Greater Manchester Antimicrobial Guidelines - October 2021 Version 10.0 Planned review date: January 2022 - GMMMG
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Greater Manchester Antimicrobial Guidelines October 2021 Version 10.0 Planned review date: January 2022
Greater Manchester Antimicrobial Guidelines October2021 DOCUMENT CONTROL Document location Copies of this document can be obtained from: Name: Strategic Medicines Optimisation Address: Greater Manchester Joint Commissioning Team Civic Centre West Street Oldham OL1 1UT Email: Oldccg.medsman@nhs.net Revision history The latest and master version of this document is held by Greater Manchester Health and Care Commissioning Medicines Optimisation team: REVISION ACTIONED BY SUMMARY OF CHANGES VERSION DATE E Radcliffe 12/08/2021 V9.0 approved by GMMMG 9.0 18/08/2021 E Radcliffe Amended C diff section and other following commen ts received 9.1 Updated following responses from GM AMS task and finish group to 07/10/2021 E Radcliffe 9.2 clinical queries 25/10/2021 MGSG Approved v 10 10.0 Approvals This document has been provided for information to: NAME DATE OF ISSUE VERSION GMMMG GMMMG website 9.0 GM AMS T&F group 11/10/2021 9.2 MGSG 25/10/2021 10.0 Changes to version 9.0 – see end of document. Version 10.0 2 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 Aims • to provide a simple, empirical approach to the treatment of common infections • to promote the safe and effective use of antibiotics • to minimise the emergence of bacterial resistance in the community Principles of Treatment 1. This guidance is based on the best available evidence, but use professional judgement and involve patients in decisions. 2. Please ensure you are using the most up to date version. The latest version will be held on the GMMMG website. 3. Prescribe an antibiotic only when there is likely to be a clear clinical benefit. 4. When recommending analgesia or treatment with products available f rom pharmacies please follow the guidance issued by NHS England (Conditions for which over the counter items should not routinely be prescribed in primary care: Guidance for CCGs [Gateway approval number: 07851]). See the guidance for exceptions to recommending self-care. 5. Consider a no, or delayed, antibiotic strategy for acute self -limiting infections e.g. upper respiratory tract infections. 6. When prescribing an antibiotic it should be based on the severity of symptoms, risk of developing complications, previous laboratory tests and any previous antibiotic use. 7. Limit prescribing over the telephone to exceptional cases. Except during COVID-19 pandemic where face-to- face contact should be minimised by using telephone or video consultations 8. A dose and duration of treatment for adults is usually suggested, but may need modification for age, weight and renal function. In severe or recurrent cases consider a larger dose or longer course. 9. Unless treatment choice is listed separately for children, then choices given are considered appropriate for adults and children; bearing in mind any specific age limitations for use listed in the BNF for Children. A link to the UK Paediatric Antimicrobial Guidelines can be found here 10. Lower threshold for antibiotics in immunocompromised or those with multiple morbidities; con sider culture and seek advice. 11. Use simple generic antibiotics if possible. Avoid broad spectrum antibiotics (eg co-amoxiclav, quinolones and cephalosporins) when narrow spectrum antibiotics remain effective, as they increase risk of Clostridiodes difficile, MRSA and resistant UTIs. 12. Where Off-label use is recommended: Prescribers should follow relevant professional guidance, taking full responsibility for the decision, and obtaining and documenting informed consent. See the GMC's Good practice in prescribing and managing medicines for more information. 13. Avoid widespread use of topical antibiotics (especially those agents also available as systemic pre parations, e.g. fusidic acid). 14. In pregnancy AVOID tetracyclines, aminoglycosides, quinolones and high dose metronidazole. 15. We recommend clarithromycin as the preferred macrolide as it has less side-effects than erythromycin, greater compliance as twice rather than four times daily & generic ta blets are similar cost. The syrup formulation of clarithromycin is only slightly more expensive than erythromycin and could al so be considered for children. Erythromycin remains the drug of choice in pregnancy and should be used where clarithromycin is indicated. 16. Always advise to seek medical help if symptoms worsen at any time or do not improve within 48 hours of starting an antibiotic or the person becomes systemically unwell. 17. Review antibiotic choice once culture and susceptibility results are available . 18. Wh e re an empirical therapy has failed or special circumstances exist, microbiological advice can be obtained f r om your local hos pital microbiology department. 19. This guidance should not be used in isolation; it should be supported with patient information about back- up/delayed antibiotics, infection severity and usual duration, clinical staff education, and audits. Materials are available on the RCGP TARGET website. 20. This guidance is developed alongside the NHS England Antibiotic Quality Premium (QP). In 2017/19 QP expects: at least a 10% reduction in the number of E. coli blood stream infections across the whole health economy; at least a 10% reduction in trimethoprim:nitrofurantoin prescribing rati o for UTI in primary care, and at least a 10% reduction in trimethoprim items in patients > 70 years, based on CCG baseline data from 2015/16; and sustained reduction in antimicrobial items per STAR-PU. 21. This guidance should be facilitated by the adoption of Antibiotic Stewards from front line to board level within organisations, in line with NICE NG15: Antimicrobial stewardship, August 2015 . This sets out key activities and responsibilities for individuals and organisations in responding to the concern of antimicrobial resistance. 22. Please note MHRA safety alert (issued 21 March 2019): Fluoroquinolone antibiotics: ciprofloxacin, levofloxacin,moxifloxacin, ofloxacin: New restrictions and precautions due to very rare reports of disabling and potentially long-lasting or irreversible side effects. Key details are below and referenced where the relevant antimicrobials are advised in the guideline. Full letter can be viewed at DDL_fluoroquinolones_March- 2019_final.pdf. Version 10.0 3 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 Contents SECTION Page UPPER RESPIRATORY TRACT INFECTIONS 6 Influenza treatment 6 Acute sore throat 6 Acute otitis media 6 Acute otitis externa 6 Acute sinusitis 7 LOWER RESPIRATORY TRACT INFECTIONS 7 Acute cough bronchitis 7 Acute exacerbation of Bronchiectasis (non-cystic fibrosis) 7 Acute exacerbation of COPD 8 Acute exacerbation of COPD – PROPHYLAXIS 8 Community acquired pneumonia treatment in the community (Adults) DURING 9 COVID-19 pandemic Community acquired pneumonia treatment in the community (Children & young 10 people under 18 years. MENINGITIS 11 Suspected meningococcal disease 11 URINARY TRACT INFECTIONS 11 Lower UTI in non-pregnant women 11 Catheter associated UTI 12 Lower UTI in pregnancy 12 Lower UTI in men 12 Recurrent UTI in non-pregnant women 3 or more UTIs per year 13 Acute prostatitis 13 Acute pyelonephritis in adults (Upper UTI) 13 Lower UTI in children 14 Acute Pyelonephritis in children (Upper UTI) 14 GASTRO INTESTINAL TRACT INFECTIONS 14 Oral candidiasis 14 Eradication of Helicobacter pylori 14 Infectious diarrhoea 14 Clostridioides difficile 15 Acute diverticulitis 15 Traveller’s diarrhoea 16 Version 10.0 4 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 SECTION Page GENITAL TRACT INFECTIONS 17 STI screening 17 Chlamydia trachomatis/ urethritis 17 Epididymitis 17 Vaginal candidiasis 17 Bacterial vaginosis 17 Gonorrhoea 17 Trichomoniasis 17 Pelvic inflammatory disease 18 SKIN INFECTIONS 18 MRSA 18 Impetigo 18 Eczema 19 Leg ulcer 20 Diabetic Foot 20 Cellulitis and erysipelas 21 Mastitis - Lactational 21 Mastitis – Non-Lactational 22 Insect Bites and Stings 22 Bites - Human and Animal 23 Lyme disease – Tick bite 24 Dermatophyte infection - skin 24 Dermatophyte infection - nail 24 Varicella zoster/chicken pox 24 Herpes zoster/shingles 24 Scarlet Fever (GAS) Cold sores 25 Acne Vulgaris 25 PARASITES 26 Scabies 26 Head lice 26 Threadworms 26 EYE INFECTIONS 26 Conjunctivitis 26 Changes to version 9.0 27 Version 10.0 5 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 Greater Manchester Antimicrobial Guidelines UPPER RESPIRATORY TRACT INFECTIONS Annual vaccination is essential for all those at risk of influenza. For otherwise healthy adults antivirals not Influenza recommended. treatment Treat ‘at risk’ patients, when influenza is circulating in the community and ideally within 48 hours of onset (do not wait for lab report) or in a care home where influenza is likely. At risk: pregnant (including up to two weeks Back to Contents post-partum), 65 years or over, chronic respiratory disease (including COPD and asthma) significant cardiovascular disease (not hypertension), immunocompromised, diabetes mellitus, chronic neurological, renal or liver disease, morbid obesity (BMI 40 or greater). See PHE seasonal influenza guidance for current treatment advice and: GMMMG: GP guide - Influenza outbreak in an adult care homes, January 2019 ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE Avoid antibiotics as 90% resolve in 7 days without, and pain only reduced by 16 hours. Acute sore Advise self-care in line with NHS England guidance. throat Use FeverPAIN Score Phenoxymethylpenicillin 500mg Penicillin Allergy: (this has replaced CENTOR): four times a day or Clarithromycin 500mg twice a ▪ Fever in last 24 hours 1g twice a day day ▪ Purulence ▪ Attend rapidly under 3d ays Duration: 10 days Duration: 5 days ▪ severely Inflamed tonsils NICE Visual Summary ▪ No cough or coryza Phenoxymethylpenicillin is first NG 84 choice due to a significantly Score: Back to Contents lower rate of resistance in Group 0 to 1: 13 to 18% streptococci. Do not A streptococcus compared with offer an antibiotic. clarithromycin. 2 to 3: 34 to 40% streptococci. Consider* no antibiotic or a back-up antibiotic prescription. Greater than 4: 62 to 65% streptococci. Consider* an immediate antibiotic or a back-up antibiotic prescription. See NICE NG84 (Sore throat (acute): antimicrobial prescribing). No antibiotics – 80% resolve without antibiotics. Advise self-care in line with NHS England guidance. Acute otitis Recommend appropriate analgesia. Amoxicillin 500mg to 1g three Penicillin Allergy: media times a day Clarithromycin 500mg twice a 60% are better in 24hrs without antibiotics, which only reduce pain at day 2 days and do not prevent deafness. Duration: 5 days Duration: 5 days Consider 2 or 3-day delayed or immediate antibiotics for pain relief if: NICE Visual Summary ➢ Less than 2 years AND bilateral NG 91 acute otitis media or Back to Contents ➢ any age with otorrhoea See NICE NG91 (Otitis media (acute): antimicrobial prescribing). Mild infection: No antibiotics. Advise self-care in line with NHS England guidance. Acute otitis First recommend analgesia. Moderate infection: Moderate infection: externa Cure rates similar at 7 days for topical Acetic acid 2% Neomycin sulphate with Back to Contents acetic acid or antibiotic plus or minus a 1 spray three times a day corticosteroid steroid. 3 drops three times a day Duration: 7 days Duration: 7 to 14 days If cellulitis or disease extends outside Severe infection: ear canal, or systemic signs of Flucloxacillin 250mg/ 500mg four times a day infection. If the inner ear is exposed, treat as per Duration: 7 days Acute Otitis Media If microbiology is consistent with Pseudomonas infection for age >1year: pseudomonas infection Ciprofloxacin (as hydrochloride) 2 mg/ ml Ear drops Instil contents of one ampoule into affected ear twice daily Duration: 7 days Version 10.0 6 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE No antibiotics – 80% resolve in 14 days and only 2% are complicated by bacterial infection. Acute Sinusitis Advise self-care in line with NHS England guidance. Symptoms less than 10 days: No Amoxicillin Penicillin allergy: antibiotics. Recommend self-care. 500mg to 1g three times a day Doxycycline (not for under 12 Paracetamol / ibuprofen for pain / fever. years) 200mg stat then 100mg Nasal decongestant may help. Duration: 5 days daily Symptoms greater than 10days: Only consider back-up antibiotics if no Duration: 5 days NICE Visual summary improvement in symptoms. NG 79 Mometasone 50microgram Consider* high dose nasal steroid if Back to Contents older than 12 years. nasal spray. Two actuations (100mcg) in For children under 12 years: At any time if the person is: each nostril twice a day for 14 days (off-label use) Clarithromycin ▪ systemically very unwell, Duration 5 days ▪ or has symptoms and signs of a more Preferred choice if serious illness or condition, systemically very unwell, ▪ or has high risk of complications symptoms and signs of a Offer* immediate antibiotic or investigate more serious illness or and manage in line with NICE guidance condition, or at high risk of on respiratory tract infections (self- complications: limiting) Co-amoxiclav 625mg three See NICE NG79 (Sinusitis (acute): times a day antimicrobial prescribing) Duration: 5 days LOWER RESPIRATORY TRACT INFECTIONS Low doses of penicillins are more likely to select out resistance, we recommend at least 500mg of amoxicillin. Do not use quinolone (ciprofloxacin, ofloxacin) first line due to poor pneumococcal activity. Reserve all quinolones for proven resistant organis ms. Only offer* / consider* treatment if: Acute cough Acute cough and higher risk of complications $ (at face-to-face examination): consider* immediate or bronchitis back-up antibiotic. Acute cough and systemically very unwell (at face to face examination): offer* immediate antibiotic. Acute cough with upper respiratory Doxycycline 200mg stat then Amoxicillin 500mg three times tract infection: no antibiotic. 100mg daily a day. Acute bronchitis: no routine antibiotic. Duration: 5 days Duration: 5 days NICE Visual summary Advise self-care in line with NHS England NG 120 guidance. Preferred choice for children For children less than 12 Back to Contents less than 12 years: years with Penicillin allergy: Do not offer a mucolytic, an oral or inhaled bronchodilator, or an oral or Amoxicillin Clarithromycin inhaled corticosteroid unless otherwise indicated. Duration 5 days Duration 5 days $Higher risk of complications includes people with pre-existing comorbidity; young children born prematurely; people over 65 with 2 or more of, or over 80 with 1 or more of: hospitalisation in previous year, type 1 or 2 diabetes, history of congestive heart failure, current use of oral corticosteroids. An acute exacerbation of bronchiectasis Amoxicillin 500mg three times a Doxycycline 200mg stat, then Acute is sustained worsening of symptoms from day 100mg daily exacerbation of a person’s stable state. OR Duration #: 7 to 14 days # Bronchiectasis Send a sputum sample for culture and Clarithromycin 500mg twice a (non-cystic susceptibility testing. When results day available, review choice of antibiotic. fibrosis) Duration #: 7 to 14 days # Offer* an antibiotic When choosing antibiotics, take account of: ▪ the severity of symptoms ▪ previous exacerbations,hospitalisations NICE Visual summary and risk of complications NG 117 ▪ previous sputum culture and Back to Contents susceptibility results Version 10.0 7 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 #Course length based on an assessment of the person’s severity of bronchiectasis, exacerbation history, severity of exacerbation symptoms, previous culture and susceptibility results, and response to treatment. Where a person is receiving antibiotic prophylaxis, treatment should be with an antibiotic from a different class. Prophylaxis should only be offered on specialist advice. ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE Many exacerbations (including some severe exacerbations) are not caused by bacterial infections so Acute will not respond to antibiotics. exacerbation of Sending sputum samples for culture is Doxycycline 200mg stat, then In severe infection: COPD not recommended in routine practice. 100mg daily Doxycycline 200mg stat, then Consider* an antibiotic: or 100mg twice a day ▪ Based on the severity of symptoms, particularly sputum colour changes Amoxicillin 500mg three times a or and increases in volume or thickness day from the patient’s normal. Amoxicillin 1g three times a NICE Visual summary ▪ Previous exacerbations and hospital Duration: 5 days. day NG 114 admission history, and the risk of Duration 5 days Back to Contents developing complications ▪ Previous sputum culture and susceptibility results where available. ▪ The risk of AMR with repeated courses of antibiotics. Patients identified as suitable for having ‘rescue packs’ should normally only be provided with steroids, as these have been shown to improve lung function alone, with advice to seek medical attention if symptoms suddenly worsen or do not improve within 48 hours of starting treatment. Any decision to include antibiotics should be based on clinical need, do not use the higher dose in ‘rescue packs’. Patients will need to notify prescribers when they use their ‘rescue pack’ medication, and to ask for replacements. Refer to a respiratory specialist for a Duration: Review treatment after the first 3 months and then at Acute decision to prescribe oral prophylactic least every 6 months. Only continue treatment if continued exacerbation of antibiotic therapy in patients with COPD. benefits outweigh the risks. COPD – Consider* treatment only for people if Before starting prophylactic antibiotics, ensure that the person has PROPHYLAXIS they: had: ▪ do not smoke and Back to Contents ▪ sputum culture and sensitivity (including tuberculosis culture), ▪ have optimised non -pharmacological to identify other possible causes of persistent or recurrent management and in haled therapies, infection that may need specific treatment relevant vaccinations and (if ▪ training in airway clearance techniques to optimise sputum appropriate) have been referred for clearance pulmonary rehabilitation and ▪ a CT scan of the thorax to rule out bronchiectasis and other ▪ continue to have 1 or more of the lung pathologies. following, particularly if they have Also carry out the following: significant daily sputum production: ▪ an electrocardiogram (ECG) to rule out prolonged QT interval • frequent (typically 4 or more per and year) exacerbations with sputum production ▪ baseline liver function tests. For people who are still at risk of exacerbations, provide an • prolonged exacerbations with antibiotic from a different class. to keep at home as part of their sputum production ‘rescue pack’ • exacerbations resulting in Be aware that it is not necessary to stop prophylactic treatment hospitalisation. during an acute exacerbation of COPD. NICE guidance - Chronic obstructive Monitoring for long-term therapy: See BNF pulmonary disease in over 16s: diagnosis and management (NG115) Version 10.0 8 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE If a patient shows typical COVID 19 As COVID-19 pneumonia is Alternative : COVID-19 symptoms, follow UK government caused by a virus, antibiotics are Community guidance on investigation and initial ineffective. Amoxicillin 500mg three times acquired clinical management of possible cases. Do not offer an antibiotic for a day This includes information on testing and Duration: 5 days pneumonia isolating patients. treatment or prevention of pneumonia if: treatment in the For patients with known or suspected community • COVID-19 is likely to be the If atypical pathogens COVID-19 follow UK guidance on cause and suspected AND moderately (Adults) infection prevention and control Minimise face-to-face contact. Use the • symptoms are mild. severe symptoms based on clinical judgement (or CRB =1 BMJ remote assessment tools. [DURING or 2): Offer an oral antibiotic for Amoxicillin COVID-19 • The clinical diagnosis of community- treatment of pneumonia in people 500 mg 3 times a day (higher pandemic] acquired pneumonia of any cause in who can or wish to be treated in doses can be used – see BNF) an adult can be informed by clinical the community if: Duration: 5 days signs or symptoms such as: PLUS Back to Contents temperature >38°C • the likely cause is bacterial or Clarithromycin 500 mg twice a day • respiratory rate >20 breaths per • it is unclear whether the cause Duration: 5 days minute is bacterial or viral and • heart rate >100 beats per minute symptoms are more concerning or • new confusion If high severity based on Assessing shortness of breath • they are at high risk of clinincal judgement (or CRB65 (dyspnoea) is important but may be complications because, for = 3 or 4) & patient able to take difficult via remote consultation. Use example, they are older or frail, oral medicines and safe to online tools such as dyspnoea scale, or or have a pre-existing remain at home CEBM review. comorbidity such as Co-amoxiclav 500/125mg immunosuppression or three times a day significant heart or lung disease Duration: 5 days Where pulse oximetry is available use (for example bronchiectasis or AND oxygen saturation levels below 92% COPD), or have a history of Clarithromycin 500mg twice a (below 88% in people with COPD) on severe illness following previous day room air at rest to identify seriously ill lung infection. Duration 5 days patients. OR Erythromycin (in pregnancy) Use of the NEWS2 tool in the Doxycycline 200mg stat then 500 mg 4 times a day orally community for predicting the risk of 100mg daily Duration: 5 days clinical deterioration may be useful. Duration: 5 days However a face to face consultation If penicillin allergy AND high should not be arranged solely to severity calculate a NEWS2 score. Levofloxacin (consider safety Doxycycline is preferred because it has broader spectrum of cover issues) than amoxicillin, particularly 500 mg twice a day orally against Mycoplasma Duration: 5 days pneumoniae and Staphylococcus aureus, which are more likely to If preferred choice not suitable be secondary bacterial causes of consult microbiology or pneumonia during the COVID-19 consider* urgent referral to pandemic. hospital. If unable to take oral Doxycycline should not be used medication refer urgently to in pregnancy hospital. In Pregnancy Erythromycin 500 mg 4 times a day Duration: 5 days Version 10.0 9 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE Offer an antibiotic(s) within 4 hours of Children aged 1 month and Children aged 1 month and Community establishing a diagnosis. over - if non-severe symptoms over - if non-severe symptoms acquired Severity is assessed by clinical or signs (based on clinical or signs (based on clinical pneumonia judgement. judgement) judgement) treatment in the Amoxicillin Clarithromycin community Give advice about: Duration: 5 days Duration: 5 days (Children and ▪ possible adverse effects of antibiotics If severe symptoms or signs young people ▪ seeking medical help if symptoms (based on clinical judgement); Alternative choice for under 18 years) worsen rapidly or significantly, or do guided by microbiological results when available: children aged 12 years to 17 not improve within 3 days, or the years. person becomes systemically very Co-amoxiclav unwell. PLUS (if atypical pathogen Doxycycline 200mg on first suspected) day, then 100mg once a day. Stop antibiotic treatment after 5 days Clarithromycin Duration: 5 days unless microbiological results suggest a Duration: 5 days longer course length is needed or the person is not clinically stable. Version 10.0 10 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE MENINGITIS Transfer all patients to hospital Benzylpenicillin by intravenous or intramuscular injection Suspected immediately. Age 10 plus years: 1200mg meningococcal If time before hospital admission and if Children 1 to 9 years: 600mg disease suspected meningococcal septicaemia or Children less than1 years: 300mg non-blanching rash, give intravenous or Stat doses Back to Contents intramuscular benzylpenicillin as soon as Give by intramuscular injection if vein cannot be found. possible. Do not give antibiotics if there is a definite history of anaph ylaxis; rash is not a contraindication. Prevention of secondary case of meningitis. Only prescribe following advice from Public Health England North West: 03442250562 option 3 (9 to 5 Mon to Fri) Out of hours contact 0151 434 4819 and ask for PHE on call. URINARY TRACT INFECTIONS As antimicrobial resistance and E. coli bacteraemia is increasing use nitrofurantoin first line. Always give safety net and s elf-care advice and consider risks for resistance. Give the appropriate TARGET Treat Your Infection UTI leaflet. Do not perform urine dipsticks – For men and women over 65 years Dipsticks become more unreliable with increasing age over 65 years. Up to half of older adults, and most with a urinary catheter, will have bacteria present in the bladder/urine without an infection. This “asymptomatic bacteriuria” is not harmful, and although it c auses a positive urine dipstick, antibiotics are not beneficial and may cause harm. For guidance on diagnosing UTIs and the need for dipsticks , in all ages, see PHE’s quick reference tool for primary care. Treat women with severe/or 3 or more Nitrofurantoin MR (if eGFR 45 If preferred choice Lower UTI in symptoms. ml/minute or greater) 100mg unsuitable: Non-pregnant Women mild/or 2 or less symptoms twice a day Fosfomycin Women advise self-care in line with NHS Duration: 3 days 3 g single dose sachet England guidance and consider* back up / delayed prescription. If low risk+ of resistance and CHECK AVAILABILITY AS People over 65 years: do not treat preferably if susceptibility NOT ALL PHARMACIES asymptomatic bacteriuria; it is demonstrated & no risk HOLD STOCK. common but is not associated with factors£ (below): NICE Visual summary increased morbidity. Treat if fever AND Trimethoprim 200mg twice a day NG 109 dysuria OR 2 or more other symptoms. Duration: 3 days Back to Contents In treatment failure: always perform culture. +A Symptoms: lower risk of resistance may be more likely if not used in the Increased need to urinate. past 3 months, previous urine culture suggests susceptibility (but Pain or discomfort when urinating. this was not used) or it is the first presentatio n of a UTI, and in Sudden urges to urinate. younger women. Feeling unable to empty bladder fully. £ Risk factors for increased resistance include: care home Pain low down in your tummy. resident, recurrent UTI, hospitalisation for greater than 7 days in Urine is cloudy, foul-smelling or contains the last 6 months, unresolving urinary symptoms, recent travel to a blood. country with increased resistance, previous known UTI resistant to Feeling unwell, achy and tired. trimethoprim, cephalosporins or quinolones. If risk of resistance send urine for culture for susceptibility testing & give safety net advice. Version 10.0 11 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE DO NOT DIPSTICK Lower UTI symptoms Catheter Do not treat asymptomatic bacteriuria in Nitrofurantoin MR (if eGFR 45 Pivmecillinam associated UTI people with a catheter. ml/minute or greater) 100mg 400mg initial dose, then Advise paracetamol for pain. twice a day 200mg three times a day Advise drinking enough fluids to avoid Duration: 7 days Duration: 7 days dehydration. Advise seeking medical help if symptoms OR worsen at any time or do not start to Trimethoprim (if low risk of NICE Visual summary improve within 48 hours, or the person resistance) 200mg twice a day NG 113 becomes systemically very unwell Duration: 7 days Back to Contents Consider* removing or, if not possible, changing the catheter if it has been in Upper UTI symptoms place for more than 7 days. But do not delay antibiotic treatment if considered Cefalexin 500mg twice or three Ciprofloxacin 500mg twice a appropriate. times a day (up to 1g to 1.5g day three times a day or four times a Send a urine sample for culture and Duration: 7 days day for severe infections) susceptibility testing. (See MHRA Safety Alert - note When results of urine culture are Duration: 7 to 10 days 21 page 3) available: ▪ review choice of antibiotic Pregnant women aged 12 years and over ▪ change antibiotic according to Cefalexin 500mg twice or three If vomiting, unable to take oral susceptibility results if bacteria are times a day (up to 1g to 1.5g antibiotics or severely unwell resistant, using narrow spectrum three times a day or four times a refer to hospital. antibiotics when possible day for severe infections) Duration: 7 to 10 days Low risk of resistance is likely if not used in the past 3 months and previous urine culture suggests susceptibility (but this was not used) or it is the first presentation of a UTI . Higher risk of resistance is likely with recent use. Send MSU for culture and start Up to 34 weeks Amoxicillin (only if culture Lower UTI in antibiotics. Nitrofurantoin MR (if eGFR 45 results available and pregnancy Short-term use of nitrofurantoin in ml/minute or greater) 100mg susceptible) twice a day 500mg to 1g three times a day pregnancy is unlikely to cause problems to the foetus but avoid at term (from 34 OR Duration: 7 days weeks onwards). Cefalexin 500mg twice a day After 34 weeks use alternative Duration: All for 7 days Treatment of asymptomatic bacteriuria in NICE Visual summary pregnant women: choose from NG 109 nitrofurantoin (avoid at term), amoxicillin Back to Contents or cefalexin based on recent culture and susceptibility results. Consider prostatitis and send pre- Trimethoprim 200mg twice a day Consider alternative diagnoses Lower UTI in treatment MSU basing antibiotic choice on Duration: 7 days Men Consider STIs. recent culture and Or susceptibility results Nitrofurantoin MR (if eGFR 45 ml/minute or greater and no prostate involvement) 100mg twice a day NICE Visual summary Duration: 7 days NG 109 Back to Contents Version 10.0 12 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE First advise about behavioural and Choice should be based on culture and susceptibility results. Recurrent UTI personal hygiene measures, and self- in non pregnant care (with D-mannose or cranberry Single dose when exposed to a Single dose when exposed to products) to reduce the risk of UTI. women having 3 trigger a trigger or more UTIs For postmenopausal women, if no Trimethoprim 200mg (off-label) Amoxicillin 500 mg (off-label) improvement, consider vaginal oestrogen per year (review within 12 months). Or Or Nitrofurantoin MR (if eGFR 45 Cefalexin 500 mg (off-label) If no improvement, consider single-dose ml/minute or greater) 100mg antibiotic prophylaxis for exposure to a (off-label) trigger (review within 6 months). If no improvement or no identifiable Continuous prophylaxis NICE Visual summary trigger consider a trial of daily antibiotic Continuous prophylaxis NG 112 Trimethoprim 100mg at night prophylaxis (review within 6 months). Or Amoxicillin 250mg at night (off- Back to Contents Advice to be given: label) Nitrofurantoin (if eGFR 45 ▪ how to use (in particular for single ml/minute or greater) 50mg to Or dose prophylaxis) 100mg at night Cefalexin 125mg at night (off- label) ▪ possible adverse effects of antibiotics, Duration for all: 3 to 6 months particularly diarrhoea and nausea Duration for all: 3 to 6 months then review ▪ returning for review within 3 to 6 then review months Monitoring for long-term therapy: See BNF ▪ seeking medical help if symptoms of an acute UTI develop Send MSU for culture and start Ciprofloxacin (See MHRA Safety If unable to take quinolone: Acute antibiotics. Alert – note 21 page 3) Trimethoprim 200mg twice a prostatitis Review antibiotic treatment after 14 days 500mg twice a day day and either stop antibiotics or continue for Duration: up to 28 days Duration: up to 28 days a further 14 days if needed (based on assessment of history, symptoms, clinical examination, urine and blood tests). NICE Visual summary NG 110 Back to Contents Send MSU for culture & susceptibility. Cefalexin 500mg twice a day or Co-amoxiclav (only if culture Acute Offer an antibiotic. three times a day (up to 1g to results available and pyelonephritis in When prescribing antibiotics, take 1.5g three times a day or four susceptible) 500/125mg three adults times a day for severe times a day account of severity of symptoms, risk of infections) (Upper UTI) complications, previous urine culture and Duration: 7 to 10 days susceptibility results, previous antibiotic Duration: 7 to 10 days Or use which may have led to resistant If known ESBL positive in urine, Trimethoprim (only if culture bacteria. please discuss with results available and If no response within 24 hours, admit for microbiologist. susceptible) IV antibiotics. 200mg twice a day Pregnant women: NICE Visual summary Consider referral. Duration: 14 days NG 111 If cefalexin contraindicated or Or Back to Contents not tolerated consult microbiologist. Ciprofloxacin (See MHRA Safety Alert – note 21 page 3) 500mg twice a day Duration: 7 days Version 10.0 13 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE Child under 3 mths: refer urgently for assessment. Lower UTI in 3 months and over 3 months and over children Child ≥ 3 mths: use positive nitrite to guide. Start antibiotics, also send pre- Nitrofurantoin (if eGFR 45 Amoxicillin (only if culture treatment MSU. ml/minute or greater) results available and If recurrent UTI, refer to paediatrics. If [If children can swallow them, susceptible) antibiotics required in recurrent UTI, 100mg M/R capsules (older than OR 12yrs) should be used in preference seek specialist advice. Cefalexin to the liquid formulation. 50mg NICE Visual summary tablets can be considered for lower Duration: 3 days NG 109 doses. Do not crush tablets or open capsules] Back to Contents OR Trimethoprim (if low risk of resistanceΩ) Duration: 3 days Ω A lower risk of resistance may be more likely if not used in the past 3 months and previous urine culture suggests susceptibility (but this was not used) or it is the first presentation of a UTI . A higher risk of resistance may be more likely with recent use. Refer children under 3 months to paediatric specialist Acute Send a urine sample for culture and Cefalexin Co-amoxiclav (only if culture pyelonephritis susceptibility testing in line with the NICE results available and in children guideline, Urinary tract infection in under Duration: 7 to 10 days susceptible) under 16 years 16s: diagnosis and management (CG54). Duration: 7 to 10 days (Upper UTI) Offer* an antibiotic. When prescribing antibiotics, take account of severity of symptoms, risk of complications, previous urine culture and susceptibility results, previous antibiotic NICE Visual summary use which may have led to resistant NG 109 bacteria. Assess and manage fever in under 5s in line with NICE guidance - If no response within 24 hours, admit for Fever in under 5s: assessment and initial management (CG160) Back to Contents intravenous antibiotics. GASTRO INTESTINAL TRACT INFECTIONS Oral candidiasis is a minor condition that can be treated without the need for a GP consultation or Oral candidiasis prescription in the first instance. Advise self-care in line with NHS England guidance. Back to Contents Topical azoles are more effective than Fluconazole capsules If miconazole not tolerated: topical nystatin. 50mg to 100mg daily Nystatin suspension 100,000 units four times a day Oral candidiasis rare in Duration: 7 days & further 7 after meals immunocompetent adults. days if persistent Or Duration: 7 days or until 2 days after symptoms Miconazole oral gel 2.5ml four times a day after meals Duration: 7 days or until 2 days after symptoms. Refer to BNF or GMMMG Eradication of Do not offer eradication for GORD. (PPI for 4 weeks). Helicobacter Do not use clarithromycin, metronidazole or quinolone if used in past year for any infection. pylori Retest for H.pylori post DU/GU or relapse after second line therapy: using breath or stool test OR consider Back to Contents endoscopy for culture and susceptibility. Refer previously healthy children with acute painful or bloody diarrhoea to exclude E. coli 0157 infection. Infectious Antibiotic therapy usually not indicated unless systemically unwell. diarrhoea If systemically unwell and campylobacter suspected consider Clarithromycin 250 to 500mg twice a day for 7 Back to Contents days, if treated within 3 days of onset. Version 10.0 14 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE Consult microbiology for all cases. First episode; mild moderate First episode; mild moderate Clostridioides Stop unnecessary antibiotics and/or PPIs or severe: or severe: difficile and gastro drugs e.g. laxatives Vancomycin Fidaxomicin Back to Contents Review Medicines that may cause 125mg four times a day 200 mg orally twice a day problems during dehydration. E.g. Duration: 10 days Duration: 10 days NSAIDs, ACEi, AIIRA, diuretics CHECK AVAILABILITY AS Treating suspected or confirmed C. NOT ALL PHARMACIES HOLD STOCK. If first and second line difficile infection in adults ineffective for the first episode Offer an oral antibiotic In the community, REFER for specialist advice in consider seeking prompt specialist advice secondary care NICE Visual summary Further episode (relapsed before starting treatment If oral medicines NG 199 within 12 weeks of symptom cannot be taken, seek specialist advice resolution): about other enteral routes for antibiotics (nasogastric tube or rectal catheter) Fidaxomicin 200 mg orally twice a day ADVICE: • drinking enough to avoid dehydration Duration: 10 days • preventing the spread of infection • seek medical help if symptoms worsen Further episode (recurrence Further episode (recurrence rapidly or significantly at any time more than 12 weeks after more than 12 weeks after symptom resolution): symptom resolution): Use clinical judgement to determine Fidaxomicin whether antibiotic treatment Vancomycin 200 mg orally twice a day for C. difficile is ineffective. It is not 125mg four times a day usually possible to determine this until Duration: 10 days day 7 because diarrhoea may take 1 to Duration: 10 days 2 weeks to resolve. Consider referring people in the community to hospital if they could be at high risk of complications or recurrence because of individual factors such as age, frailty or comorbidities. With severe symptoms (below) review progress closely and/or consider hospital referral. Definition of severe: Temperature greater than 38.5oC, or WCC greater than 15, or rising creatinine or signs/symptoms of severe colitis. Consider watchful waiting if person: For patients who do not Trimethoprim 200mg BD Acute require urgent hospital ▪ Systemically well PLUS metronidazole 400mg Diverticulitis ▪ admission and infection is No co-morbidities TDS Back to Contents ▪ No suspected infection. suspected: Advise analgesia (avoid NSAIDs and Co-amoxiclav 625mg three Only if switching from IV opioids), clear liquids with gradual times a day reintroduction of solid food if symptoms ciprofloxacin with improve. Consider checking for raised Duration: 5 days specialist advice; white cell count and CRP, which may consider safety issues suggest infection. Ciprofloxacin (See MHRA Safety Alert – note 21 page 3) ng147-visual- Patients should be reviewed after 72 500mg twice a day summary hours and if there is n o improvement, and/or fever and leukocytosis persist, PLUS urgent hospital admission is advised. Metronidazole 400mg three times a day Duration: 5 days Version 10.0 15 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 Arrange immediate urgent hospital admission for those with: Rectal bleeding Unmanageable abdominal pain Dehydrated or at risk of dehydration Unable to take or tolerate oral antibiotics (if needed) at home Frail / significant co -morbidities and or / is immunocompro mised. Prophylaxis rarely, if ever indicated. If standby treatment appropriate If prophylaxis / treatment Traveller’s Only consider standby antibiotics for give azithromycin 500mg each consider bismuth subsalicylate diarrhoea high risk areas for people at high -risk of day for 3 days on a private (Pepto Bismol) (Private severe illness. prescription. purchase) Back to Contents 2 tablets four times a day for 2 days. Version 10.0 16 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE GENITAL TRACT INFECTIONS People with risk factors should be screened for chlamydia, gonorrhoea, HIV, syphilis. Refer individual and STI screening partners to GUM service. Risk factors: less than 25 years, no condom use, recent (less than 12momths)/frequent change of partner, Back to Contents symptomatic partner, area of high HIV. Opportunistically screen all sexually Doxycycline 100mg twice a day Pregnant, breastfeeding, Chlamydia active patients aged 15 to 24 years for Duration: 7 days allergy, or intolerance: trachomatis/ chlamydia annually and on change of Azithromycin 1g stat, then urethritis sexual partner. 500mg daily for the following 2 If positive, treat index case, refer to GUM days. Back to Contents and initiate partner notification, testing and treatment. Advise patient with chlamydia to abstain from sexual intercourse until doxycycline is completed or for 7 days after treatment with As single dose azithromycin has led to azithromycin (14 days after azithromycin started and until increased resistance in GU infections, symptoms resolved if urethritis). doxycycline should be used first line for chlamydia and urethritis. If chlamydia, test for reinfection at 3 to 6 months following treatment if under 25 years; or consider if over 25 years and high Consider referring all patients with risk of re-infection. symptomatic urethritis to GUM as testing As lower cure rate in pregnancy, test for cure at least 3 weeks should include Mycoplasma genitalium and Gonorrhoea. after end of treatment. If M.genitalium is proven, use doxycycline followed by azithromycin using the same dosing regimen and advise to avoid sex for 14 days after start of treatment and until symptoms have resolved. For suspected epididymitis in men over Ofloxacin 200mg twice a day Doxycycline 100mg twice a Epididymitis 35 years with low risk of STI. (See MHRA Safety Alert – note day (High risk, refer to GUM) 21 page 3) Back to Contents Duration: 14 days Duration : 14 days All topical and oral azoles give 75% Clotrimazole 500mg pessary Fluconazole 150mg orally Vaginal cure. or 10% cream stat stat candidiasis Pregnant: In pregnancy: avoid oral azoles and Pregnant: Back to Contents Clotrimazole 100mg pessary use intravaginal treatment for 7 days. Miconazole 2% cream, 5g at night intravaginally twice a day Duration: 6 nights Duration: 7 days Oral metronidazole is as effective as Metronidazole 400mg twice a Metronidazole 0.75% vaginal Bacterial topical treatment and is cheaper. day gel 5g applicator at night vaginosis Less relapse with 7 day than 2g stat. Duration: 7 days Duration: 5 nights Back to Contents Pregnant/breastfeeding: avoid 2g stat. Or or Treating partners does not reduce Metronidazole 2g stat (use 5 x Clindamycin 2% cream 5g relapse. 400mg tablets) applicator at night. Duration: 7 nights Refer to GUM for treatment. Gonorrhoea Antibiotic resistance is now very high. Ceftriaxone 1g stat, by Ciprofloxacin 500mg stat Back to Contents intramuscular injection [ONLY IF KNOWN TO BE SENSITIVE] (See MHRA Safety Alert – note 21 page 3) Treat partners and refer to GUM service. Metronidazole 400mg twice a Clotrimazole In pregnancy or breastfeeding: avoid 2g day 100mg pessary at night Trichomoniasis single dose metronidazole. Duration: 7 days Duration: 6 nights Consider clotrimazole for symptom relief Back to Contents (not cure) if metronidazole declined. OR Metronidazole 2g stat (use 5 x 400mg tablets) Version 10.0 17 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE Children under 12 years must be referred to a paediatrician. Pelvic Refer woman and contacts to GUM Ceftriaxone 1g stat by These treatment choices inflammatory service for treatment. intramuscular injection [This is should only be used for true disease Raised CRP supports diagnosis, absent an essential part of treatment cephalosporin allergy and a pus cells in HVS smear good negative – refer patients to local low risk of gonococcal PID. Back to Contents predictive value. services if injection not Metronidazole 400mg twice a available via GP practice] day Exclude: ectopic pregnancy, appendicitis, endometriosis, UTI, irritable PLUS PLUS bowel, complicated ovarian cyst, Metronidazole 400mg twice a Ofloxacin 400mg twice a day functional pain. day Or Moxifloxacin has greater activity against PLUS likely pathogens, but always test for Moxifloxacin 400mg daily Doxycycline 100mg twice a day alone. gonorrhoea, chlamydia, and Duration : 14 days (If M. genitalium tests positive M. genitalium. use moxifloxacin as an Ofloxacin and moxifloxacin should be alternative.) avoided in patients who are at high risk of gonococcal PID. (See MHRA Safety Alert – note 21 page 3) Duration : 14 days SKIN INFECTIONS For active MRSA infection, refer to microbiology and only treat according to antibiotic susceptibilities confirmed MRSA by lab results. If identified as part of pre-op screening, treatment should be provided at that time by secondary care. Back to Contents Advise people with impetigo, and their Localised non-bullous impetigo (not systemically unwell or at Impetigo parents or carers if appropriate, about high risk of complications) good hygiene measures to reduce the spread of impetigo to other areas of the Consider*: If hydrogen peroxide unsuitable body and to other people. (e.g., if impetigo is around Hydrogen peroxide 1% cream eyes) or ineffective: Do not prescribe mupirocin (reserved Apply two or three times a day NICE Visual summary for MRSA), unless advised by Fusidic acid 2% cream NG 153 microbiology. Duration: 5 days § Apply thinly three times a day Back to Contents Do not offer combination treatment with a Duration: 5 days § topical and oral antibiotic to treat impetigo. Widespread non‑ bullous impetigo who are not systemically unwell or at high risk of complications. Advise people with impetigo, and their parents or carers if appropriate, to seek Fusidic acid 2% cream Penicillin allergy or medical help if symptoms worsen rapid ly flucloxacillin unsuitable: Apply thinly three times a day or significantly at any time, or have not Clarithromycin 250mg ¥ twice a improved after completing a course of Duration: 5 days § day treatment. Or: Duration: 5 days § See NICE NG153 (Impetigo: Flucloxacillin 500mg four times antimicrobial prescribing) for further a day guidance. Duration: 5 days § § A 5-day course is appropriate for most Bullous impetigo or impetigo in people who are systemically people with impetigo but can be unwell or at high risk of complications increased to 7 days based on clinical judgement, depending o n the severity Flucloxacillin 500mg four times Penicillin allergy or and number of lesions. a day flucloxacillin unsuitable: ¥ Dosage can be increased to 500 mg Duration: 5 days § Clarithromycin 250mg ¥ twice a twice a day, if needed for severe day infections. Duration: 5 days § Version 10.0 18 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 If no visible signs of infection, do not use antibiotics (alone or with steroids) as this encourages resistance and Eczema does not improve healing. Do not routinely take a skin swab for microbiological testing in people with secondary bacterial infe ction of eczema at the initial presentation. In people who are not systemically unwell, do not routinely offer either a topical or oral antibiotic for secondary bacterial infection of eczema. Prescribing considerations Take account of: • the evidence, whi ch suggests a limited benefit with antibiotics • NICE Visual summary the risk of antimicrobial resistance with repeated courses of antibiotics • the extent and severity of symptoms or NG 190 signs • the risk of complications Symptoms and signs of bacterial IF choosing between a topical or Alternative ORAL: Back to Contents secondary infection can include oral antibiotic (topical might be For Penicillin allergy or weeping, pustules, crusts, no more appropriate if the infection is flucloxacillin unsuitable or treatment response, rapidly localised and not severe), also worsening eczema, fever and take account of: malaise Not all eczema flares are Clarithromycin: 250 mg twice a day • patient preferences caused by a bacterial infection, Duration: 5 to 7 days • possible adverse effects even if there are crusts and • previous topical antibiotic use The dosage can be increased to weeping Eczema is often 500 mg twice a day for severe colonised with bacteria but may • local antimicrobial resistance infections not be clinically infected data Pregnancy: First Choice TOPICAL: Erythromycin: 250 mg to 500 mg Fusidic acid 2%: Apply three times four times a day a day Duration: 5 to 7 days Duration: 5 to 7 days For localised infections only. Extended or recurrent use may increase the risk of developing antimicrobial resistance. First Choice ORAL: Flucloxacillin: 500 mg four times a day Duration: 5 to 7 days Version 10.0 19 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE Background: If active infection Leg ulcer ▪ There are many causes of leg ulcer; Flucloxacillin 500mg to 1g four If penicillin allergic: any underlying conditions, such as times a day # Clarithromycin 500mg twice a venous insufficiency and oedema, Duration: 7 days day should be managed to promote or healing Doxycycline 200mg stat then NICE Visual summary ▪ Few leg ulcers are clinically infected NG 152 100mg twice a day ▪ Most leg ulcers are colonised by bacteria Duration: All 7 days Back to Contents ▪ Antibiotics don't promote healing Do not take a sample for microbiological testing at initial when a leg ulcer is not clinically presentation, even if the ulcer might be infected. infected Refer to hospital if there are symptoms or signs of a more serious Symptoms and signs of an illness or condition such as sepsis, necrotising fasciitis or infected leg ulcer include: osteomyelitis ▪ redness or swelling spreading beyond the ulcer Consider* referring or seeking specialist advice if the person: ▪ localised warmth ▪ has a higher risk of complications because of comorbidities ▪ increased pain such as diabetes or immunosuppression ▪ fever ▪ has lymphangitis When choosing an antibiotic, ▪ has spreading infection not responding to oral antibiotics take account of: ▪ cannot take oral antibiotics (to explore possible options for ▪ the severity of symptoms or signs intravenous or intramuscular antibiotics at home or in the ▪ the risk of complications community) ▪ previous antibiotic use A longer course (up to a further 7 days) may be needed based on clinical assessment. However, skin does take some time to return Reassess if symptoms worsen rapidly or to normal, and full resolution of symptoms at 7 days is not significantly at any time, do not start to expected. improve within 2 to 3 days, or the person becomes systemically unwell or has severe pain out of proportion to the infection. #The upper dose of 1 g four times a day would be off-label. Prescribers should follow relevant professional guidance, taking full responsibility for the decision, and obtaining and documenting informed consent. See the GMC's Good practice in prescribing and managing medicines for more information. In diabetes, all foot wounds are likely to Flucloxacillin 500mg to 1g four If penicillin allergic: Diabetic Foot be colonised with bacteria. times a day # Clarithromycin 500mg twice a Diabetic foot infection has at least 2 of: Duration: 7 days day ▪ local swelling or induration or ▪ erythema Doxycycline 200mg on first ▪ local tenderness or pain day then 100mg twice a day NICE Visual summary ▪ local warmth Duration: All 7 days NG 19 ▪ purulent discharge Back to Contents Severity is classified as: Refer to hospital immediately and inform multidisciplinary foot care ▪ Mild - local infection with 0.5 to less service if there are limb- or life-threatening problems such as: than 2 cm erythema ▪ ulceration with fever or any signs of sepsis, or Refer the following to hospital: ▪ ulceration with limb ischaemia, or ▪ suspected deep-seated soft tissue or bone infection, or ▪ Moderate - local infection withmore ▪ gangrene than 2 cm erythema or involving For all other active diabetic foot problems, refer to foot service deeper structures (such as abscess, within 1 working day osteomyelitis, septic arthritis or A longer course (up to a further 7 days) may be needed based on fasciitis) clinical assessment. However, skin does take s ome time to return ▪ Severe - local infection with signs of a to normal, and full resolution of symptoms at 7 days is not systemic inflammatory response. expected. #The upper dose of 1 g four times a day would be off-label. Prescribers should follow relevant professional guidance, taking full responsibility for the decision, and obtaining and documenting informed consent. See the GMC's Good practice in prescribing and managing medicines for more information. Version 10.0 20 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
Greater Manchester Antimicrobial Guidelines October2021 ILLNESS GOOD PRACTICE POINTS PREFERRED CHOICE ALTERNATIVE Exclude other causes of skin redness Flucloxacillin 500mg to 1g four If penicillin allergic: Cellulitis and (inflammatory reactions or non-infectious times a day # Clarithromycin 500mg twice a erysipelas causes). Give oral unless person unable day Consider marking extent of infection with to take oral or severely unwell. Give oral unless person a single-use surgical marker pen. unable to take oral or severely Offer an antibiotic. Take account of If infection near eyes or nose unwell. severity, site of infection, risk of (consider seeking specialist Clarithromycin 500mg twice a uncommon pathogens, any advice): day IV NICE Visual summary microbiological results and MRSA status. NG141 Co-amoxiclav 625mg three or Infection around eyes or nose is more times a day Doxycycline 200mg stat then Back to Contents concerning because of serious 100mg twice a day intracranial complications. Consider referring to hospital or seeking Duration: All 7 days . specialist advice if the person: Pregnancy: ▪ is severely unwell or has lymphangitis Erythromycin 500mg four ▪ has infection near the eyes or nose times a day ▪ may have uncommon pathogens e.g. after a penetrating injury, exposure to If infection near eyes or water-borne organisms, or an infection nose (Consider seeking acquired outside the UK specialist advice): ▪ has spreading infection not responding Clarithromycin 500mg twice a to oral antibiotics day AND ▪ cannot take oral antibiotics (to explore Metronidazole 400mg three giving IV antibiotics at home or in the times a day (only add in community if approp riate) children if anaerobes Refer people to hospital if they have any suspected). symptoms or signs suggesting a more Duration: All 7 days . serious illness or condition, such as A longer course (up to 14 days in total) may be needed but skin orbital cellulitis, osteomyelitis, septic arthritis, necrotising fasciitis or sepsis. takes time to return to normal, and full resolution at 5 to 7 days is # The upper dose of 1 g four times a day not expected. would be off-label. Prescribers should If not responding after 14 days of antibiotic therapy then a holistic follow relevant professional guidance, review of the wound and prescribing to date should be undertaken. taking full responsibility for the decision, Consider: and obtaining and documenting informed ▪ other possible diagnoses, such as an inflammatory reaction to consent. See the GMC's Good practice in an immunisation or an insect bite, gout, superficial prescribing and managing medicines for thrombophlebitis, eczema, allergic dermatitis or deep vein more information. thrombosis ▪ any underlying condition that may predispose to cellulitis or erysipelas, such as oedema, diabetes, venous insufficiency or eczema ▪ any symptoms or signs suggesting a more serious i llness or condition, such as lymphangitis, orbital cellulitis, osteomyelitis, septic arthritis, necrotising fasciitis or sepsis ▪ any results from microbiological testing ▪ any previous antibiotic use, which may have led to resistant bacteria. Most cases of lactational mastitis are Flucloxacillin 500mg to 1g four If penicillin allergic: Mastitis – not caused by an infection and do not times a day Clarithromycin♦ 500mg twice a Lactational require antibiotics. Duration: 7 to 14 days day Advice is to take paracetamol or Back to Contents Duration: 7 to 14 days ibuprofen to reduce pain and fever, drink plenty of fluids, rest and apply a warm compress. ♦Epidemiologic evidence indicates that the risk of hypertrophic Breastfeeding: oral antibiotics are safe pyloric stenosis in infants might be increased by use of maternal and appropriate, where indicated. macrolides, especially in infants exposed in the first 2 weeks after Women should continue feeding, birth. The risk may be greater with erythromycin, which is why including from the affected breast and be clarithromycin is recommended here. advised to monitor the child for adverse drug reactions e.g. diarrhoea and thrush . Version 10.0 21 *NICE uses ‘offer’ when there is more certainty of benefit and ‘consider’ when evidence of benefit is less clear.
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