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Medical Wearables: Market and Technology Trends 2019 Sample - From Technologies to Markets - i ...
From Technologies to Markets

Medical Wearables:
Market and Technology
    Trends 2019

       Sample

                                                @2019
Medical Wearables: Market and Technology Trends 2019 Sample - From Technologies to Markets - i ...
TABLE OF CONTENTS
   • Executive summary                                            08

   • Context                                                      28   • Technology trends                                                                                132
       •   Definition of medical wearables                                 •   Technology description of sensors for medical wearables
       •   A little beat of History                                        •   Sensors
       •   What’s new?                                                     •   Manufacturing process and material
       •   Product launch, collaboration and fundraising                   •   Roadmaps
                                                                           •   Overview on emerging flexible, Stretchable, printed, and hybrid
                                                                               electronics for medical applications.

   • Market forecasts                                             53
       •   Global market data and Market forecasts                     • Supply chain                                                                                     185
       •   Market data and forecasts 2017-2024 in $M by segment            •   Ecosystems
       •   Market forecasts by sensor types                                •   Business models and player’s strategy
       •   Market shares                                                   •   Supply chain analysis
                                                                           •   Regulation, reimbursement aspects
                                                                           •   Market access
   • Market trends                                                69       •   Technical challenges of fabrication, packaging, and assembly
       •   Market drivers, challenges                                          technics
       •   R&D Development time and investments related
       •   Market segmentation and segment description
       •   Technology requirement/ application                         • Conclusion                                                                                       233
       •   Key players/ segment                                            • Perspectives
       •   Top Medical Devices: how they position themselves?              • What’s next

                                                                                           Medical Wearables: Market & Technology Analysis 2019 | Sample | www.yole.fr | ©2019   2
Medical Wearables: Market and Technology Trends 2019 Sample - From Technologies to Markets - i ...
ABOUT THE AUTHORS
   Biography & contact

            Asma Siari
            As a Technology & Market Analyst, Biotechnologies & Molecular Innovations, Medical Technologies in the Life Sciences & Healthcare division at Yole
            Développement (Yole), Asma Siari is involved in the development of technology & market reports as well as the production of custom consulting projects. After a
            Master’s degree in Biotechnologies, Diagnostic Therapeutics & Management, Asma served as Research Assistant at the Moores Cancer Center (San Diego, CA).
            She is a coauthor in three scientific publications published in the Molecular Cancer Research Journal. Asma Siari is graduated with an Advanced Master’s degree in
            International Strategy & Marketing BtoB from EM Lyon Business School (France).

            Email: siari@yole.fr

             Jérôme Mouly
             Jerôme Mouly serves as a Senior Technology & Market Analyst & Business Developer specialized in microtechnologies for inkjet & bioMEMS sensors.
             Since 2000, he has participated in more than 100 marketing and technological analyses for industrial groups, start-ups and institutes. Previously, Jerome
             was involved in a support action for value creation of smart miniaturized systems research projects at Yole Finance Innovation, part of Yole
             Développement. Jérôme holds a Master of Physics from the University of Lyon (France).
             Email: mouly@yole.fr

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Medical Wearables: Market and Technology Trends 2019 Sample - From Technologies to Markets - i ...
LIST OF COMPANIES MENTIONED IN THIS REPORT

                                          230+ slides of market and technology analysis

   3M, AAC Technologies, Abbott, Alertgy, AliveCor, Amazon, Amphenol, AMS, Analog Devices, Apple, Artefact, Ava, BACtrack, Biogen,
      Biolinq, Biometrics, Bittium, Bioserenity, Bloomlife, Bonbouton, Capsule, Cardionet, CarePredict, CareWear Corp, CEA Léti,
       Cefaly Technology, Chrono Therapeutics, Chronolife, Comepa, Covestro, Dakota, Delsys, Dexcom, D Free, Ectosens, Elvie,
       Empatica, Excelitas Technologies, Exosystems, Feel, Feetme, Fitbit, Food & Drug Administration, GI Logic, Global Kinetics,
    Glucowise, Google, G-Tech Medical, Halo Neuroscience, Healthcare Origins, Healthwatch, Heimann Sensor, Hexoskin, Hocoma,
   Honeywell, IBM, IHealth, Imec, Infineon, Insound, iRythm, JRC, Jari Electrode Supply, Johnson & Johnson, Knowles Acoustics, Kolo
     Medical, Lifesense, Lifewatch, L’Oréal & La Roche-Posay, MC10, Maxim Integrated, Medatec, Medtronic, Merit Sensor, Melexis,
   Microsoft, Micralyne, Monica Healthcare, Motiv, Murata, Muse, Mymdband, Neofect, Neucognic, NeuroMetrix, Novioscan, Nonin,
   Novartis, Nuheara, Nuubo, NVK, NXP, Omron, Orpyx, Oska, OSRAM, Oticon, Oura, Pet Pace, Pfizer, Phonak, Philips Healthcare,
      Philips Innovation Services, Pkvitality, Preventice, Qardiocore, Renesas, Resmed, ReSound GN, Robert Bosch, Roche, Rohm
     Semiconductor, Senseonics, Sensimed AG, Sentio Solutions, Shade, Silicon Labs, SleepOn, SMI, Somnarus Inc , Sonova, Sonion,
     Starkey, STMicroelectronics, Sunfriend, TDK, TE Connectivity, TempTraq, Tempdrop, The Electrode Store, Thync, UCB Pharma,
    Upright, TTP Ventus,Valencell,Verily, Vicardio, Vishay, VitalConnect, Vivosens Medical,Voyce, Wellbrain, Whistle, Withings, Wolfson,
                                                                 Xiaomi, ZoLL,
                                                           …and many more.

                  Information gathered through direct discussions with players all along the supply chain

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Medical Wearables: Market and Technology Trends 2019 Sample - From Technologies to Markets - i ...
THE OBJECTIVES OF THE REPORT

   • Examine medical wearable device market trends, competitive forces and dynamics, and market drivers

   • Offer an applications overview of medical wearables for diagnostic, therapeutic, and prevention, along with
     disruptive technologies (products)

   • Explain which sensors are used in which healthcare applications, and why

   • Provide an overview of the main players at each level of the supply chain, with market share

   • Furnish business models and market projections for 2018 – 2024

   • Identify promising technologies and booming applications

   • Deliver an overview of emerging flexible, stretchable, printed, and hybrid electronics for medical applications

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Medical Wearables: Market and Technology Trends 2019 Sample - From Technologies to Markets - i ...
SCOPE OF THE REPORT (1/3)

                     Medical wearables for patient activity monitoring and smart treatment
                                                    delivery

                            Medical wearables for people lacking autonomy and requiring
                                                assistance and alerts

                                  Medical wearables for animals activity monitoring

                        No prosthesis and implants (pacemakers, neuronal implants, retinal implant…)

                      No wellness, fitness devices and geolocation devices (sport smartwatch,
                                                wellness wirst worn…)

                                    Not included in the report’s scope

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Medical Wearables: Market and Technology Trends 2019 Sample - From Technologies to Markets - i ...
TIMELINE OF WEARABLES: A LITTLE BIT OF HISTORY
                                                                                                       Medical-functions

                                                                                                                                                        Appel’s ECG
                                                                                                           Ingestible sensors and
                                                        Multi-functions                                    wearables devices                                                            …
         Single function                                                            Philips lifeline
                                                                                                                                                               2019

                                                                                                                       2012
                                                              Fitness tracking                                                                                               Next step:
                                                                                                                                                                           Medical devices
                                                                                 2009                                                                                          more
                                                                                                                                                                            conformable
                             Hearing aid              2000                                                   Proteus Digital Health
                                                                                                            developed an ingestible                              Apple launched the
                                           1938                            Activity trackers,               sensor approved by the                                 first approved
 Thomish Meter                                                             wireless enables                     FDA in 2012 to                                   ECG integrated in
                 1788                                                          wearable                     improve patients habits                                  smartwatch
                                                                             technology
                                       Aurex Corp
                                      developed the
                                      1st wearables                         Consumer fitness and sport
            Thomas Jefferson:          hearing aid                          products enter the market
           introduced the first                                              starting with Bluetooth
            pedometer to the                                                         headset
                   US                                                                                     Medical Wearables: Market & Technology Analysis 2019 | Sample | www.yole.fr | ©2019   7
Medical Wearables: Market and Technology Trends 2019 Sample - From Technologies to Markets - i ...
WHAT IS A WEARABLE MEDICAL DEVICE
    Definitions
                 • According to the US Food and Drug Administration (FDA): a medical device is intended by its manufacturer to be
                   used for humans in order to :
                      • Diagnosis, prevention, monitoring, treatment or alleviation of disease.
                      • Diagnosis, monitoring, treatment, alleviation of or compensation for an injury or handicap.
                      • Investigation, replacement or modification of the anatomy or of a physiological process.
Wearable
medical          Can a wearable be a medical device?
technologies
have emerged     • A wearable medical device is a device that is autonomous, noninvasive or minimally invasive, and that performs a
as a growing       specific medical function such as health monitoring or prevention over a prolonged period of time which could be
trend, with        long (>6hours) or short time (
Medical Wearables: Market and Technology Trends 2019 Sample - From Technologies to Markets - i ...
MEDICAL WEARABLES BUT FOR WHAT?
   Information and data value
         Reduce healthcare cost                        Improve healthcare efficiency                       Improve patient adherence
                                                   •    Great impact on both doctors and
    •   Wearables can replace some hospital                                                          •      Check data and history of medication
                                                        patients, as they can be in constant
        devices for homecare devices                                                                 •      Alert/remind patient or family of any
                                                        connectivity.
    •   Daily monitoring of chronic disease                                                                 risk for non-adherence
                                                   •    Improved learning from daily
    •   Increased efficiency for doctors to                                                          •      Provide safer working conditions and
                                                        monitoring of patient reaction to
        get access to patient data with less                                                                predict employee injuries and fatal
                                                        treatment
        administration                                                                                      accidents because of fatigue or other
                                                   •    Improve personalized medicine in
    •   Turn hospitals towards urgent cases                                                                 factors
                                                        chronic disease and oncology
        only                                                                                         •      Develop a business model to improve
                                                   •    Develop machine learning / artificial
                                                        intelligence                                        adherence (through insurance
                                                                                                            incentives…)

                                 Move to preventive medicine                       Improve medical research
                             •    Make wearables devices discreet and
                                                                              •   Use data generated to better
                                  easy to use for daily monitoring
                                                                                  understand medicine effects
                             •    Develop incentives to help
                                                                              •   Use data generated to better prevent
                                  monitoring vital signs
                                                                                  events through population categories
                             •    Connect more data from
                                                                              •   Engage pharmaceutical companies in
                                  environment to prevent from events
                                                                                  digital clinical trials

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Medical Wearables: Market and Technology Trends 2019 Sample - From Technologies to Markets - i ...
AN INCREASING NUMBER OF PRODUCTS WILL REACH THE MARKET*

       * Non exhaustive list of products
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SENSING TECHNOLOGY: WHAT CAN WE SENSE USING MEDICAL WEARABLES?

                           Hearing aids                                                                                               EEG
                        Correction and                      microphones                                                              Monitoring and
                        improvement of hearing                                           Electrodes                                  tracking of behavioral
                        function                                                                                                     health brain, nerve
                                                                                                                                     activity and stress

                                                                                                                                 CGM
                            Temperature &
                        galvanic skin response                                   Micropumps             Glucose sensors Diagnosis and monitoring
                                                            Termophile sensors
                                                                                                                             of chronic conditions
A wide variety                Superior thermal and
                              fluidic transport
                                                                                                                             such as glucose level in
                                                                                                                             blood
of wearable
devices                                                                                                           Heart rate/ECG/optical sensors
facilitate                    UV
                                                                                                                  Continuous monitoring of vital signs such
personalized              UV sensing on the                     Biochips             Pressure sensors
                                                                                                                  as cardiac arrhythmias and heart rate
healthcare                body to prevent sun
                          damage
                                                                                                                  enables whole health profiling, versus
                                                                                                                  today’s standard of sporadic sampling

                   Activity tracker                                                                      EMG
                                                Accelerometer      Gyroscope                             Capture of local muscle
                 Superior mechanical                                              Electrodes
                 coupling to the body ,                                                                  activation for rehabilitation,
                 reduces motion artifacts                                                                motion study and tone
                 that cause noise                                                                        assessment

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AT SYSTEM LEVEL
    A convergence

Consumer electronics
companies

                                               Consumer
                                               healthcare
                                                                                                          Medical device
                •   Good access to consumers                                                              companies
                    (distribution channels)                               •     Experience with medical grade
                •   Well known by consumers                                     systems
                                                                          •     Reliable devices
                •   Lack of experience with medical
                    grade systems                                         •     Lower access to volume market
                •   Not used to long-term development                     •     Low reputation in consumer
                    (including clinical trials)                                 market
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M&A, COLLABORATIONS, FUNDRAISING AND RELEASED PRODUCTS SINCE 2016
   Analysis of the strategic moves in the industry

                                  • Definition of medical wearables and history
         • The transition from fitness and sport to medical wearables and identification of new products
        • Who are the main players and the new entrants developing new medical devices for the market?
                  • What strategic moves are driving the medical wearables market growth?

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MARKET DATA AND FORECASTS

              • Market data and forecasts 2018-2024 for per medical wearable systems
                   • Market data and forecasts 2018-2024 for per sensor types
                       • Market share and dynamics per segment for 2018

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MARKET TRENDS AND KEY APPLICATIONS

            • Market segmentation depending on key technological and economical/behavioral criteria
       • Each segment has its whole chapter with detailed description, market data, key products examples, key
                                      players, requirements and market insights.
                     • Development timeline and price analysis of medical wearable devices

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ANALYSIS OF TECHNOLOGY TRENDS

        • Description of the technological challenges and technical requirements, focus on sensors technology
      • Key players developing technologies for medical wearables and technology roadmap, a dedicated chapter
                                   describing and analyzing who is developing what
                               • What are the sweet spots for today and tomorrow

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SUPPLY CHAIN ANALYSIS

                         • Detailed supply chain and collaboration examples
                 • Who’s producing in-house, who is outsourcing, for which volumes?
            • How can companies all along the supply chain make value with medical wearables?
                                   • Regulation and market access

                                                                   Medical Wearables: Market & Technology Analysis 2019 | Sample | www.yole.fr | ©2019   17
RELATED REPORTS

   BioMEMS & Non-Invasive Sensors: Microsystems for Life Sciences & Healthcare 2018

  Ultrasound Sensing Technologies for Medical, Industrial and Consumer Applications 2018

              Connected Medical Devices Market and Business Models 2017

                                                                                  Medical Wearables: Market & Technology Analysis 2019 | Sample | www.yole.fr | ©2019   18
MEDICAL WEARABLES
Market & Technology report - March 2019
New technologies and faster market launches are driving the medical wearables market.
                                          HOW MEDICAL WEARABLES WILL MAKE PATIENTS HEALTHIER
 REPORT’S KEY FEATURES
 •	Yole Développement's vision and       In today’s wearable technology market, the vast                               An increasing number of wearable devices are
    definition of medical wearables       majority of growth has been in consumer sports,                               approaching medical-grade level: for instance,
 •	A nalysis of market dynamics for      fitness, and wellness. However, wearable devices                              the Ava wristband, Apple watch, Cefaly patch,
    human and veterinary monitoring,      are rapidly expanding for health and medical                                  and Ectosens patch, along with smartwatches
    therapeutics, and prevention          uses, and are expected to reach a market value                                from Omron and Verily. But even though these
 •	M edical wearables’ technical and     of $32B by 2024. Smartphone ubiquity, sensor                                  products hold considerable promise as consumer
                                          miniaturization, and ease of integration have                                 medical wearables, they still must be comfortable
    economic requirements?
                                          increased the number of wearable products on                                  and easy to use, with functions serving very
 •	Key challenges at system and
                                          the market, to the point where such products                                  different purposes from activity tracking to
    sensor level                          are now achieving performance levels suitable for                             glucose monitoring, through atrial fibrilation
 •	Market segmentation including         medical use-cases. But how will medical wearables                             detection. And what about the Apple Watch
    main players, product examples,       make patients healthier - and why now?                                        Series 4 that was supposedly FDA-approved not
    and market share for each segment                                                                                   so long ago: was this a real event? This segues into
                                          Medical wearables’ purpose is to monitor a patient’s
 •	Market data and forecasts for the                                                                                   another important discussion: what to do with the
                                          vital signs in order to prevent health issues, as well
    period 2018 - 2024 for systems                                                                                      data, who will exploit the data (and how), and for
                                          as contribute to treatment and rehabilitation.
    and sensors                                                                                                         what purpose?
                                          Wearable makers face the same challenges
 •	Regulatory, market access, and        long associated with the medical industry - for                               This report details these new product launches
    target customers in the USA,          example, the need for several layers of validation,                           and describes what is in the pipeline. Yole
    Europe, and China                     i.e. a CE mark and FDA approval. However, with                                Développement's (Yole) analysts also explore
 •	Technology trends and supply          the increasing prevalence of chronic diseases like                            the medical wearable technologies used across
    chain, along with business models     cardiovascular issues and diabetes (approx. 425M                              different market segments, highlight the reasons
    adopted by this field’s key players   diabetics worldwide), medical wearables’ huge                                 why such technologies are used, and discuss how
                                          upside far outweighs the red tape involved.                                   they could evolve.
 OBJECTIVES OF THE REPORT                                                   Timeline of wearables: a little bit of history
 •	E xamine medical wearable device
                                                                                                                                      Medical-functions
    market trends, competitive forces
    and dynamics, and market drivers                                                                                                                                     Appel’s ECG

 •	O ffer an applications overview of                                                           Multi-functions                                Ingestible sensors and                          …
                                                                                                                                                                                       9
                                                                                                                                                                               201
                                                                                                                                                wearables devices
    medical wearables for diagnostic,            Single function                                                             Philips lifeline

    therapeutic, and prevention,                                                                          Fitness tracking                           201
                                                                                                                                                           2
                                                                                                                                                                                             Next step:
    along with disruptive technologies                                                                                                                                                     Medical devices
                                                                                                                             9                                                                 more
    (products)                                                                                                        200                                                                   conformable
 •	E xplain which sensors are used in                                 Hearing aid              200
                                                                                                      0                                          Proteus Digital Health
    which healthcare applications, and                                               193
                                                                                         8
                                                                                                                                                developed an ingestible
                                                                                                                                                sensor approved by the
                                                                                                                                                                                 Apple launched the
                                                                                                                                                                                   first approved
    why                                      Thomish Meter                                                           Activity trackers,
                                                                                                                     wireless enables
                                                                                                                                                    FDA in 2012 to               ECG integrated in
                                                                   8
                                                             178
                                                                                                                                                improve patients habits
 •	Provide an overview of the main                                                                                      wearable                                                    smartwatch
                                                                                                                       technology
    players at each level of the supply
    chain, with market share                                                    Aurex Corp
                                                                               developed the
                                                                                                                     Consumer fitness and sport
                                                     Thomas Jefferson:                                               products enter the market
 •	Furnish business models and                     introduced the first       1st wearables
                                                                                                                      starting with Bluetooth
                                                     pedometer to the           hearing aid
    market projections for 2018 - 2024                      US
                                                                                                                             headset

 •	Identify promising technologies                                    (Yole Développement, March 2019)
    and booming applications
 •	Deliver an overview of emerging       MEDICAL WEARABLES AND SENSORS ECOSTYSTEM IS MATURING
    flexible, stretchable, printed, and   TO SUSTAIN 31% MARKET GROWTH!
    hybrid electronics for medical
    applications                          The overall market for medical wearable devices                               in a smartwatch so that doctors and hospitals can
                                          will grow at a rate of 31% year-over-year, reaching                           get accurate information on a patient’s cardiac
                                          more than $32B in 2024. In the meantime, the global                           status. At sensor level, increasing complexity of
                                          sensor market for medical wearables, including                                medical wearables turns electronic companies to
                                          continuous glucose monitoring (CGM), is expected                              medical grade sensor experts, like AMS, Maxim
                                          to reach $2.8B in 2024, with a compound annual                                Integrated or Valencell developing dedicated
                                          growth rate (CAGR) of 21.6% from 2018 - 2024.                                 platforms. It enables an optimized integration (in
                                                                                                                        terms of footprint and power consumption) while
                                          Led by the Apple Watch Series 4, there is                                     reducing development time with the guarantee of
                                          increasingly strong interest to add ECG capability                            measurement accuracy.
MEDICAL WEARABLES: MARKET AND TECHNOLOGY TRENDS 2019

                                                     Since 2014, Yole Développement's analysts have                                        Pharmaceutical companies are also turning to
                                                     identified more than $550M raised by medical                                          wearables in order to improve R&D through strategic
                                                     device and diagnostic companies, and the pace                                         collaborations. For example, Pfizer, UCB Pharma,
                                                     at which new medical wearable products are                                            Apple, J & J, and IBM are just some of the companies
                                                     being commercialized is accelerating. Moreover,                                       testing mobile technology for patients with
                                                     investments in different acquisitions between large                                   Parkinson’s. As well, smartwatches and wristband
                                                     diagnostic companies and consumer companies                                           generates information for the consumer, with a clear
                                                     (i.e. Apple acquiring Glimpse, Medtronic acquiring                                    objective to be later prescribed and work with health
                                                     Nutrino,…) amount to an impressive $900M since                                        insurance and doctors.
                                                     2016, further confirming the medical wearable
                                                                                                                                           In this context, Yole’s report provides market data and
                                                     market’s positive dynamic.
                                                                                                                                           forecasts along with a focus on the emerging business
                                                                                                                                           models.

                                                                     Medical wearables and sensors: 2018 – 2024 market forecast (in B$)

                                                                                           Medical wearables
                                                                                                               35                                                                          5

                                                                                                                                                                                               Sensors
                                                                                                                           Medical wearables:
                                                                                                                           CAGR2018-2024 : 31%                                             4.5
                                                                                                               30
                                                                                                                                                     Sensors:                              4
                                                                                                                                                 CAGR2018-2024 : 21,6%
                                                                                                               25                                                                          3.5

                                                                                                                                                                                           3
                                                                                                               20

                                                                                                                                                                                           2.5

                                                                                                               15
                                                       Medical wearables segments:                                                                                                         2
                                                            Veterinary
                                                            Maternal & neonatal care                                                                                                       1.5
                                                                                                               10
                                                            Medical prevention
                                                            Rehabilitations systems & therapeutics                                                                                         1
                                                            Metabolic & cardiovascular monitoring 5
                                                            Respiratory & movement disorder                                                                                                0.5
                                                            Glucose monitoring & drug delivery
                                                                                                                0                                                                          0
                                                            Sensors for wearables                                   2018      2019       2020        2021       2022     2023       2024

                                                                                        (Yole Développement, March 2019)

                                                     REMAINING CHALLENGES, BUT A MYRIAD OF ADVANCED TECHNOLOGIES ARE
                                                     UNDER DEVELOPMENT TO SOLVE THE ISSUES
                                                     Medical wearables are the convergence of two                                          that are ready for integration. For example, a
                                                     worlds: the world of medical-grade devices and the                                    photoplethysmogram (PPG) device for heart-rate
                                                     world of consumer wearables. Medical wearables                                        measurement combines, among other elements, LEDs
                                                     also feature two major player types: medical device                                   and a photodiode. The LEDs emit light through the
                                                     manufacturers willing to reach consumer healthcare                                    skin to the blood vessels, and the photodiode receives
                                                     with the promise of higher volumes, and consumer                                      the unabsorbed portion of light. Sensor designers are
                                                     device companies willing to reach the high-value                                      developing sensor modules that integrate LEDs and
                                                     healthcare market. Medical wearables development is                                   photodiode with the right packaging and electronic
                                                     quickening and competition is intensifying, prompting                                 architecture, ensuring accuracy of measurement
                                                     players to ensure a high level of quality as well as                                  with miniaturized, low-power devices. These turnkey
                                                     medical-grade accuracy for the generated data.                                        solutions contribute to a faster time-to-market for
                                                     Sensor and electronics manufacturers are facilitating                                 medical wearable makers and help sensor makers
                                                     a faster time-to-market via optimized modules                                         move up the value chain with high-value solutions.
                                                                                                                                           A high level of integration and low-power consumption
           Medical wearables today - convergence of two worlds                                                                             are not the only challenges described in this report,
Volume
                                                                                                                                           which aims to answer the question, “What could be
                                                                                                                                           the key enabling technologies for medical wearables?”
                                                        •   From discrete to dedicated platform                                            Readers will also discover how medical wearable
                                                        •   Turnkey solution
                                                        •   Time to market optimization for short                                          players investigate innovative materials and solutions
                                                            cycle times                                                                    that meet the patient’s requirements for comfort and
 10M                                                                                                                                       painless monitoring. Supple, conformable materials
                                                                                                                                           using printed electronic technologies should
                                                                                                                                           increasingly benefit high-quality measurement and
                                                                                                                                           help avoid errors due to patient movement.
  1M                                                                                                                                       This report describes the technology trends and
                                                                                                                                           roadmaps that promote a better understanding of
                                                                                                                                           how the medical wearables industry and its players
                                                                                                                                           are answering patient and user requirements while
         Long cycle time Application                                 Short cycle time Application                              Time
         oriented 'prescribed medical devices'                       oriented 'consumer healthcare'
                                                                                                                                           contributing to lower overall healthcare costs.
          Photo credits: Osram

                  (Yole Développement, March 2019)
MARKET & TECHNOLOGY REPORT

COMPANIES CITED IN THE REPORT (non exhaustive list)
3M, AAC Technologies, Abbott, Alertgy, AliveCor, Amazon, Amphenol, AMS, Analog
Devices , Apple, Artefact, Ava, BACtrack, Biogen, Biolinq, Biometrics, Bittium, Bioserenity,
Bloomlife, Bonbouton, Capsule, Cardionet, CarePredict, CareWear Corp, CEA Léti, Cefaly
Technology, Chrono Therapeutics, Chronolife, Comepa, Covestro, Dakota, Delsys, Dexcom,
D Free, Ectosens, Elvie, Empatica, Excelitas Technologies, Exosystems, Feel, Feetme, Fitbit,
Food & Drug Administration, GI Logic, Global Kinetics, Glucowise, Google, G-Tech Medical,                    AUTHORS
Halo Neuroscience, Healthcare Origins, Healthwatch, Heimann Sensor, Hexoskin, Hocoma,                        As a Technology & Market
Honeywell, IBM, IHealth, Imec, Infineon, Insound, iRythm, JRC, Jari Electrode Supply, Johnson                Analyst, Biotechnologies
                                                                                                             & Molecular Innovations,
& Johnson, Knowles Acoustics, Kolo Medical, Lifesense, Lifewatch, L’Oréal & La Roche-Posay,
                                                                                                             Medical Technologies in the Life Sciences &
MC10, Maxim Integrated, Medatec, Medtronic, Merit Sensor, Melexis, Microsoft, Micralyne,                     Healthcare division at Yole Développement
Monica Healthcare, Motiv, Murata, Muse, Mymdband, Neofect, Neucognic, NeuroMetrix,                           (Yole), Asma Siari is involved in the
Novioscan, Nonin, Novartis, Nuheara, Nuubo, NVK, NXP, Omron, Orpyx, Oska, OSRAM,                             development of technology & market
Oticon, Oura, Pet Pace, Pfizer, Phonak, Philips Healthcare, Philips Innovation Services,                     reports as well as the production of custom
Pkvitality, Preventice, Qardiocore, Renesas, Resmed, ReSound GN, Robert Bosch, Roche,                        consulting projects. After a Master’s degree
                                                                                                             in Biotechnologies, Diagnostic Therapeutics
Rohm Semiconductor, Senseonics, Sensimed AG, Sentio Solutions, Shade, Silicon Labs,
                                                                                                             & Management, Asma served as Research
SleepOn, SMI, Somnarus Inc , Sonova, Sonion, Starkey, STMicroelectronics, Sunfriend, TDK,                    Assistant at the Moores Cancer Center
TE Connectivity, TempTraq, Tempdrop, The Electrode Store, Thync, UCB Pharma, Upright,                        (San Diego, CA). She is a coauthor in
TTP Ventus, Valencell, Verily, Vicardio, Vishay, VitalConnect, Vivosens Medical, Voyce,                      three scientific publications published in
Wellbrain, Whistle, Withings, Wolfson, Xiaomi, ZoLL, and many more...                                        the Molecular Cancer Research Journal.
                                                                                                             Asma Siari graduated with an Advanced
                                                                                                             Master’s degree in International Strategy
 TABLE OF CONTENTS (complete content on i-Micronews.com)                                                    & Marketing BtoB from EM Lyon Business
                                                                                                             School (France).
 Executive summary                             08      > Manufacturing process and materials
 Context                                       28      > Roadmaps
                                                       > Overview of emerging flexible, stretchable,
   > Definition of medical wearables                      printed, and hybrid electronics for medical
   > A little bit of history                              applications
   > What’s new?
   > Product launches, collaborations, and            Technology trends                            132       Jérôme Mouly serves
   fundraising                                         > Technological description of sensors for           as a Senior Technology &
 Market forecasts                              53         medical wearables                                  Market Analyst & Business
                                                       > Sensors
   > Global market data and market forecasts                                                                 Developer specialized in microtechnologies
                                                       > Manufacturing process and materials
   >M arket data and forecasts 2018-2024 in           > Roadmaps                                            for inkjet & bioMEMS sensors at
     $M, by segment                                    > Overview of emerging flexible, stretchable,        Yole Développement (Yole). Jérôme is
   > Market forecasts, by sensor type                     printed, and hybrid electronics for medical        supporting the development of strategic
   > Market share                                         applications                                       projects, following leading customers of
 Market trends                                 69     Supply chain                                 185       the company, within the Life Sciences
   > Market drivers and challenges                                                                           & Healthcare division. Since 2000, he is
                                                       > Ecosystems
   >R &D development time, and related                                                                      also engaged in more than 100 marketing
                                                       > Business models and players’ strategy
     investments                                                                                             and technological analyses for industrial
                                                       > Supply chain analysis
   >M arket segmentation and segment                                                                        groups, start-ups and institutes related
     description                                       > Regulation and reimbursement aspects
                                                                                                             to semiconductor & medical technologies
   > Technology requirements/application               > Market access
                                                                                                             industry, in the field of inkjet functional
   > Key players/segment                               > Technical challenges regarding fabrication,
                                                                                                             printing, wearable sensors and connected
   >T op medical devices: how do they position           packaging, and assembly techniques
     themselves?                                                                                             medical devices. Jérôme is also regularly
                                                       > Conclusion
   > Technology trends                                                                                       involved in international conferences, giving
                                                       > Perspectives
   >T echnological description of sensors for                                                               presentations and delivering keynotes.
                                                       > What’s next
     medical wearables                                                                                       Jérôme Mouly holds a Master of Physics from
   > Sensors                                          Conclusion                                   233       the University of Lyon (France).

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      corporate finance services, reverse engineering and reverse costing services and well as IP and patent analysis. With a strong focus on emerging applications
      using silicon and/or micro manufacturing, the Yole group of companies has expanded to include more than 80 collaborators worldwide covering MEMS and Image
      Sensors, Compound Semiconductors, RF Electronics, Solid-State Lighting, Displays, Software, Optoelectronics, Microfluidics & Medical, Advanced Packaging,
      Manufacturing, Nanomaterials, Power Electronics and Batteries & Energy Management.
      The “More than Moore” market research, technology and strategy consulting company Yole Développement, along with its partners System Plus Consulting,
      PISEO and KnowMade, support industrial companies, investors and R&D organizations worldwide to help them understand markets and follow technology
      trends to grow their business.
      CONSULTING AND ANALYSIS                                                          REPORTS
      • Market data & research, marketing analysis                                     • Market & technology reports
      • Technology analysis                                                            • Patent investigation and patent infringement risk analysis
      • Strategy consulting                                                            • Structure, process and cost analysis
      • Reverse engineering & costing                                                  • Cost simulation tool
      • Patent analysis                                                                More information on www.i-micronews.com/reports
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      More information on www.yole.fr
      MEDIA & EVENTS                                                                   CONTACTS
      • i-Micronews.com website & related @Micronews e-newsletter                     For more information about :
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      More information on www.i-Micronews.com                                          • Press Relations & Corporate Communication: Sandrine Leroy (leroy@yole.fr)
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      Please enter my order for above named report:                                             • Western US & Canada - Steve Laferriere:
          One user license*: Euro 5,990                                                            + 1 310 600-8267 – laferriere@yole.fr
          Multi user license: Euro 6,490                                                        • Eastern US & Canada - Troy Blanchette:
      - The report will be ready for delivery from March 29, 2019                                  +1 704 859 0453 – troy.blanchette@yole.fr
      - For price in dollars, please use the day’s exchange rate. All reports are              • Europe & RoW - Lizzie Levenez:
         delivered electronically at payment reception. For French customers,                      + 49 15 123 544 182 – levenez@yole.fr
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                                                                                                • Specific inquiries: +33 472 830 180 – info@yole.fr
                                                                                                (1)
                                                                                                      Our Terms and Conditions of Sale are available at
      *One user license means only one person at the company can use the report.                      www.yole.fr/Terms_and_Conditions_of_Sale.aspx
                                                                                                      The present document is valid 24 months after its publishing date:
                                                                                                      March 14, 2019
SHIPPING CONTACT
      First Name:                                                                      Last Name:
      Email:                                                                           Phone:

ABOUT YOLE DEVELOPPEMENT
      Founded in 1998, Yole Développement has grown to become a group of companies providing marketing, technology and strategy consulting, media and
      corporate finance services, reverse engineering and reverse costing services and well as IP and patent analysis. With a strong focus on emerging applications
      using silicon and/or micro manufacturing, the Yole group of companies has expanded to include more than 80 collaborators worldwide covering MEMS and Image
      Sensors, Compound Semiconductors, RF Electronics, Solid-State Lighting, Displays, Software, Optoelectronics, Microfluidics & Medical, Advanced Packaging,
      Manufacturing, Nanomaterials, Power Electronics and Batteries & Energy Management.
      The “More than Moore” market research, technology and strategy consulting company Yole Développement, along with its partners System Plus Consulting,
      PISEO and KnowMade, support industrial companies, investors and R&D organizations worldwide to help them understand markets and follow technology
      trends to grow their business.
      CONSULTING AND ANALYSIS                                                          REPORTS
      • Market data & research, marketing analysis                                     • Market & technology reports
      • Technology analysis                                                            • Patent investigation and patent infringement risk analysis
      • Strategy consulting                                                            • Structure, process and cost analysis
      • Reverse engineering & costing                                                  • Cost simulation tool
      • Patent analysis                                                                More information on www.i-micronews.com/reports
      • Design and characterization of innovative optical systems
      • Financial services (due diligence, M&A with our partner)
      More information on www.yole.fr
      MEDIA & EVENTS                                                                   CONTACTS
      • i-Micronews.com website & related @Micronews e-newsletter                     For more information about :
      • Communication & webcast services                                               • Consulting & Financial Services: Jean-Christophe Eloy (eloy@yole.fr)
      • Events: TechDays, forums…                                                      • Reports: David Jourdan (jourdan@yole.fr) Yole Group of Companies
      More information on www.i-Micronews.com                                          • Press Relations & Corporate Communication: Sandrine Leroy (leroy@yole.fr)
Source: Wikimedia Commons

 Yole Développement
     From Technologies to Market

                                   © 2019
YOLE DEVELOPPEMENT – FIELDS OF EXPERTISE

Life Sciences                                                    Semiconductor                              Semiconductor
& Healthcare                                                       & Software                                  & Software
o   Microfluidics                                                                             o   Package,Assembly & Substrates
o   BioMEMS & Medical Microsystems                                                            o   Semiconductor Manufacturing
o   Inkjet and accurate dispensing                                                            o   Memory
o   Solid-State Medical Imaging & BioPhotonics                                                o   Software & Computing
o   BioTechnologies
                                                    Life                         Photonics,
                                                 Sciences &                       Sensing
                                                 Healthcare
                                                                                 & Display

Power                                                                                                           Photonics,
& Wireless                                                                                               Sensing & Display
o    RF Devices & Technologies                                                                o   Solid-State Lighting
o    Compound Semiconductors & Emerging Materials             Power & Wireless                o   Display
o    Power Electronics                                                                        o   MEMS, Sensors & Actuators
o    Batteries & Energy Management                                                            o   Imaging
                                                                                              o   Photonics & Optoelectronics

                                                                                                   ©2019 | www.yole.fr | About Yole Développement   2
4 BUSINESS MODELS

o   Consulting and Analysis
      •   Market data & research,
          marketing analysis
      •   Technology analysis
                                               o   Syndicated reports
      •   Strategy consulting
                                                     •   Market & technology reports
      •   Reverse engineering & costing
                                                     •   Patent investigation and patent
      •   Patent analysis
                                                         infringement risk analysis        o   Monitors
      •   Design and characterization                                                            •   Monthly and/or Quarterly
                                                     •   Teardowns & reverse costing
          of innovative optical systems                                                              update
                                                         analysis
      •   Financial     services      (due                                                       •   Excel database covering supply,
                                                     •   Cost simulation tool
          diligence, M&A with our                                                                    demand, and technology
                                                             www.i-Micronews.com/reports                                               o      Media
          partner)                                                                               •   Price, market, demand and
                                 www.yole.fr                                                         production forecasts                        •    i-Micronews.com website
                                                                                                 •   Supplier market shares                      •    @Micronews e-newsletter
                                                                                                                                                 •    Communication & webcast
                                                                                                                                                      services
                                                                                                         www.i-Micronews.com/reports
                                                                                                                                                 •    Events: TechDays, forums,…
                                                                                                                                                                  www.i-Micronews.com

                                                                                                                                           ©2019 | www.yole.fr | About Yole Développement   3
6 COMPANIES TO SERVE YOUR BUSINESS
                                                        Yole Group of Companies

 Market, technology and strategy      Manufacturing costs analysis             IP analysis
            consulting             Teardown and reverse engineering        Patent assessment
                                         Cost simulation tools
            www.yole.fr                                                      www.knowmade.fr
                                            www.systemplus.fr

                                    Design and characterization of
                                                                      Innovation and business maker           Due diligence
                                     innovative optical systems
                                                                             www.bmorpho.com                      www.yole.fr
                                              www.piseo.fr

                                                                                                      ©2019 | www.yole.fr | About Yole Développement   4
OUR GLOBAL ACTIVITY
                               Europe office
                                  Frankfurt

Paris

Nantes
                                                                  Yole Korea       Yole Inc.
                                   HQ in Lyon
                                                                        Seoul       Phoenix
Vénissieux
                                                                  Yole Japan
                                                                       Tokyo
Nice                                                                              Palo Alto

             40%
                                                                   Greater
                                                                   China office
                                                                      Hsinchu

             of our business
                                                                                               30%
                                                30%
                                                                                               of our business

                                                of our business

                                                                                               ©2019 | www.yole.fr | About Yole Développement   5
ANALYSIS SERVICES - CONTENT COMPARISON
              High

                                     Technology
                                     and Market
                                       Report
           Breadth of the analysis
                                     Leadership
                                      Meeting

                                                   Q&A        Meet the    Custom
                                                  Service     Analyst     Analysis

                     Low

                                                  Depth of the analysis                    High
                                                                                     ©2019 | www.yole.fr | About Yole Développement   6
SERVING THE ENTIRE SUPPLY CHAIN

               Integrators, end-
               users and software
               developers

Our analysts   Device manufacturers
   provide
   market
   analysis,
 technology
 evaluation,   Suppliers: material, equipment,
and business
 plans along
               OSAT, foundries…
  the entire
supply chain

               Financial investors, R&D centers

                                                  ©2019 | www.yole.fr | About Yole Développement   7
SERVING MULTIPLE INDUSTRIAL FIELDS

                                  Industrial       Medical
   We work                       and defense       systems
    across
   multiples
industries to
 understand                    Energy
the impact of                management                 Automotive
 More-than-
    Moore
technologies
 from device                                     Mobile phone
  to system                     Transportation        and
                                   makers         consumer
                                                  electronics
                                                                From A to Z…

                                                                      ©2019 | www.yole.fr | About Yole Développement   8
REPORTS COLLECTION
   o Over the course of more than 20 years, Yole Développement has grown to become a group of companies. Together with System Plus Consulting and KnowMade, we now
     provide marketing, technology and strategy consulting, media and corporate finance services, reverse costing, structure, process and cost analysis services and well as
     intellectual property (IP) and patent analysis. Together, our group of companies is collaborating ever closer and therefore will offer, in 2019, a collection of over 125 reports
     and 10 new monitors. Combining respective expertise and methodologies from the three companies, they cover:

          •    MEMS & Sensors                                •    Power electronics
          •    RF devices & technologies                     •    Compound semiconductors
          •    Medical technologies                          •    Solid state lighting
          •    Semiconductor Manufacturing                   •    Displays
          •    Advanced packaging                            •    Software
          •    Memory                                        •    Imaging
          •    Batteries and energy management               •    Photonics

   o If you are looking for:
          • An analysis of your product market and technology
          • A review of how your competitors are evolving
          • An understanding of your manufacturing and production costs
          • An understanding of your industry’s technology roadmap and related IPs
          • A clear view supply chain evolution
          Our reports and monitors are for you!                                                                                                                      www.i-Micronews.com

   o Our team of over 70 analysts, including PhD and MBA qualified industry veterans from Yole Développement, System Plus Consulting and KnowMade, collect information,
     identify trends, challenges, emerging markets, and competitive environments. They turn that information into results and give you a complete picture of your industry’s
     landscape. In the past 20 years, we have worked on more than 2,000 projects, interacting with technology professionals and high-level opinion makers from the main
     players of their industries and realized more than 5,000 interviews per year.
   WHAT TO EXPECT IN 2019?
   In 2019 we will extend our offering with a new ‘monitor’ product which provides more updates on your industry during the year. The Yole Group of Companies is also building
   on and expanding its investigations of the memory industry. Moreover, in parallel, the Yole Group reaffirms its commitment to a new collection of reports mixing software and
   hardware and is increasing its involvement in displays, radio-frequency (RF) technology, advanced substrates, batteries and compound semiconductors. Discover our 2019
   program right now, and ensure you get a true vision of the industry. Stay tuned!

                                                                                                                                              ©2019 | www.yole.fr | About Yole Développement   9
OUR 2019 REPORTS COLLECTION (1/4)
  18 fields of excellence combined with six markets to provide a complete picture of your industry landscape

  Market – Technology – Strategy – by Yole Développement
  Yole Développement (Yole) offers market reports including quantitative market forecasts,
  technology trends, company strategy evaluation and indepth application analyses. Yole will   The markets targeted are :
  publish more than 55 reports in 2019, with our partner PISEO contributing to some of
  the lighting reports.                                                                        • Mobile & Consumer
  Reverse Costing® – Structure, Process and Cost Analysis – by                                 • Automotive & Transportation
  System Plus Consulting
  The Reverse Costing® report developed by System Plus Consulting provides full                • Medical
  teardowns, including detailed photos, precise measurements, material analyses,
  manufacturing process flows, supply chain evaluations, manufacturing cost analyses and       • Industrial
  selling price estimations. The reports listed below are comparisons of several analyzed
  components from System Plus Consulting. More reports are however available, and over
  60 reports will be released in 2019.The complete list is available at www.systemplus.fr.
                                                                                               • Telecom & Infrastructure

  Patent Reports – by KnowMade                                                                 • Defense & Aerospace
  More than describing the status of the IP situation, these analyses provide a missing link
  between patented technologies and market, technological and business trends. They offer
                                                                                               • Linked reports are dealing with the same topic to provide
  an understanding of the competitive landscape and technology developments from a
  patent perspective. They include key insights into key IP players, key patents and future
                                                                                               • a more detailed analysis.
  technology trends. For 2019 KnowMade will release over 15 reports.

                                                                                                                             ©2019 | www.yole.fr | About Yole Développement   10
OUR 2019 REPORTS COLLECTION (1/5)
      18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
 MEMS & SENSORS                                                                             RF DEVICES AND TECHNOLOGIES
 o MARKET AND TECHNOLOGY REPORT                                                             o MARKET AND TECHNOLOGY REPORT
      • Status of the MEMS Industry 2019 - Update                                                • RF GaN Market: Applications, Players, Technology,
      • Status of the Audio Industry 2019 - New                                                    and Substrates 2019 - Update
      • Uncooled Infrared Imagers and Detectors 2019 – Update                                    • 5G’s Impact on RF Front-End Module and Connectivity
      • Consumer Biometrics:Technologies and Market Trends 2018                                    for Cell Phones 2019 – Update
      • MEMS Pressure Sensor Market and Technologies 2018                                        • 5G Impact on Wireless Infrastructure 2019
      • Gas & Particle Sensors 2018                                                              • Radar and V2X Market & Technology for Automotive 2019 - Update
 o STRUCTURE, PROCESS & COST REPORT                                                              • Advanced RF Antenna Market & Technology 2019 - New
      • MEMS & Sensors Comparison 2019                                                           • RF Standards and Technologies for Connected Objects 2018
      • MEMS Pressure Sensor Comparison 2018                                                o STRUCTURE, PROCESS & COST REPORT
      • Particle Sensors Comparison 2019                                                         • RF Front-End Module Comparison 2019 - Update
      • Miniaturized Gas Sensors Comparison 2018                                                 • Automotive Radar RF Chipset Comparison 2018
 o PATENT REPORT                                                                            o PATENT REPORT
      • MEMS Foundry Business Portfolio 2019 - New                                               • Antenna for 5G Wireless Communications 2019 - New
      • Miniaturized Gas Sensors 2019 - New                                                      • RF Front End Modules for Cellphones 2018
                                                                                                 • RF Filter for 5G Wireless Communications: Materials and Technologies 2019
 PHOTONIC AND OPTOELECTRONICS                                                                    • RF GaN : Materials, Devices and Modules 2018
 o MARKET AND TECHNOLOGY REPORT
      • Photonic Integrated Circuit 2019 - New
      • LiDARs for Automotive and Industrial Applications 2019 - Update
      • Silicon Photonics 2018
 o PATENT REPORT
      • Silicon Photonics for Data Centers: Optical Transceiver 2019 - New
      • LiDAR for Automotive 2018

                                                                             Update : 2018 version still available                         ©2019 | www.yole.fr | About Yole Développement   11
OUR 2019 REPORTS COLLECTION (2/5)
      18 fields of excellence combined with six markets to provide a complete picture of your industry landscape

 IMAGING                                                                                       MICROFLUIDICS
 o MARKET AND TECHNOLOGY REPORT                                                                o MARKET AND TECHNOLOGY REPORT
      • Status of the CIS Industry 2019: Technology                                                 • Status of the Microfluidics Industry 2019 - Update
        and Foundry Business - Update                                                               • Next Generation Sequencing & DNA Synthesis - Technology,
      • Imaging for Automotive 2019 - Update                                                          Consumables Manufacturing and Market Trends 2019 - New
      • Neuromorphic Technologies for Sensing 2019 - Update                                         • Organ-on-a-Chip Market & Technology Landscape 2019 - Update
      • Status of the CCM and WLO Industry 2019 - Update                                            • Point-of-Need Testing Application of Microfluidic Technologies 2018
      • Machine Vision for Industry and Automation 2018                                             • Liquid Biopsy: from Isolation to Downstream Applications 2018
      • Sensors for Robotic Vehicles 2018                                                           • Chinese Microfluidics Industry 2018
 o STRUCTURE, PROCESS & COST REPORT                                                            o PATENT REPORT
      • Compact Camera Modules Comparison 2019                                                      • Microfluidic Manufacturing Technologies 2019 – New
      • CMOS Image Sensors Comparison 2019
 o PATENT REPORT                                                                               INKJET AND ACCURATE DISPENSING
      • Facial & Gesture Recognition Technlogies in Mobile Devices 2019 - New                  o MARKET AND TECHNOLOGY REPORT
      • Apple iPhone X Proximity Sensor & Flood Illuminator 2018                                    • Inkjet Printheads - Dispensing Technologies
                                                                                                      & Market Landscape 2019 - Update
 MEDICAL IMAGING AND BIOPHOTONICS                                                                   • Emerging Printing Technologies
 o MARKET AND TECHNOLOGY REPORT                                                                       for Microsystem Manufacturing 2019 - New
      • X-Ray Detectors for Medical, Industrial                                                     • Piezoelectric Materials from Bulk to Thin Film 2019 - New
      • and Security Applications 2019- New                                                         • Inkjet Functional and Additive Manufacturing for Electronics 2018
      • Microscopy Life Science Cameras: Market and Technology Analysis 2019                   o STRUCTURE, PROCESS & COST REPORT
      • Ultrasound technologies for Medical, Industrial                                             • Piezoelectric Materials from Bulk to Thin Film Comparison 2019
        and Consumer Applications 2018
 o PATENT REPORT
      • Optical Coherence Tomography Medical Imaging 2018

                                                                                Update : 2018 version still available                          ©2019 | www.yole.fr | About Yole Développement   12
OUR 2019 REPORTS COLLECTION (3/5)
      18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
 BIOTECHNOLOGIES                                                                        MEMORY
 o MARKET AND TECHNOLOGY REPORT                                                         o MARKET AND TECHNOLOGY REPORT
      • CRISPR-Cas9 Technology: From Lab to Industries 2018                                  • Status of the Memory Business 2019 - New
 o PATENT REPORT                                                                             • MRAM Technology and Business 2019 - New
      • Personalized Medicine 2019 – New                                                     • Emerging Non Volatile Memory 2018
                                                                                        o STRUCTURE, PROCESS & COST REPORT
 BIOMEMS & MEDICAL MICROSYSTEMS                                                              • Memory Comparison 2019
 o MARKET AND TECHNOLOGY REPORT                                                         o PATENT REPORT
      • Medical Wearables: Market & Technology Analysis 2019 - New                           • Magnetoresistive Random-Access Memory (MRAM) 2019 - New
      • Neurotechnologies and Brain Computer Interface 2018                                  • 3D Non-Volatile Memory 2018
      • BioMEMS & Non-Invasive Sensors: Microsystems for Life Sciences
        & Healthcare 2018                                                               ADVANCED PACKAGING
 o PATENT REPORT
                                                                                        o MARKET AND TECHNOLOGY REPORT
      • 3D Cell Printing 2019 - New                                                          • Fan Out Packaging Technologies and Market Trends 2019 - Update
      • Circulating Tumor Cells Isolation 2019 - New                                         • 3D TSV Integration and Monolithic Business Update 2019 - Update
      • Nanopore Sequencing 2019 - New                                                       • Advanced RF SiP for Cellphones 2019 - Update
                                                                                             • Status of Advanced Packaging 2019 - Update
 SOFTWARE AND COMPUTING                                                                      • Status of Advanced Substrates 2019 - Update
 o MARKET AND TECHNOLOGY REPORT                                                              • Panel Level Packaging Trends 2019 - Update
     • Artificial Intelligence Computing For Automotive 2019 - New
                                                                                             • System in Package (SiP) Technology and Market Trends 2019 - New
     • Hardware and Software for Artificial Intelligence (AI)
                                                                                             • Trends in Automotive Packaging 2018
       in Consumer Applications 2019 - Update
                                                                                             • Thin-Film Integrated Passive Devices 2018
     • From Image Processing to Deep Learning 2019 - Update
                                                                                        o STRUCTURE, PROCESS & COST REPORT
     • xPU (Processing Units) for Cryptocurrency, Blockchain, HPC
       and Gaming 2019 – New                                                                 • Advanced RF SiP for Cellphones Comparison 2019

                                                                         Update : 2018 version still available                       ©2019 | www.yole.fr | About Yole Développement   13
OUR 2019 REPORTS COLLECTION (4/5)
      18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
 SEMICONDUCTOR MANUFACTURING                                                         SOLID STATE LIGHTING
 o MARKET AND TECHNOLOGY REPORT                                                      o MARKET AND TECHNOLOGY REPORT
      • Nano Imprint Lithography 2019 - New                                               • Status of the Solid State Light Source Industry 2019 - New
      • Equipment and Materials for Fan Out Packaging 2019 - Update                       • Edge Emitting Lasers (EELS) 2019 - New
      • Equipment for More than Moore: Thin Film Deposition                               • Light Shaping Technologies 2019 - New
        & Etching 2019 - New                                                              • Automotive Advanced Front Lighting Systems 2019 - New
      • Wafer Starts for More Than Moore Applications 2018                                • VCSELs - Technology, Industry and Market Trends 2019 - Update
      • Polymeric Materials at Wafer-Level                                                • IR LEDs and Laser Diodes – Technology, Applications,
        for Advanced Packaging 2018                                                         and Industry Trends 2018
      • Bonding and Lithography Equipment Market                                          • Automotive Lighting 2018: Technology, Industry and Market Trends
        for More than Moore Devices 2018                                                  • UV LEDs - Technology, Manufacturing and Application Trends 2018
 o STRUCTURE, PROCESS & COST REPORT                                                       • LiFi: Technology, Industry and Market Trends 2018
      • Wafer Bonding Comparison 2018                                                o STRUCTURE, PROCESS & COST REPORT
 o PATENT REPORT                                                                          • VCSEL Comparison 2019
      • Hybrid Bonding for 3D Stack 2019 – New                                       o PATENT REPORT
                                                                                          • VCSELs 2018

                                                                                     DISPLAY
                                                                                     o MARKET AND TECHNOLOGY REPORT
                                                                                          • Next Generation 3D Display 2019 - New
                                                                                          • Next Generation Human Machine Interaction (HMI)in Displays 2019 - New
                                                                                          • Micro-and Mini-LED Displays 2019 - Update
                                                                                          • QD and Wide Color gamut (WCG)
                                                                                            Display Technologies 2019 - Update
                                                                                          • Displays & Optical Vision Systems for VR,AR & MR 2018
                                                                                     o PATENT REPORT
                                                                                          • MicroLED Displays : Intellectual Property Landscape 2018
                                                                      Update : 2018 version still available                         ©2019 | www.yole.fr | About Yole Développement   14
OUR 2019 REPORTS COLLECTION (5/5)
      18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
 POWER ELECTRONICS                                                                    BATTERY & ENERGY MANAGEMENT
 o MARKET AND TECHNOLOGY REPORT                                                       o MARKET AND TECHNOLOGY REPORT
      • Power SiC: Materials, Devices and Applications 2019 - Update                       • Status of the Rechargeable Li-ion Battery Industry 2019 - New
      • Power Electronics for EV/HEV and e-mobility:                                       • Li-ion Battery Packs for Automotive and Stationary Storage
        Market, Innovations and Trends 2019 - Update                                         Applications 2019 - Update
      • Status of the Power Electronics Industry 2019 - Update                        o PATENT REPORT
      • Discrete Power Packaging : Material Market                                         • Battery Energy Density Increase: Materials
        and Technology Trends 2019 - New                                                     and Emerging Technologies 2019 - New
      • Status of the Power ICs Industry 2019 - Update                                     • Solid-State Batteries 2019 - New
      • Status of the Passive Components for the Power Electronics                         • Status of the Battery Patents 2018
        Industry 2019 - Update
      • Status of the Inverter Industry 2019 - Update                                 COMPOUND SEMI.
      • Status of the Power Module Packaging Industry 2019 - Update                   o MARKET AND TECHNOLOGY REPORT
      • Wireless Charging Market Expectations                                              • Emerging Compound Semiconductor
        and Technology Trends 2018                                                           Market & Technology Trends 2019 - New
      • Power GaN 2018: Epitaxy, Devices, Applications                                     • Status of the Compound Semiconductor Industry 2019 - New
        and Technology Trends                                                              • InP Materials, Devices and Applications 2019 - New
 o STRUCTURE, PROCESS & COST REPORT                                                        • GaAs Wafer and Epiwafer Market: RF, Photonics,
      • Automotive Power Module Packaging Comparison 2018                                    LED and PV Applications 2018
      • GaN-on-Silicon Transistor Comparison 2019                                     o PATENT REPORT
      • SiC Transistor Comparison 2019                                                     • GaN-on-Silicon Substrate: Materials, Devices
 o PATENT REPORT                                                                             and Applications 2019 - Update
      • Power SiC : Materials, Devices and Modules 2019 - New
      • Power GaN : Materials, Devices and Modules 2019 – Update

                                                                       Update : 2018 version still available                         ©2019 | www.yole.fr | About Yole Développement   15
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