HYWEL DDA HEALTH BOARD DIABETES CARE PATHWAY
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Contributors Dr Jonathan Williams GP Church Surgery, Aberystwyth Dr Christine Kotonya Consultant Physician & Diabetologist, Bronglais Hospital Dr Nia Llewelyn GP Llyn Y Fran, Llandysul Carol Evans Senior Diabetes Specialist Nurse, Bronglais Hospital Dr Gethin Roberts Consultant Biochemist, Bronglais Hospital Jenny Pugh-Jones Pharmacist Hywel Dda Health Board Dr Karen Poyser Principal Biochemist, Bronglais Hospital Glenys Jones Diabetes Specialist Dietician, Bronglais Hospital Rhiannon Roberts Podiatrist, Bronglais Hospital Liz Newbury-Davies Senior Health Promotion Specialist, Public Health Wales This document has been approved by the following Hywel Dda wide bodies: Hywel Dda DPDG Hywel Dda Diabetes Clinical Network Hywel Dda Community and Chronic Conditions Management Board Special acknowledgement to NHS Enfield NSF Diabetes Team for permitting us to adapt their diabetes treatment care pathway which is based on NICE CG66 Type 2 diabetes guidelines for Diabetes 2008 and NICE CG 87 Type 2 diabetes: partial update 2009 The Preventing Type 2 Diabetes section of the care pathway is based on NICE (2011) Preventing type 2 diabetes: population and community level interventions in high risk groups and the general population. NICE public health guidance 35. This document has been revised and modified in September 2012. Review date will be September 2013
PREVENTING TYPE 2 DIABETES For most people, type 2 diabetes can be prevented or delayed by maintaining a healthy weight, improving dietary intake, being physically active, not smoking and drinking alcohol within the recommended units. Lifestyle interventions for example aimed at changing an individual’s diet and increasing physical activity levels can halve the number of people with impaired glucose tolerance who develop type 2 diabetes (Gillies et al., 2007). The greatest impact on the prevalence of type 2 diabetes and associated costs is however likely to be achieved by addressing these behavioural risk factors in whole communities and populations (NICE, 2011). Type 2 diabetes shares these common risk factors with other non-communicable diseases including cardiovascular disease and some cancers. In addition to these individual risk factors, people from certain communities and population groups are particularly at risk, including people of South Asian, African- Caribbean, black African and Chinese descent and those from lower socioeconomic groups. Action to address the wider determinants of health, health inequalities and inequities however fundamentally underpins improving the health of our population. Prevention of type 2 diabetes and non-communicable diseases and early intervention should therefore be considered as part of an integrated package of local measures aimed at empowering individuals and communities and to promote and improve the health of the population. Needs assessment and planning to prevent type 2 diabetes • identify local communities at high risk of developing type 2 diabetes, assess their knowledge, awareness, attitudes and beliefs about the risk factors and assess their specific cultural, language and literacy needs. Through development of Hywel Dda Obesity Pathway • Identify successful local interventions and gaps in service provision • Identify local resources and existing community groups that could help promote healthy eating, physical activity and weight management, particularly within local communities at high risk of developing type 2 diabetes. Developing local strategies and action plans Through development of the Obesity Pathway consider actions at level 1 and 2 to address increasing people’s physical activity levels and improve people's diet and weight management in order to contribute to preventing type 2 diabetes and related non-communicable diseases (including cardiovascular disease). Ensure that actions to address increasing people’s physical activity levels and improve people's diet and weight management, creating supportive environments and the wider determinants of health and health inequalities are addressed in local areas Health, Social Care and Wellbeing Strategies/Integrated Strategy; Children and Young People’s Plans; Local physical activity action plans Implement the Hywel Dda Self Care Strategy which aims to support individuals
Training to promote a healthy lifestyle Developing the public health and health promoting competences and skills of the NHS workforce is a priority action identified through the Public Health Strategic Framework. More fundamental is the support and management needed for the change in the basic culture of health services and to ensure that promoting health is part of everyone’s role Conveying healthy lifestyle messages to the local population – in particular, to groups at risk of type 2 diabetes Ensure key public health messages are current, evidence based, consistent, clear and culturally appropriate. Work with local practitioners, role models and peers and through mechanisms such as Siarad Iechyd/Talking Health and 10 pledges to tailor national messages for the local community about preventing type 2 diabetes and other non-communicable diseases (such as cardiovascular disease and some cancers). Ensure messages and information are disseminated locally to groups at higher risk of type 2 diabetes than the general population, including black and minority ethnic and lower socioeconomic groups. .
DIABETES CARE PATHWAY TYPE 2 DIABETES MILESTONE 1 MILESTONE 2 MILESTONE 3 MILESTONE 4 MILESTONE 5 Diagnostic phase Treatment management Complication / risk Maintenance phase Educative phase phase management a. Lifestyle changes* a. Check and recheck a. - Offer dietary advice a. Hypertension a. Regular review if unstable understanding - Trial of lifestyle 2 – 3 monthly interventions including b. Lifestyle issues* increased activity b. Patients given Inc Smoking and physical information booklet s activity b. Lipid Management b. 6 monthly review once c. Medication b. Treat all co – existent stabilized c. Patient given hand held pathology e.g. BP, lipids record c. Anti-platelet therapy d. Complications Arrange screening for c. Annual review complications (see Appendix 2) d.Referral to Dietitian (see appendix for referral criteria) e. Importance of regular See Milestone 4 d. Microalbuminuria review e.Referral to group education d. Ongoing review of f. Driving c. See medication algorithm sessions via Diabetes Referral educational needs e. Management of CKD & Triage g. Importance of good BP f.Regular review control d. Continued education & support e. Review of dietary needs f. Management of painful see maintenance phase h. Importance of good neuropathy f. People with existing diabetes glycaemic control HbA1c (mmol/mol ) e. 3 – 4 monthly HbA1c should have mental and g. Assessment of emotional mmol / mol emotional health monitored and wellbeing i. Eye examinations with dilated g. Retinopathy / be monitored for depression pupils & retinal camera Foot care h. People with severe j. Foot health f. Continue to follow medication mental health diagnosis g. Information about monitoring algorithm should be checked h. Erectile Dysfunction and glucose meters where annually for diabetes k. Sexual health appropriate g. Once stabilised, regular review l. Travel See Maintenance phase i. Obesity m. Diabetes UK / support groups j. Peripheral arterial disease n. Offer structured education programme
MILESTONE 1: DIAGNOSIS OF DIABETES MELLITUS PRESENTING SYMPTOMS 1. Patient presents with signs and symptoms suggestive of Type 2 diabetes Excessive thirst Polyuria especially at night Lethargy Weight loss Blurred vision Infections e.g. pruritis, balanitis None of the above 2. At routine /ad hoc health review patient has glycosuria 3. Increased suspicion due to risk factors Ethnicity Family history ≥ 40 years of age Previous gestational diabetes Polycystic ovarian syndrome Existing severe mental illness such as schizophrenia WHO DIAGNOSTIC CRITERIA FOR DIABETES MELLITUS NB: In the absence of osmotic symptoms 2 consecutive venous samples are required to diagnose Diabetes Mellitus PLASMA DIABETES CONFIRMED IMPAIRED GLUCOSE IMPAIRED FASTING GLYCAEMIA TOLERANCE FBG ≥ 7.0 mmol/L < 7.0 mmol/L ≥ 6.1 mmol/L < 7.0 mmol/L OGTT ≥ 11.1 mmol/L ≥ 7.8 mmol/L Do OGTT to exclude diabetes 2 hour value
Early Detection of Type 2 Diabetes and Management of Pre- Diabetes Presentation with symptoms and raised Identification of more than 1 risk factor plasma glucose≥11.1mmol/L • IGT/IFG • Age >45yrs (≥35 yrs in high risk ethnic groups) with BMI >30 and hypertension • Cardiovascular disease • Polycystic ovarian syndrome • Previous gestational diabetes • Family history with BMI >30 • Metabolic syndrome • No Symptoms Risk assessment questionnaire Annual risk questionnaire above threshold? Yes Check fasting plasma glucose or Oral glucose tolerance test if previous IGT/IFG high risk FBG ≥7mmol/L FBG 6.0-6.9 mmol/L
MILESTONE 2: EDUCATION IN TYPE 2 DIABETES STEP 1 STEP 2 STEP 3 STEP 4 STEP 5 STEP 6 STEP 7 Assess Review Discuss Discuss Facilitate Understanding Review learning needs understanding Lifestyle issues Complications Dietetic referral the annual understanding review Determine first What is diabetes? Eyes Give “stop gap” Height, weight, Importance of language Diet dietary advice BMI, waist regular diabetes circumference checks CVD Physical Is the patient Importance of Has patient been BP Review activity literate in referred to concordance with Welsh/English? regular diabetes Kidney dietitian? medication checks Routine blood Smoking tests / urine tests Review YES • HbA1c concordance with Is the patient What to expect at Erectile mmol/mol Alcohol Recheck healthy eating literate in own an Annual Review Dysfunction • U&E understanding • TFT regimen language? • LFT Importance of • Lipid profile medication Neuropathy NO • eGFR Assess gaps in Diabetes UK / knowledge and Cymru e.g. Refer to • ACR dietitian provide www.diabetes.org.uk/cy Arrange mru education as Social appointments as PVD Foot assessment appropriate adjustments necessary with • Pedal pulses • Neuropathy interpreter mental and status Foot emotional Offer patient structured well being Retinopathy diabetes status education Enrolment onto Driving programme regulations DRRSW Programme
MILESTONE 3: TREATMENT MANAGEMENT IN TYPE 2 DIABETES (Hywel Dda Health Board Prescribing Formulary) = Usual approach = Alternative approach IN THE FIRST INSTANCE, UNLESS THERE IS A CONTRA – INDICATION AIM FOR HbA1c 48 mmol/mol (6.5%) This will need to be reviewed on an annual basis, as diabetes progresses, HbA1c treatment target for intervention can be increased to 59 mmol/mol (7.5%) INITIATE HEALTHY EATING PLAN AND INCREASED ACTIVITY FOR AT LEAST 12 – 16 WEEKS UNLESS SYMPTOMATIC AGREE LEVEL OF HbA1C (mmol/mol) FOR INTERVENTION Consider first METFORMIN SULPHONYLUREAS METFORMIN SHOULD NOT TO BE INITIATED IF SERUM CREATININE If not overweight , or Metformin not tolerated, LEVEL IS > 150 µmol/L OR eGFR < 30 or a rapid therapeutic response is required because of hyperglycaemia Review response to medication using the step guidelines, within 28 days in the first Consider a rapid-acting secretagogue for people with erratic lifestyles instance, then 3 – 4 monthly using HbA1c mmol/mol GLICLAZIDE GLIMEPIRIDE Commence 500mgs BD / TDS Further increase as tolerated 80 mgs OD/ 40 mgs 1 mg OD 1 gm BD/TDS. BD If unable to tolerate Metformin, or compliance issues, consider reducing current dose 80 mgs BD 2 mgs OD or change to slow release Metformin up to 2 gm OD 160 mgs AM / 4 mgsOD Review Metformin dose if serum Creatinine 130 µmol/L or eGFR 45 80 mgs PM SEE CKD PATHWAY FOR LONG TERM MONITORING 160 mgs BD max 6mgs max nd Consider second when HbA1c 48 mmol/mol or 6.5% if sulphonylurea is not appropriate 2 line or risk of hypoglycaemia THIAZOLIDINEDIONES (TZD) DPP-4 INHIBITORS Can be added to Metformin or sulphonylurea If significant risk of hypoglycaemia Licensed for monotherapy use in patients who cannot tolerate Metformin If sulphonylurea or Metformin is not tolerated or contraindicated Can be used with a sulphonylurea if control sub-optimal and cannot tolerate Metformin Not Can be used combination with Metformin when Metformin plus diet and recommended in patients with evidence of heart failure*or a higher risk of fractures. Check LFT exercise, does not provide adequate glycaemic control. prior to starting treatment, 2 months after & annually thereafter It can also be used in combination with either a sulphonylurea or a glitazone**. PIOGLITAZONE Continue only if > 0.5% (5-6 mmol/mol) reduction in HbA1c at 6 *Can be used with insulin months which is maintained NOT recommended in patients with microscopic haematuria or history of bladder SITAGLIPTIN SAXAGLIPTIN cancer **has triple licence Can be used as add on to insulin Can be used as add-on to 5 mg OD 15 - 30 mg OD Maximum 45 mgs OD insulin If on sulphonylurea dose may 100MG OD need to be reduced CAUTION WHEN USED WITH SULPHONYLUREAS, RESPONSE MAY NOT BE APPARENT FOR 6 – 12 WEEKS In mod-severe renal failure a dose of If on sulphonylurea dose may 2.5mg OD need to be reduced
MILESTONE 3: TREATMENT MANAGEMENT IN TYPE 2 DIABETES Consider third when HbA1c 59 mmol/mol (or > 7.5% ) or higher than individually agreed target TZD DPP-4 GLP-1 NPH INSULIN OTHER INSULIN ALPHA INHIBITOR If BMI ≥ 35 kg/m2 and other Ensure training course in GLUCOSIDASE psychological/medical problem associated with Ensure insulin initiation done INHIBITOR See overleaf See above and raised BMI training course and If insulin is not If BMI ≥ 35kg/ m2 for whom insulin is in insulin ACARBOSE If insulin is acceptable or unacceptable because of occupational implications initiation 50 mg OD not inappropriate or where weight loss would benefit other co- Can be considered if Increase to 50 mg TDS acceptable or Only Sitagliptin morbidities. patient requires assistance after 6 weeks 100mg inappropriate can be used in Continue GLP-1 only if beneficial response seen At bedtime or TDS combination and maintained (>1.0% reduction in HbA1C at 6 twice daily 200 mg TDS with Metformin months and weight loss of at least according to and a 3% at 6 months) need. from a carer/HCP to Sulphonylurea Check SPC for contraindications administer If lifestyle is restricted by EXENATIDE LIRAGLUTIDE recurrent hypoglycaemia Prolonged Release Once Once daily dose 1.2mg If would otherwise need WEEKLY max BD insulin and oral OHAs or Not meal related If cannot manage injection 1.8mg dose is not device for NPH Twice daily recommended by NICE Meal related The initiation of insulin or GLP-1 to people with diabetes should only be carried out by: Practices that have attended an appropriate training course on insulin initiation and management and regularly maintain education update and use GLP-1 in accordance with NICE guidelines or discussed with secondary care Consider fourth if HbA1c remains 59 mmol/mol or 7.5% NPH INSULIN OTHER INSULIN Consider Pioglitazone or Ensure training course in insulin Sitagliptin with insulin if: • Ensure initiation training 1. Long acting insulin analogue Pioglitazone or Sitagliptin has course in See above and switch if: previously had a marked insulin Target HbA1c not reached due to significant glucose lowering effect or initiation hypoglycaemia Blood glucose is inadequate has been Cannot manage device for insulin done without high dose insulin Requires assistance from carer/ HCP to administer 2. Premix insulin
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT 1. Aim for Blood Pressure HYPERTENSION measurement of: Step 1 If NO microvascular Offer ACE inhibitor complications are Ramipril caps 2.5 – 10mg OD or Lisinopril 2.5-80mg OD. present (Offer contraception advice to women of childbearing age) ≤ 140 / 80 mmHg For people of African – Caribbean descent, offer ACE inhibitor plus Diuretic If eye or renal complications Bendroflumethiazide no more than 2.5mg OD as maximum dosage (check U&Es prior commencing and monitor are present aim for
REFER TO SPECIALIST SERVICE IN CASES OF UNRESOLVED HYPERTENSION
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONT’D… LIPIDS RAISED LIPID PROFILE: 1. Statin should be offered to all those aged 40 or above with either Type 1 or Type 2 diabetes (If 6.0 mmol /L • Features of metabolic syndrome • Family history of premature cardiovascular disease in a first degree relative Step 1. Simvastatin 40mg nocte (if patient on Warfarin or is intolerant of Simvastatin, try Pravastatin up to 40mg nocte) Patients on amlodopine or diltiazem should not exceed 20mg dose of simvastatin. NB Intolerance is typically muscle or liver related: myalgia and/or rhabdomyolysis, CK > 10x or LFTs (AST/ALT) >3x normal Increase to 80mg simvastatin (unless poor response and/or side-effects to 40mg dose) Step 2. Atorvastatin 40mg once daily (may wish to consider initiating 20mg due to individual patient response) Step 3. Atorvastatin 80 mg once daily Step 4. Consider Ezetimibe 10mg as monotherapy if statin contraindicated or not tolerated Step 5. In patients who have not reached target, cannot tolerate statins, or who have high CV risk and TG = 2.3 – 4.5 mmol/L despite statin, consider addition of a fibrate (e.g.Fenofibrate) on case by case basis and consider referral to specialist services. Omega-3 is not recommended for the routine treatment of raised TGs in diabetic patients.
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONT’D… ANTI PLATELET THERAPY: Primary prevention: Anti platelet therapy should only be prescribed following an assessment of patient’s individual CV risk and a review of the risks: benefits for that patient. Secondary Prevention: Anti platelet therapy should be prescribed st 1 line: Soluble aspirin 75 mg daily. This is to be given unless there is an absolute contraindication nd 2 line: For patients who cannot tolerate soluble aspirin, or have a history of ulceration, add in either Lansoprazole Capsules 15mg OD or Omeprazole Capsules 20mg OD and continue with soluble aspirin rd 3 line: If aspirin is still poorly tolerated, contra-indicated, has had a previous cardiovascular event, or compliance issues favour monotherapy Clopidogrel 75mg daily
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT OBESITY ASSESSMENT All patients with diabetes should have their BMI recorded annually Classification of BMI*: CLASSIFICATION BMI RISK OF CO-MORBIDITIES Underweight 30.0 Increased Class i 30.0 – 34.9 Moderate Class ii 35.0 – 39.9 High Class iii >40 V High *DoH Waist circumference: SEX METRIC IMPERIAL Male >102 cm ≥ 40 inches Asian male ≥ 90cm ≥ 35 Female ≥88 cm ≥ 35 Asian female ≥80 cm ≥ 31 Medical history e.g. Current glycaemic control, hypothyroidism, hypertension, hyperlipidaemia, CHD, PCOS, sleep apnoea, osteoarthritis, learning disabilities, mental health issues Family history Social history e.g. Alcohol, smoking status Drug history e.g. sulphonylureas, anti-psychotics, steroids Dietary history Physical activity status Readiness to change: Explore how person feels. Inform about solutions. Provide insight into risks Active treatment of the obese person with diabetes should commence when BMI is greater than 28
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT OBESITY CONT’D TREATMENT OF OBESITY Aim of treatment is to: Reduce calorie intake – 59 mmol/mol or 7.5% and BMI >35 Or Refer to secondary care IF BMI IS > 40, CONSIDER BARIATRIC SURGERY and refer to secondary care
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONT’D MANAGEMENT OF PERIPHERAL ARTERIAL DISEASE Patient presents with - Intermittent Claudication (IC): A cramp like pain in the legs when walking or exercising (can be found in calf or thigh muscles and buttocks) - Known Arterial Disease (Coronary, Carotid or renal artery disease) - Absent or diminished Dorsalis Pedis or Posterior Tibial pulses - Rest pain or gangrene of leg / foot - Poorly healing / non healing wounds on leg or foot - People who have increased risk of arterial disease e.g smokers, dyslipidaemia, hypertension, Ankle:Brachial Pressure Index to be calculated.If this facility is not available “in –house” please refer to Community diabetes/ District nurses for neurovascular assessment using Podiatry referral form and stating level of urgency A:BPI < 0.9 **Actively A:BPI > 0.9 treat risk factors** BP Aim to be < 130/ 80 The A:BPI may be falsely elevated due to medial artery calcification. This will Aim for good glycaemic control (see Milestone 3:Treatment management ) elevate the A:BPI to above 1.3 Commence antiplatelet therapy If IC symptoms present, patient will need to be referred for an exercise Doppler If Cholesterol > 4 mmol/L commence statin (See Milestone 4: Complications / examination at via referral and triage form Risk management) If drop in A:BPI post exercise occurs, PAD is diagnosed and patient to be treated Smoking cessation as if A:BPI is < 0.9 See text box opposite Weight loss If A:BPI shows no reduction other causes for painful symptoms may to be Exercise therapy “ Keep walking” investigate If lifestyle impairment SEVERE MILD IMPAIRMENT IMPAIRMENT Refer to Vascular Team Exercise therapy Glangwili hospital Review 3/12 Consider naftidrofuryl oxalate 100mg 1-2 tds if no improvement on exercise therapy alone (stop if ineffective after 3/12) (NICE TA 223) Referral criteria to Specialist services (6Ps) Rapid onset of symptoms: Pain, pulselessness, pallor, paraesthesia, paralysis, perishingly cold = Emergency referral Deterioration in chronic symptoms: Ischaemic rest pain, gangrene, non healing wound or ulceration, infection = Urgent referral References: SIGN, TASC II, CFH guideline for management of PAD Diabetic foot protocol
MILESTONE 4 COMPLICATIONS/RISK MANAGEMENT: ALL WALES DIABETIC FOOT CARE PATHWAY All people with diabetes should be offered routine annual foot assessment ANNUAL REVIEW – CALL AND RECALL To be undertaken by a person appropriately trained (National Minimum Skills Framework): Primary care team, GP Practice Nurse District Nurse DSN, Link Nurse Health Care Worker, Podiatrist RISK FACTORS – Glycaemic control, Hyperlipidaemia, hypertension, weight management, Retinopathy, Nephropathy, Smoking Assessment of social & educational needs FOOT ASSESSMENT - callus / corns, deformities, muscle strength, amputations, ulceration, scarring, condition of nails, footwear VASCULAR ASSESMENT - pedal pulses / Doppler (8 MHz), signs/ symptoms NEUROLOGICAL ASSESSMENT - 10 g monofilament and 128 Hz tuning fork (Rydel Seiffer tuning fork) LOW RISK INCREASED RISK HIGH RISK VERY HIGH RISK Normal sensation, palpable pulses, no foot Neuropathy or absent pulses or foot pathology or Neuropathy or absent pulses AND deformity Ulcerated foot, acute cellulitis, sepsis – pathology other risk factor or skin changes or previous Urgent referral to MDT/Podiatry Tissue Annual Review Community Podiatry ulceration/amputation Viability wound management team Management by the primary care team Review 3-6months Specialist Podiatry Management Revascularisation Basic Foot care Education/ Structured Proactive foot care education Review 0-3 months Infection control education Contact numbers for foot emergencies Proactive specific foot care education Glycaemic Control/ medical management Empowerment for self care Assess footwear and insoles requirements Radiological investigations Contact numbers for foot emergencies Offloading/pressure relief Community Podiatry Routine Care Intermediate/ Specialist ULCER CLINIC Treatment Plan High Risk Podiatry Clinics Wound Healing / Management including education Advanced neurological and vascular Tissue Viability Orthotics /Appropriate Footwear assessment Specialist treatment plan MULTIDISCIPLINARY DIABETIC FOOT CLINIC (where available) Acute foot problems, cellulitus, new or chronic ulceration, trauma, acute onset of pain (charcot foot, infection. painful neuropathy Diabetologist & Diabetic Hospital Team Orthotist Specialist Footwear / Insoles Podiatrist Diabetes Specialist Nurse Review HBA1c & Control Vascular Consultant & Vascular Team- (Dedicated pathway) Dietician (Dedicated Pathway) Orthopaedic Referral (Dedicated Pathway) Pain Team (Dedicated Pathway) Plaster Technician (Dedicated Pathway) Tissue Viability Specialist
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONT’D… TREATMENT OF ERECTILE DYSFUNCTION (ED) Identify and treat curable causes of ED where possible: Endocrine cause: Poor control of DM, Hypogonadism, Hyperprolactinaemia, Hypo / Hyperthyroidism, Cushing’s syndrome (will need Endocrine referral) Vascular cause: PVD, CKD Urological: Previous injury, Pelvic / Prostatic surgery or radiation therapy (may need urology referral) Neurological cause: MS, Alzheimers, Parkinson’s, spinal cord injury (may need neurology referral) Medications: Beta-blockers, Alpha Adrenergic Antagonists, Diuretics, Sedatives, tranquilizers, anxiolytics, antidepressants, antipsychotics, Corticosteroids, digoxin, NSAIDs, H2 Antagonists etc Lifestyle / habit / addiction: Substance abuse, smoking, alcoholism, anabolic steroids, Heroin, Marijuana Psychological Lifestyle changes and risk factor Education for patients and partners Counselling for patients and partners modification Describe treatments available Refer for psychosexual therapy Send blood for hormone levels Assess current CV risk & medication history (e.g.nitrates) PRESCRIBE PDE5 INHIBITORS TRIAL: ALTERNATIVE THERAPIES: The prescribing physician should be aware of mode of action, cautions, contra- NB: PATIENT NEEDS TO BE REFERRED TO UROLOGIST / ED indications, side effects as per BNF CLINIC TO BE TRAINED IN USE OF THESE PRODUCTS Frequency of treatment needs to be considered on a case by case basis. One treatment per week is usually appropriate (DoH) Intracavernosal injections:Caverject, Viridal Duo DRUG DOSE MINIMUM INFORMATION FOR Intraurethral alprostadil: Muse PATIENTS Vacuum devices 50 – 100 mg Start at 50 mg and titrate Effective 30-60 mins in Penile implants SILDENAFIL presence of sexual stimulation Viagra according to response and Effect reduced by fatty meal side effects Half life 4 hours ASSESS THERAPEUTIC OUTCOMES 5 – 20 mg Start at 10mg and titrate Effective after 25 – 60 mins in IT IS ESSENTIAL IN DIABETES TO ADVISE PATIENTS TO TAKE ORAL presence of sexual stimulation VARDENAFIL according to response and MEDICATION APPROXIMATELY 4 HOURS PRIOR TO SEXUAL (can be as early as 10 mins) Levitra side effects ACTIVITY AS IT HAS BEEN OBSERVED THAT ONSET OF ACTION MAY Effect reduced by fatty meal Half life 4.5 hours BE DELAYED IN MEN WITH DIABETES. 5 – 20mg IF SILDENAFIL IS INEFFECTIVE CHANGE TO ANOTHER PDE5 Start at 10mg and titrate Effective after 30 mins in INHIBITOR VARDENAFIL CURRENTLY IS THE MOST COST TADALAFIL presence of sexual stimulation EFFECTIVE ALTERNATIVE according to response and Effect not reduced by food Cialis side effects and alcohol Half life 17.5 hours
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONTD… RENAL COMPLICATIONS / MICROALBUMINURIA SCREENING ** PLEASE NOTE THAT THESE TESTS ARE IN ADDITION TO THE eGFR ** DIPSTICK URINE FOR PROTEIN USING MULTISTIX / ALBUSTIX IF NEGATIVE IF POSITIVE st Refer to local laboratory guidelines for EMU collection protocol If 1 specimen is abnormal exclude UTI (collect MSU) nd Collect EMU for Albumin / Creatinine ratio If 2 specimen is abnormal quantify proteinuria by albumin / creatinine ratio (ACR). Normal A : C Ratio Males < 2.5 mg / mmol Females < 3.5 mg / mmol Treat to target 1. BP (Aim < 130 / 80) If specimen is within normal range retest annually 2. Glycaemic control HbA1c ≤ 48 mmol/mol (7.5%) 3. Commence ACE inhibitor or ARB if intolerant to ACEI (Irbesartan has licence in microalbuminuria) Repeat ACR after 6 months If specimen is abnormal, refer to specialist care according to local CKD guidelines SEE eGFR GUIDELINES NICE Clinical Guideline 66 Management of Type 2 diabetes mellitus, May 2008
MILESTONE 4: RENAL COMPLICATIONS- Annual albumin screening Annual urine microalbumin screening Raised Values Normal Values ≥ 2.5 mg/mmol, males < 2.5 mg/mmol, males ≥ 3.5 mg/mmol, females < 3.5 mg/mmol, females NO First high reading Established microalbuminuria or proteinuria YES Ensure urine sample obtained under appropriate conditions (exclude UTI) Titrate to highest recommended dose of ACE-I/ A2RB to Repeat early morning urine on 2 separate mornings to confirm target BP < 130/80 level of microalbuminuria* Optimise HbA1c to 48-59 mmol/mol (6.5-7.5%) (Positive test - if 2 out of 3 samples elevated. Repeat samples positive Commence statin and aspirin. tested one week apart. Urge smoking cessation In the event of negative tests – return to annual screening If proteinuria persistent over 6-12 months arrange USS kidneys and refer to secondary care services If proteinuria confirmed (alb/creat ≥ 30mg/mmol) in the absence of significant retinopathy investigate for non-diabetic causes N.B. Refer to nephrologists if eGFR < 30 ml/minute/1.73m2 or if non diabetic aetiology suspected e.g. short duration of diabetes, the presence of the nephritic syndrome, collagen vascular disease, haematuria with a structurally normal urinary tract, or rapid worsening of GFR or proteinuria.
MILESTONE 4: RENAL COMPLICATIONS - Microalbuminuria Lifestyle measures • Brief intervention on smoking, signposting to cessation support service Stop Smoking Wales • Restrict dietary salt. (Unrestricted salt intake can virtually eliminate the antiproteinuric effect of an ACE inhibitor.) • All patients with chronic renal disease (stage 3: National Kidney Foundation) should undergo nutritional screening. Individuals identified as having an inadequate dietary intake should have identifiable causes corrected, in addition to receiving appropriate advice from a registered dietitian. • Advice on weight reduction if obese (and has not received this as a part of diabetes care to date) Pharmacotherapy • Begin or titrate ACE or if intolerant A2RB to maximum tolerated dose irrespective of initial blood pressure. Check serum creatinine and potassium 2 weeks after initial dose and after subsequent increases in dose. A stable rise in creatinine of up to 20% or a 15% fall in eGFR does not require dose adjustment. If serum creatinine continues to rise then ACE/A2RB should be stopped and the possibility of renal artery stenosis considered. • Treat with Statin and attend to glycaemic control • Aspirin 75 mg od (given due to increased cardiovascular risk) Treatment Targets: Blood pressure control Target blood pressure to: ≤ 140/80 in all diabetic patients ≤ 130/80 in microalbuminuria/proteinuria Glycaemic control: HbA1c 48-59 mmol/mol (6.5 - 7.5 %) The risk of hypoglycaemia increases as renal disease progresses. This needs to be balanced against the benefit of tight control Lipids Commence lipid-lowering therapy unless contra-indicated in all patients with microalbuminuria or proteinuria. Lipid Targets Total cholesterol < 4 mmol/L OR LDL cholesterol < 2 mmol/L HDL cholesterol ≥ 1.0 mmol/L These guidelines are based on: CG73 NICE Guideline: Early Identification and management of Chronic Kidney Disease in adults in primary and secondary care, September 2008
Chronic Kidney Disease (CKD) and the estimated Glomerular Filtration Rate (eGFR) • Chronic Kidney Disease (CKD) is common. It affects approx 10% of the population and is often asymptomatic until renal function is severely reduced. • Serum creatinine has traditionally been the mainstay for the initial identification of renal disease. Serum creatinine on its own does not detect minor degrees of kidney impairment and is not directly related to the GFR. • eGFR forms the basis for the classification and management of CKD. • CKD is an important risk factor for cardiovascular problems. eGFR makes it easier to tell who should be offered treatment. • DoH has recommended a formula-based eGFR calculation which is used for the identification and initial staging and monitoring of CKD patients being ml/ minute / 1.73 m2. • eGFR is not applicable in people < 18 years, acute renal failure, pregnancy, amputees, extremes of body weight, 1 kidney. eGFR result Severity of CKD Frequency of testing 1/2 60 - > 90 Normal/Mild Annually 6 months (12 months if stable) Refer to secondary care if not 3 30-59 Moderate renal impairment stable or rapid decline 3 months if stable Refer to nephrology if not 4 15-29 Severe kidney disease stable or rapid decline
MILESTONE 4: Management of Chronic Kidney Disease (CKD) Annual estimated eGFR) (MDRD*); serum creatinine Dipstick urine for blood and protein (as above) Abnormal eGFR < 60 eGFR ≥ 60 ml/min/1.73m2 (
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONT’D - PAINFUL NEUROPATHY DIAGNOSIS HISTORY - Consider differential diagnosis (alcohol excess, B12 deficiency, malignancy) - Sometimes acute, sometimes insidious onset and progressive - Paraesthesia in toes, feet and shins - Anaesthesia - Hyperaesthesia Symptoms often worse at night or at rest PAIN - A wide variety of descriptions of peripheral symptoms can be present. - Careful patient questioning is necessary as symptoms can be confusing - Consider use of Pain Pictures or S-LANNS assessment questionnaire Symptoms may include: - Numbness - Tingling - Prickling - Pins and Needles - Aching - Dull pain - Burning - Buzzing - Cold - Sharp - Knife – like - Electric shocks The severity of individual patient symptoms will influence which step of the care pathway is appropriate for commencement of treatment SIGNS WEAKNESS - Distal and/or proximal - Loss of reflexes NEUROPATHIC EXAMINATION - 10 g Monofilament - Vibration perception (tuning fork 128 Hz), calibrated tuning fork, Bio / Neurothesiometer) - Proprioception - Light touch - Sensory loss glove and stocking distribution
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONT’D - PAINFUL NEUROPATHY PERIPHERAL NEUROPATHY HAS BEEN DIAGNOSED STEP 1 Improve glycaemic control. Liaise with diabetes nursing team / dietician if appropriate. Aim for normoglycaemia Prescribe Amitriptylline 10-75mg at night or Duloxetine 60mg daily (child and adolescent under 18 years not recommended) If patient is experiencing night time cramps only, consider prescribing: - Quinine sulphate 200 – 300 mg nocte (Inform patient that it may take up to 1 month to see an improvement) - May benefit from low calorie Indian tonic water (not available on FP10) Reassure. (Use of pain diary may be useful) Review in 1 month If patient is reluctant to take oral medication consider Capsaicin cream 45 g, noting that initially there may be an intense burning sensation. STEP 2 Review symptoms, pain and glycaemic control If pain still present, reassure Check concordance with 1st line treatment and consider the alternative as in Step 1 Review in 1 month STEP 3 Review symptoms, pain and glycaemic control If pain still present / no improvement in symptoms, refer for specialist input Monitor therapy, and increase, up to maximum licensed dosage. Consider prescribing in place of previous medication: - Pregabalin 150 – 600 mg in divided doses - Consider addition of Tramadol 50mg – 150 mg tds STEP 4 Review symptoms, pain and glycaemic control If pain is not controlled referral to specialist pain clinic Updated NICE Guidance May 2010
MILESTONE 4: COMPLICATIONS / RISK MANAGEMENT CONTINUED FOOT CARE: 1. Ensure that feet are assessed including foot pulses, vibration, sensation by a competent practitioner annually (See also Milestone 4: Peripheral Arterial Disease – [PAD]) 2. Record results on diabetes template 3. Ensure that principles of good foot care are reiterated at each review 4. Refer for podiatry treatment as appropriate 5. Refer URGENTLY TO RAPID ACCESS FOOT CLINIC / DIABETES TEAM if any of the following problems occur: Acute foot injury (including any penetrating foot injury) Foot ulcer present Signs of infection Evidence of ischaemia noted Suspicion of Charcot’s neuropathy RETINOPATHY: 1. Ensure that patient understands the importance of annual retinopathy screening 2. Ensure that patient is enrolled on the Diabetes Retinal Screening Service for Wales for digital photography. Please contact DRSSW Telephone 01443 844244 3. At annual review, check that a result is present in the patient records dated within the last 12 months 4. Results of retinal screening should be discussed with patient
MILESTONE 5: MAINTENANCE 1. Regular review if unstable 2-3 monthly BP Lipids Glycaemic control (there is no benefit to repeating HbA1c reading more frequently than 3 monthly) Diet Lifestyle 2. 6 monthly review As above 3. Annual review Weight / BMI BP Review of medication Review of diet Review of glycaemic control Review of investigations - HbA1c - Lipids - U&E including eGFR - TFT - LFT if taking Glitazone or Statin - Albumin / Creatinine ratio (ACR) Foot examination - Shoes, socks, stockings MUST be removed - Observation of colour, warmth, sensation, symptoms, general appearance of nails, skin, callus etc. - Pedal pulses at Dorsalis Pedis and Posterior Tibial points -10gm Monofilament and vibration perception on BOTH feet Lifestyle issues - Driving - Physical Activity levels - Smoking - Alcohol - Sexual health/ contraception - Mental and emotional health(Assess Stress and depression)
FOR HDHB BILINGUAL FIRST LINE ADVICE SHEET – ‘HEALTHY EATING WITH APPENDIX 1 LIFESTYLE CHANGES DIABETES’ (SEE APPENDIX 8) HEALTHY EATING (STOP GAP INFORMATION) ADVICE TO BE GIVEN EXAMPLES Regular meals that include carbohydrates High fibre low salt and low fat breakfast cereals This will help to control blood glucose levels* Wholemeal / whole grain breads, including pitta, crackers, crispbreads Pasta and noodles Potatoes Rice Foods that are high in fibre* Beans Lentils Bran Wholemeal and wholegrain breads and cereals Fruit and vegetables Cut down / Eat less saturated fat* Less animal fats and fatty foods Choose olive oil, rapeseed oil or other vegetable oils Grill, steam ,bake food Use less butter, margarine, cheese and fatty meats Use low fat dairy foods like skimmed or semi skimmed milk, low fat yoghurt Reducing salt* Less processed food Leave out salt in cooking Buy reduced salt versions of food Use herbs and spices instead of salt Five a day* Try to eat five portions of fruit or vegetables a day, but limit fruit intake to no more than 3 – 4 portions a day A portion is a handful of fruit or vegetables Cut down on sugar / sugary foods* This does NOT mean a sugar free diet Sugar can be used as an ingredient in foods in small quantities Use sugar free, diet or low sugar squashes and fizzy drinks
APPENDIX 1 LIFESTYLE CHANGES CONT’D INCREASING PHYSICAL ACTIVITY ADVICE TO BE GIVEN EXAMPLES Aim to be active daily ncrease physical activity levels gradually until over a week activity builds up to at least 150 minutes (2 ½ hours) of moderate intensity activity in bouts of 10 minutes or more. One way to do this is 30 minutes of activity on at least 5 days of the week Brisk Walking daily Moderate intensity activity means activity that makes you feel warm and slightly breathless but you should still be able to talk Increase distance and speed Once exercising regularly, try cycling, swimming etc. Housework / gardening if mobility is limited If immobile teach armchair exercises Refer to National Exercise Referral Scheme (NERS) Recommend community based physical activity opportunities e.g. walking groups, activity classes If heart problems consider referral to cardiac rehab STOPPING SMOKING ADVICE TO BE GIVEN WHAT TO DO Give information about Stop Smoking Wales smoking cessation support service Assess smoking status Refer client to Stop Smoking Wales as this offers the best chance of quitting •Give client a Stop Smoking Wales referral card and encourage them to contact the Brief intervention on smoking, harms of continuing, benefits of stopping service for an appointment Accessing free Stop Smoking Service can support patients to stop smoking NICE (2006) guidance on Brief intervention for Smoking Cessation recommends that •Everyone who smokes should be advised to quit. People who smoke should be asked how interested they are in quitting •Health professionals and those who work with clients should refer people who smoke to an intensive support service such as Stop Smoking Wales Contact Stop Smoking WalesFREEPHONE 0800 085 2219 or www.stopsmokingwales.com
ALCOHOL ADVICE ADVICE TO BE GIVEN EXAMPLE Consume alcohol in moderation and within the recommended guidelines for 1 unit of alcohol = half a pint of ordinary strength beer or lager at 3.5% abv alcohol consumption 1 standardglass (125 ml)of wine at 8% abv 1 single standard measure (25ml) spirits at 40% abv (abv = alcohol by volume) Men should drink no more than 3 units a day/ 21 units per week Women should drink no more than 2 units a day / 14 units per week These rough alcohol units however are ineffective at calculating the actual amounts of alcohol consumed and can be misleading. Therefore recommended to calculate accurate alcohol units by the following formula: ABV x Amount in mls= 1000 = Unit value So a pint of Stella Artois would be:5.2 x 568 = 1000 = 2.9 units Both men and women should have at least 2 days per week where no alcohol is consumed and no binge drinking. (A binge is regarded as being half or more of the recommended allowance beign consumed in one drinking session i.e. 10.5 units for men and 7 units for women) Prism Generic Alcohol Services for Adults tel 01267 231634 Free, open access service to people who have difficulties with their own or someone elses use of alcohol, for adults over 18 in Pembrokeshire, Carmarthenshire and Ceredigion Alcoholics Anonymous NationalHelpline0845769555
*Diabetes UK Patient information www.diabetes.org.uk Mental and Emotional Health ADVICE TO BE GIVEN EXAMPLES How to cope with a diagnosis of diabetes Talking to your healthcare professional about how you feel and how you are coping. Healthcare professional giving support and reassurance. www.diabetes.org.uk has section on coping with diabetes. 10 positive steps – keeping active, eating well, drinking in moderation, talking about your feelings, keeping in touch with friends and loved ones, asking for help, taking a break, doing something you are good at, valuing yourself and others, caring for others.(Mental Health Foundation – website below) Maintain and protect and your mental and emotional health www.mentalhealth.org.uk
APPENDIX 2 PATIENT EDUCATION After diagnosis it is essential that education is given at a level appropriate to individual needs. EDUCATION CHECKLIST INFORMATION TO BE GIVEN SIGN OFF WHEN GIVEN Patient information booklet given (Specify) Patient hand held record given What is diabetes Causes of diabetes The Annual Review - what care to expect HbA1c normal ranges Lifestyle issues: Diet Physical activity Smoking Alcohol Mental and emotional health Medication – relevant information about current medication Hypoglycaemia Hyperglycaemia Driving What / when to report to DVLA Sick day rules Possible complications associated with poor control: Retinopathy and importance of annual screening Renal problems Arterial problems Neuropathy Foot problems / foot care Travel Fasting / feasting Blood glucose monitoring Sexual Health – women (see appendix) Sexual Health – men (Erectile Dysfunction) Diabetes UK info Yearly Flu immunization recommendation and review pneumococcal status
Appendix 3: Blood glucose monitoring in Primary Care All patients monitoring blood glucose levels should be advised to check the accuracy (Quality Assurance) of the blood glucose meter on a monthly basis. Control solutions used to carry out this procedure are, in most cases, available free of charge from the manufacturer. FREQUENCY OF TESTING Type 1 diabetes Type 2 diabetes If on diet and physical activity Blood glucose testing is essential for ALL people with type 1 diabetes If taking - Patients do not need to monitor blood glucose levels on a daily basis. Ensure HbA1c is undertaken regularly. basal bolus regimen this could be up to 6 times a day If on diet, physical activity and Metformin (+/- Glitazone) Frequency may be increased during intercurrent illness - As above Ketone testing equipment should be available for times of acute illness If on sulphonylurea / Insulin secretagogue Drivers should maintain a record (as per DVLA recommendations) and test - Increased risk of hypoglycaemia. Testing may be necessary to confirm or avoid this prior to all journeys including those on sulphonylureas Type 2 on conventional insulin therapy Pre Pregnancy and pregnancy - may be necessary to test up to 6 times daily - If stable, 2 – 3 times a week at different times - If unstable, once daily testing at different times of the day until stability achieved Approximate usage - See Type 1 diabetes for DVLA recommendations Six tests per day = 48 boxes (50 strips each) per year Type 2 on intensive insulin therapy = 4 boxes per month - May be necessary up to 6 times daily One test per day = 8 boxes per year - See Type 1 for DVLA recommendations Pre Pregnancy and pregnancy Three tests per week = 4 boxes per year (This includes extra strips for testing when ill & accidental wastage) - May be necessary up to 6 times daily PTO… An annual assessment of self-monitoring skills, quality and frequency of testing, the use made of results, impact on quality of life and equipment used is essential.
Appendix 3: Blood glucose monitoring in Primary Care cont’d When considering suitability for blood glucose monitoring the following points should be considered: Visual acuity Manual dexterity Ability to use blood glucose meter Willingness of patient to perform tests When initiating blood glucose monitoring the following process should take place: Offer choice from standardised range of meters ONLY according to patient needs Demonstrate chosen meter and finger pricking device, identifying procedure for patient to follow Give information on the safe disposal of sharps Issue blood glucose monitoring diary indicating agreed individual target range and frequency of testing (See previous page) Give information to patient regarding what to do with self testing results Ensure patient has a contact number for access to HCP advice Arrange to review self testing results at a suitable interval
Appendix 4: Nutrition and Dietetic Services Hywel Dda Health Board Draft of Referral Criteria for Diabetes 2011 Referral Criteria for Diabetes Referral Details / Notes Evidence Base First Line Advise / Signposting Newly Diagnosed Type 1 Referred to structured group Consensus Guidelines for the www.diabetes.org.uk is a reliable education programme (as Management of Adults with evidence based website for HCP and appropriate) after 1:1 with Diabetes across Wales (2008) all patients with Diabetes Urgent Dietitian NICE Guidance: Type 1 Diagnosis & Management (2010) Poorly controlled Type 1 Diabetes Referred to structured group Consensus Guidelines for the www.diabetes.org.uk is a reliable education programme where Management of Adults with evidence based website for HCP and available, otherwise please Diabetes across Wales (2008) all patients with Diabetes Routine complete Dietetic referral form with detail to enable NICE Guidance:Type 1 Diagnosis effective/optimal problem & Management (2010) solving Carbohydrate Counting for Insulin Structured Group Education Consensus Guidelines for Wales www.diabetes.org.uk is a reliable Dose Adjusting - Education Programme when possible. (2008) evidence based website for HCP and all patients with Diabetes Refer to Dietetic service if NICE Guidance: Type 1 (2010) programme not available / if Routine patient prefers individual NICE Guidance: Insulin Pump consultation Therapy (2008)
Appendix 4: Dietetic referral criteria Diabetes in Pregnancy/Gestational Urgent 1:1 consultation Consensus Guidelines for Wales (2008) www.diabetes.org.uk is a reliable evidence Dietetic Referral Criteria HDHB April 2011 required Diabetes based website for HCP and all patients with Refer to Dietetic service & NICE Guidance: Diabetes in Pregnancy Diabetes Urgent contact service to enable (March 2008) combined appointment when possible Type 2 Diabetes (new or poorly First choice: XPERT structured Consensus Guidelines for Wales (2008) First line advice from HCP controlled) group education programme for people with Type 2 diabetes. The Diabetes National Service The Health Board’s Dietetic Service ‘First Line XPERT referral form need to be Framework NSF for Wales (2003) Advice’ booklet is available for use by HCP completed & forwarded to local Routine diabetes team. NICE Guidance: The Management of Refer for 1:1 consultation with type 2 Diabetes (2008) Dietitian if the patient is not appropriate for group education The Implementation of Nutritional Advice for People with Diabetes: Diabetes UK (2003) Type 2 Diabetes progressing onto First choice: XPERT structured Consensus Guidelines for Wales (2008) www.diabetes.org.uk is a reliable evidence insulin therapy group education programme, based website for HCP and all patients with Refer for 1:1 consultation with NICE Guidance (2008) Diabetes Dietitian if the patient is not appropriate for group education NSF (2003) Routine IGT/IFG Consensus Guidelines for Wales (2008) First line advice from HCP Routine NICE Guidance:Type 2 (2008) The Health Board’s first line weight management patient information leaflet can be used by HCP Encouraged to increase physical exercise & consider referral to Exercise for Life programme www.food.gov.uk/healthiereating/eatwellplate/ Reliable information on healthy eating for HCP and patients
Appendix 4: Dietetic referral criteria Referrals to the Dietetic Service should include the following information as a minimum: Full Name: D.O.B. Address: NHS number: Contact details: Reason for Referral: Medical History (& relevant family history), including height, weight, BMI and recent biochemistry results. Current Medication: Other Information:
Appendix 5: Pregnancy and Diabetes/IGT Ask patient if she is planning pregnancy No, not planning pregnancy Yes, thinking of pregnancy Check HbA1c if Screen for Review all meds Offer / refer to none within last 6 complications Commence folic acid 5mg pre-conception Check she is taking effective months Retinal/ Advice smoking cessation clinic contraception microalbuminuria Advise to seek advice if she Check U/E, TFT, wishes to be pregnant rubella HbA1c >7% (53mmol/mol), HbA1c
Appendix 6: HbA1c Conversion Chart. Older DCCT-aligned (%) and newer IFCC-standardised (mmol/mol) concentrations DCCT (%) IFCC DCCT (%) IFCC DCCT (%) IFCC DCCT (%) IFCC DCCT (%) IFCC (mmol/mol) (mmol/mol) (mmol/mol) (mmol/mol) (mmol/mol) 5.0 31 6.0 42 7.0§ 53 8.0 64 9.0 75 5.1 32 6.1 43 7.1 54 8.1 65 9.1 76 5.2 33 6.2 44 7.2 55 8.2 66 9.2 77 5.3 34 6.3 45 7.3 56 8.3 67 9.3 78 5.4 36 6.4 46 7.4 57 8.4 68 9.4 79 5.5 37 6.5†,‡ 48 7.5†,‡ 58 8.5 69 9.5 80 5.6 38 6.6 49 7.6 60 8.6 70 9.6 81 5.7 39 6.7 50 7.7 61 8.7 72 9.7 83 5.8 40 6.8 51 7.8 62 8.8 73 9.8 84 5.9 41 6.9 52 7.9 63 8.9 74 9.9 85 DCCT (%) IFCC DCCT (%) IFCC DCCT (%) IFCC DCCT (%) IFCC DCCT (%) IFCC (mmol/mol) (mmol/mol) (mmol/mol) (mmol/mol) (mmol/mol) 10.0 86 11.0 97 12.0 108 13.0 119 14.0 130 10.1 87 11.1 98 12.1 109 13.1 120 14.1 131 10.2 88 11.2 99 12.2 110 13.2 121 14.2 132 10.3 89 11.3 100 12.3 111 13.3 122 14.3 133 10.4 90 11.4 101 12.4 112 13.4 123 14.4 134 10.5 91 11.5 102 12.5 113 13.5 124 14.5 135 10.6 92 11.6 103 12.6 114 13.6 125 14.6 136 10.7 93 11.7 104 12.7 115 13.7 126 14.7 137 10.8 95 11.8 105 12.8 116 13.8 127 14.8 138 10.9 96 11.9 107 12.9 117 13.9 128 14.9 139
Appendix 7: Useful Telephone Contacts Locality Carmarthenshire Ceredigion Pembrokeshire Diabetes Consultant 01267 227869 01970 635749 01437 774358 Diabetes Specialist nurses 01267 227746 01970 635750 01437 773329 Dietetics 01267 227067 01970 635730 01437 774356 Community nurse 07964109694 Podiatry 01267 227058 01970 635987 / 01239 615302 Vascular surgeon 01267 227951 01267 227951 01437 773399 Tissue viability nurse 01267 227761 07974962716 01437 773122 Stop Smoking Wales 0800 085 2219 0800 085 2219 0800 085 2219 Retinal screening 01443 844244 01443 844244 01443 844244 Ophthalmology 01267 227749 Consultant Biochemist 01267 227454 01970 635784/5836 01437 773232
Exercise referral programme 01269 590234 01970 633610 Alcohol support service PRISM 01267 231634 West Wales Substance Misuse West Wales Substance Misuse West Wales Substance Misuse Service Service 01267 244442 Service Tel: 01970 636340 Tel: 01646 690327 Mental and Emotional health Primary Care mental health team support stress control programme 01269 Primary care mental health team 833368
Appendix 8
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