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THE HEARTBEAT OF NATIONAL UNIVERSITY HEART CENTRE, SINGAPORE ISSUE 37 JULY 2021 WWW.NUHCS.COM.SG COVER STORY At The Helm Leadership changes hands at NUHCS IN THIS PG 10 PG 18 PG 31 ISSUE The New The Next Frontier of Every Second Cath Labs Thoracic Surgery Counts MCI (P)081/12/2020. All information is correct at time of print.
PULSE | ISSUE 37 | TABLE OF CONTENTS 04 TABLE OF Message from CONTENTS Prof Tan Huay Cheem Outgoing Director of NUHCS 05 Message from THE TEAM A/Prof Yip Wei Luen James Incoming Director of NUHCS with Editorial Directors effect from 1 July 2021 Prof Tan Huay Cheem A/Prof Poh Kian Keong COVER STORY Editors Mr Don Chan Ms Juliette Lim Publications & Abstracts Ms Fion Tay Ms Lin Xiao Yun Ms Tan Sze Hwee COVER STORY | Publishing Agency At The Helm The Orange Press Pte. Ltd Pulse is a biannual publication 06 CLINICAL by the National University At The Helm Heart Centre, Singapore Leadership changes hands at (NUHCS) NUHCS 1E Kent Ridge Road, NUHS EVENT Tower Block, Level 9, Singapore 119228 16 Detecting A Lesser Known nuhcs@nuhs.edu.sg Disease Cardiac scintigraphy for the www.nuhcs.com.sg diagnosis of transthyretin www.youtube.com/NUHCS 10 amyloid cardiomyopathy The New Cath Labs www.facebook.com/NUHCS NUHCS builds modern cardiac 17 invasive catherisation laboratories First Of Many with new upgrades First Uniportal Non-Intubated Video Assisted Thoracic Surgery Copyright © is held by the publishers. All rights reserved. 12 (UNIVATS) performed in Singapore Reproduction in whole or in Ladies First parts without permission is Throwing a spotlight on women’s prohibited. heart health 2
PULSE | ISSUE 37 | TABLE OF CONTENTS FACES OF NUHCS NEWSBYTES 24 In Pursuit Of Answers To The Heart Researchers at the Cardiovascular Research Institute look at broad 18 spectrum of issues to improve disease burden in Singapore The Next Frontier Of Thoracic Surgery 33 Adoption of advanced robotic What's On TV? surgical system pushes thoracic Guest medical experts on surgery possibilities with better MediaCorp’s Channel 8 Body SOS patient outcomes 19 Expansion Of Thoracic Surgery At Ng Teng Fong 26 General Hospital The Accidental Career NUHCS works with NTFGH as Perfusion Week highlights critical OneNUHS role of perfusionists 33 Planting A Tree For Future Generations NUS Yong Loo Lin School of Medicine’s 115th Anniversary Plant-A- Tree programme 34 20 28 Awards & Promotions Safer, Quicker Discharge Never Walk Alone Congratulations to all our award- After Heart Surgery The role of patient support winners and newly-promoted Evidence-based protocols to groups doctors! optimise patient care RESEARCH 36 EDUCATION Publications & Abstracts 21 Finding Home With NUHCS Dr Kent Anthony Tan shares his fellowship experience at NUHCS 23 Covid-19, The Vaccine, 31 And Our Heart Every Second Counts Getting the facts straight The impact of the Covid-19 pandemic on the Western STEMI Network 3
PULSE | ISSUE 37 OUTGOING DIRECTOR'S MESSAGE Parting words from Prof Tan Huay Cheem after serving as the Director of National University Heart Centre, Singapore (NUHCS) for the past 13 years. Dear readers and colleagues, NUHCS family. It has always NUHCS into what it is today, a been my belief that our team heart centre which all of us and To many, NUHCS is not just can only be as strong as we Singapore can be proud of. This a medical heart centre. It is are, because of the support has been my legacy. known for its soul where a we receive from our families. strong cohesiveness and a colle- Besides, the enthusiastic perfor- It has been my privilege and gial working culture perme- mances have been always been honour to have the opportu- ates, where strong bonds and a crowd wow factor! nity to lead the Centre as its friendships are forged amongst director. I found my calling here, the people working in and with The time has now come for me and every day has truly been a NUHCS. to step aside for another to take joy for me, to work alongside the helm. But certainly, this is some of the most talented and Many of the staff, including not a farewell. I will always be passionate people you can find doctors, nurses and medical a strong supporter of NUHCS as in healthcare. technologists have committed I take on other roles outside of the best parts of their lives to the Centre. To James, I wish you good working here, devoting their health and luck. May you time and energy to care for I have worked with James on retain your sense of humour patients. I am eternally grate- numerous occasions, and there and contagious laughter as you ful for the support and contri- is no doubt in my mind that he take on the Directorship. bution of each staff, and wish I is one of the best cardiologists could embrace each individual that we are blessed with. With with thanks. his gifts in digital science and Tan Huay Cheem technology, I cannot wait to Prof Tan Huay Cheem One of the key highlights of see the digital transformation Senior Consultant, Department of my year has always been our of NUHCS in the years ahead. Cardiology, NUHCS annual Family Day celebrations when I get to meet colleagues While no leadership is perfect, I and gather with their fami- can say with all honesty that I lies for fun and food, bonding have done my best to contrib- together as part of the larger ute towards the building of 4
PULSE | ISSUE 37 INCOMING DIRECTOR'S MESSAGE A/Prof Yip Wei Luen James takes on the role of Director, National University Heart Centre, Singapore (NUHCS) with effect from 1 July 2021. Dear colleagues, Having benefited from their tute- lage, I aspire to pay it forward; to It is my privilege to address you, for continue their good work and pave the first time, as Director of NUHCS. the way for those who will come Prof Tan Huay Cheem has left me after me. with big shoes to fill, to say the least. During my term, I will continue my I remember feeling this way back in lifelong focus on People, Process and 2003 when I was newly promoted to Technology, in this order of priority. I be a consultant in cardiology. I was believe that as an organisation, we feeling a little overwhelmed and must put our people first if we are perhaps it showed. Prof Tan, who to expect our people to put patients was just taking over the mantle of first. We will give you the support chief then, looked at me reassur- and skills you need to ensure that ingly and said, “The only difference the right workflow, organisational between the two of us is just a little structure and technology are in experience.” place, so that, together, we can fulfil National University Health System’s Those words assured me that with tripartite mission of patient care, the passage of time, we would education and research. become better prepared for all of life’s challenges. I have had the priv- I look forward to working with each ilege of standing on the shoulders and every one of you in the days to of the ones who have come before come. me — Prof Tan included — and what a view it has been! James Yip A/Prof Yip Wei Luen James Director and Senior Consultant, NUHCS 5
PULSE | ISSUE 37 | COVER STORY A fter serving five years as At The Helm the Chief of the Cardiac Department, and the next 13 years as Director of National University Heart Centre, Singapore (NUHCS), Prof Tan Huay Cheem is pass- ing on the leadership role to senior consultant cardiologist, A/Prof Yip Wei Luen James. Leadership changes hands at NUHCS Stepping into the new direc- tor role, A/Prof Yip says of the transition, “With the passage of time, we would become better prepared of all of life’s It is not only about challenges. I have had the priv- ilege of standing on the shoul- adding years to life ders on the one who has come but life to years – before me and what a view it that would be our has been!” Centre’s mission A/Prof Yip Wei Luen, James, Two defining moments in Director and Senior Consultant, NUHCS Prof Tan’s tenure was when the Severe Acute Respiratory Syndrome (SARS) epidemic hit Singapore in 2003, and more recently, the ongoing corona- virus pandemic that broke out in 2020, requiring NUHCS to pivot and respond quickly in efforts to contain the outbreak. Few other leaders can claim the same of steering a heart centre through two global health crises. Not only has NUHCS survived the stress tests of these infec- tious disease outbreaks, the Centre has evolved and emerged stronger, transform- ing itself into the world-class academic heart centre, as it is known today. Prof Tan’s leadership at NUHCS was one that has led the path 6
PULSE | ISSUE 37 | COVER STORY of the Centre on an upwards Today, NUHCS provides a trajectory. From fewer than wide spectrum of tertiary and eight cardiology consultants, quaternary services organ- and just two surgeons in the ised uniquely into six different department, NUHCS has grown core clinical programmes with into a team of over 60 cardi- a focus on patient-centric care ologists and 20 surgeons over in a multidisciplinary and inte- three hospital sites, managing grated set-up. The Centre has almost three times its patient not only transform its facilities load in a span of 17 years. with modern technology incor- porating the latest treatment “It is however not the number techniques in the field of cardi- that matters, but rather ovascular medicine, but has the talents these individu- also expanded its capabilities als possess, the public service offering specialised care such ethos and values they uphold as geriatric cardiology, complex that distinguishes the Centre,” cardiac pregnancy manage- affirms Prof Tan. ment, pulmonary hypertension and vascular medicine with Leaning on the support and specialists trained cardiologists expertise from two interna- and cardiothoracic surgeons. tional advisory panels, Prof Tan worked with his small team Furthermore, NUHCS has estab- to conceive a heart centre lished a research arm, the Cardi- designed to meet the grow- ovascular Research Institute ing cardiovascular disease (CVRI), which delves deeper burden, and provide higher into the issues of heart failure quality care and treatment with wide ranging research outcomes for patients in areas including immunoassays, Singapore. mass spectroscopy, molecular biology, epigenetic infrastruc- ture, animal models and clini- cal cohort studies across several clinical sites. The greatest In just over a decade, CVRI has already received nota- fulfilment is the ble commendations from ability to effect other established institutions change and make acknowledging the quality things happen research it has put out, having published more than 50 papers Prof Tan Huay Cheem, Senior Consultant, Department of in the top 10 percent of high Cardiology, NUHCS impact medical and scientific journals in the last three years. 7
PULSE | ISSUE 37 | COVER STORY “There are strategic transfor- towards computer science and mational plans that have been information technology has mapped out to take NUHCS to kept NUHCS ahead in digital even greater heights, enabled science and applications, which by a solid organisation struc- will be instrumental in taking ture, a capable leadership team, NUHCS to its next digital trans- and supported by rapid techno- formation, turning it into a logical adoption and a strong future-ready medical centre. corporate culture,” opined Prof Tan. As the current Group Chief Medical Informatics Officer On A/Prof Yip as his succes- within National University sor, Prof Tan is in full support Health System (NUHS), it is no of his appointment. “There is secret that A/Prof Yip is a firm no doubt in my mind he is one advocate of technology and of the best cardiologists that healthcare analytics as a means NUHCS is blessed with. Besides to improve healthcare stand- his clinical competence, James ards for the people. is a genuine person with so much compassion for everyone “It is always first about the around him.” patients and the people whom we need to look after; followed In particular, Prof Tan high- by developing the process lighted A/Prof Yip’s inclination and infrastructure to help our organisation function effec- tively,” expounded A/Prof Yip 8
PULSE | ISSUE 37 | COVER STORY on his top priorities as NUHCS’ Singapore. Every new advance- ity is to help our patients fulfil Director. “Finally, technology ment in technology that poten- their life goals and to prepare will be the answer to help us tially increases human longev- for the end.” provide cost effective solutions ity, brings on the added cost for the public and to achieve of caring for older, frailer As the baton of leadership the first two priorities.” and medically more complex passes onward, the evolution patients. of NUHCS will continue on its The most concerning for A/Prof trajectory -- improving commu- Yip is reaching the increasing Hence, it is A/Prof Yip’s aspira- nity health with better and number of people who are at tion that NUHCS will be able to more cost-effective care that risk of cardiovascular diseases predict the value of interven- will empower people to take in what he terms as the “hidden tions for healthy longevity and ownership of their own health; epidemic”. “These are patients manage the cost effectiveness nurture the next generation who do not know they are in of therapies for the payors of of cardiovascular profession- trouble, or who think they are healthcare, such as the govern- als and further expand on its doing well until something ment and insurance companies. world-class research facilities. happens.” Enthusiastic about future possi- On this front, NUHCS has bilities in the field, A/Prof Yip ARTICLE BY already initiated the use of quipped, “Cardiologists always NUHCS Pulse Editorial remote cardiac monitoring seem to have one more trick up technology for some heart our sleeves to prevent death patients. However, epidemio- or disease progression that we logical trends show that cardi- often forget our responsibil- ovascular disease remains the biggest disease burden in 9
PULSE | ISSUE 37 | EVENT THE New CATH LABS NUHCS builds modern cardiac invasive catherisation laboratories with new upgrades National University Heart Centre, and improved clinical outcomes Diagnostic physiologic modalities Singapore (NUHCS) first set-up compared to traditional sternot- such as fractional flow reserve, its cardiac invasive catherisation omy procedures, the demand for thermodilution for coronary flow laboratories (also known as “cath modern cath lab facilities has since reserve (CFR), and the index for labs”) facility in 1992, sharing the been on the rise. microvascular resistance (IMR) al- same space with the radiology low cardiologists to assess coro- department. This meant that the In fact, many changes have been nary artery function more precisely. time allowed for procedures in the made to the standard require- facility has to be divided between ments of a modern cath lab in In addition, the cath labs are the two departments. the past decade alone. This pre- equipped with the latest calcium cipitated an expert panel from the modifying therapies such as orbit- Cath labs are specialised proce- Society for Cardiovascular Angiog- al atherectomy and intravascular dure rooms where doctors per- raphy and Interventions to release lithotripsy. These are used to tackle form minimally invasive tests and a consensus statement this year, issues with heavily calcified coro- procedures to diagnose and treat with specific recommendations on nary lesions which pose technical cardiovascular diseases. At that setting up, operating, maintaining difficulty during angioplasty and time, the shared facility was suffi- the highest standards of quality can translate to adverse outcome cient to support the relatively low and establishing current best prac- of stent restenosis and thrombosis. volume of about 300 coronary an- tices of modern cath labs. gioplasty cases each year. Implanting mechanical circulatory Over the years, NUHCS has been support systems such as non-sur- With the growing geriatric popu- progressively updating its cardiac gical heart pumps in patients with lation and rising incidence of car- invasive cath labs (ICL) to meet more complex and high-risk coro- diovascular diseases, advanced current and future healthcare chal- nary artery diseases can be carried diagnostic cardiac catherisation lenges. Today, they are equipped out in these cath labs. and angiography procedures have with many advanced coronary in- since been introduced to support tervention technologies, such as In addition, the electrophysiologist the burden of coronary disease lo- intravascular ultrasound and op- (EP) team which utilises the same cally. tical coherence imaging for intra- facility performs tertiary complex vascular imaging which is used to arrhythmia ablations and device Coupled with the advent of min- assess the severity of coronary ar- implantation using advanced pro- imally invasive cardiac surgery tery disease by providing a tomo- cedures such as cryoablation and and innovative catheter-based graphical image of the coronary His bundle pacing (HBP)1 for con- approaches which have generally arteries. duction system pacing in the labs. resulted in shorter recovery times 10
PULSE | ISSUE 37 | EVENT In January this year, NUHCS up- graded all three cath labs with Cath Lab in 1990 modern biplane imaging systems. These advanced medical imag- ing technologies use two rotating cameras to take simultaneous im- ages, forming a 3D portrait of the body area with highly detailed im- ages of blood vessels, soft tissue and blood flow in real-time. Furthermore, the cath labs are connected to a hybrid operating theatre equipped with an angio- graphic imaging capability, ena- bling the entire facility to support a wide range of endovascular, cath- eter-based interventional therapies in the field of coronary, peripheral, congenital and structural inter- ventions, as well as electrophys- iological studies, radiofrequency ablation, and pacemaker device implantation. These new upgrades mark yet an- other milestone in the expansion of the cath lab facility and services at NUHCS, ensuring the allocated space remains highly efficient to serve the current annual load of about 1,700 cases of percutane- ous coronary intervention and 660 cases of EP ablation and device im- plantation procedures. New Cath Lab in 2021 1 His bundle pacing (HBP) – A therapy with the intent of overcoming sites of atrioven- tricular (AV) conduction disease and delay. affecting a large area of the heart. ARTICLE BY Prof Tan Huay Cheem Senior Consultant, Department of Cardiology, NUHCS Prof Tan is a Professor of Medicine, Yong Loo Lin School of Medicine, NUS and has a master of Medicine in Internal Medicine. He is an active clinical researcher, visiting professor at several hospitals in China and invited speaker at many international cardiology meetings. 11
Ladies PULSE | ISSUE 37 | EVENT First h rowing a s T potligh t on women’s heart health Commemorating International Women’s Day in March 2021, the National University Heart Centre, Singapore’s (NUHCS) Women’s Heart Health Programme launched a public education campaign focusing on women’s heart health issues. The message was clear – women need to put themselves first and prioritise their heart health as well. In a commentary published in The Straits Times and Lianhe Zaobao, Dr Wang Yi Ting Laureen, Associate Consultant, Department of Cardiology, "Celebrating Strong Women" NUHCS wrote about the cardiovascular risks at every life stage of a woman, and the preventa- Scan the code tive steps that can be taken. In her article, she to watch the inspirational emphasised the need to keep the heart in tip-top video: condition as crucial to the process of aging gracefully. NUHCS also released an inspirational video across its online platforms, honouring the “Wonder Women” in the healthcare industry. These women took on the role of caring for others in their profession, continuously delivering high standards of patient care, whilst caring for others in their personal lives. 12
PULSE | ISSUE 37 | EVENT Wearing multiple hats and managing expec- tations in both their personal and profes- sional lives, these nurses, cardiac techni- cians and doctors from NUHCS share their greatest pride at work in caring for patients with cardiac conditions. At the same time, they made the call for all women to protect their hearts. In collaboration with Something Private podcast, Asst Prof Low Ting Ting, Consult- ant, Department of Cardiology, NUHCS c u r e a b r o k en h e art" joined Dr Wang and the producer to discuss "The doctors who c an women’s heart health in a 40-minute podcast show, “Ladies, let’s have a Heart- Watch the to-Heart about your Heart”. The show podcast here: was broadcast on Spotify, YouTube, Insta- gram, and Facebook. Asst Prof Low and Dr Wang described the warning signs of heart diseases, discussed the consequences of self-neglect, and called for the need to raise awareness of heart disease in women. Working with digital publisher, Our Grand- father Story, a comic strip was conceptu- alised to depict the symptoms of a heart attack in women. These are often subtle and ignored, further increasing the risk for women. Published and shared across multi- ple media platforms, the comic communi- cated the need for women to prioritise the health of their hearts. ARTICLE BY Asst Prof Low Ting Ting To the busy everyday Consultant, Department of Cardiology, NUHCS women – self-care is not a luxury, it is a Asst Prof Low Ting Ting is currently the clinical director of the Women’s Heart Health Programme, which provides gender-tailored cardiac care necessity. Be heart and subspecialty management in pregnancy and heart disease, female phenotype coronary syndromes and smart and treat your heart failure conditions with a predilection for women. She is active in leading clinical trials and multi-centre heart right. registry work as well as research in advancing therapies for rarer conditions. She is also passionate about mentor- Asst Prof Low Ting Ting, Consultant, ing and leads the undergraduate cardiology programme Department of Cardiology, NUHCS in the National University of Singapore (NUS). 13
PULSE | ISSUE 37 | EVENT Read our What Women's Heart Health brochure: How To Recognise a Heart Attack In Symptoms in Men & Women Symptoms both men & in women: women: Shortness of Breath Dizziness Jaw, Neck, Extreme Fatigue or Back Pain Lower Chest or Chest Pain Upper Abdomen Pain (not always for women) Indigestion Cold Sweat Oestrogen may play a strong role in protecting women from heart disease which could explain why women are at higher risk of a heart attack after menopause. Women are MORE likely to ignore the symptoms of a heart attack or Nausea or delay seeking treatment. As a Vomiting result, they are LESS likely than men to receive timely treatment. 14
PULSE | ISSUE 37 | EVENT Need to Know 10 Vital Statistic about W Heart H s omen's ealth 1 in 3 women die of Only 6 out of 10 women know that shortness of breath is the more cardiovascular disease every year common warning sign of a heart attack Women are 2 times at risk of death 7 out of 10 women correctly identified chest pain as a heart within 30 days after a heart attack attack symptom 3 out of 10 women know that Only 8 % of women surveyed talked heart attack symptoms in women about cardiovascular- related topics with are different than in men their doctor in the past 12 months 445 lives were claimed by breast Women are 3. 9 times at risk of a cancer while cardiovascular disease heart attack from stress claimed 2,689 women lives in 2019 Women are 5 5% less likely than men 10 years after a heart attack, to participate in cardiac rehabilitation, women are 2.1 times more likely to even after a heart attack die compared to men E C HARGE TAK E ND REDUC A RISKS YOUR ART Healthy Diet Avoid Lose Weight Check Blood OF HE E Alcohol Sugar S DISEA Here are some things you can do to aid in the prevention of heart disease! Sleep Well Stop Exercise Check Blood Source: National University Heart Centre, Singapore Smoking Pressure (NUHCS), a survey conducted by Singapore Heart Foundation in 2020 and American Heart Foundation 15
PULSE | ISSUE 37 | CLINICAL DETECTING A LESSER KNOWN DISEASE Cardiac scintigraphy1 for the diagnosis of transthyretin amyloid cardiomyopathy2 Amyloidosis is a protein for the purpose of removing mis-folding disorder, occurring small samples of heart muscle when native blood proteins tissue for microscopic examina- aggregate abnormally into tion. insoluble fibrils (amyloid) and deposit into various end- In collaboration with the organs. The heart can be Department of Diagnos- affected in some forms of tic Imaging, National Univer- amyloidosis, one of them being sity Hospital, National Univer- transthyretin (TTR) amyloidosis. sity Heart Centre, Singapore (NUHCS) recently started the TTR is a transporter protein technetium pyrophosphate produced by the liver. In the scintigraphy3 service for the presence of genetic mutation diagnosis of ATTR-CM. or with age, TTR can mis-fold into insoluble amyloid fibrils This nuclear scan modality has and deposit in the heart. been shown to be as reliable as an endomyocardial biopsy Transthyretin amyloid cardio- for the diagnosis of ATTR-CM We envision that the myopathy (ATTR-CM) patients in the right clinical context, availability of this typically present with heart and allows patients to be diag- service will allow early failure and low blood pressure. nosed without going through diagnosis and prompt An echocardiogram will reveal an invasive procedure. treatment of ATTR-CM marked left ventricular wall patients in the future. thickening. About 20 patients have under- Asst Prof Lin Weiqin, Clinical Director, Heart gone the scan since its introduc- Failure Programme and Consultant, Department ATTR-CM was previously tion in November 2020, helping of Cardiology, NUHCS thought to be a rare cause of doctors to diagnose and treat heart failure amongst elderly them accordingly for ATTR-CM. ARTICLE BY men. However, recent studies Asst Prof Lin Weiqin scintigraphy – Procedure where a small amount have shown that ATTR-CM is 1 Clinical Director, Heart of radioactive chemical is injected into the vein Failure Programme and likely underdiagnosed due to to produce scans of the body’s internal structures Consultant, Department of used to diagnose, stage and monitor disease such a lack of awareness about the as cancer Cardiology, NUHCS disease. 2 cardiomyopathy – A condition caused by Asst Prof Lin is trained in the management of acute abnormalities in the heart muscles, resulting in heart failure with temporary mechanical circulatory dysfunctional heart pumping support, as well as caring for advanced heart failure In the past, the only way to diag- patients with implanted durable left ventricular 3 technetium pyrophosphate scintigraphy – nose ATTR-CM was through A radiotracer scan used to differentiate transthy- assist devices (LVADs) or heart transplantation. Besides heart failure, his other subspecialty interests endomyocardial biopsy, which retin from light-chain amyloidosis, in patients with cardiac amyloidosis include cardiomyopathies and echocardiography. is an invasive procedure done 16
PULSE | ISSUE 37 | CLINICAL FIRST OF MANY First Uniportal Non-Intubated Video Assisted Thoracic Surgery (UNIVATS) performed in Singapore The thoracic surgery and anaesthesia teams at the National University Hospital (NUH) successfully introduced UNIVATS for the treatment of a patient with a rare nerve tumour called Schwannoma on 21 January 2021. This marks the first UNIVATS procedure performed here in Singapore. UNIVATS is a new procedure combining Uniportal Video Assisted Thoracic Surgery (UVATS) with Non-Intubated Video Assisted Thoracic Surgery (NIVATS). UVATS is performed through a single port thora- coscopic1 surgery via a small 1-inch incision on the patient’s chest. NIVATS is a more natural way of administering anaesthe- sia during surgery, as there is no need for an endotracheal2 tube to go deep into the airway, and compared to the usual 2 to 3 ARTICLE BY milder forms of anaesthetic days. After the operation, the A/Prof John Tam Kit Chung Head and Senior Consultant, medications are being used. patient’s chest discomfort from Division of Thoracic Surgery, the nerve tumor is relieved, Department of Cardiac Thoracic and Vascular Surgery By combining both UVATS and the patient expressed high (CTVS), NUHCS and NIVATS, UNIVATS can be levels of satisfaction with the A/Prof John Tam is the founding Head performed with even smaller surgery, the anaesthetic tech- of Thoracic Surgery at the NUHCS. He is a thoracic incisions, allowing patients to nique, as well as the overall surgeon specialising in performing minimally inva- sive single-port keyhole surgery using advanced benefit from less physiological experience. techniques in Uniportal Video-Assisted Thoraco- scopic Surgery (UVATS). His research has been stress, airway trauma, thereby published across many high-impact medical and reducing the risk of respiratory UNIVATS is currently the most scientific journals. He also serves as a member on the Singapore Residency Advisory Committee for infection, resulting in faster advanced minimally invasive Cardio-Thoracic Surgery. He has won many awards recovery from anesthesia, over- thoracic surgery procedure in in recognition for his service to patients and his contribution to the field of academic surgery. all recovery time, and a shorter the field, which combines the hospital stay. expertise from the surgical and anaesthetic teams to achieve In particular, the first patient, the best outcomes for thoracic Dr Deborah Khoo Xian Li Consultant, Department of who had a successful UNIVATS surgery patients. Anaesthesia, NUH procedure to resect a rare nerve tumour in the chest stayed Dr Deborah Khoo is a Consultant at the Department of Anaesthesia, National 1 thoracoscopic – A minimally invasive procedure in the hospital for 23 hours in the chest that is performed using an edoscopic University Hospital with research interests in the camera field of difficult airway management and training, in a day surgery ward, which medical education and methodology, as well as the is a substantial improvement endotracheal – Inside the trachea 2 use of anti-fibrinolytics in spine operations. 17
PULSE | ISSUE 37 | CLINICAL THE NEXT FRONTIER OF THORACIC SURGERY Adoption of advanced robotic surgical system pushes thoracic surgery possibilities with better patient outcomes The division of thoracic surgery The division’s coherent move in the National University Heart to adopt the advanced robotic Centre, Singapore (NUHCS) has system has been proven to aug- always been at the forefront ment thoracic surgical proce- of minimally invasive thoracic dures and accelerate the capa- surgery in Asia, adopting the bilities of thoracic surgery for latest surgical technologies lung and mediastinal1 surgery. to achieve better patient out- comes in a safe and reliable way. The first robotic thoracic sur- gery performed for a mediasti- Employing video-assisted thor- nal tumor was carried out by Dr acoscopic surgery, the divi- Mithiran, with the guidance of sion led by A/Prof John Tam, a robotic proctor Dr Aneez D.B together with Dr Harish Ahmed, Director and Senior Mithiran Muthiah and Asst Prof Consultant at the International Ooi Oon Cheong, have per- Centre for Thoracic Surgery, in formed more than 3,000 tho- March 2021 at the National racic surgeries to date. University Hospital (NUH). The surgery was a success with the Recently, the division invested patient discharged the follow- resources in robotic-assisted ing day. surgery where significant advancements have been Equipped with this technology, ARTICLE BY made. With the intuitive da NUHCS’ thoracic surgery divi- Dr Harish Mithiran Muthiah Consultant, Division Vinci Robotic system, surgeons sion is able to offer a compre- of Thoracic Surgery, control the robotic arms from hensive suite of minimally inva- Department of Cardiac, Thoracic and Vascular a console situated within the sive thoracic surgery options for Surgery (CTVS), NUHCS operating room. The robotic both lung and mediastinal dis- arms are inserted through tiny eases with better precision and Dr Mithiran trained at NUH in cardiothoracic surgery. He completed his advance surgical incisions, acting as an better outcomes. surgical training in 2014 where he was awarded extension of the surgeon’s arms, the Fellowship of the Royal College of Surgeons of Edinburgh. He has a special interest in minimally mirroring every hand move- 1 mediastinal – Refers to conditions that affect the invasive thoracic surgery which include Video-As- mediastinum, the space in the chest, surrounded sisted Thoracic Sugery(VATS) and Robotic Assisted ment. This enables delicate by the breastbone, spine and the lungs. Thoracic Surgery(RATS) for lung and chest diseases. and complex operations to be He also currently serves as the Asst Programme Director for the Cardiothoracic Surgery Residency carried out with high precision Programme. and safety. 18
PULSE | ISSUE 37 | CLINICAL EXPANSION OF THORACIC SURGERY AT NG TENG FONG GENERAL HOSPITAL NUHCS works with NTFGH as OneNUHS We share the common vision of providing high quality services to our patients, and to realise the vision of OneNUHS for thoracic surgery services across our cluster. A/Prof John Tam Kit Chung, Head and Senior Consultant, Division of Thoracic Surgery, Department of CTVS, NUHCS Following its opening in 2015, sion. The deliberation included Ng Teng Fong General Hospital a walking tour of NTFGH facili- ARTICLE BY (NTFGH) has been receiving an ties to review the patient flow A/Prof John Tam increasing number of patients process. Kit Chung Head and Senior Consultant, requiring thoracic surgery, Division of Thoracic Surgery, Department of CTVS, NUHCS leading to a subsequent need To avoid a long waiting time to scale up the provision of for thoracic surgeries at NTFGH, A/Prof John Tam is the founding thoracic surgery services. the thoracic surgical team from Head of Thoracic Surgery at the NUHCS. He is a thoracic surgeon specialising in performing mini- NUHCS will perform urgent and mally invasive single-port keyhole surgery using advanced techniques in Uniportal Video-Assisted For that reason, the surgery emergent thoracic surgeries Thoracoscopic Surgery (UVATS). His research has and operations team led by A/ at NTFGH. The hospital's surgi- been published across many high-impact medical and scientific journals. He also serves as a member Prof Theodoros Kofidis and A/ cal team will provide in-house on the Singapore Residency Advisory Committee Prof John Tam Kit Chung from support to facilitate intraop- for Cardio-Thoracic Surgery. He has won many awards in recognition for his service to patients and the Department of Cardiac erative assistance and post- his contribution to the field of academic surgery. Thoracic and Vascular Surgery operative care management. (CTVS) at the National Univer- Patients can now also receive Dr Harish Mithiran sity Heart (NUHCS) collab- after surgery care through the Muthiah Consultant, Division orated with the team from outpatient thoracic surgery of Thoracic Surgery, NTFGH headed by Adj A/Prof services in NTFGH. Department of CTVS, NUHCS Noel Stanley Tay to detail the Dr Mithiran trained at National provision of urgent and outpa- By increasing the thoracic University Hospital (NUH) in cardiothoracic surgery. tient thoracic services at NTFGH. surgery capacity at NTFGH, resi- He completed his advance surgical training in 2014 where he was awarded the Fellowship of the Royal Weighing in these discussions, dents in the Western region of College of Surgeons of Edinburgh. He has a special interest in minimally invasive thoracic surgery which from NTFGH, were Prof Philip Singapore will be better served include Video-Assisted Thoracic Surgery (VATS) and Lau, Head of Surgery, and Asst and can expect a more efficient Robotic Assisted Thoracic Surgery (RATS) for lung and chest diseases. He also currently serves as the Prof Soon Yuen, Head of Upper system under the OneNUHS Asst Programme Director for the Cardiothoracic Surgery Residency Programme. Gastrointestinal Surgery Divi- cluster. 19
PULSE | ISSUE 37 | CLINICAL SAFER, QUICKER DISCHARGE AFTER HEART SURGERY Evidence-based protocols to optimise patient care National University Heart tive team involving surgeons, ARTICLE BY Centre, Singapore (NUHCS) anaesthesiologists, intensiv- Dr Chang Guohao recently implemented the ists, haematologists, endo- Consultant, Department of Cardiac Thoracic and Enhanced Recovery After crinologists, nephrologists, Vascular Surgery (CTVS), Surgery (ERAS®) protocol for nurses, physiotherapists, dieti- NUHCS cardiac surgery – one of the tians, counsellors, perfusionists Dr Chang is an accredited specialist in cardiotho- most resource-intensive and and case managers to develop racic surgery by Singapore’s Ministry of Health and was awarded the College of Surgeons Gold complex surgeries. a comprehensive periopera- Medal in Cardiothoracic Surgery. He is currently a tive programme, guided by Consultant in the Department of CTVS at NUHCS with interests in all aspects of adult cardiac surgery In 2019, the ERAS® protocol for the protocols from the ERAS® including extracorporeal life support. cardiac surgery was published Cardiac Society, as well as by the ERAS Cardiac Soci- published studies with further A/Prof Ti Lian Kah ety following a multi-discipli- recommendations from hospi- Director of Cardiac Anaesthesia & Senior nary systematic review of the tals in the United States of Consultant, Department current literature. This protocol America, Germany and China. of Anaesthesia, National University Hospital (NUH) has adopted many principles from abdominal surgery proto- NUHCS will be closely rev- A/Prof Ti is a tenured associate professor with the cols, and also incorporated iewing pre- and post-protocol Yong Loo Lin School of Medicine, National Univer- sity of Singapore. He did his cardiac anaesthesia recommendations that reflect implementation with a series fellowship at Duke University in the United States the unique nature of cardiac of preoperative, intraopera- of America (USA), and is accredited for perioper- ative transesophageal echocardiography by the surgery. tive and postoperative inter- National Board of Echocardiography, USA. His research interest is on outcomes after surgery and ventions (involving medical has published over 80 papers, including on compli- Implementation of the proto- subspecialties and allied health cations such as acute kidney injury, atrial fibrillation and poor neurological outcomes. col requires establishing a support) to optimise overall multi-disciplinary collabora- patient outcomes. 20
PULSE | ISSUE 37 | EDUCATION DELVING DEEPER ARTICLE BY NUHCS Pulse Editorial INTO CARDIOLOGY Dr Kent Anthony Tan shares his experience of the interventional cardiology fellowship at NUHCS In September 2018, Dr Kent the 2019 AICT-Asia PCR meet- Anthony Tan from the Phil- ing,” shared Dr Tan. “Some of ippines was accepted into my mentors from back home the Interventional Cardiol- were in attendance, so it ogy Fellowship Programme at was a proud moment for me the National University Heart when they commended my Centre, Singapore (NUHCS) progress.” after completing seven years of his residency programme at Reminiscing his night duty the Philippines Heart Centre. calls, he recollected being stretched and challenged to He spent one year train- meet the standards expected ing in various contempo- at NUHCS when dealing with rary atherectomy modalities1 the acute heart failure cases and the second year delving that came rushing through deeper into cardiovascular the hospital’s emergency structural intervention. doors. The team’s razor sharp NUHCS Fellowship / focus and vigilance for possi- Clinical Attachment “Good judgement comes from ble complexities was inspiring NUHCS offers a Fellowship / Clinical experience, and experience for Dr Tan. Attachment Programme to foreign comes from bad judgment,” doctors to gain firsthand experience shared Prof Tan Huay Cheem, “The hardest part of the in the Singapore healthcare industry, develop and strengthen the regional Senior Consultant, Depart- programme was turning in my referral network, whilst acquiring ment of Cardiology, who was hospital pass,” said Dr Tan. “It specific clinical skills under the then the Director of NUHCS. was an act of finality, marking mentorship of leading medical Dr Tan has since made it his the end of my time at NUHCS professionals at NUHCS. To find out own maxim in becoming a and having to say goodbye. As more about the eligibility criteria better doctor. all good things must come to and application process, please email the programme coordinator at an end, I am eagerly looking fellowship_application@nuhs.edu.sg. He was actively engaged on forward to the next step in my various levels in procedural career, where I can apply my AICT-Asia PCR meeting and clinical work — treat- learnings from NUHCS.” Formed in 2019, AICT-Asia PCR is ing patients with pulmonary built by local practitioners with the atherectomy modalities – Methods of treat- hypertension (PH)2, adult 1 support of centres of excellence in ment to remove plaque build-up in diseased congenital heart diseases and arteries, limiting the flow of oxygen-rich blood the Asia Pacific region and Europe, to valve disorders, whilst being to organs and other parts of the body. focus on the diverse needs of patients PH – A type of high blood pressure affecting 2 in the interventional landscape. As trained in various approaches the lung arteries and the right side of the a global educational meeting in the to heart diseases and valve heart. Asia Pacific region, the platform pathologies. orbital atherectomy – A new methodology 3 allows knowledge exchange between for treating arterial disease within the major and branch arteries of the leg. peers and the opportunity for “One of the highlights for me healthcare professionals to showcase their research and innovation, aimed was being part of a live trans- at contributing to the development mission working on an orbital of treatment and care possibilities to atherectomy3 case along- better serve the region’s patients. side A/Prof Adrian Low at 21
PULSE | ISSUE 37 | EDUCATION COVID-19, THE VACCINE, AND OUR HEART Getting the facts straight ARTICLE BY Prof Tan Huay Cheem Senior Consultant, Department of Cardiology, National University Heart While Covid-19 initially affects However, it is also important to Centre, Singapore (NUHCS) the airways and lungs, mount- note that many patients with Prof Tan is a Professor of ing evidence has shown that the mild Covid-19 infection, includ- Medicine, Yong Loo Lin School of Medicine, NUS and has a master of Medicine in Internal Medicine. heart muscle and the cardiovas- ing those with heart condi- He is an active clinical researcher, visiting professor cular system are also affected, tions, have managed to recover at several hospitals in China and invited speaker at many international cardiology meetings. and can be severely damaged fully. Nonetheless, research- as a result of the viral infection. ers are still compiling data to better understand the long- Scientists found that the SARS- term impact of the coronavirus CoV-2 coronavirus can cause on the heart and the overall high levels of inflammation in health of those who recover. the body including the heart muscles (myocarditis) or cause As a consequence of the damage to the blood vessels, higher risks of developing seri- compromising the cardiovascu- ous life-threatening compli- lar system. In severe cases, this cations, experts encourage could lead to a heart attack those with heart conditions, (acute myocardial infarction), including those who are on heart failure, abnormal heart blood thinners such rhythm (arrhythmias), shock, as antiplatelets (aspi- and cardiac arrest. rin or clopidogrel), to protect themselves As heart patients tend to be from the Covid-19 older (over the age of 65 years) virus by taking the and usually suffer from multi- vaccination as soon as ple comorbidities such as diabe- possible. Those on anti- tes mellitus, hypertension, high coagulants (e.g. warfa- cholesterol and kidney diseases, rin or newer agents further contracting the Covid- such as rivarox- 19 infection makes them more aban, apixaban, likely to develop severe compli- or dabigatran) are cations. further advised to apply compression This explains why Covid-19 over the site of injec- patients with underlying heart tion for an additional five conditions are six times more minutes. likely to be hospitalised and 12 times more likely to die, compared with those without any heart condition. 22
PULSE | ISSUE 37 | EDUCATION WHY VACCINE: VACCINATE? MYTHS & FACTS Lowers your risk of severe MYTH complications from Covid-19 The vaccines were developed too fast to be trusted for their efficacy. Prevents the virus from spreading to another person FACT Protects you and your loved ones The science is very clear on the efficacy of the vaccine. It was developed much Creates a protective web if many people quicker than usual because there are in a community are vaccinated many eligible patients for testing in a pandemic, instead of having to wait Allows business and other for patients to enroll in the tests. Addi- social activities to resume tionally, the phases of vaccine testing were carried out concomitantly during this pandemic which shortens the time. Finally, there has been a total commit- ment by manufacturers for rapid vaccine development and co-operation by the governing bodies to speed up review and accreditation processes. MYTH The new mRNA technology of vaccines may potentially transform recipients from humans into “hybrids” through alteration of the cell’s DNA structure. FACT The mRNA vaccine is made up of a gene, which codes for a viral protein, wrapped up in a fat droplet, and administered intramuscularly. The mRNA gene makes the cell produce the viral protein to stimulate our body’s immune response to the virus but does not alter the host cell's DNA structure. This is the very basis of the science behind cells and cellular function. A genetic modification would involve the deliberate insertion of foreign DNA into the nucleus of a human cell which is not how a vaccine works. 23
PULSE | ISSUE 37 | FACES OF NUHCS IN PURSUIT OF ANSWERS TO THE HEART Researchers at the Cardiovascular Research Institute look at broad spectrum of issues ARTICLE BY to improve disease burden in Singapore NUHCS Pulse Editorial “In the 1980s, 80 to 90 percent ment including wet lab facili- of the people who had heart ties, research animal breeding failure were likely to die in the colonies, high-definition digital next few weeks. Now, about imaging equipment, and high half of these people will be throughput platforms to run able to live for another five to and perform a wide array of six years,” reflected Prof Arthur proteomic, metabolomic and Mark Richards, Deputy Direc- nucleic acid assays and analysis. tor, National University Heart Centre, Singapore (NUHCS) on At any one time, CVRI tackles the changes he has seen over around 50 different projects the years in his career. relating to cardiovascular issues, from looking at a particular Even so, he added, such odds molecule in a cell in a lab to leave plenty of room for running clinical trials of novel improvement and many chal- approaches to the treatment of lenges for clinicians and scien- heart failure. tists to answer. “One thing that stood out to Describing the field as a me was the great deal of heart specialty with many unan- and arterial diseases here, but swered questions, Prof Rich- research funding for cardiovas- ards is intent on finding these cular research was dispropor- answers at the Cardiovascular tionately small compared to Research Institute (CVRI) – the that going to other biomedical research arm of NUHCS, where domains,” Prof Richards said in he has led as Director since itsobservation when he was part inception in 2009. of the Cardiovascular Disease Taskforce to develop research Hailing from New Zealand, roadmaps for Singapore. Prof Richards has built CVRI from ground up with a hand- Singapore has a high rate of ful of researchers to a centre diabetes which is the key back- with about 100 dedicated ground contributing factor to staff working in an advanced heart diseases in people here. research centre equipped The combination of diabetes with specialised lab equip- with risk factors such as high 24
PULSE | ISSUE 37 | FACES OF NUHCS blood pressure appears to be rebuilding and regenerating able to encourage institutes far more toxic to the heart in the heart. in Singapore to collaborate, Singapore than in western which not only avoids duplica- countries. “It’s very ambitious but kind tion of resources but combines of aspirational. It is the foun- institutional strengths and has “We don’t really understand the dational mission for our work, fostered communication and problem,” he let on. “Rather and directs the advances we closer working ties between than focus solely on the heart have made,” he said. the different institutes. organ, we need to think about the things that injure it – such Some of the work that have “I don’t think this has happened as diabetes, blood pressure, come out of CVRI include the in other countries,” said Prof hypertension, all of which are design and development of a Richards. very prevalent here.” new heart replacement valve made from natural materials; Looking ahead, he is hopeful In the race for answers, he the re-engineering of a protein that CVRI will expand to tackle said, “One of the next steps from a bacterium to encap- the multitude of cardiovascular for me, is to encourage cardi- sulate another protein for issues confounding experts. He ovascular research. We could targeted purposes, and identi- also sees the institute progress- have another five or six senior fying new biomarkers that can ing further into the research research investigators who predict heart failure after a which they have made head- could bring CVRI to a heart attack. way. critical mass, where it can really keep CVRI performs clinical trials in He chimed, “We have a whole its momentum, collaboration with other insti- atlas of biomarkers now that have lots of tutes in Singapore and in other we would like to explore from cross-polli- countries on related studies our previous work. We want to such as looking into the asso- see if they do actually work for ciation of poor sleep and coro- prognostic or diagnostic uses nary heart disease to address a in the clinic and whether they patient’s survival rate. point to entirely new treat- ments. There is a lot going on!” Having been here for over a decade, Prof Richards acknowl- edged that Singapore has some unique strengths conducive for medical research such as the high education and good work ethics of the talent pool. “People here typically really When you get on the trail want to do a good job and take of asking questions and things to the next level.” finding answers, and nation of ideas He further commented on the making discoveries, you with each other, research support structure in tend to stay on the path. share facilities and Singapore which he thought Prof Arthur Mark Richards, Deputy Director, NUHCS and Director, CVRI generate more synergy.” was “far-sighted”. The govern- ment provides grants to support CVRI has been paying atten- junior clinician scientists to tion to heart failure, focus- pursue research whilst they ing on a broad spectrum from continue with clinical work. pure prevention to complete Grants are also made avail- 25
PULSE | ISSUE 37 | FACES OF NUHCS THE ACCIDENTAL CAREER Perfusion Week highlights critical role of perfusionists The first week of May is dedi- cated as Perfusion Week to Ms Clara Anne Lim bring about awareness of the Perfusionist, Department of CTVS, perfusionist’s role in cardiovas- NUHCS cular surgery and extracorpor- eal membrane oxygenation (ECMO). What got you interested in the What do you like best about job of a perfusionist? being a perfusionist? Many cardiovascular surger- Clara: It was a recruiter from I love the challenges I face in ies need the heart to be still in whom I first heard about this fast-paced job. It requires order to be operated on. This the job of a perfusionist. I quick thinking on your feet, is where perfusionists step in. had to google it as it was and is also demanding as we They are specially trained to my first time hearing about are required to support the operate, maintain and record this job! However, the job various number of surgeries the output of the heart-lung piqued my interest as it was going on. machine, designed to maintain related to my studies – car- the circulation of blood and It is a very rewarding job, diac technology and bio- oxygen through the body. when I play a part in help- medical sciences. I decided to take up the challenge as ing someone survive surgery Outside the operating theatres that will help him or her the human heart has always (OT), perfusionists also provide lead a better quality of life. fascinated me. cardiac and respiratory sup- port with the ECMO machines, On the day of my inter- What are the most challenging which are smaller heart-lung view, I remember a senior aspects of the job? machines designed for long- perfusionist sprung a sur- term life support. prise tour to the OT where I There are some days which would need to work in, and can be more physically and Working as a perfusionist observed my response to mentally challenging than within the Department of Car- being present during open others. diac, Thoracic and Vascular Sur- heart surgeries. I certainly We are rostered to be on gery (CTVS) at the National did not expect that. Luckily, I call 24 hours to respond to University Heart Centre, Singa- did not faint or I would have medical emergencies. When pore (NUHCS), Ms Clara Anne been rejected. these situations occur, it Lim shares more about the could mean long hours as profession. 26
PULSE | ISSUE 37 | FACES OF NUHCS emergency procedures can and machinery to be smaller the patient once they are be very complicated. which also meant that we on bypass, constantly mon- need to be very precise in itoring and responding to There was one difficult night managing these cases. In haemodynamic, brain func- call during the Covid-19 addition, congenital car- tion, and blood gas changes, Circuit Breaker in 2020. A diac surgeries on paediatrics making clinical decisions on patient had a heart attack tend to be more complex as patient management during and went into cardiogenic they could have different the surgery. shock. He was also a sus- anatomies and physiologies pected Covid-19 case which compared to adults. Any tips for aspiring required the procedure to perfusionists? be done in isolation, and for What are some common us to don on full personal Understand the anatomy misconceptions about and physiology of the entire protection equipment (PPE). perfusionists? human body, and not just This meant that we could Like me at the start of my the heart. We perfuse the not leave the OT even for career, many people have entire body which has a crit- a toilet break, as the PPE not heard about perfusion- ical impact on the functions made it a hassle. Since it was ists. They think the job is of other organs, including an emergency, the entire related to perfumes, when it the brain and kidneys. team was basically stuck in is actually about the body’s the room the entire night as circulatory system. ARTICLE BY there was no backup team! Mr Goh Si Guim Senior Principal Another misconception is Perfusionist, Department In general, I find paediat- that people liken our job of CTVS, NUHCS ric cases more stressful and to a technician operating Mr Goh joined a team of three demanding, especially when a machine. However, our perfusionists at the National they are fragile newborns. responsibility goes beyond University Hospital (NUH) to help support the Department of CTVS in 1993. With the expansion They are much smaller in that. We take over the oxy- and growth of cardiovascular surgical procedures at NUH, the Perfusion Service team has likewise size, requiring our circuits genation and perfusion of grown in parallel to a team of 12, to date. He was previously trained to become a qualified perfusion- ist at the Singapore General Hospital and holds a Bachelor’s in Biological Sciences. 27
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