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       Disturbi dell’alimentazione (DA)
            Informazioni generali
                     Dr. Riccardo Dalle Grave
          Responsabile Unità di Riabilitazione Nutrizionale
                     Casa di Cura Villa Garda

                         www.dallegrave.it

                         Argomenti

Descrizione generale
Decorso
Distribuzione
Cause
Aree danneggiate
Trattamento

                                                                                    1
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale

                              Argomenti

Descrizione generale
Decorso
Distribuzione
Cause
Aree danneggiate
Trattamento

            Disturbi dell’alimentazione
Definizione
I disturbi dell'alimentazione sono condizioni caratterizzati da un persistente
disturbo dell’alimentazione che danneggia significativamente il
funzionamento psicosociale e la salute fisica

La maggior parte dei disturbi dell’alimentazione ha caratteristiche cliniche
distintive e criteri diagnostici positivi

                                                                                        2
Chapter 4                                                                                                                            C

                                        3. Eating disorders and their    The course of AN varies greatly. It may be s
                                                                         may require some form of intervention; or
                                           management                    treatment-resistant and persist for many ye
                         Copyright dr. Riccardo Dalle Grave (2017). Solo per      uso personale
                                                                         life-threatening. For those with longstandin
                                                                                                                             becomes increasingly poor over time, altho
                                            3.1 Clinical features                                                            still occur.10 In the early years, it is common
                                            Figure 4.1 shows the typical distribution of the four eating                     into BN or an OED.
                                            disorder diagnoses among adult outpatients.4 The OEDs
                                            are the most common diagnosis, followed by BN and then                           3.3 Bulimia nervosa
                                            AN. Eating disorder services see relatively few cases of BED.                    BN generally starts in late adolescence or e
                                            Among adolescents, the diagnostic distribution differs (ie that                  It begins in much the same way as AN, but
                                            AN is more common than BN), but the OEDs remain the most                         months or years the dieting becomes punc
                                            common diagnosis.5 BED is not often seen in this age group.5                     episodes of binge eating with the result tha
                                            AN, BN and the OEDs mainly affect girls or young women:                          lost tends to be regained. (‘Binges’ are epis

              Disturbi dell’alimentazione   about one in ten patients is male.3 In contrast, men constitute
                                            about a third of patients with BED. A typical distribution of
                                            the eating disorder diagnoses among adult outpatients6 is
                                                                                                                             in which large amounts of food are consum
                                                                                                                             a sense of loss of control at the time.) The
                                                                                                                             followed by self-induced vomiting or laxativ
                      Distribuzione negli Adolescenti
                                            shown here (Figure 4.1).                                                         attempt to minimise the amount of food ab
                                            Figure 4.1 Typical distribution of the eating disorder                           Once fully developed, BN tends to be self-p
                                                       diagnoses among adult outpatients in England                          may persist for years or even decades with
• Anoressia nervosa                                                                                                          on self-esteem, career and relationships. It
                                                                                                                             sufferers to delay seeking help due to the s
• Bulimia nervosa                                                            BED
                                                                             BED
                                                                                                                             with binge eating,11 and it is easy for them
                                                                                                 BN
                                                                                                AN                           problem secret as their weight is generally
• Altri disturbi dell’alimentazione (ADA)
                                                                                                                             3.4 Other eating disorders
• Disturbo da binge-eating (BED)                                                                                             Most OEDs are very similar to AN and BN.12
                                                                                                                             same over-concern about eating, shape an

• Disturbo evitante/restrittivo                                     ADA
                                                                   OEDs                                                      same tendency to engage in persistent and
                                                                                                     AN
                                                                                                     BN                      and other forms of weight-control behavio
  dell’assunzione di cibo (ARFID?)                                                                                           OEDs are mixed states in which the feature
                                                                                                                             are combined in such a way that it is not p
                                                                                                                             either diagnosis. Body weight may be low i
                                                                                                                             restriction is marked.

                                                                                                                             Many people with an OED have a history o
                                            Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford
                                                                                                                             both, reflecting the diagnostic migration th
                                                                                                                             among the eating disorders9,14 (see Figure 4
                                            Chapter 4                                                                        Fairburn and Harrison15).The OEDs are as imC
                                            3.2 Anorexia nervosa                                                             the level of eating disorder features is the s
                                            AN typically starts in early to mid-adolescence with a period                    duration and their impact on everyday func
                                            of dieting that gets out of control and becomes persistent,
                                            3. Eating disorders and their
                                            inflexible and extreme.3 Progressive weight loss results and is
                                            accompanied by over-concern about body shape and weight,
                                                                                                                             The
                                                                                                                             One course
                                                                                                                             may    requirein
                                                                                                                             specialising
                                                                                                                                             of AN varies
                                                                                                                                    small subgroup
                                                                                                                                              some
                                                                                                                                                       alsogreatly.   It may be s
                                                                                                                                                             merits mentioning
                                                                                                                                                    form of intervention;
                                                                                                                                                the treatment   of young child  or
                                               management
                                            although this may not be acknowledged and may be absent                          treatment-resistant
                                                                                                                             adolescents with eating
                                                                                                                             life-threatening.
                                                                                                                             restrict
                                                                                                                                                      and persist
                                                                                                                                                  Forbut
                                                                                                                                       their eating
                                                                                                                                                           problems
                                                                                                                                                       those
                                                                                                                                                          notwith
                                                                                                                                                                    for see
                                                                                                                                                                         many
                                                                                                                                                               in anlongstandin
                                                                                                                                                                        attempt t
                                                                                                                                                                                 ye
                                                                                                                                                                              some
                                            at the outset. There is a fear of weight gain and fatness, and
                                            this drives further dieting. The dieting may be accompanied                      becomes
                                                                                                                             shape        increasingly
                                                                                                                                      or weight.   Thesepoor  overvary
                                                                                                                                                           states    time,   altho
                                                                                                                                                                          in natur
                                            3.1other
                                            by    Clinical
                                                       forms features
                                                               of weight-control behaviour including                         still occur.
                                                                                                                             been
                                                                                                                                          10
                                                                                                                                             In the early years,
                                                                                                                                     well characterised.    They ithave
                                                                                                                                                                     is common
                                                                                                                                                                           recently
                                            over-exercising,
                                            Figure 4.1 showsself-induced         vomiting and
                                                                  the typical distribution       oflaxative
                                                                                                     the fourmisuse.
                                                                                                                 eating      into  BN or an OED. food intake disorder’.3
                                                                                                                             ‘avoidant/restrictive
                                            Typically,  sufferers do
                                            disorder diagnoses          not acknowledge
                                                                     among     adult outpatients.having4 a problem;
                                                                                                         The OEDs            prevalence in specialist clinics for children r
                                            theirthe
                                            are    lowmost
                                                        weight    and extreme
                                                             common      diagnosis,weight-control
                                                                                        followed by behaviour
                                                                                                        BN and then   are    3.3 16,
                                                                                                                             14%.    Bulimia
                                                                                                                                       17
                                                                                                                                          In our nervosa
                                                                                                                                                  experience, they are rarely
                                            consistent
                                            AN.   Eatingwith    theirservices
                                                          disorder     desire toseemaintain
                                                                                      relativelystrict
                                                                                                   fewcontrol
                                                                                                         cases of over
                                                                                                                    BED.     BN generally starts in late adolescence or e
                                            their eating,
                                            Among          shape and
                                                      adolescents,     theweight.
                                                                            diagnostic distribution differs (ie that         It begins in much the same way as AN, but
                                            AN is more common than BN), but the OEDs remain the most                         months or years the dieting becomes punc
                                            common diagnosis.5 BED is not often seen in this age group.5                     episodes of binge eating with the result tha
                                            AN, BN and the OEDs mainly affect girls or young women:                          lost tends to be regained. (‘Binges’ are epis

              Disturbi dell’alimentazione   about one in ten patients is male.3 In contrast, men constitute
                                            about a third of patients with BED. A typical distribution of
                                            the eating disorder diagnoses among adult outpatients6 is
                                                                                                                             in which large amounts of food are consum
                                                                                                                             a sense of loss of control at the time.) The
                                                                                                                             followed by self-induced vomiting or laxativ
                        Distribuzione negli Adulti
                                            Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women
                                            shown here (Figure 4.1).                                                         attempt to minimise the amount of food ab
                                            Figure 4.1 Typical distribution of the eating disorder                           Once fully developed, BN tends to be self-p
                                                       diagnoses among adult outpatients in England                          may persist for years or even decades with
• Anoressia nervosa                                                                                                          on self-esteem, career and relationships. It
                                                                                                                             sufferers to delay seeking help due to the s
• Bulimia nervosa                                                            BED                                             with binge eating,11 and it is easy for them
                                                                             BED                 AN                          problem secret as their weight is generally
                                                                                                AN
• Altri disturbi dell’alimentazione (ADA)
                                                                                                                             3.4 Other eating disorders
• Disturbo da binge-eating (BED)                                                                                             Most OEDs are very similar to AN and BN.12
                                                                                                                             same over-concern about eating, shape an
• (ARFID)                                                           ADA
                                                                   OEDs                                                      same tendency to engage in persistent and
                                                                                                     BN
                                                                                                     BN                      and other forms of weight-control behavio
                                                                                                                             OEDs are mixed states in which the feature
                                                                                                                             are combined in such a way that it is not p
                                                                                                                             either diagnosis. Body weight may be low i
                                                                                                                             restriction is marked.

                                                                                                                             Many people with an OED have a history o
                                            Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford
                                                                                                                             both, reflecting the diagnostic migration th
                                                                                                                             among the eating disorders9,14 (see Figure 4
                                                                                                                             Fairburn and Harrison15).The OEDs are as im
                                            3.2 Anorexia nervosa                                                             the level of eating disorder features is the s
                                            AN typically starts in early to mid-adolescence with a period                    duration and their impact on everyday func
                                            of dieting that gets out of control and becomes persistent,
                                            inflexible and extreme.3 Progressive weight loss results and is                  One small subgroup also merits mentioning
                                            accompanied by over-concern about body shape and weight,                         specialising in the treatment of young child
                                            although this may not be acknowledged and may be absent                          adolescents with eating problems see some
                                            at the outset. There is a fear of weight gain and fatness, and                   restrict their eating but not in an attempt t
                                            this drives further dieting. The dieting may be accompanied                      shape or weight. These states vary in natur
                                            by other forms of weight-control behaviour including                             been well characterised. They have recently
                                            over-exercising, self-induced vomiting and laxative misuse.                      ‘avoidant/restrictive food intake disorder’.3
                                            Typically, sufferers do not acknowledge having a problem;                        prevalence in specialist clinics for children r
                                            their low weight and extreme weight-control behaviour are                        14%.16, 17 In our experience, they are rarely
                                            consistent with their desire to maintain strict control over
                                            their eating, shape and weight.

                                                                                                                                                                     3

                                            Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women
Chapter 4                                                                                                                            C

                                               3. Eating disorders and their    The course of AN varies greatly. It may be s
                                                                                may require some form of intervention; or
                                                  management                    treatment-resistant and persist for many ye
                                Copyright dr. Riccardo Dalle Grave (2017). Solo per      uso personale
                                                                                life-threatening. For those with longstandin
                                                                                                                                        becomes increasingly poor over time, altho
                                                       3.1 Clinical features                                                            still occur.10 In the early years, it is common
                                                       Figure 4.1 shows the typical distribution of the four eating                     into BN or an OED.
                                                       disorder diagnoses among adult outpatients.4 The OEDs
                                                       are the most common diagnosis, followed by BN and then                           3.3 Bulimia nervosa
                                                       AN. Eating disorder services see relatively few cases of BED.                    BN generally starts in late adolescence or e
                                                       Among adolescents, the diagnostic distribution differs (ie that                  It begins in much the same way as AN, but
                                                       AN is more common than BN), but the OEDs remain the most                         months or years the dieting becomes punc
                                                       common diagnosis.5 BED is not often seen in this age group.5                     episodes of binge eating with the result tha
                                                       AN, BN and the OEDs mainly affect girls or young women:                          lost tends to be regained. (‘Binges’ are epis
                                                       about one in ten patients is male.3 In contrast, men constitute                  in which large amounts of food are consum

                  Disturbi dell’alimentazione          about a third of patients with BED. A typical distribution of
                                                       the eating disorder diagnoses among adult outpatients6 is
                                                       shown here (Figure 4.1).
                                                                                                                                        a sense of loss of control at the time.) The
                                                                                                                                        followed by self-induced vomiting or laxativ
                                                                                                                                        attempt to minimise the amount of food ab
                                                       Figure 4.1 Typical distribution of the eating disorder                           Once fully developed, BN tends to be self-p
                                                                  diagnoses among adult outpatients in England                          may persist for years or even decades with
• Anoressia nervosa                                                                                                                     on self-esteem, career and relationships. It
                                                                                                                                        sufferers to delay seeking help due to the s
• Bulimia nervosa                                                                                                                       with binge eating,11 and it is easy for them
                                                                                        BED
                                                                                        BED                 AN
                                                                                                           AN                           problem secret as their weight is generally
• Altri disturbi dell’alimentazione (ADA)
                                                                                                                                        3.4 Other eating disorders
• Disturbo da binge-eating (BED)                                                                                                        Most OEDs are very similar to AN and BN.12
                                                                                                                                        same over-concern about eating, shape an
• (ARFID)                                                                      ADA
                                                                              OEDs                                                      same tendency to engage in persistent and
                                                                                                                BN
                                                                                                                BN                      and other forms of weight-control behavio
                                                                                                                                        OEDs are mixed states in which the feature
Anoressia nervosa                                                                                                                       are combined in such a way that it is not p
                                                                                                                                        either diagnosis. Body weight may be low i
• Restrizione dietetica calorica persistente,                                                                                           restriction is marked.
  rigida ed estrema                                                                                                                     Many people with an OED have a history o
• Basso peso                                           Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford
                                                                                                                                        both, reflecting the diagnostic migration th
                                                                                                                                        among the eating disorders9,14 (see Figure 4
• Eccessiva valutazione del peso e della forma
                                             Chapter 4                                                                                  Fairburn and Harrison15).The OEDs are as imC
                                             3.2 Anorexia nervosa
  del corpo                                                                                                                             the level of eating disorder features is the s
                                             AN typically starts in early to mid-adolescence with a period                              duration and their impact on everyday func
• Soprattutto adolescenti                    of dieting that gets out of control and becomes persistent,
                                                       3. Eating disorders and their
                                                       inflexible and extreme.3 Progressive weight loss results and is
                                                       accompanied by over-concern about body shape and weight,
                                                                                                                                        The
                                                                                                                                        One course
                                                                                                                                        may    requirein
                                                                                                                                        specialising
                                                                                                                                                        of AN varies
                                                                                                                                               small subgroup
                                                                                                                                                         some
                                                                                                                                                                  alsogreatly.   It may be s
                                                                                                                                                                        merits mentioning
                                                                                                                                                               form of intervention;
                                                                                                                                                           the treatment   of young child  or
                                                          management
                                                       although this may not be acknowledged and may be absent                          treatment-resistant
                                                                                                                                        adolescents with eating
                                                                                                                                        life-threatening.
                                                                                                                                        restrict
                                                                                                                                                                 and persist
                                                                                                                                                             Forbut
                                                                                                                                                  their eating
                                                                                                                                                                      problems
                                                                                                                                                                  those
                                                                                                                                                                     notwith
                                                                                                                                                                               for see
                                                                                                                                                                                    many
                                                                                                                                                                          in anlongstandin
                                                                                                                                                                                   attempt t
                                                                                                                                                                                            ye
                                                                                                                                                                                         some
                                                       at the outset. There is a fear of weight gain and fatness, and
                                                       this drives further dieting. The dieting may be accompanied                      becomes
                                                                                                                                        shape        increasingly
                                                                                                                                                 or weight.   Thesepoor  overvary
                                                                                                                                                                      states    time,   altho
                                                                                                                                                                                     in natur
                                                       3.1other
                                                       by    Clinical
                                                                  forms features
                                                                          of weight-control behaviour including                         still occur.
                                                                                                                                        been
                                                                                                                                                     10
                                                                                                                                                        In the early years,
                                                                                                                                                well characterised.    They ithave
                                                                                                                                                                                is common
                                                                                                                                                                                      recently
                                                       over-exercising,
                                                       Figure 4.1 showsself-induced         vomiting and
                                                                             the typical distribution       oflaxative
                                                                                                                the fourmisuse.
                                                                                                                            eating      into  BN or an OED. food intake disorder’.3
                                                                                                                                        ‘avoidant/restrictive
                                                       Typically,  sufferers do
                                                       disorder diagnoses          not acknowledge
                                                                                among     adult outpatients.having4 a problem;
                                                                                                                    The OEDs            prevalence in specialist clinics for children r
                                                       theirthe
                                                       are    lowmost
                                                                   weight    and extreme
                                                                        common      diagnosis,weight-control
                                                                                                   followed by behaviour
                                                                                                                   BN and then   are    3.3 16,
                                                                                                                                        14%.    Bulimia
                                                                                                                                                  17
                                                                                                                                                     In our nervosa
                                                                                                                                                             experience, they are rarely
                                                       consistent
                                                       AN.   Eatingwith    theirservices
                                                                     disorder     desire toseemaintain
                                                                                                 relativelystrict
                                                                                                              fewcontrol
                                                                                                                    cases of over
                                                                                                                               BED.     BN generally starts in late adolescence or e
                                                       their eating,
                                                       Among          shape and
                                                                 adolescents,     theweight.
                                                                                       diagnostic distribution differs (ie that         It begins in much the same way as AN, but
                                                       AN is more common than BN), but the OEDs remain the most                         months or years the dieting becomes punc
                                                       common diagnosis.5 BED is not often seen in this age group.5                     episodes of binge eating with the result tha
                                                       AN, BN and the OEDs mainly affect girls or young women:                          lost tends to be regained. (‘Binges’ are epis
                                                       about one in ten patients is male.3 In contrast, men constitute                  in which large amounts of food are consum

                  Disturbi dell’alimentazione          about a third of patients with BED. A typical distribution of
                                                       the eating disorder diagnoses among adult outpatients6 is
                                                       Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women
                                                       shown here (Figure 4.1).
                                                                                                                                        a sense of loss of control at the time.) The
                                                                                                                                        followed by self-induced vomiting or laxativ
                                                                                                                                        attempt to minimise the amount of food ab
                                                       Figure 4.1 Typical distribution of the eating disorder                           Once fully developed, BN tends to be self-p
                                                                  diagnoses among adult outpatients in England                          may persist for years or even decades with
• Anoressia nervosa                                                                                                                     on self-esteem, career and relationships. It
                                                                                                                                        sufferers to delay seeking help due to the s
• Bulimia nervosa                                                                                                                       with binge eating,11 and it is easy for them
                                                                                        BED
                                                                                        BED                 AN
                                                                                                           AN                           problem secret as their weight is generally
• Disturbo da binge-eating (BED)
                                                                                                                                        3.4 Other eating disorders
• Altri disturbi dell’alimentazione (ADA)                                                                                               Most OEDs are very similar to AN and BN.12
                                                                                                                                        same over-concern about eating, shape an
• (ARFID)                                                                      ADA
                                                                              OEDs                                                      same tendency to engage in persistent and
                                                                                                                BN
                                                                                                                BN                      and other forms of weight-control behavio
                                                                                                                                        OEDs are mixed states in which the feature
Bulimia nervosa                                                                                                                         are combined in such a way that it is not p
                                                                                                                                        either diagnosis. Body weight may be low i
• Restrizione dietetica calorica persistente,                                                                                           restriction is marked.
  rigida ed estrema                                                                                                                     Many people with an OED have a history o
• Episodi di abbuffate ricorrenti seguiti da           Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford
                                                                                                                                        both, reflecting the diagnostic migration th
                                                                                                                                        among the eating disorders9,14 (see Figure 4
  comportamenti di compenso                                                                                                             Fairburn and Harrison15).The OEDs are as im
                                             3.2 Anorexia nervosa
• Non sottopeso                                                                                                                         the level of eating disorder features is the s
                                             AN typically starts in early to mid-adolescence with a period                              duration and their impact on everyday func
• Eccessiva valutazione del peso e della forma
                                             of dieting that gets out of control and becomes persistent,
                                                                                                                                        One small subgroup also merits mentioning
  del corpo                                  inflexible and extreme. Progressive weight loss results and is
                                                                                          3

                                             accompanied by over-concern about body shape and weight,                                   specialising in the treatment of young child
• Soprattutto giovani donne                  although this may not be acknowledged and may be absent                                    adolescents with eating problems see some
                                                       at the outset. There is a fear of weight gain and fatness, and                   restrict their eating but not in an attempt t
                                                       this drives further dieting. The dieting may be accompanied                      shape or weight. These states vary in natur
                                                       by other forms of weight-control behaviour including                             been well characterised. They have recently
                                                       over-exercising, self-induced vomiting and laxative misuse.                      ‘avoidant/restrictive food intake disorder’.3
                                                       Typically, sufferers do not acknowledge having a problem;                        prevalence in specialist clinics for children r
                                                       their low weight and extreme weight-control behaviour are                        14%.16, 17 In our experience, they are rarely
                                                       consistent with their desire to maintain strict control over
                                                       their eating, shape and weight.

                                                                                                                                                                                4

                                                       Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women
Chapter 4                                                                                                                            C

                                        3. Eating disorders and their    The course of AN varies greatly. It may be s
                                                                         may require some form of intervention; or
                                           management                    treatment-resistant and persist for many ye
                         Copyright dr. Riccardo Dalle Grave (2017). Solo per      uso personale
                                                                         life-threatening. For those with longstandin
                                                                                                                              becomes increasingly poor over time, altho
                                             3.1 Clinical features                                                            still occur.10 In the early years, it is common
                                             Figure 4.1 shows the typical distribution of the four eating                     into BN or an OED.
                                             disorder diagnoses among adult outpatients.4 The OEDs
                                             are the most common diagnosis, followed by BN and then                           3.3 Bulimia nervosa
                                             AN. Eating disorder services see relatively few cases of BED.                    BN generally starts in late adolescence or e
                                             Among adolescents, the diagnostic distribution differs (ie that                  It begins in much the same way as AN, but
                                             AN is more common than BN), but the OEDs remain the most                         months or years the dieting becomes punc
                                             common diagnosis.5 BED is not often seen in this age group.5                     episodes of binge eating with the result tha
                                             AN, BN and the OEDs mainly affect girls or young women:                          lost tends to be regained. (‘Binges’ are epis
                                             about one in ten patients is male.3 In contrast, men constitute                  in which large amounts of food are consum

              Disturbi dell’alimentazione    about a third of patients with BED. A typical distribution of
                                             the eating disorder diagnoses among adult outpatients6 is
                                             shown here (Figure 4.1).
                                                                                                                              a sense of loss of control at the time.) The
                                                                                                                              followed by self-induced vomiting or laxativ
                                                                                                                              attempt to minimise the amount of food ab
                                             Figure 4.1 Typical distribution of the eating disorder                           Once fully developed, BN tends to be self-p
                                                        diagnoses among adult outpatients in England                          may persist for years or even decades with
• Anoressia nervosa                                                                                                           on self-esteem, career and relationships. It
                                                                                                                              sufferers to delay seeking help due to the s
• Bulimia nervosa                                                                                                             with binge eating,11 and it is easy for them
                                                                              BED
                                                                              BED                 AN
                                                                                                 AN                           problem secret as their weight is generally
• Altri disturbi dell’alimentazione (ADA)
                                                                                                                              3.4 Other eating disorders
• Disturbo da binge-eating (BED)                                                                                              Most OEDs are very similar to AN and BN.12
                                                                                                                              same over-concern about eating, shape an
• (ARFID)                                                            ADA
                                                                    OEDs                                                      same tendency to engage in persistent and
                                                                                                      BN
                                                                                                      BN                      and other forms of weight-control behavio
                                                                                                                              OEDs are mixed states in which the feature
Altri disturbi dell’alimentazione                                                                                             are combined in such a way that it is not p
                                                                                                                              either diagnosis. Body weight may be low i
• Soprattutto disturbi sottosoglia o misti                                                                                    restriction is marked.
• La stessa psicopatologia dell’AN e BN                                                                                       Many people with an OED have a history o
• Un sottogruppo sottopeso                   Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford
                                                                                                                              both, reflecting the diagnostic migration th
                                                                                                                              among the eating disorders9,14 (see Figure 4
• Soprattutto giovani donne                  Chapter 4                                                                        Fairburn and Harrison15).The OEDs are as imC
                                             3.2 Anorexia nervosa                                                             the level of eating disorder features is the s
                                             AN typically starts in early to mid-adolescence with a period                    duration and their impact on everyday func
                                             of dieting that gets out of control and becomes persistent,
                                             3. Eating disorders and their
                                             inflexible and extreme.3 Progressive weight loss results and is
                                             accompanied by over-concern about body shape and weight,
                                                                                                                              The
                                                                                                                              One course
                                                                                                                              may    requirein
                                                                                                                              specialising
                                                                                                                                              of AN varies
                                                                                                                                     small subgroup
                                                                                                                                               some
                                                                                                                                                        alsogreatly.   It may be s
                                                                                                                                                              merits mentioning
                                                                                                                                                     form of intervention;
                                                                                                                                                 the treatment   of young child  or
                                                management
                                             although this may not be acknowledged and may be absent                          treatment-resistant
                                                                                                                              adolescents with eating
                                                                                                                              life-threatening.
                                                                                                                              restrict
                                                                                                                                                       and persist
                                                                                                                                                   Forbut
                                                                                                                                        their eating
                                                                                                                                                            problems
                                                                                                                                                        those
                                                                                                                                                           notwith
                                                                                                                                                                     for see
                                                                                                                                                                          many
                                                                                                                                                                in anlongstandin
                                                                                                                                                                         attempt t
                                                                                                                                                                                  ye
                                                                                                                                                                               some
                                             at the outset. There is a fear of weight gain and fatness, and
                                             this drives further dieting. The dieting may be accompanied                      becomes
                                                                                                                              shape        increasingly
                                                                                                                                       or weight.   Thesepoor  overvary
                                                                                                                                                            states    time,   altho
                                                                                                                                                                           in natur
                                             3.1other
                                             by    Clinical
                                                        forms features
                                                                of weight-control behaviour including                         still occur.
                                                                                                                              been
                                                                                                                                           10
                                                                                                                                              In the early years,
                                                                                                                                      well characterised.    They ithave
                                                                                                                                                                      is common
                                                                                                                                                                            recently
                                             over-exercising,
                                             Figure 4.1 showsself-induced         vomiting and
                                                                   the typical distribution       oflaxative
                                                                                                      the fourmisuse.
                                                                                                                  eating      into  BN or an OED. food intake disorder’.3
                                                                                                                              ‘avoidant/restrictive
                                             Typically,  sufferers do
                                             disorder diagnoses          not acknowledge
                                                                      among     adult outpatients.having4 a problem;
                                                                                                          The OEDs            prevalence in specialist clinics for children r
                                             theirthe
                                             are    lowmost
                                                         weight    and extreme
                                                              common      diagnosis,weight-control
                                                                                         followed by behaviour
                                                                                                         BN and then   are    3.3 16,
                                                                                                                              14%.    Bulimia
                                                                                                                                        17
                                                                                                                                           In our nervosa
                                                                                                                                                   experience, they are rarely
                                             consistent
                                             AN.   Eatingwith    theirservices
                                                           disorder     desire toseemaintain
                                                                                       relativelystrict
                                                                                                    fewcontrol
                                                                                                          cases of over
                                                                                                                     BED.     BN generally starts in late adolescence or e
                                             their eating,
                                             Among          shape and
                                                       adolescents,     theweight.
                                                                             diagnostic distribution differs (ie that         It begins in much the same way as AN, but
                                             AN is more common than BN), but the OEDs remain the most                         months or years the dieting becomes punc
                                             common diagnosis.5 BED is not often seen in this age group.5                     episodes of binge eating with the result tha
                                             AN, BN and the OEDs mainly affect girls or young women:                          lost tends to be regained. (‘Binges’ are epis
                                             about one in ten patients is male.3 In contrast, men constitute                  in which large amounts of food are consum

              Disturbi dell’alimentazione    about a third of patients with BED. A typical distribution of
                                             the eating disorder diagnoses among adult outpatients6 is
                                             Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women
                                             shown here (Figure 4.1).
                                                                                                                              a sense of loss of control at the time.) The
                                                                                                                              followed by self-induced vomiting or laxativ
                                                                                                                              attempt to minimise the amount of food ab
                                             Figure 4.1 Typical distribution of the eating disorder                           Once fully developed, BN tends to be self-p
                                                        diagnoses among adult outpatients in England                          may persist for years or even decades with
• Anoressia nervosa                                                                                                           on self-esteem, career and relationships. It
                                                                                                                              sufferers to delay seeking help due to the s
• Bulimia nervosa                                                                                                             with binge eating,11 and it is easy for them
                                                                              BED
                                                                              BED                 AN
                                                                                                 AN                           problem secret as their weight is generally
• Altri disturbi dell’alimentazione (ADA)
                                                                                                                              3.4 Other eating disorders
• Disturbo da binge-eating (BED)                                                                                              Most OEDs are very similar to AN and BN.12
                                                                                                                              same over-concern about eating, shape an
• (ARFID)                                                            ADA
                                                                    OEDs                                                      same tendency to engage in persistent and
                                                                                                      BN
                                                                                                      BN                      and other forms of weight-control behavio
                                                                                                                              OEDs are mixed states in which the feature
Disturbo da binge-eating                                                                                                      are combined in such a way that it is not p
                                                                                                                              either diagnosis. Body weight may be low i
• Episodi di abbuffata ricorrenti non seguiti da                                                                              restriction is marked.
  comportamenti di compenso                                                                                                   Many people with an OED have a history o
• Tendenza generale a mangiare in eccesso    Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford
                                                                                                                              both, reflecting the diagnostic migration th
                                                                                                                              among the eating disorders9,14 (see Figure 4
• Spesso coesiste con l’obesità                                                                                               Fairburn and Harrison15).The OEDs are as im
• Ampia fascia di età, un terzo sono maschi3.2 Anorexia nervosa                                                               the level of eating disorder features is the s
                                             AN typically starts in early to mid-adolescence with a period                    duration and their impact on everyday func
                                             of dieting that gets out of control and becomes persistent,
                                             inflexible and extreme.3 Progressive weight loss results and is                  One small subgroup also merits mentioning
                                             accompanied by over-concern about body shape and weight,                         specialising in the treatment of young child
                                             although this may not be acknowledged and may be absent                          adolescents with eating problems see some
                                             at the outset. There is a fear of weight gain and fatness, and                   restrict their eating but not in an attempt t
                                             this drives further dieting. The dieting may be accompanied                      shape or weight. These states vary in natur
                                             by other forms of weight-control behaviour including                             been well characterised. They have recently
                                             over-exercising, self-induced vomiting and laxative misuse.                      ‘avoidant/restrictive food intake disorder’.3
                                             Typically, sufferers do not acknowledge having a problem;                        prevalence in specialist clinics for children r
                                             their low weight and extreme weight-control behaviour are                        14%.16, 17 In our experience, they are rarely
                                             consistent with their desire to maintain strict control over
                                             their eating, shape and weight.

                                                                                                                                                                      5

                                             Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women
Chapter 4                                                                                                                            C

                                                  3. Eating disorders and their    The course of AN varies greatly. It may be s
                                                                                   may require some form of intervention; or
                                                     management                    treatment-resistant and persist for many ye
                                   Copyright dr. Riccardo Dalle Grave (2017). Solo per      uso personale
                                                                                   life-threatening. For those with longstandin
                                                                                                                                               becomes increasingly poor over time, altho
                                                              3.1 Clinical features                                                            still occur.10 In the early years, it is common
                                                              Figure 4.1 shows the typical distribution of the four eating                     into BN or an OED.
                                                              disorder diagnoses among adult outpatients.4 The OEDs
                                                              are the most common diagnosis, followed by BN and then                           3.3 Bulimia nervosa
                                                              AN. Eating disorder services see relatively few cases of BED.                    BN generally starts in late adolescence or e
                                                              Among adolescents, the diagnostic distribution differs (ie that                  It begins in much the same way as AN, but
                                                              AN is more common than BN), but the OEDs remain the most                         months or years the dieting becomes punc
                                                              common diagnosis.5 BED is not often seen in this age group.5                     episodes of binge eating with the result tha
                                                              AN, BN and the OEDs mainly affect girls or young women:                          lost tends to be regained. (‘Binges’ are epis
                                                              about one in ten patients is male.3 In contrast, men constitute                  in which large amounts of food are consum

                   Disturbi dell’alimentazione                about a third of patients with BED. A typical distribution of
                                                              the eating disorder diagnoses among adult outpatients6 is
                                                              shown here (Figure 4.1).
                                                                                                                                               a sense of loss of control at the time.) The
                                                                                                                                               followed by self-induced vomiting or laxativ
                                                                                                                                               attempt to minimise the amount of food ab
                                                              Figure 4.1 Typical distribution of the eating disorder                           Once fully developed, BN tends to be self-p
                                                                         diagnoses among adult outpatients in England                          may persist for years or even decades with
• Anoressia nervosa                                                                                                                            on self-esteem, career and relationships. It
                                                                                                                                               sufferers to delay seeking help due to the s
• Bulimia nervosa                                                                                                                              with binge eating,11 and it is easy for them
                                                                                               BED
                                                                                               BED                 AN
                                                                                                                  AN                           problem secret as their weight is generally
• Altri disturbi dell’alimentazione (ADA)
                                                                                                                                               3.4 Other eating disorders
• Disturbo da binge-eating (BED)                                                                                                               Most OEDs are very similar to AN and BN.12
                                                                                                                                               same over-concern about eating, shape an
• ARFID                                                                               ADA
                                                                                     OEDs                                                      same tendency to engage in persistent and
                                                                                                                       BN
                                                                                                                       BN                      and other forms of weight-control behavio
                                                                                                                                               OEDs are mixed states in which the feature
ARFID                                                                                                                                          are combined in such a way that it is not p
                                                                                                                                               either diagnosis. Body weight may be low i
• Restrizione alimentare selettiva persistente                                                                                                 restriction is marked.
 -   apparente mancanza d’interesse per il mangiare
                                                                                                                                               Many people with an OED have a history o
 -   evitamento basato sulle caratteristiche Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford                     both, reflecting the diagnostic migration th
     sensoriali del cibo                                                                                                                       among the eating disorders9,14 (see Figure 4
                                              Chapter 4                                                                                        Fairburn and Harrison15).The OEDs are as imC
 -   preoccupazioni relativa alle conseguenze 3.2 Anorexia nervosa                                                                             the level of eating disorder features is the s
     negative del mangiare                    AN typically starts in early to mid-adolescence with a period                                    duration and their impact on everyday func
                                                              of dieting that gets out of control and becomes persistent,
• Malnutrizione
                                                              3. Eating disorders and their
                                                              inflexible and extreme.3 Progressive weight loss results and is                  The
                                                                                                                                               One course      of AN varies
                                                                                                                                                      small subgroup     alsogreatly.   It may be s
                                                                                                                                                                               merits mentioning
• Soprattutto nell’infanzia                                   accompanied by over-concern about body shape and weight,                         may    requirein
                                                                                                                                               specialising     some  form of intervention;
                                                                                                                                                                  the treatment   of young child  or
                                                                 management
                                                              although this may not be acknowledged and may be absent                          treatment-resistant
                                                                                                                                               adolescents with eating
                                                                                                                                               life-threatening.
                                                                                                                                               restrict
                                                                                                                                                                        and persist
                                                                                                                                                                    Forbut
                                                                                                                                                         their eating
                                                                                                                                                                             problems
                                                                                                                                                                         those
                                                                                                                                                                            notwith
                                                                                                                                                                                      for see
                                                                                                                                                                                           many
                                                                                                                                                                                 in anlongstandin
                                                                                                                                                                                          attempt t
                                                                                                                                                                                                   ye
                                                                                                                                                                                                some
                                                              at the outset. There is a fear of weight gain and fatness, and
                                                              this drives further dieting. The dieting may be accompanied                      becomes
                                                                                                                                               shape        increasingly
                                                                                                                                                        or weight.   Thesepoor  overvary
                                                                                                                                                                             states    time,   altho
                                                                                                                                                                                            in natur
                                                              3.1other
                                                              by    Clinical
                                                                         forms features
                                                                                 of weight-control behaviour including                         still occur.
                                                                                                                                               been
                                                                                                                                                            10
                                                                                                                                                               In the early years,
                                                                                                                                                       well characterised.    They ithave
                                                                                                                                                                                       is common
                                                                                                                                                                                             recently
                                                              over-exercising,
                                                              Figure 4.1 showsself-induced         vomiting and
                                                                                    the typical distribution       oflaxative
                                                                                                                       the fourmisuse.
                                                                                                                                   eating      into  BN or an OED. food intake disorder’.3
                                                                                                                                               ‘avoidant/restrictive
                                                              Typically,  sufferers do
                                                              disorder diagnoses          not acknowledge
                                                                                       among     adult outpatients.having4 a problem;
                                                                                                                           The OEDs            prevalence in specialist clinics for children r
                                                              theirthe
                                                              are    lowmost
                                                                          weight    and extreme
                                                                               common      diagnosis,weight-control
                                                                                                          followed by behaviour
                                                                                                                          BN and then   are    3.3 16,
                                                                                                                                               14%.    Bulimia
                                                                                                                                                         17
                                                                                                                                                            In our nervosa
                                                                                                                                                                    experience, they are rarely
                                                              consistent
                                                              AN.   Eatingwith    theirservices
                                                                            disorder     desire toseemaintain
                                                                                                        relativelystrict
                                                                                                                     fewcontrol
                                                                                                                           cases of over
                                                                                                                                      BED.     BN generally starts in late adolescence or e
                                                              their eating,
                                                              Among          shape and
                                                                        adolescents,     theweight.
                                                                                              diagnostic distribution differs (ie that         It begins in much the same way as AN, but
                                                              AN is more common than BN), but the OEDs remain the most                         months or years the dieting becomes punc
                                                              common diagnosis.5 BED is not often seen in this age group.5                     episodes of binge eating with the result tha
                                                              AN, BN and the OEDs mainly affect girls or young women:                          lost tends to be regained. (‘Binges’ are epis
                                                              about one in ten patients is male.3 In contrast, men constitute                  in which large amounts of food are consum

                   Disturbi dell’alimentazione                about a third of patients with BED. A typical distribution of
                                                              the eating disorder diagnoses among adult outpatients6 is
                                                              Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women
                                                              shown here (Figure 4.1).
                                                                                                                                               a sense of loss of control at the time.) The
                                                                                                                                               followed by self-induced vomiting or laxativ
                                                                                                                                               attempt to minimise the amount of food ab
                                                              Figure 4.1 Typical distribution of the eating disorder                           Once fully developed, BN tends to be self-p
                                                                         diagnoses among adult outpatients in England                          may persist for years or even decades with
Disturbi tradizionali                                                                                                                          on self-esteem, career and relationships. It
                                                                                                                                               sufferers to delay seeking help due to the s
• Anoressia nervosa                                                                                                                            with binge eating,11 and it is easy for them
                                                                                               BED
                                                                                               BED                 AN
                                                                                                                  AN                           problem secret as their weight is generally
• Bulimia nervosa
                                                                                                                                               3.4 Other eating disorders
• Altri disturbi dell’alimentazione                                                                                                            Most OEDs are very similar to AN and BN.12
                                                                                                                                               same over-concern about eating, shape an
  (sottosoglia o condizioni miste)                                                    ADA
                                                                                     OEDs                                                      same tendency to engage in persistent and
                                                                                                                       BN
                                                                                                                       BN                      and other forms of weight-control behavio
Altre condizioni                                                                                                                               OEDs are mixed states in which the feature
                                                                                                                                               are combined in such a way that it is not p
• Disturbo da binge-eating (BED)                                                                                                               either diagnosis. Body weight may be low i
                                                                                                                                               restriction is marked.
• ARFID                                                                                                                                        Many people with an OED have a history o
                                                              Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford
                                                                                                                                               both, reflecting the diagnostic migration th
                                                                                                                                               among the eating disorders9,14 (see Figure 4
                                                                                                                                               Fairburn and Harrison15).The OEDs are as im
                                                              3.2 Anorexia nervosa                                                             the level of eating disorder features is the s
                                                              AN typically starts in early to mid-adolescence with a period                    duration and their impact on everyday func
                                                              of dieting that gets out of control and becomes persistent,
                                                              inflexible and extreme.3 Progressive weight loss results and is                  One small subgroup also merits mentioning
                                                              accompanied by over-concern about body shape and weight,                         specialising in the treatment of young child
                                                              although this may not be acknowledged and may be absent                          adolescents with eating problems see some
                                                              at the outset. There is a fear of weight gain and fatness, and                   restrict their eating but not in an attempt t
                                                              this drives further dieting. The dieting may be accompanied                      shape or weight. These states vary in natur
                                                              by other forms of weight-control behaviour including                             been well characterised. They have recently
                                                              over-exercising, self-induced vomiting and laxative misuse.                      ‘avoidant/restrictive food intake disorder’.3
                                                              Typically, sufferers do not acknowledge having a problem;                        prevalence in specialist clinics for children r
                                                              their low weight and extreme weight-control behaviour are                        14%.16, 17 In our experience, they are rarely
                                                              consistent with their desire to maintain strict control over
                                                              their eating, shape and weight.

                                                                                                                                                                                       6

                                                              Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale

                              Argomenti

Descrizione generale
Decorso
Distribuzione
Cause
Aree danneggiate
Trattamento

                                Decorso
Anoressia nervosa
•   Inizia nell’adolescenza, spesso breve durata ed auto-limitata
•   Se persiste, frequentemente evolve nella BN o in ADA
•   La minoranza rimane come AN, il disturbo diventa grave di lunga durata.
Bulimia nervosa
•   Inizia nella tarda adolescenza o nella giovane età adulta
•   Frequentemente preceduta da AN o condizioni simil-AN
•   Può persistere come BN o ADA
Altri disturbi dell’alimentazione
•   Decorso non ben caratterizzato
•   Iniziano nell’adolescenza o nella giovane età adulta
•   Spesso preceduti da AN o BN

                                                                                         7
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                            Decorso

                       Migrazione diagnostica

                                      AN

                          ADA              BN

                          Argomenti

Descrizione generale
Decorso
Distribuzione
Cause
Aree danneggiate
Trattamento

                                                                                  8
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                                 Distribuzione

Punti generali
• La distribuzione non è stabile – Modificazioni secolari
• Emergenza della BN negli anni 70 (nord Europa e America, poi
  Italia del Nord)
• Emergenza dei DA nei Paesi asiatici negli anni 90
• Distribuzione globale irregolare

                             Distribuzione
                           Anoressia nervosa Bulimia nervosa                         BED

  Distribuzione mondiale     Società occidentali    Società occidentali         Non conosciuta

                            Principalmente razza   Principalmente razza
  Origine etnica                                                            Distribuzione irregolare
                                   bianca                 bianca

                            Adolescenza (alcuni    Giovani adulti (alcuni
  Età                                                                             Età adulta
                              giovani adulti)          adolescenti)

  Sesso                        90% femmine            90% femmine                2/3 femmine

  Prevalenza                      0,1-0,5%               1,0-2.0%                     3%

  Modificazioni secolari    Possibile incremento   Possibile incremento         Non conosciuto

                                                                                                       9
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                              Argomenti
Descrizione generale
Decorso
Distribuzione
Cause
Aree danneggiate
Trattamento

                                       Cause
Punti generali
Le cause non sono conosciute
Molte sfide metodologiche
• I DA non sono comuni
• I DA sono difficili da individuare
• I campioni clinici non sono rappresentativi
• I DA sono difficili da diagnosticare, sono usate delle definizioni inconsistenti
• Non vi sono dei fenotipi ovvi da studiare
    – Per es. AN o AN persistente
• Problema della comorbilità
    – Molto ignorata, anche se appare esista una relazione tra DA e depressione

                                                                                          10
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale

                                   Cause
Punti generali (cont.)
Familiarità indubbia
• Rischio aumentato di 10 volte nei familiari di primo grado
• Trasmissione crociata tra i DA tradizionali
Gli studi sui gemelli suggeriscono un importante contributo genetico
•   I fattori genetici sembrano contribuire al 40-60% della predisposizione

                                   Cause
Punti generali (cont.)
Studi di associazione genome-wide (GWAS)
• Risultati negativi nel primo studio (1000 partecipanti)
• Studio con 3495 AN e 10982 controlli (Duncan et al, 2017)
    – Identificato un locus genome-wide significativo per l’anoressia nervosa
      sul cromosoma 12
         • (index variant rs4622308, p=4.3x10-9) nella regione
           (chr12:56,372,585-56,482,185) che include 6 geni.
    – Correlazioni positive con schizofrenia, neuroticismo, livello di istruzione
      e HDL colesterolo
    – Correlazioni negative con alcuni fenotipi (BMI, insulina, glucosio e lipidi)
• Un nuovo studio è in corso (obiettivo N = 25000)

                                                                                         11
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                                       Cause
Punti generali (cont.)
Le modificazioni secolari suggeriscono il contributo di processi sociali
Alcuni fattori di rischio potenziali sono stati individuati

                                        AN          BN        BED          Psych
 Esperienze avverse nell’infanzia        ++        +++        ++            ++
 Depressione nei genitori                +          ++         +            +
 Abuso di sostanze nei genitori           -         ++         -             -
 Fattori di vulnerabilità alla dieta     +         +++         +             -
 - Obesità nell’infanzia                  -        +++         +             -
 - Obesità nei genitori                   -        +++         -             -
 Menarca precoce                          -         ++         -             -
 Perfezionismo                          +++         ++         -             -
 Bassa autostima                        +++        +++         +            ++

                                    Argomenti

Classificazione DSM-5
Distribuzione
Decorso
Cause
Aree danneggiate
Trattamento

                                                                                            12
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                          Aree danneggiate
Relazioni interpersonali
•   Trascurare le amicizie per perseguire il controllo del peso
•   Isolamento sociale e attività solitarie che richiedono consumo di energia
•   Riduzione degli interessi
•   Difficoltà nella relazione di coppia

Profitto scolastico/lavorativo
• Organizzazione della giornata secondo rituali precisi e stereotipati
• Difficoltà di concentrazione, di attenzione e comprensione
• Interruzione del lavoro/scuola
• Eccessivo impegno scolastico

                          Aree danneggiate
Funzionamento psicologico
•   Ansia
•   Apatia
•   Senso di colpa
•   Prolungati episodi di irritabilità
•   Scoppi di rabbia
•   Depressione, demoralizzazione
•   Sbalzi d’umore
•   Bassa autostima e pensieri suicidari
•   Presenza di atti impulsivi abuso di alcool o di droghe, autolesionismo

                                                                                          13
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale

                       Aree danneggiate
Aree danneggiate (cont)
Salute fisica
Complicanze mediche                   Conseguenti a
• Elettrolitiche                      • dieta ipocalorica
• Cardiache                           • perdita di peso
• Endocrine                           • vomito auto-indotto
• Orali                               • uso improprio di lassativi, diuretici
• Gastrointestinali                   • attività fisica eccessiva
• Renali                              Il recupero del peso e la sospensione dei
• Polmonari                           comportamenti non salutari di controllo
• Neurologiche                        del peso risolve la gran parte delle
• Ossee                               complicanze mediche
• Cutanee
• Ematologiche e immunologiche
• Funzione mestruale e riproduttiva

                              Argomenti

Classificazione DSM-5
Distribuzione
Decorso
Cause
Aree danneggiate
Trattamento

                                                                                       14
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                       Terapie farmacologiche
Anoressia nervosa
Nessun trattamento farmacologico

Bulimia nervosa
Antidepressivi – effetto a breve termine sulla frequenza delle abbuffate

Altri disturbi dell’alimentazione
Nessuno studio

Binge-eating disorder
Lisdexamfetamina – effetto a breve termine sulla frequenza delle abbuffate

         Trattamenti psicologici evidence-based
                          (NICE guideline May 2017 – NG69)

                     Bulimia          Binge Eating           Anoressia          OSFED
                    Nervosa              Disorder             Nervosa
Adulti          GSH                  GSH                 CBT-E o “Mantra” Trattamento del
                Se inefficace        Se inefficace       o SSCM            DA che più gli
                CBT-ED               CBT-ED              Se inefficace FPT assomiglia
Adolescenti FT-BN                    GSH                 FT-AN                   Trattamento del
            Se inefficace            Se inefficace       Se inefficace           DA che più gli
            CBT-ED                   CBT-ED              CBT-ED o ANFT           assomiglia

AFP-AN = Adolescent- Focused Psychotherapy for Anorexia Nervosa; CBT-ED = Cognitive
Behaviour Therapy for Eating Disorders; GSH = Guided Self-Help; FPT= Focal psychodynamic
therapy: MANTRA = Maudsley Anorexia Nervosa Treatment for Adults; OSFED = other specied
feeding and eating disorders; SSCN = Specialist Supportive Clinical Management

N.B. La CBT-ED per gli adolescenti è stata sviluppata e valutata a Villa Garda in tre studi di coorte

                                                                                                        15
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