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Helm At The - National University Heart Centre ...
THE HEARTBEAT OF NATIONAL UNIVERSITY HEART CENTRE, SINGAPORE

                                                                                                  ISSUE 37
                                                                                                  JULY 2021
                                                                                                  WWW.NUHCS.COM.SG

                                                     COVER STORY

                             At The
                             Helm Leadership changes hands at NUHCS

           IN THIS        PG 10                        PG 18                                       PG 31
           ISSUE          The New                      The Next Frontier of                        Every Second
                          Cath Labs                    Thoracic Surgery                            Counts

                               MCI (P)081/12/2020. All information is correct at time of print.
Helm At The - National University Heart Centre ...
PULSE | ISSUE 37 | TABLE OF CONTENTS

                                        04
    TABLE OF                            Message from

    CONTENTS
                                        Prof Tan Huay Cheem
                                        Outgoing Director of NUHCS

                                        05
                                        Message from
    THE TEAM                            A/Prof Yip Wei Luen James
                                        Incoming Director of NUHCS with
     Editorial Directors                effect from 1 July 2021
     Prof Tan Huay Cheem
     A/Prof Poh Kian Keong                   COVER STORY

     Editors
     Mr Don Chan
     Ms Juliette Lim

     Publications & Abstracts
     Ms Fion Tay
     Ms Lin Xiao Yun
     Ms Tan Sze Hwee
                                          COVER STORY |
     Publishing Agency                    At The Helm
     The Orange Press Pte. Ltd

     Pulse is a biannual publication    06                                       CLINICAL
     by the National University         At The Helm
     Heart Centre, Singapore            Leadership changes hands at
     (NUHCS)                            NUHCS

     1E Kent Ridge Road, NUHS              EVENT
     Tower Block, Level 9,
     Singapore 119228

                                                                              16
                                                                              Detecting A Lesser Known
         nuhcs@nuhs.edu.sg                                                    Disease
                                                                              Cardiac scintigraphy for the
         www.nuhcs.com.sg                                                     diagnosis of transthyretin

         www.youtube.com/NUHCS
                                        10                                    amyloid cardiomyopathy
                                        The New Cath Labs
         www.facebook.com/NUHCS         NUHCS builds modern cardiac           17
                                        invasive catherisation laboratories   First Of Many
                                        with new upgrades                     First Uniportal Non-Intubated
                                                                              Video Assisted Thoracic Surgery
     Copyright © is held by the
     publishers. All rights reserved.
                                        12                                    (UNIVATS) performed in
                                                                              Singapore
     Reproduction in whole or in        Ladies First
     parts without permission is        Throwing a spotlight on women’s
     prohibited.                        heart health

2
Helm At The - National University Heart Centre ...
PULSE | ISSUE 37 | TABLE OF CONTENTS

                                       FACES OF NUHCS                            NEWSBYTES

                                    24
                                    In Pursuit Of Answers To The
                                    Heart
                                    Researchers at the Cardiovascular
                                    Research Institute look at broad
18                                  spectrum of issues to improve
                                    disease burden in Singapore
The Next Frontier Of Thoracic
Surgery
                                                                            33
Adoption of advanced robotic                                                What's On TV?
surgical system pushes thoracic                                             Guest medical experts on
surgery possibilities with better                                           MediaCorp’s Channel 8 Body SOS
patient outcomes

19
Expansion Of Thoracic
Surgery At Ng Teng Fong             26
General Hospital                    The Accidental Career
NUHCS works with NTFGH as           Perfusion Week highlights critical
OneNUHS                             role of perfusionists
                                                                            33
                                                                            Planting A Tree For Future
                                                                            Generations
                                                                            NUS Yong Loo Lin School of
                                                                            Medicine’s 115th Anniversary Plant-A-
                                                                            Tree programme

                                                                            34
20                                  28                                      Awards & Promotions
Safer, Quicker Discharge            Never Walk Alone                        Congratulations to all our award-
After Heart Surgery                 The role of patient support             winners and newly-promoted
Evidence-based protocols to         groups                                  doctors!
optimise patient care

                                       RESEARCH
                                                                            36
   EDUCATION                                                                Publications & Abstracts

21
Finding Home With NUHCS
Dr Kent Anthony Tan shares his
fellowship experience at NUHCS

23
Covid-19, The Vaccine,              31
And Our Heart                       Every Second Counts
Getting the facts straight          The impact of the Covid-19
                                    pandemic on the Western STEMI
                                    Network

                                                                                                                    3
Helm At The - National University Heart Centre ...
PULSE | ISSUE 37

                 OUTGOING
                 DIRECTOR'S
                 MESSAGE
                 Parting words from Prof Tan Huay Cheem after
                 serving as the Director of National University Heart
                 Centre, Singapore (NUHCS) for the past 13 years.

    Dear readers and colleagues,       NUHCS family. It has always         NUHCS into what it is today, a
                                       been my belief that our team        heart centre which all of us and
    To many, NUHCS is not just         can only be as strong as we         Singapore can be proud of. This
    a medical heart centre. It is      are, because of the support         has been my legacy.
    known for its soul where a         we receive from our families.
    strong cohesiveness and a colle-   Besides, the enthusiastic perfor-   It has been my privilege and
    gial working culture perme-        mances have been always been        honour to have the opportu-
    ates, where strong bonds and       a crowd wow factor!                 nity to lead the Centre as its
    friendships are forged amongst                                         director. I found my calling here,
    the people working in and with     The time has now come for me        and every day has truly been a
    NUHCS.                             to step aside for another to take   joy for me, to work alongside
                                       the helm. But certainly, this is    some of the most talented and
    Many of the staff, including       not a farewell. I will always be    passionate people you can find
    doctors, nurses and medical        a strong supporter of NUHCS as      in healthcare.
    technologists have committed       I take on other roles outside of
    the best parts of their lives to   the Centre.                         To James, I wish you good
    working here, devoting their                                           health and luck. May you
    time and energy to care for        I have worked with James on         retain your sense of humour
    patients. I am eternally grate-    numerous occasions, and there       and contagious laughter as you
    ful for the support and contri-    is no doubt in my mind that he      take on the Directorship.
    bution of each staff, and wish I   is one of the best cardiologists
    could embrace each individual      that we are blessed with. With
    with thanks.                       his gifts in digital science and    Tan Huay Cheem
                                       technology, I cannot wait to
                                                                           Prof Tan Huay Cheem
    One of the key highlights of       see the digital transformation
                                                                           Senior Consultant, Department of
    my year has always been our        of NUHCS in the years ahead.
                                                                           Cardiology, NUHCS
    annual Family Day celebrations
    when I get to meet colleagues      While no leadership is perfect, I
    and gather with their fami-        can say with all honesty that I
    lies for fun and food, bonding     have done my best to contrib-
    together as part of the larger     ute towards the building of

4
Helm At The - National University Heart Centre ...
PULSE | ISSUE 37

                                                      INCOMING
                    DIRECTOR'S
                     MESSAGE
                                 A/Prof Yip Wei Luen James takes on the role of
                            Director, National University Heart Centre, Singapore
                                           (NUHCS) with effect from 1 July 2021.

Dear colleagues,                            Having benefited from their tute-
                                            lage, I aspire to pay it forward; to
It is my privilege to address you, for      continue their good work and pave
the first time, as Director of NUHCS.       the way for those who will come
Prof Tan Huay Cheem has left me             after me.
with big shoes to fill, to say the least.
                                            During my term, I will continue my
I remember feeling this way back in         lifelong focus on People, Process and
2003 when I was newly promoted to           Technology, in this order of priority. I
be a consultant in cardiology. I was        believe that as an organisation, we
feeling a little overwhelmed and            must put our people first if we are
perhaps it showed. Prof Tan, who            to expect our people to put patients
was just taking over the mantle of          first. We will give you the support
chief then, looked at me reassur-           and skills you need to ensure that
ingly and said, “The only difference        the right workflow, organisational
between the two of us is just a little      structure and technology are in
experience.”                                place, so that, together, we can fulfil
                                            National University Health System’s
Those words assured me that with            tripartite mission of patient care,
the passage of time, we would               education and research.
become better prepared for all of
life’s challenges. I have had the priv-     I look forward to working with each
ilege of standing on the shoulders          and every one of you in the days to
of the ones who have come before            come.
me — Prof Tan included — and what
a view it has been!
                                            James Yip
                                            A/Prof Yip Wei Luen James
                                            Director and Senior Consultant,
                                            NUHCS

                                                                                       5
Helm At The - National University Heart Centre ...
PULSE | ISSUE 37 | COVER STORY

    A
           fter serving five years as         At The
                                              Helm
           the Chief of the Cardiac
           Department, and the
    next 13 years as Director of
    National     University    Heart
    Centre, Singapore (NUHCS),
    Prof Tan Huay Cheem is pass-
    ing on the leadership role to
    senior consultant cardiologist,
    A/Prof Yip Wei Luen James.                    Leadership changes hands at NUHCS

    Stepping into the new direc-
    tor role, A/Prof Yip says of the
    transition, “With the passage
    of time, we would become
    better prepared of all of life’s      It is not only about
    challenges. I have had the priv-
    ilege of standing on the shoul-
                                          adding years to life
    ders on the one who has come            but life to years –
    before me and what a view it           that would be our
    has been!”                               Centre’s mission
                                                 A/Prof Yip Wei Luen, James,
    Two defining moments in             Director and Senior Consultant, NUHCS
    Prof Tan’s tenure was when
    the Severe Acute Respiratory
    Syndrome (SARS) epidemic hit
    Singapore in 2003, and more
    recently, the ongoing corona-
    virus pandemic that broke out
    in 2020, requiring NUHCS to
    pivot and respond quickly in
    efforts to contain the outbreak.
    Few other leaders can claim the
    same of steering a heart centre
    through two global health
    crises.

    Not only has NUHCS survived
    the stress tests of these infec-
    tious disease outbreaks, the
    Centre has evolved and
    emerged stronger, transform-
    ing itself into the world-class
    academic heart centre, as it is
    known today.

    Prof Tan’s leadership at NUHCS
    was one that has led the path

6
Helm At The - National University Heart Centre ...
PULSE | ISSUE 37 | COVER STORY

of the Centre on an upwards         Today, NUHCS provides a
trajectory. From fewer than         wide spectrum of tertiary and
eight cardiology consultants,       quaternary services organ-
and just two surgeons in the        ised uniquely into six different
department, NUHCS has grown         core clinical programmes with
into a team of over 60 cardi-       a focus on patient-centric care
ologists and 20 surgeons over       in a multidisciplinary and inte-
three hospital sites, managing      grated set-up. The Centre has
almost three times its patient      not only transform its facilities
load in a span of 17 years.         with modern technology incor-
                                    porating the latest treatment
“It is however not the number       techniques in the field of cardi-
 that matters, but rather           ovascular medicine, but has
 the talents these individu-        also expanded its capabilities
 als possess, the public service    offering specialised care such
 ethos and values they uphold       as geriatric cardiology, complex
 that distinguishes the Centre,”    cardiac pregnancy manage-
 affirms Prof Tan.                  ment, pulmonary hypertension
                                    and vascular medicine with
Leaning on the support and          specialists trained cardiologists
expertise from two interna-         and cardiothoracic surgeons.
tional advisory panels, Prof Tan
worked with his small team          Furthermore, NUHCS has estab-
to conceive a heart centre          lished a research arm, the Cardi-
 designed to meet the grow-         ovascular Research Institute
   ing cardiovascular disease       (CVRI), which delves deeper
    burden, and provide higher      into the issues of heart failure
    quality care and treatment      with wide ranging research
     outcomes for patients in       areas including immunoassays,
     Singapore.                     mass spectroscopy, molecular
                                    biology, epigenetic infrastruc-
                                    ture, animal models and clini-
                                    cal cohort studies across several
                                    clinical sites.

      The greatest                  In just over a decade, CVRI
                                    has already received nota-
      fulfilment is the
                                    ble    commendations        from
      ability to effect             other established institutions
      change and make               acknowledging the quality
      things happen                 research it has put out, having
                                    published more than 50 papers
      Prof Tan Huay Cheem, Senior
      Consultant, Department of
                                    in the top 10 percent of high
      Cardiology, NUHCS             impact medical and scientific
                                    journals in the last three years.

                                                                        7
Helm At The - National University Heart Centre ...
PULSE | ISSUE 37 | COVER STORY

                                 “There are strategic transfor-      towards computer science and
                                  mational plans that have been      information technology has
                                  mapped out to take NUHCS to        kept NUHCS ahead in digital
                                  even greater heights, enabled      science and applications, which
                                  by a solid organisation struc-     will be instrumental in taking
                                  ture, a capable leadership team,   NUHCS to its next digital trans-
                                  and supported by rapid techno-     formation, turning it into a
                                  logical adoption and a strong      future-ready medical centre.
                                  corporate culture,” opined Prof
                                  Tan.                               As the current Group Chief
                                                                     Medical Informatics Officer
                                 On A/Prof Yip as his succes-        within National University
                                 sor, Prof Tan is in full support    Health System (NUHS), it is no
                                 of his appointment. “There is       secret that A/Prof Yip is a firm
                                 no doubt in my mind he is one       advocate of technology and
                                 of the best cardiologists that      healthcare analytics as a means
                                 NUHCS is blessed with. Besides      to improve healthcare stand-
                                 his clinical competence, James      ards for the people.
                                 is a genuine person with so
                                 much compassion for everyone “It is always first about the
                                 around him.”                     patients and the people whom
                                                                  we need to look after; followed
                                 In particular, Prof Tan high- by developing the process
                                 lighted A/Prof Yip’s inclination and infrastructure to help our
                                                                  organisation function effec-
                                                                  tively,” expounded A/Prof Yip

8
Helm At The - National University Heart Centre ...
PULSE | ISSUE 37 | COVER STORY

on his top priorities as NUHCS’    Singapore. Every new advance-       ity is to help our patients fulfil
Director. “Finally, technology     ment in technology that poten-      their life goals and to prepare
will be the answer to help us      tially increases human longev-      for the end.”
provide cost effective solutions   ity, brings on the added cost
for the public and to achieve      of caring for older, frailer        As the baton of leadership
the first two priorities.”         and medically more complex          passes onward, the evolution
                                   patients.                           of NUHCS will continue on its
The most concerning for A/Prof                                         trajectory -- improving commu-
Yip is reaching the increasing     Hence, it is A/Prof Yip’s aspira-   nity health with better and
number of people who are at        tion that NUHCS will be able to     more cost-effective care that
risk of cardiovascular diseases    predict the value of interven-      will empower people to take
in what he terms as the “hidden    tions for healthy longevity and     ownership of their own health;
epidemic”. “These are patients     manage the cost effectiveness       nurture the next generation
who do not know they are in        of therapies for the payors of      of cardiovascular profession-
trouble, or who think they are     healthcare, such as the govern-     als and further expand on its
doing well until something         ment and insurance companies.       world-class research facilities.
happens.”
                                   Enthusiastic about future possi-
On this front, NUHCS has           bilities in the field, A/Prof Yip   ARTICLE BY
already initiated the use of       quipped, “Cardiologists always      NUHCS Pulse Editorial
remote cardiac monitoring          seem to have one more trick up
technology for some heart          our sleeves to prevent death
patients. However, epidemio-       or disease progression that we
logical trends show that cardi-    often forget our responsibil-
ovascular disease remains the
biggest disease burden in

                                                                                                            9
Helm At The - National University Heart Centre ...
PULSE | ISSUE 37 | EVENT

     THE New
     CATH LABS
     NUHCS builds modern cardiac invasive catherisation
     laboratories with new upgrades

     National University Heart Centre,      and improved clinical outcomes         Diagnostic physiologic modalities
     Singapore (NUHCS) first set-up         compared to traditional sternot-       such as fractional flow reserve,
     its cardiac invasive catherisation     omy procedures, the demand for         thermodilution for coronary flow
     laboratories (also known as “cath      modern cath lab facilities has since   reserve (CFR), and the index for
     labs”) facility in 1992, sharing the   been on the rise.                      microvascular resistance (IMR) al-
     same space with the radiology                                                 low cardiologists to assess coro-
     department. This meant that the        In fact, many changes have been        nary artery function more precisely.
     time allowed for procedures in the     made to the standard require-
     facility has to be divided between     ments of a modern cath lab in          In addition, the cath labs are
     the two departments.                   the past decade alone. This pre-       equipped with the latest calcium
                                            cipitated an expert panel from the     modifying therapies such as orbit-
     Cath labs are specialised proce-       Society for Cardiovascular Angiog-     al atherectomy and intravascular
     dure rooms where doctors per-          raphy and Interventions to release     lithotripsy. These are used to tackle
     form minimally invasive tests and      a consensus statement this year,       issues with heavily calcified coro-
     procedures to diagnose and treat       with specific recommendations on       nary lesions which pose technical
     cardiovascular diseases. At that       setting up, operating, maintaining     difficulty during angioplasty and
     time, the shared facility was suffi-   the highest standards of quality       can translate to adverse outcome
     cient to support the relatively low    and establishing current best prac-    of stent restenosis and thrombosis.
     volume of about 300 coronary an-       tices of modern cath labs.
     gioplasty cases each year.                                                    Implanting mechanical circulatory
                                            Over the years, NUHCS has been         support systems such as non-sur-
     With the growing geriatric popu-       progressively updating its cardiac     gical heart pumps in patients with
     lation and rising incidence of car-    invasive cath labs (ICL) to meet       more complex and high-risk coro-
     diovascular diseases, advanced         current and future healthcare chal-    nary artery diseases can be carried
     diagnostic cardiac catherisation       lenges. Today, they are equipped       out in these cath labs.
     and angiography procedures have        with many advanced coronary in-
     since been introduced to support       tervention technologies, such as       In addition, the electrophysiologist
     the burden of coronary disease lo-     intravascular ultrasound and op-       (EP) team which utilises the same
     cally.                                 tical coherence imaging for intra-     facility performs tertiary complex
                                            vascular imaging which is used to      arrhythmia ablations and device
     Coupled with the advent of min-        assess the severity of coronary ar-    implantation using advanced pro-
     imally invasive cardiac surgery        tery disease by providing a tomo-      cedures such as cryoablation and
     and innovative catheter-based          graphical image of the coronary        His bundle pacing (HBP)1 for con-
     approaches which have generally        arteries.                              duction system pacing in the labs.
     resulted in shorter recovery times

10
PULSE | ISSUE 37 | EVENT

                                          In January this year, NUHCS up-
                                          graded all three cath labs with
                       Cath Lab in 1990   modern biplane imaging systems.
                                          These advanced medical imag-
                                          ing technologies use two rotating
                                          cameras to take simultaneous im-
                                          ages, forming a 3D portrait of the
                                          body area with highly detailed im-
                                          ages of blood vessels, soft tissue
                                          and blood flow in real-time.

                                          Furthermore, the cath labs are
                                          connected to a hybrid operating
                                          theatre equipped with an angio-
                                          graphic imaging capability, ena-
                                          bling the entire facility to support a
                                          wide range of endovascular, cath-
                                          eter-based interventional therapies
                                          in the field of coronary, peripheral,
                                          congenital and structural inter-
                                          ventions, as well as electrophys-
                                          iological studies, radiofrequency
                                          ablation, and pacemaker device
                                          implantation.

                                          These new upgrades mark yet an-
                                          other milestone in the expansion
                                          of the cath lab facility and services
                                          at NUHCS, ensuring the allocated
                                          space remains highly efficient to
                                          serve the current annual load of
                                          about 1,700 cases of percutane-
                                          ous coronary intervention and 660
                                          cases of EP ablation and device im-
                                          plantation procedures.

New Cath Lab in 2021
                                          1
                                           His bundle pacing (HBP) – A therapy with
                                          the intent of overcoming sites of atrioven-
                                          tricular (AV) conduction disease and delay.
                                          affecting a large area of the heart.

                                              ARTICLE BY

                                          Prof Tan Huay Cheem
                                          Senior Consultant,
                                          Department of Cardiology,
                                          NUHCS

                                          Prof Tan is a Professor of
                                          Medicine, Yong Loo Lin School
                                          of Medicine, NUS and has a master of Medicine in
                                          Internal Medicine. He is an active clinical researcher,
                                          visiting professor at several hospitals in China and
                                          invited speaker at many international cardiology
                                          meetings.

                                                                                                    11
Ladies
PULSE | ISSUE 37 | EVENT

                   First       h rowing a s
                               T           potligh
                                                   t   on women’s heart health

     Commemorating International Women’s Day
     in March 2021, the National University Heart
     Centre, Singapore’s (NUHCS) Women’s Heart
     Health Programme launched a public education
     campaign focusing on women’s heart health
     issues.

     The message was clear – women need to put
     themselves first and prioritise their heart health
     as well.

     In a commentary published in The Straits Times
     and Lianhe Zaobao, Dr Wang Yi Ting Laureen,
     Associate Consultant, Department of Cardiology,
                                                                     "Celebrating Strong Women"
     NUHCS wrote about the cardiovascular risks at
     every life stage of a woman, and the preventa-        Scan the code
     tive steps that can be taken. In her article, she     to watch the
                                                           inspirational
     emphasised the need to keep the heart in tip-top
                                                           video:
     condition as crucial to the process of aging
     gracefully.

     NUHCS also released an inspirational video across
     its online platforms, honouring the “Wonder
     Women” in the healthcare industry. These
     women took on the role of caring for others in
     their profession, continuously delivering high
     standards of patient care, whilst caring for others
     in their personal lives.

12
PULSE | ISSUE 37 | EVENT

                                                                Wearing multiple hats and managing expec-
                                                                tations in both their personal and profes-
                                                                sional lives, these nurses, cardiac techni-
                                                                cians and doctors from NUHCS share their
                                                                greatest pride at work in caring for patients
                                                                with cardiac conditions. At the same time,
                                                                they made the call for all women to protect
                                                                their hearts.

                                                                In collaboration with Something Private
                                                                podcast, Asst Prof Low Ting Ting, Consult-
                                                                ant, Department of Cardiology, NUHCS

                      c u r e a b r o k en h e    art"          joined Dr Wang and the producer to discuss

"The doctors who c an                                           women’s heart health in a 40-minute
                                                                podcast show, “Ladies, let’s have a Heart-
                                         Watch the              to-Heart about your Heart”. The show
                                       podcast here:            was broadcast on Spotify, YouTube, Insta-
                                                                gram, and Facebook. Asst Prof Low and
                                                                Dr Wang described the warning signs of
                                                                heart diseases, discussed the consequences
                                                                of self-neglect, and called for the need to
                                                                raise awareness of heart disease in women.

                                                                Working with digital publisher, Our Grand-
                                                                father Story, a comic strip was conceptu-
                                                                alised to depict the symptoms of a heart
                                                                attack in women. These are often subtle
                                                                and ignored, further increasing the risk for
                                                                women. Published and shared across multi-
                                                                ple media platforms, the comic communi-
                                                                cated the need for women to prioritise the
                                                                health of their hearts.

                                                                 ARTICLE BY

                                                                Asst Prof Low Ting Ting
                       To the busy everyday                     Consultant, Department of
                                                                Cardiology, NUHCS
                        women – self-care is
                         not a luxury, it is a
                                                                Asst Prof Low Ting Ting is currently
                                                                the clinical director of the Women’s Heart Health
                                                                Programme, which provides gender-tailored cardiac care
                         necessity. Be heart                    and subspecialty management in pregnancy and heart
                                                                disease, female phenotype coronary syndromes and
                       smart and treat your                     heart failure conditions with a predilection for women.
                                                                She is active in leading clinical trials and multi-centre
                                 heart right.                   registry work as well as research in advancing therapies
                                                                for rarer conditions. She is also passionate about mentor-
                         Asst Prof Low Ting Ting, Consultant,   ing and leads the undergraduate cardiology programme
                            Department of Cardiology, NUHCS     in the National University of Singapore (NUS).

                                                                                                                             13
PULSE | ISSUE 37 | EVENT

         Read our

                             What
         Women's Heart
         Health brochure:

                            How To Recognise
                            a Heart Attack In
          Symptoms in         Men & Women           Symptoms
          both men &                                in women:
            women:

     Shortness of Breath                                  Dizziness

           Jaw, Neck,                              Extreme Fatigue
           or Back Pain

                                                     Lower Chest or
         Chest Pain                                Upper Abdomen Pain
 (not always for women)

                                                       Indigestion
       Cold Sweat
                                            Oestrogen may play a strong role
                                            in protecting women from heart
                                            disease which could explain why
                                            women are at higher risk of a
                                            heart attack after menopause.
                                            Women are MORE likely to ignore
                                            the symptoms of a heart attack or
            Nausea or                       delay seeking treatment. As a
            Vomiting                        result, they are LESS likely than
                                            men to receive timely treatment.
14
PULSE | ISSUE 37 | EVENT

  Need to
                                           Know                                       10 Vital
                                                                                     Statistic
                                                                                  about W
                                                                                   Heart H
                                                                                              s
                                                                                           omen's
                                                                                           ealth

              1 in 3 women die of                                    Only 6    out of 10 women know that
                                                                     shortness of breath is the more
              cardiovascular disease every year
                                                                     common warning sign of a heart attack

              Women are         2
                              times at risk of death
                                                                     7 out of 10 women correctly
                                                                     identified chest pain as a heart
              within 30 days after a heart attack
                                                                     attack symptom

              3 out of 10 women know that                            Only 8    % of women surveyed talked
              heart attack symptoms in women                         about cardiovascular- related topics with
              are different than in men                              their doctor in the past 12 months

              445 lives were claimed by breast                       Women are 3.  9    times at risk of a
              cancer while cardiovascular disease
                                                                     heart attack from stress
              claimed 2,689 women lives in 2019

              Women are         5
                               5% less likely than men               10 years after a heart attack,
              to participate in cardiac rehabilitation,              women are 2.1 times more likely to
              even after a heart attack                              die compared to men

               E C HARGE
          TAK           E
             ND  REDUC
           A
                   RISKS
            YOUR
                     ART
                                                      Healthy Diet    Avoid        Lose Weight      Check Blood
             OF HE E                                                 Alcohol                           Sugar
                      S
               DISEA
         Here are some things you can
         do to aid in the prevention of
         heart disease!
                                                      Sleep Well      Stop            Exercise      Check Blood
Source: National University Heart Centre, Singapore                  Smoking                          Pressure
(NUHCS), a survey conducted by Singapore Heart
Foundation in 2020 and American Heart Foundation                                                                    15
PULSE | ISSUE 37 | CLINICAL

     DETECTING A
     LESSER KNOWN
     DISEASE
     Cardiac scintigraphy1 for the diagnosis of transthyretin
     amyloid cardiomyopathy2
     Amyloidosis is a protein             for the purpose of removing
     mis-folding disorder, occurring      small samples of heart muscle
     when native blood proteins           tissue for microscopic examina-
     aggregate abnormally into            tion.
     insoluble    fibrils  (amyloid)
     and deposit into various end-        In collaboration with the
     organs. The heart can be             Department      of    Diagnos-
     affected in some forms of            tic Imaging, National Univer-
     amyloidosis, one of them being       sity Hospital, National Univer-
     transthyretin (TTR) amyloidosis.     sity Heart Centre, Singapore
                                          (NUHCS) recently started the
     TTR is a transporter protein         technetium      pyrophosphate
     produced by the liver. In the        scintigraphy3 service for the
     presence of genetic mutation         diagnosis of ATTR-CM.
     or with age, TTR can mis-fold
     into insoluble amyloid fibrils       This nuclear scan modality has
     and deposit in the heart.            been shown to be as reliable
                                          as an endomyocardial biopsy
     Transthyretin amyloid cardio-        for the diagnosis of ATTR-CM                                         We envision that the
     myopathy (ATTR-CM) patients          in the right clinical context,                                         availability of this
     typically present with heart         and allows patients to be diag-                                   service will allow early
     failure and low blood pressure.      nosed without going through                                        diagnosis and prompt
     An echocardiogram will reveal        an invasive procedure.                                            treatment of ATTR-CM
     marked left ventricular wall                                                                            patients in the future.
     thickening.                          About 20 patients have under-
                                                                                                    Asst Prof Lin Weiqin, Clinical Director, Heart
                                          gone the scan since its introduc-                      Failure Programme and Consultant, Department
     ATTR-CM      was    previously       tion in November 2020, helping                                                  of Cardiology, NUHCS
     thought to be a rare cause of        doctors to diagnose and treat
     heart failure amongst elderly        them accordingly for ATTR-CM.                           ARTICLE BY
     men. However, recent studies                                                                Asst Prof Lin Weiqin
                                           scintigraphy – Procedure where a small amount
     have shown that ATTR-CM is
                                          1
                                                                                                 Clinical Director, Heart
                                          of radioactive chemical is injected into the vein      Failure Programme and
     likely underdiagnosed due to         to produce scans of the body’s internal structures     Consultant, Department of
                                          used to diagnose, stage and monitor disease such
     a lack of awareness about the        as cancer
                                                                                                 Cardiology, NUHCS

     disease.                             2
                                           cardiomyopathy – A condition caused by                Asst Prof Lin is trained in the management of acute
                                          abnormalities in the heart muscles, resulting in       heart failure with temporary mechanical circulatory
                                          dysfunctional heart pumping                            support, as well as caring for advanced heart failure
     In the past, the only way to diag-                                                          patients with implanted durable left ventricular
                                          3
                                           technetium pyrophosphate scintigraphy –
     nose ATTR-CM was through             A radiotracer scan used to differentiate transthy-
                                                                                                 assist devices (LVADs) or heart transplantation.
                                                                                                 Besides heart failure, his other subspecialty interests
     endomyocardial biopsy, which         retin from light-chain amyloidosis, in patients with
                                          cardiac amyloidosis
                                                                                                 include cardiomyopathies and echocardiography.
     is an invasive procedure done

16
PULSE | ISSUE 37 | CLINICAL

FIRST OF MANY
First Uniportal Non-Intubated Video Assisted Thoracic Surgery
(UNIVATS) performed in Singapore
The thoracic surgery and
anaesthesia teams at the
National University Hospital
(NUH) successfully introduced
UNIVATS for the treatment
of a patient with a rare nerve
tumour called Schwannoma
on 21 January 2021. This marks
the first UNIVATS procedure
performed here in Singapore.

UNIVATS is a new procedure
combining Uniportal Video
Assisted     Thoracic    Surgery
(UVATS) with Non-Intubated
Video Assisted Thoracic Surgery
(NIVATS). UVATS is performed
through a single port thora-
coscopic1 surgery via a small
1-inch incision on the patient’s
chest. NIVATS is a more natural
way of administering anaesthe-
sia during surgery, as there is no
need for an endotracheal2 tube
to go deep into the airway, and      compared to the usual 2 to 3                         ARTICLE BY

milder forms of anaesthetic          days. After the operation, the                      A/Prof John Tam Kit Chung
                                                                                         Head and Senior Consultant,
medications are being used.          patient’s chest discomfort from                     Division of Thoracic Surgery,
                                     the nerve tumor is relieved,                        Department of Cardiac
                                                                                         Thoracic and Vascular Surgery
By combining both UVATS              and the patient expressed high                      (CTVS), NUHCS
and NIVATS, UNIVATS can be           levels of satisfaction with the
                                                                                         A/Prof John Tam is the founding Head
performed with even smaller          surgery, the anaesthetic tech-                      of Thoracic Surgery at the NUHCS. He is a thoracic
incisions, allowing patients to      nique, as well as the overall                       surgeon specialising in performing minimally inva-
                                                                                         sive single-port keyhole surgery using advanced
benefit from less physiological      experience.                                         techniques in Uniportal Video-Assisted Thoraco-
                                                                                         scopic Surgery (UVATS). His research has been
stress, airway trauma, thereby                                                           published across many high-impact medical and
reducing the risk of respiratory     UNIVATS is currently the most                       scientific journals. He also serves as a member on
                                                                                         the Singapore Residency Advisory Committee for
infection, resulting in faster       advanced minimally invasive                         Cardio-Thoracic Surgery. He has won many awards
recovery from anesthesia, over-      thoracic surgery procedure in                       in recognition for his service to patients and his
                                                                                         contribution to the field of academic surgery.
all recovery time, and a shorter     the field, which combines the
hospital stay.                       expertise from the surgical and
                                     anaesthetic teams to achieve
In particular, the first patient,    the best outcomes for thoracic                      Dr Deborah Khoo Xian Li
                                                                                         Consultant, Department of
who had a successful UNIVATS         surgery patients.                                   Anaesthesia, NUH
procedure to resect a rare nerve
tumour in the chest stayed                                                               Dr Deborah Khoo is a Consultant at
                                                                                         the Department of Anaesthesia, National
                                     1
                                      thoracoscopic – A minimally invasive procedure
in the hospital for 23 hours         in the chest that is performed using an edoscopic   University Hospital with research interests in the
                                     camera                                              field of difficult airway management and training,
in a day surgery ward, which                                                             medical education and methodology, as well as the
is a substantial improvement             endotracheal – Inside the trachea
                                     2
                                                                                         use of anti-fibrinolytics in spine operations.

                                                                                                                                              17
PULSE | ISSUE 37 | CLINICAL

     THE NEXT
     FRONTIER OF
     THORACIC
     SURGERY
     Adoption of advanced robotic surgical system pushes thoracic
     surgery possibilities with better patient outcomes
     The division of thoracic surgery    The division’s coherent move
     in the National University Heart    to adopt the advanced robotic
     Centre, Singapore (NUHCS) has       system has been proven to aug-
     always been at the forefront        ment thoracic surgical proce-
     of minimally invasive thoracic      dures and accelerate the capa-
     surgery in Asia, adopting the       bilities of thoracic surgery for
     latest surgical technologies        lung and mediastinal1 surgery.
     to achieve better patient out-
     comes in a safe and reliable way.   The first robotic thoracic sur-
                                         gery performed for a mediasti-
     Employing video-assisted thor-      nal tumor was carried out by Dr
     acoscopic surgery, the divi-        Mithiran, with the guidance of
     sion led by A/Prof John Tam,        a robotic proctor Dr Aneez D.B
     together with Dr Harish             Ahmed, Director and Senior
     Mithiran Muthiah and Asst Prof      Consultant at the International
     Ooi Oon Cheong, have per-           Centre for Thoracic Surgery, in
     formed more than 3,000 tho-         March 2021 at the National
     racic surgeries to date.            University Hospital (NUH). The
                                         surgery was a success with the
     Recently, the division invested     patient discharged the follow-
     resources in robotic-assisted       ing day.
     surgery     where     significant
     advancements       have     been    Equipped with this technology,                         ARTICLE BY

     made. With the intuitive da         NUHCS’ thoracic surgery divi-                         Dr Harish Mithiran Muthiah
                                                                                               Consultant, Division
     Vinci Robotic system, surgeons      sion is able to offer a compre-                       of Thoracic Surgery,
     control the robotic arms from       hensive suite of minimally inva-                      Department of Cardiac,
                                                                                               Thoracic and Vascular
     a console situated within the       sive thoracic surgery options for                     Surgery (CTVS), NUHCS
     operating room. The robotic         both lung and mediastinal dis-
     arms are inserted through tiny      eases with better precision and                       Dr Mithiran trained at NUH in
                                                                                               cardiothoracic surgery. He completed his advance
     surgical incisions, acting as an    better outcomes.                                      surgical training in 2014 where he was awarded
     extension of the surgeon’s arms,                                                          the Fellowship of the Royal College of Surgeons of
                                                                                               Edinburgh. He has a special interest in minimally
     mirroring every hand move-          1
                                          mediastinal – Refers to conditions that affect the   invasive thoracic surgery which include Video-As-
                                         mediastinum, the space in the chest, surrounded       sisted Thoracic Sugery(VATS) and Robotic Assisted
     ment. This enables delicate         by the breastbone, spine and the lungs.               Thoracic Surgery(RATS) for lung and chest diseases.
     and complex operations to be                                                              He also currently serves as the Asst Programme
                                                                                               Director for the Cardiothoracic Surgery Residency
     carried out with high precision                                                           Programme.
     and safety.
18
PULSE | ISSUE 37 | CLINICAL

   EXPANSION OF THORACIC
      SURGERY AT NG TENG
 FONG GENERAL HOSPITAL                                      NUHCS works with NTFGH as OneNUHS

                                                                       We share the common vision
                                                                       of providing high quality
                                                                       services to our patients, and to
                                                                       realise the vision of OneNUHS
                                                                       for thoracic surgery services
                                                                       across our cluster.
                                                                       A/Prof John Tam Kit Chung, Head and
                                                                       Senior Consultant, Division of Thoracic Surgery,
                                                                       Department of CTVS, NUHCS

Following its opening in 2015,      sion. The deliberation included
Ng Teng Fong General Hospital       a walking tour of NTFGH facili-     ARTICLE BY

(NTFGH) has been receiving an       ties to review the patient flow    A/Prof John Tam
increasing number of patients       process.                           Kit Chung
                                                                       Head and Senior Consultant,
requiring    thoracic    surgery,                                      Division of Thoracic Surgery,
                                                                       Department of CTVS, NUHCS
leading to a subsequent need        To avoid a long waiting time
to scale up the provision of        for thoracic surgeries at NTFGH,   A/Prof John Tam is the founding
thoracic surgery services.          the thoracic surgical team from    Head of Thoracic Surgery at the NUHCS. He is a
                                                                       thoracic surgeon specialising in performing mini-
                                    NUHCS will perform urgent and      mally invasive single-port keyhole surgery using
                                                                       advanced techniques in Uniportal Video-Assisted
For that reason, the surgery        emergent thoracic surgeries        Thoracoscopic Surgery (UVATS). His research has
and operations team led by A/       at NTFGH. The hospital's surgi-    been published across many high-impact medical
                                                                       and scientific journals. He also serves as a member
Prof Theodoros Kofidis and A/       cal team will provide in-house     on the Singapore Residency Advisory Committee
Prof John Tam Kit Chung from        support to facilitate intraop-     for Cardio-Thoracic Surgery. He has won many
                                                                       awards in recognition for his service to patients and
the Department of Cardiac           erative assistance and post-       his contribution to the field of academic surgery.
Thoracic and Vascular Surgery       operative care management.
(CTVS) at the National Univer-      Patients can now also receive      Dr Harish Mithiran
sity Heart (NUHCS) collab-          after surgery care through the     Muthiah
                                                                       Consultant, Division
orated with the team from           outpatient thoracic surgery        of Thoracic Surgery,
NTFGH headed by Adj A/Prof          services in NTFGH.                 Department of CTVS, NUHCS

Noel Stanley Tay to detail the
                                                                       Dr Mithiran trained at National
provision of urgent and outpa-      By increasing the thoracic         University Hospital (NUH) in cardiothoracic surgery.
tient thoracic services at NTFGH.   surgery capacity at NTFGH, resi-   He completed his advance surgical training in 2014
                                                                       where he was awarded the Fellowship of the Royal
Weighing in these discussions,      dents in the Western region of     College of Surgeons of Edinburgh. He has a special
                                                                       interest in minimally invasive thoracic surgery which
from NTFGH, were Prof Philip        Singapore will be better served    include Video-Assisted Thoracic Surgery (VATS) and
Lau, Head of Surgery, and Asst      and can expect a more efficient    Robotic Assisted Thoracic Surgery (RATS) for lung
                                                                       and chest diseases. He also currently serves as the
Prof Soon Yuen, Head of Upper       system under the OneNUHS           Asst Programme Director for the Cardiothoracic
                                                                       Surgery Residency Programme.
Gastrointestinal Surgery Divi-      cluster.
                                                                                                                               19
PULSE | ISSUE 37 | CLINICAL

     SAFER, QUICKER
     DISCHARGE AFTER
     HEART SURGERY
     Evidence-based protocols to optimise patient care

     National    University Heart        tive team involving surgeons,        ARTICLE BY
     Centre, Singapore (NUHCS)           anaesthesiologists,     intensiv-   Dr Chang Guohao
     recently   implemented   the        ists, haematologists, endo-         Consultant, Department
                                                                             of Cardiac Thoracic and
     Enhanced     Recovery  After        crinologists,     nephrologists,    Vascular Surgery (CTVS),
     Surgery (ERAS®) protocol for        nurses, physiotherapists, dieti-    NUHCS

     cardiac surgery – one of the        tians, counsellors, perfusionists   Dr Chang is an accredited specialist in cardiotho-
     most resource-intensive and         and case managers to develop        racic surgery by Singapore’s Ministry of Health
                                                                             and was awarded the College of Surgeons Gold
     complex surgeries.                  a comprehensive periopera-          Medal in Cardiothoracic Surgery. He is currently a
                                         tive programme, guided by           Consultant in the Department of CTVS at NUHCS
                                                                             with interests in all aspects of adult cardiac surgery
     In 2019, the ERAS® protocol for     the protocols from the ERAS®        including extracorporeal life support.
     cardiac surgery was published       Cardiac Society, as well as
     by the ERAS Cardiac Soci-           published studies with further
                                                                             A/Prof Ti Lian Kah
     ety following a multi-discipli-     recommendations from hospi-         Director of Cardiac
                                                                             Anaesthesia & Senior
     nary systematic review of the       tals in the United States of        Consultant, Department
     current literature. This protocol   America, Germany and China.         of Anaesthesia, National
                                                                             University Hospital (NUH)
     has adopted many principles
     from abdominal surgery proto-       NUHCS will be closely rev-          A/Prof Ti is a tenured associate professor with the
     cols, and also incorporated         iewing pre- and post-protocol       Yong Loo Lin School of Medicine, National Univer-
                                                                             sity of Singapore. He did his cardiac anaesthesia
     recommendations that reflect        implementation with a series        fellowship at Duke University in the United States
     the unique nature of cardiac        of preoperative, intraopera-        of America (USA), and is accredited for perioper-
                                                                             ative transesophageal echocardiography by the
     surgery.                            tive and postoperative inter-       National Board of Echocardiography, USA. His
                                                                             research interest is on outcomes after surgery and
                                         ventions (involving medical         has published over 80 papers, including on compli-
     Implementation of the proto-        subspecialties and allied health    cations such as acute kidney injury, atrial fibrillation
                                                                             and poor neurological outcomes.
     col requires establishing a         support) to optimise overall
     multi-disciplinary collabora-       patient outcomes.

20
PULSE | ISSUE 37 | EDUCATION

                          DELVING DEEPER
                               ARTICLE BY

                    NUHCS Pulse Editorial

                       INTO CARDIOLOGY
  Dr Kent Anthony Tan shares his experience of the interventional cardiology fellowship at NUHCS

In September 2018, Dr Kent                  the 2019 AICT-Asia PCR meet-
Anthony Tan from the Phil-                  ing,” shared Dr Tan. “Some of
ippines was accepted into                   my mentors from back home
the Interventional Cardiol-                 were in attendance, so it
ogy Fellowship Programme at                 was a proud moment for me
the National University Heart               when they commended my
Centre, Singapore (NUHCS)                   progress.”
after completing seven years
of his residency programme at               Reminiscing his night duty
the Philippines Heart Centre.               calls, he recollected being
                                            stretched and challenged to
He spent one year train-                    meet the standards expected
ing in various contempo-                    at NUHCS when dealing with
rary atherectomy modalities1                the acute heart failure cases
and the second year delving                 that came rushing through
deeper into cardiovascular                  the hospital’s emergency
structural intervention.                    doors. The team’s razor sharp                    NUHCS Fellowship /
                                            focus and vigilance for possi-                   Clinical Attachment
“Good judgement comes from                  ble complexities was inspiring                   NUHCS offers a Fellowship / Clinical
 experience, and experience                 for Dr Tan.                                      Attachment Programme to foreign
 comes from bad judgment,”                                                                   doctors to gain firsthand experience
 shared Prof Tan Huay Cheem, “The hardest part of the                                        in the Singapore healthcare industry,
                                                                                             develop and strengthen the regional
 Senior Consultant, Depart- programme was turning in my
                                                                                             referral network, whilst acquiring
 ment of Cardiology, who was hospital pass,” said Dr Tan. “It                                specific clinical skills under the
 then the Director of NUHCS. was an act of finality, marking                                 mentorship of leading medical
 Dr Tan has since made it his the end of my time at NUHCS                                    professionals at NUHCS. To find out
 own maxim in becoming a and having to say goodbye. As                                       more about the eligibility criteria
 better doctor.                all good things must come to                                  and application process, please
                                                                                             email the programme coordinator at
                               an end, I am eagerly looking                                  fellowship_application@nuhs.edu.sg.
 He was actively engaged on forward to the next step in my
 various levels in procedural career, where I can apply my                                   AICT-Asia PCR meeting
 and clinical work — treat- learnings from NUHCS.”                                           Formed in 2019, AICT-Asia PCR is
 ing patients with pulmonary                                                                 built by local practitioners with the
                                atherectomy modalities – Methods of treat-
 hypertension (PH)2, adult
                                            1
                                                                                             support of centres of excellence in
                               ment to remove plaque build-up in diseased
 congenital heart diseases and arteries, limiting the flow of oxygen-rich blood              the Asia Pacific region and Europe, to
 valve disorders, whilst being
                               to organs and other parts of the body.                        focus on the diverse needs of patients
                                PH – A type of high blood pressure affecting
                                            2                                                in the interventional landscape. As
 trained in various approaches the lung arteries and the right side of the                   a global educational meeting in the
 to heart diseases and valve   heart.
                                                                                             Asia Pacific region, the platform
 pathologies.                   orbital atherectomy – A new methodology
                                            3
                                                                                             allows knowledge exchange between
                                            for treating arterial disease within the major
                                            and branch arteries of the leg.                  peers and the opportunity for
“One of the highlights for me                                                                healthcare professionals to showcase
                                                                                             their research and innovation, aimed
 was being part of a live trans-
                                                                                             at contributing to the development
 mission working on an orbital                                                               of treatment and care possibilities to
 atherectomy3    case    along-                                                              better serve the region’s patients.
 side A/Prof Adrian Low at
                                                                                                                                 21
PULSE | ISSUE 37 | EDUCATION

     COVID-19,
     THE VACCINE,
     AND OUR HEART
     Getting the facts straight
                                                                               ARTICLE BY

                                                                              Prof Tan Huay Cheem
                                                                              Senior Consultant,
                                                                              Department of Cardiology,
                                                                              National University Heart
     While Covid-19 initially affects      However, it is also important to   Centre, Singapore (NUHCS)

     the airways and lungs, mount-         note that many patients with
                                                                              Prof Tan is a Professor of
     ing evidence has shown that the       mild Covid-19 infection, includ-   Medicine, Yong Loo Lin School of Medicine, NUS
                                                                              and has a master of Medicine in Internal Medicine.
     heart muscle and the cardiovas-       ing those with heart condi-        He is an active clinical researcher, visiting professor
     cular system are also affected,       tions, have managed to recover     at several hospitals in China and invited speaker at
                                                                              many international cardiology meetings.
     and can be severely damaged           fully. Nonetheless, research-
     as a result of the viral infection.   ers are still compiling data to
                                           better understand the long-
     Scientists found that the SARS-       term impact of the coronavirus
     CoV-2 coronavirus can cause           on the heart and the overall
     high levels of inflammation in        health of those who recover.
     the body including the heart
     muscles (myocarditis) or cause        As a consequence of the
     damage to the blood vessels,          higher risks of developing seri-
     compromising the cardiovascu-         ous life-threatening compli-
     lar system. In severe cases, this     cations, experts encourage
     could lead to a heart attack          those with heart conditions,
     (acute myocardial infarction),        including those who are on
     heart failure, abnormal heart         blood thinners such
     rhythm (arrhythmias), shock,          as antiplatelets (aspi-
     and cardiac arrest.                   rin or clopidogrel),
                                           to protect themselves
     As heart patients tend to be          from the Covid-19
     older (over the age of 65 years)      virus by taking the
     and usually suffer from multi-        vaccination as soon as
     ple comorbidities such as diabe-      possible. Those on anti-
     tes mellitus, hypertension, high      coagulants (e.g. warfa-
     cholesterol and kidney diseases,      rin or newer agents
     further contracting the Covid-        such as rivarox-
     19 infection makes them more          aban,     apixaban,
     likely to develop severe compli-      or dabigatran) are
     cations.                              further advised to
                                           apply     compression
     This explains why Covid-19            over the site of injec-
     patients with underlying heart        tion for an additional five
     conditions are six times more         minutes.
     likely to be hospitalised and
     12 times more likely to die,
     compared with those without
     any heart condition.
22
PULSE | ISSUE 37 | EDUCATION

WHY                                            VACCINE:
VACCINATE?                                 MYTHS & FACTS
 Lowers your risk of severe                 MYTH
 complications from Covid-19                The vaccines were developed too
                                            fast to be trusted for their efficacy.
 Prevents the virus from
 spreading to another person
                                            FACT
 Protects you and your loved ones           The science is very clear on the efficacy
                                            of the vaccine. It was developed much
 Creates a protective web if many people    quicker than usual because there are
 in a community are vaccinated              many eligible patients for testing in a
                                            pandemic, instead of having to wait
 Allows business and other
                                            for patients to enroll in the tests. Addi-
 social activities to resume
                                            tionally, the phases of vaccine testing
                                            were carried out concomitantly during
                                            this pandemic which shortens the time.
                                            Finally, there has been a total commit-
                                            ment by manufacturers for rapid
                                            vaccine development and co-operation
                                            by the governing bodies to speed up
                                            review and accreditation processes.

                                            MYTH
                                            The new mRNA technology of vaccines
                                            may potentially transform recipients
                                            from humans into “hybrids” through
                                            alteration of the cell’s DNA structure.

                                            FACT
                                            The mRNA vaccine is made up of a
                                            gene, which codes for a viral protein,
                                            wrapped up in a fat droplet, and
                                            administered intramuscularly. The
                                            mRNA gene makes the cell produce the
                                            viral protein to stimulate our body’s
                                            immune response to the virus but does
                                            not alter the host cell's DNA structure.
                                            This is the very basis of the science
                                            behind cells and cellular function. A
                                            genetic modification would involve the
                                            deliberate insertion of foreign DNA
                                            into the nucleus of a human cell which
                                            is not how a vaccine works.

                                                                                         23
PULSE | ISSUE 37 | FACES OF NUHCS

     IN PURSUIT OF
     ANSWERS TO
     THE HEART
     Researchers at the Cardiovascular Research
     Institute look at broad spectrum of issues      ARTICLE BY
     to improve disease burden in Singapore          NUHCS Pulse Editorial

 “In the 1980s, 80 to 90 percent        ment including wet lab facili-
  of the people who had heart           ties, research animal breeding
  failure were likely to die in the     colonies, high-definition digital
  next few weeks. Now, about            imaging equipment, and high
  half of these people will be          throughput platforms to run
  able to live for another five to      and perform a wide array of
  six years,” reflected Prof Arthur     proteomic, metabolomic and
  Mark Richards, Deputy Direc-          nucleic acid assays and analysis.
  tor, National University Heart
  Centre, Singapore (NUHCS) on          At any one time, CVRI tackles
  the changes he has seen over          around 50 different projects
  the years in his career.              relating to cardiovascular issues,
                                        from looking at a particular
     Even so, he added, such odds       molecule in a cell in a lab to
     leave plenty of room for           running clinical trials of novel
     improvement and many chal-         approaches to the treatment of
     lenges for clinicians and scien-   heart failure.
     tists to answer.
                                    “One thing that stood out to
     Describing the field as a       me was the great deal of heart
     specialty with many unan-       and arterial diseases here, but
     swered questions, Prof Rich-    research funding for cardiovas-
     ards is intent on finding these cular research was dispropor-
     answers at the Cardiovascular   tionately small compared to
     Research Institute (CVRI) – the that going to other biomedical
     research arm of NUHCS, where    domains,” Prof Richards said in
     he has led as Director since itsobservation when he was part
     inception in 2009.              of the Cardiovascular Disease
                                     Taskforce to develop research
     Hailing from New Zealand, roadmaps for Singapore.
     Prof Richards has built CVRI
     from ground up with a hand- Singapore has a high rate of
     ful of researchers to a centre diabetes which is the key back-
     with about 100 dedicated ground contributing factor to
     staff working in an advanced heart diseases in people here.
     research    centre   equipped The combination of diabetes
     with specialised lab equip- with risk factors such as high
24
PULSE | ISSUE 37 | FACES OF NUHCS

blood pressure appears to be        rebuilding and regenerating          able to encourage institutes
far more toxic to the heart in      the heart.                           in Singapore to collaborate,
Singapore than in western                                                which not only avoids duplica-
countries.                          “It’s very ambitious but kind        tion of resources but combines
                                     of aspirational. It is the foun-    institutional strengths and has
“We don’t really understand the      dational mission for our work,      fostered communication and
 problem,” he let on. “Rather        and directs the advances we         closer working ties between
 than focus solely on the heart      have made,” he said.                the different institutes.
 organ, we need to think about
 the things that injure it – such   Some of the work that have “I don’t think this has happened
 as diabetes, blood pressure,       come out of CVRI include the in other countries,” said Prof
 hypertension, all of which are     design and development of a Richards.
 very prevalent here.”              new heart replacement valve
                                    made from natural materials; Looking ahead, he is hopeful
In the race for answers, he         the re-engineering of a protein that CVRI will expand to tackle
said, “One of the next steps        from a bacterium to encap- the multitude of cardiovascular
for me, is to encourage cardi-      sulate another protein for issues confounding experts. He
ovascular research. We could        targeted purposes, and identi- also sees the institute progress-
have another five or six senior     fying new biomarkers that can ing further into the research
   research investigators who       predict heart failure after a which they have made head-
       could bring CVRI to a        heart attack.                   way.
          critical mass, where
             it can really keep     CVRI performs clinical trials in     He chimed, “We have a whole
                its momentum,       collaboration with other insti-      atlas of biomarkers now that
                   have lots of     tutes in Singapore and in other      we would like to explore from
                    cross-polli-    countries on related studies         our previous work. We want to
                                    such as looking into the asso-       see if they do actually work for
                                    ciation of poor sleep and coro-      prognostic or diagnostic uses
                                    nary heart disease to address a      in the clinic and whether they
                                    patient’s survival rate.             point to entirely new treat-
                                                                         ments. There is a lot going on!”
                                    Having been here for over a
                                    decade, Prof Richards acknowl-
                                    edged that Singapore has some
                                    unique strengths conducive for
                                    medical research such as the
                                    high education and good work
                                    ethics of the talent pool.

                                    “People here typically really        When you get on the trail
                                     want to do a good job and take      of asking questions and
                                     things to the next level.”          finding answers, and
              nation of ideas       He further commented on the
                                                                         making discoveries, you
            with each other,        research support structure in        tend to stay on the path.
          share facilities and      Singapore which he thought           Prof Arthur Mark Richards, Deputy Director,
                                                                         NUHCS and Director, CVRI
       generate more synergy.”      was “far-sighted”. The govern-
                                    ment provides grants to support
CVRI has been paying atten-         junior clinician scientists to
tion to heart failure, focus-       pursue research whilst they
ing on a broad spectrum from        continue with clinical work.
pure prevention to complete         Grants are also made avail-

                                                                                                                       25
PULSE | ISSUE 37 | FACES OF NUHCS

     THE
     ACCIDENTAL
     CAREER
     Perfusion Week highlights critical role of perfusionists

     The first week of May is dedi-
     cated as Perfusion Week to                         Ms Clara Anne Lim
     bring about awareness of the                       Perfusionist,
                                                        Department of CTVS,
     perfusionist’s role in cardiovas-                  NUHCS
     cular surgery and extracorpor-
     eal membrane oxygenation
     (ECMO).                             What got you interested in the       What do you like best about
                                         job of a perfusionist?               being a perfusionist?
     Many cardiovascular surger-
                                           Clara: It was a recruiter from       I love the challenges I face in
     ies need the heart to be still in
                                           whom I first heard about             this fast-paced job. It requires
     order to be operated on. This
                                           the job of a perfusionist. I         quick thinking on your feet,
     is where perfusionists step in.
                                           had to google it as it was           and is also demanding as we
     They are specially trained to
                                           my first time hearing about          are required to support the
     operate, maintain and record
                                           this job! However, the job           various number of surgeries
     the output of the heart-lung
                                           piqued my interest as it was         going on.
     machine, designed to maintain
                                           related to my studies – car-
     the circulation of blood and                                               It is a very rewarding job,
                                           diac technology and bio-
     oxygen through the body.                                                   when I play a part in help-
                                           medical sciences. I decided
                                           to take up the challenge as          ing someone survive surgery
     Outside the operating theatres                                             that will help him or her
                                           the human heart has always
     (OT), perfusionists also provide                                           lead a better quality of life.
                                           fascinated me.
     cardiac and respiratory sup-
     port with the ECMO machines,          On the day of my inter-            What are the most challenging
     which are smaller heart-lung          view, I remember a senior          aspects of the job?
     machines designed for long-           perfusionist sprung a sur-
     term life support.                    prise tour to the OT where I         There are some days which
                                           would need to work in, and           can be more physically and
     Working as a perfusionist             observed my response to              mentally challenging than
     within the Department of Car-         being present during open            others.
     diac, Thoracic and Vascular Sur-      heart surgeries. I certainly         We are rostered to be on
     gery (CTVS) at the National           did not expect that. Luckily, I      call 24 hours to respond to
     University Heart Centre, Singa-       did not faint or I would have        medical emergencies. When
     pore (NUHCS), Ms Clara Anne           been rejected.                       these situations occur, it
     Lim shares more about the
                                                                                could mean long hours as
     profession.

26
PULSE | ISSUE 37 | FACES OF NUHCS

emergency procedures can           and machinery to be smaller          the patient once they are
be very complicated.               which also meant that we             on bypass, constantly mon-
                                   need to be very precise in           itoring and responding to
There was one difficult night      managing these cases. In             haemodynamic, brain func-
call during the Covid-19           addition, congenital car-            tion, and blood gas changes,
Circuit Breaker in 2020. A         diac surgeries on paediatrics        making clinical decisions on
patient had a heart attack         tend to be more complex as           patient management during
and went into cardiogenic          they could have different            the surgery.
shock. He was also a sus-          anatomies and physiologies
pected Covid-19 case which         compared to adults.              Any tips for aspiring
required the procedure to                                           perfusionists?
be done in isolation, and for    What are some common
us to don on full personal                                              Understand the anatomy
                                 misconceptions about                   and physiology of the entire
protection equipment (PPE).      perfusionists?                         human body, and not just
This meant that we could           Like me at the start of my           the heart. We perfuse the
not leave the OT even for          career, many people have             entire body which has a crit-
a toilet break, as the PPE         not heard about perfusion-           ical impact on the functions
made it a hassle. Since it was     ists. They think the job is          of other organs, including
an emergency, the entire           related to perfumes, when it         the brain and kidneys.
team was basically stuck in        is actually about the body’s
the room the entire night as       circulatory system.
                                                                     ARTICLE BY

there was no backup team!                                           Mr Goh Si Guim
                                                                    Senior Principal
                                   Another misconception is         Perfusionist, Department
In general, I find paediat-        that people liken our job        of CTVS, NUHCS
ric cases more stressful and       to a technician operating        Mr Goh joined a team of three
demanding, especially when         a machine. However, our          perfusionists at the National
they are fragile newborns.         responsibility goes beyond
                                                                    University Hospital (NUH) to help support the
                                                                    Department of CTVS in 1993. With the expansion
They are much smaller in           that. We take over the oxy-      and growth of cardiovascular surgical procedures
                                                                    at NUH, the Perfusion Service team has likewise
size, requiring our circuits       genation and perfusion of        grown in parallel to a team of 12, to date. He was
                                                                    previously trained to become a qualified perfusion-
                                                                    ist at the Singapore General Hospital and holds a
                                                                    Bachelor’s in Biological Sciences.

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