‘ 2 3 M CM A S T E R U N I V E RS I T Y ‘ 2 3 MEDICAL HUMANITIES LI FE SCI E N CE S joshua Paranjay chong Sahanii R E S E A RCH E R MARKETING U N I V E RS I T Y O F TO RO N TO ‘ 24 U N I V E RS I T Y O F TO RO N TO ‘ 2 3 SOCI A L SCI E N CE S I R , ECO N O M I C S & PU B LI C PO LI C Y 03
Samiha Xin Yi Tahsin Lim DESIGNER DESIGNER U N I V E RS I T Y O F TO RO N TO ‘ 2 3 U N I V E RS I T Y O F TO RO N TO ‘ 2 3 A RCH I T EC T U R A L S T U D I E S LI FE SCI E N CE S & S PA N I S H Yi Lian MARKETING QU E E N ’ S U N I V E RS I T Y ‘ 24 CO M M E RCE MEET THE EXPERTS Dr. Jeremy Dr. Roizar Kamil Rosales A SSOCI AT E PRO FE SSO R O F M I CRO - R E S E A RCH FE LLOW B I O LOG Y A N D I M M U N O LOG Y U N I V E RS I T Y H E A LT H N E T WO R K , LOU I S I A N A S TAT E U N I V E RS I T Y TO RO N TO 04
MEET THE SPONSORS F U N D I N G U N I V E RS I T Y O F TO RO N TO M A R K E T I N G PROS PEC T I V E M E D I C A L K N OW PRO FE SS I O N A L S SCI E N CE 05
HOW WILL THE COVID-19 PANDEMIC AFFECT THE GLOBAL RESPONSE TO THE CLIMATE CRISIS? T he COVID-19 pandemic has including COP26 and The World Conser- led to the largest reduction in vation Congress, have been delayed due carbon emissions ever recorded. to the pandemic. As jurisdictions around the world were placed under lockdown and major Due to the pandemic, many individuals economies came to a halt, global have also adopted environmentally-det- emissions levels plummeted. Major cities rimental habits that could continue for once riddled with hazard smog are now years to come. COVID-19 has dramat- recording lower levels of air pollution; in ically increased the use of plastic such some major cities in Canada, pollution as gloves, masks, and cutlery. The use of levels dropped as much as 40 percent. cars is also expected to increase after the pandemic due to lingering fears of using But despite historic declines, experts are public transportation. warning that the change is only tempo- rary and that once economies rebound from the pandemic, so too will pollution levels. “We are certainly going to see a bounce-back as we have with previous economic recessions,” said Monica Gat- tinger of the University of Ottawa. In fact, a post-pandemic world may see accelerated levels of emissions as governments shift their attention from climate change mitigation projects to policies focusing on fast economic revo- ries. In the US, President Trump signed an executive order that allows federal agen- cies to cancel environment reviews for infrastructure projects. Additionally, mul- tiple international climate conferences, 07
The emissions rebound predicted by Yet, the changes to individual behaviour many scientists has already been detect- will not be enough to alter the course of ed. A report published by the UN reveals the climate crisis, according to several re- that by June 2020, when lockdown pol- searchers who highlight that government icies began to lift, emission levels were has a key part to play as well. “Changes within five percent of the previous year. aren’t permanent without some serious policy effort and serious investment,” said The report paints a dire picture of the Robb Barnes, executive director of Ecolo- climate crisis: in order for the world to gy Ottawa. hold below the threshold of 1.5 degrees celsius of warming (since preindustrial times), there would need to be pandem- ic-sized carbon cuts every year for the SOURCES: next decade. https://ottawacitizen.com/news/lo- cal-news/how-covid-19-could-alter- Some scientists, however, are hope- the-course-of-climate-change ful that countries around the world will adopt a green recovery plan as they https://blogs.ei.columbia. recover from the economic ramifications edu/2020/06/25/covid-19-impacts-cli- of the pandemic. The European Union, mate-change/ for example, pledged 750 billion euros dedicated to a green economic recovery https://www.bbc.com/news/science-en- vironment-54074733 which sets a 2050 goal for net carbon neutrality in the EU. South Korea also https://www.bbc.com/news/science-en- introduced a Green New Deal that would vironment-52485712 see the country become carbon neutral by 2020. Experts also point to positive habits that have been borne out of the pandemic and could be continued going forward – rou- tines such as working from home, biking and walking, and supporting more local supply chains. 08
LINKING STEROID range was within 52 to 68 years. The TREATMENT TO LOWER following patients were then divided into two groups, one was given steroids, MORTALITY RATES IN while the other was given a placebo. COVID-19 PATIENT After 28 days, the patients’ conditions Authors: Jonathan A. C. Sterne, were analyzed, and the results indicated and the WHO Rapid Evidence Ap- that the risk of death for those who took praisal for COVID-19 Therapies (RE- steroids was 32% and the risk of death ACT) Working Group for those who took a placebo was 40%. https://jamanetwork.com/journals/jama/ According to Stern and his team, ste- fullarticle/2770279 roids should be part of a standard treat- New research by Jonathan Stern ment when it comes to those suffering and his colleagues at the Universi- from a severe case of COVID-19. ty of Bristol in the UK, reveals that the mortality rate of those severely ill with COVID-19 appears to decrease when COVID-19 LINKED TO corticosteroid drugs are given. Stern’s CASES OF ENCEPHALITIS research team conducted seven ran- Authors: Antônio Kleiton de domized trials and analyzed more than Sousa, Diva de Aguiar Magalhães, 1,700 people across 12 countries on 5 Jayro dos Santos Ferreira, André Luiz continents. Moreover, the patients’ age dos Reis Barbosa range was within 52 to 68 years. The https://www.sciencedirect.com/science/ follo article/pii/S0306987720314754 A study from Medical Hypothe- ses on Elsevier suggests that Corona- virus also has a neuroinvasive capacity and therefore can cause infections in the central nervous system (CNS). Fur- thermore, triggering symptoms such as headaches, nausea, mental confusion, and the loss of smell or taste. Based on past patients who were affected by SARS-CoV, this study implies that there is a possibility that the spread of SARS- CoV-2 in the brain tissue occurs through the circulatory system. This connection between the SARS-CoV genome and 10
SARS-CoV-2 was detected because derstanding of this observation, clinical both genomes interacted with angioten- and laboratory data of 42 patients with sin-converting enzyme type 2 (ACE2), a an average age being over 65 years, were protein that is located in the brain tissue analyzed. Their results then showed that of infected patients. 81% of these patients had vitamin D de- ficiency. It was also concluded that after That being said, this study sug- 10 days of hospitalization, those with gests that SARS-CoV-2 can cause in- severe vitamin D deficiency had a 50% flammation pertaining to the brain mortality risk meanwhile, those with (Encephalitis) by having the ability to sufficient vitamin D had a 5% mortality increase the stimuli at the angiotensin risk. 2 receptor (AT2R), which then increas- es the activation of the immune system With that in mind, the observa- cells. Furthermore, leading to brain in- tions from this study suggest that pro- juries and severe inflammation through viding vitamin D supplementations as vascular damage and finally, destruc- a supportive treatment for patients of tion to the blood-brain barrier. COVID-19 could be beneficial. Further- more, the study mentions that vitamin D supplementations may not protect CORRELATION BE- against COVID-19 infections, however, TWEEN VITAMIN D DE- may reduce the severity of the disease FICIENCY AND PATIENTS itself and therefore, reducing the risk of OF COVID-19 mortality. Authors: G. E. Carpagnano, V. Di Lecce, V. N. Quaranta, A. Zito, E. Buonamico, E. Capozza, A. Palumbo, G. Di Gioia, V. N. Valerio & O. Resta https://link.springer.com/article/10.1007/ s40618-020-01370-x?ref=theprepping-com A study was completed by re- searchers of Journal of Endocrinological Investigation observing COVID-19 pa- tients with severe cases of respiratory failure, to analyze their vitamin D levels in order to determine if there is a cor- relation with the severity of the case and the treatment process. To obtain an un- 11
RELATIONSHIP BE- at a greater risk of SARS-CoV-2 infec- TWEEN ABO BLOOD tion, while patients with blood type O, were at a lower risk. Furthermore, in GROUP DISTRIBUTION terms of symptom distribution, fever AND CLINICAL CHARAC- and cough were more common in pa- TERISTICS IN PATIENTS tients with type A, and less common in WITH COVID-19 patients with type O. Authors: Yuqin Wu, Zhicai Feng, Peng Li, Qizhi Yu https://www.sciencedirect.com/science/ article/pii/S0009898120302904?casa_to- ken=OGWUKGDnwWsAAAAA:gk4Th70CREgG- pGMIi_u9-ShAHQYHQpSrypKzqmwvPwwoY_ CEZkaFPAveIUpATv_Iuj6qbzx0YQ The ABO blood group mainly con- sists of the A and B antigens and their corresponding antibodies. Therefore, establishing 4 different genetic pheno- types ( A, B, O, and AB). It is the dif- ference in antigen expression in these blood types that can either increase or decrease one’s vulnerability to various infections. A new study from Clinica Chimi- ca Acta analyzed the general and clini- cal characteristics of 187 COVID-19 pa- tients at The First Hospital of Changsha, by dividing the patients into 4 groups based on their ABO blood type. After- wards, the researchers compared the obtained data to a control group, which consisted of non-COVID-19 patients who were hospitalized during the period of this study. Finally, the ramifications conclud- ed that patients with blood type A were 12
NEWS UPDATE CHIRAG CHOPRA 13
NBA PLAYER DANUEL that House’s actions compromised the integrity of the bubble, the playoffs and HOUSE REMOVED the health and safety of all NBA mem- FROM PLAYOFFS FOR bers, so he would be disqualified from VIOLATING COVID-19 further games. This comes at a time when the Houston Rockets trail 3 to 1 in PROTOCOL a best of seven series which makes the Houston Rockets forward Danuel upcoming game that House will not par- House was removed from the playoffs ticipate in a “make it or break it” moment earlier this week for bringing an unau- for the team. thorised guest into the NDA’s Disney World campus. To prevent an outbreak of COVID-19 within NBA teams, the As- BIODEGRADABLE PPE - sociation has confined their players and THE ENVIRONMENTAL- staff to a so-called ‘bubble’ in Orlando, LY CONSCIOUS CHOICE Florida. To create this safety ‘bubble’, With the prevalence of single the NBA ensured that everyone enter- use masks, gloves and other protective ing the campus had been tested neg- equipment surging, environmentalists ative for the virus repeatedly and once are concerned about how this new type a person has entered the ‘bubble’ they of waste will impact the environment. Al- may not leave or allow others from the ready, in cities around the world, masks outside to enter. The Association claims and gloves can be seen littering the roadsides. Authorities are also report- ing large numbers of masks and gloves polluting the oceans. To tackle this issue, researchers and companies around the world have now developed and begun to commercialize biodegradable masks. Researchers at the University of British Columbia have developed the world’s first biodegradable N95 class mask. Touted as the ‘Can-Mask’, it is made from inexpensive wood fibres and en- tirely compostable. Other masks made from compostable coffee filters and even bacteria-grown masks are in the works 14
and will likely be made available to con- sumers in the near future. It is important to note that none of these products have been certified by health authorities as of yet, but once further testing is com- plete and certifications registered, these products are likely to usher the new age of public use, socially conscious PPE. COVID-19 PUTS ECO- NOMIC STRESS ON NORTH KOREA. NORTH KOREA REACTS Due to the pandemic, North Korea has had to shut down its border with Chi- na, a country that accounts for the vast majority of North Korea’s trade and aid. Needless to say, it is very difficult to as- certain the exact effects of the pandem- ic on this reclusive nation, we rely on the few sources of news that report on ex- ternal intelligence. The border shutdown has decreased the amount of essentials coming into the country which, accord- ing to the US, has fuelled an increasing demand for smuggled goods. To limit illegal crossings across the Chinese border that may bring COVID-19 to North Korea, the US claims that the North has instituted shoot to kill orders along their border with China. 15
STATISTICS & TRENDS BY HANA SHARIFI 16
CHILDREN ARE GOING BACK TO SCHOOL: WHAT THAT MEANS IN REGARDS TO FLATTENING THE CURVE I t’s early September – the time of As of reports made on August 27, 2020, year that signals back-to-school there were a total of 476,439 total child season. COVID-19 cases reported, and children represented approximately 9.5% of all America is one step ahead of Canada in cases. opening schools and the trends in cases are sending a clear message: the virus Though hospitalization and death may be is spreading, outbreaks are cropping up, rarer in children, the reopening of schools and cases are going up. has dramatically increased the number of cases. From August 13, 2020, and August In the United States, state-level reports 27, 2020, the change in child COVID-19 are the best publicly available data on cases was 70,330, a 17% increase in just child COVID-19 cases. The American two weeks. Academy of Pediatrics and the Chil- dren’s Hospital Association have collab- This upward trend in the number of cas- orated to collect and share data from es as schools reopen is far from a new states on child COVID-19 cases, and phenomenon. In fact, an analysis from on August 27, the health department May 2020, when more than 20 countries websites of 49 states provided data on began reopening schools, already re- reported COVID-19 cases, distributed vealed significant increases. The trends by age. Although children represent just of these schools which opened earlier in 9.5% of all cases in these states, over the pandemic can be examined to predict 476,000 children have tested positive what may happen to schools that are for the virus since the beginning of the now beginning to open in the fall. pandemic. However, COVID-19-asso- ciated hospitalization and death are On average, countries reopened schools uncommon in children. It appears that 25 to 30 days after the peak of new severe illness due to COVID-19 is rare cases. Of the twenty countries that have among children. reopened, only three – Madagascar, the Czech Republic, and Vietnam – appear to show an upward trend of new daily cases 17
when schools reopened. Korea, which has one of the finest test and trace systems in the world, closed Optimistically, countries that have al- around 250 schools near the capital on ready opened their schools have contin- May 28 just after they opened, since an ued their downward trend in new cases. increase of 79 cases was reported. However, there are, of course, exceptions. Governments will need to use regional and sub-regional case data to make de- cisions regarding school closures if spikes in new cases occur. For example, in South These trends can be seen in Figure 1. Figure 1: Daily new cases in countries that have reopened schools Note: Time is measured in days since schools reopened. Lines show a 7-day moving average of daily cases beginning 9 days prior to when schools closed Source: https://www.cgdev.org/blog/back-school-tracking-covid-cases-schools-reopen 18
In figure 2, it is clear that very few countries actually saw any change after schools reopened. Figure 2: Daily new cases in countries that have reopened schools (by country) Source: https://www.cgdev.org/blog/back-school-tracking-covid-cases-schools-reopen The next batch of countries to reopen schools showed yet different trends, as seen in Figure 3. 19
Figure 3: Daily new cases in countries soon to reopen schools Source: https://www.cgdev.org/blog/back-school-tracking-covid-cases-schools-reopen School closures are not the only thing that has an effect on COVID-19 cases, however. School closures and reopenings happen in tandem with other policy changes, as seen in figure 4. Figure 4 Note: This sample only includes the 20 countries shown in Figures 1-3 which have al- ready opened schools. Source: https://www.cgdev.org/blog/back-school-tracking-covid-cases-schools-reopen H owever, American schools that by the American Academy of Pediatrics have begun to open show a and the Children’s Hospital Association. wildly different trend. Over the Dr. Thomas Dobbs, Mississippis’s health last four weeks, as schools in Georgia, director, reported that at least 22 schools Mississippi, Tennessee, and Indiana are in the state saw an increase in cases beginning to open their doors, there since classes began. has been a 90% increase in the number of COVID-19 cases among students in the U.S., according to a recent analysis 20
These upward trends have pushed other schools to delay their opening. At least https://www.ctvnews.ca/health/ 27 of the largest 101 school districts in coronavirus/what-s-happened- the U.S. have delayed their first week of in-american-schools-since- classes. reopening-1.5065769 Canada is seeing similar upward trends. https://www.cbc.ca/news/canada/ Quebec has seen 46 schools (including toronto/covid-ontario-education- preschool, elementary, secondary, and minister-stephen-lecce-1.5713905 adult career centres) with at least one case since reopening, which is worrying parents in Ontario. However, Ontario has mandated masking in classrooms while Quebec has not, and additionally, more than 600 public health nurses will be stationed in schools this fall. As of September 5, Ontario reported 169 new cases of COVID-19. The total num- ber of cases in Ontario now stands at 43,003, which includes 2,811 deaths and 38,847 cases marked as resolved. SOURCES: https://services.aap.org/en/pag- es/2019-novel-coronavirus-covid-19-in- fections/children-and-covid-19-state- level-data-report/ https://www.cgdev.org/blog/back- school-tracking-covid-cases-schools- reopen 21
QUESTION & ANSWER 22
As schools across North America open, COVID-19 and kids shows us that: questions about safety are on everyone’s • Kids seem to be less likely to be mind. Hence, the Questions and Answers infected than adults section of this issue of the 21st Century • Kids seem to be less likely to Pandemic are specific to the theme of suffer severe symptoms reopening schools. • Kids seem to be less likely to transmit the virus Q1 Especially in a pandemic, there My child goes to a small school is no such thing as ‘no’ risk. Hence, all in a small town. What really we can do is try to reduce any risk that is the risk of my child getting is present. The risk can be mitigated by COVID-19? healthy policies implemented by schools and authorities. Enforcing masks, Evidently, the exact risk depends promoting social distancing, structuring on a multitude of factors - being a small free time, making symptom tracking town or far from outbreak centres is a policies, introducing safety infrastructure great advantage, but we must still be like plastic barriers, etc. are all ways that vigilant as it only takes one infected schools can prevent and limit outbreaks. person to start an outbreak. Before we Additionally, the effectiveness of these discuss risk factors further, we should policies rely on individual belief in acknowledge that recent research on the policies and adherence to them. Encourage anyone in school communities to stick to public health policies and even if it isn’t mandated, everyone is encouraged to wear masks as much as possible, socially distance, constantly wash/sanitize hands and do not touch your face/mouth. A mass cooperative effort by everyone to abide by public health recommendations is our best bet to reduce risk. Q2 What can schools do to prevent transmission? 23
• Install no-contact infrastructure Let’s be clear, there are immense • Keep surfaces clean issues in bringing back large amounts • Focus on bathroom hygiene of students and staff indoors during a pandemic. There is no perfect plan, HEALTHY POLICIES just less bad options. Moreover, there Building a culture of health, safety, and is no one strategy that can apply to all shared responsibility. schools, since schools are limited by • Establish and reinforce a culture budget, resources, access to space and of health, safety, and shared staff. After some online research, we responsibility found a concise and effective overview • Form a COVID-19 response team of what schools can and are doing made and plan by Schools For Health. • Prioritize staying home when sick • Promote viral testing and antibody HEALTHY CLASSROOMS testing Following safe practices in classrooms. • Establish plans for when there is a • Wear masks case • Wash hands frequently • Support remote learning options • Maximize physical distancing to • De-densify school buildings protect individuals • Protect high-risk students and staff • Maximize group distancing to slow • Increase outdoor air ventilation transmission chains • Disinfect objects between users HEALTHY SCHEDULES Moving between rooms and HEALTHY BUILDINGS locations safely. Breathing clean air in the school building. • Manage transition times and • Increase outdoor air ventilation locations • Filter indoor air • Make lunchtime safer • Supplement with portable air • Rethink transportation cleaners • Modify attendance • Verify ventilation and filtration performance HEALTHY ACTIVITIES • Consider advanced air quality Enjoying modified activities. techniques • Use plexiglass as physical barrier • Provide recess • Modify physical education 24
• Reimagine music and theater classes droplets and short-range aerosols • Continue sports with enhanced produced when an infected person controls coughs, sneezes, or talks in close • Add structure to free time proximity to other people. At this time, long-range airborne Q3 transmission does not appear to be a primary way COVID-19 How can Teachers and Staff spreads. There is not yet clear limit their risk of getting the evidence that ventilation systems disease? spread the virus from space to space causing exposures. Studies The CDC recommends preventative indicate that people who are actions under 3 main categories of risk not showing symptoms (i.e., mitigation: asymptomatic) can still spread the virus. COVID-19 exposure may also 1. Distance between staff and occur from touching one’s mouth, others: In addition to their primary nose, or possibly eyes after contact job functions and interaction with with contaminated surfaces or students, school staff may also be objects, such as office equipment, near (within 6 feet ) one another workstations, or break room tables. at times, such as when arriving at school and during breaks. Shared spaces and shared transportation to and from the school may increase their risk. These can be mitigated or minimized with good practices. 2. Duration of contact: Extended contact (15 minutes or greater) with potentially infectious individuals increases the risk of COVID-19 spread. Reducing contact to brief interactions can reduce risk. 3. Type of contact: Current evidence indicates that COVID-19 spreads primarily through respiratory 25
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