Disturbi dell'alimentazione (DA) Informazioni generali - Dr ...
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Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale Disturbi dell’alimentazione (DA) Informazioni generali Dr. Riccardo Dalle Grave Responsabile Unità di Riabilitazione Nutrizionale Casa di Cura Villa Garda www.dallegrave.it Argomenti Descrizione generale Decorso Distribuzione Cause Aree danneggiate Trattamento 1
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale Argomenti Descrizione generale Decorso Distribuzione Cause Aree danneggiate Trattamento Disturbi dell’alimentazione Definizione I disturbi dell'alimentazione sono condizioni caratterizzati da un persistente disturbo dell’alimentazione che danneggia significativamente il funzionamento psicosociale e la salute fisica La maggior parte dei disturbi dell’alimentazione ha caratteristiche cliniche distintive e criteri diagnostici positivi 2
Chapter 4 C 3. Eating disorders and their The course of AN varies greatly. It may be s may require some form of intervention; or management treatment-resistant and persist for many ye Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale life-threatening. For those with longstandin becomes increasingly poor over time, altho 3.1 Clinical features still occur.10 In the early years, it is common Figure 4.1 shows the typical distribution of the four eating into BN or an OED. disorder diagnoses among adult outpatients.4 The OEDs are the most common diagnosis, followed by BN and then 3.3 Bulimia nervosa AN. Eating disorder services see relatively few cases of BED. BN generally starts in late adolescence or e Among adolescents, the diagnostic distribution differs (ie that It begins in much the same way as AN, but AN is more common than BN), but the OEDs remain the most months or years the dieting becomes punc common diagnosis.5 BED is not often seen in this age group.5 episodes of binge eating with the result tha AN, BN and the OEDs mainly affect girls or young women: lost tends to be regained. (‘Binges’ are epis Disturbi dell’alimentazione about one in ten patients is male.3 In contrast, men constitute about a third of patients with BED. A typical distribution of the eating disorder diagnoses among adult outpatients6 is in which large amounts of food are consum a sense of loss of control at the time.) The followed by self-induced vomiting or laxativ Distribuzione negli Adolescenti shown here (Figure 4.1). attempt to minimise the amount of food ab Figure 4.1 Typical distribution of the eating disorder Once fully developed, BN tends to be self-p diagnoses among adult outpatients in England may persist for years or even decades with • Anoressia nervosa on self-esteem, career and relationships. It sufferers to delay seeking help due to the s • Bulimia nervosa BED BED with binge eating,11 and it is easy for them BN AN problem secret as their weight is generally • Altri disturbi dell’alimentazione (ADA) 3.4 Other eating disorders • Disturbo da binge-eating (BED) Most OEDs are very similar to AN and BN.12 same over-concern about eating, shape an • Disturbo evitante/restrittivo ADA OEDs same tendency to engage in persistent and AN BN and other forms of weight-control behavio dell’assunzione di cibo (ARFID?) OEDs are mixed states in which the feature are combined in such a way that it is not p either diagnosis. Body weight may be low i restriction is marked. Many people with an OED have a history o Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford both, reflecting the diagnostic migration th among the eating disorders9,14 (see Figure 4 Chapter 4 Fairburn and Harrison15).The OEDs are as imC 3.2 Anorexia nervosa the level of eating disorder features is the s AN typically starts in early to mid-adolescence with a period duration and their impact on everyday func of dieting that gets out of control and becomes persistent, 3. Eating disorders and their inflexible and extreme.3 Progressive weight loss results and is accompanied by over-concern about body shape and weight, The One course may requirein specialising of AN varies small subgroup some alsogreatly. It may be s merits mentioning form of intervention; the treatment of young child or management although this may not be acknowledged and may be absent treatment-resistant adolescents with eating life-threatening. restrict and persist Forbut their eating problems those notwith for see many in anlongstandin attempt t ye some at the outset. There is a fear of weight gain and fatness, and this drives further dieting. The dieting may be accompanied becomes shape increasingly or weight. Thesepoor overvary states time, altho in natur 3.1other by Clinical forms features of weight-control behaviour including still occur. been 10 In the early years, well characterised. They ithave is common recently over-exercising, Figure 4.1 showsself-induced vomiting and the typical distribution oflaxative the fourmisuse. eating into BN or an OED. food intake disorder’.3 ‘avoidant/restrictive Typically, sufferers do disorder diagnoses not acknowledge among adult outpatients.having4 a problem; The OEDs prevalence in specialist clinics for children r theirthe are lowmost weight and extreme common diagnosis,weight-control followed by behaviour BN and then are 3.3 16, 14%. Bulimia 17 In our nervosa experience, they are rarely consistent AN. Eatingwith theirservices disorder desire toseemaintain relativelystrict fewcontrol cases of over BED. BN generally starts in late adolescence or e their eating, Among shape and adolescents, theweight. diagnostic distribution differs (ie that It begins in much the same way as AN, but AN is more common than BN), but the OEDs remain the most months or years the dieting becomes punc common diagnosis.5 BED is not often seen in this age group.5 episodes of binge eating with the result tha AN, BN and the OEDs mainly affect girls or young women: lost tends to be regained. (‘Binges’ are epis Disturbi dell’alimentazione about one in ten patients is male.3 In contrast, men constitute about a third of patients with BED. A typical distribution of the eating disorder diagnoses among adult outpatients6 is in which large amounts of food are consum a sense of loss of control at the time.) The followed by self-induced vomiting or laxativ Distribuzione negli Adulti Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women shown here (Figure 4.1). attempt to minimise the amount of food ab Figure 4.1 Typical distribution of the eating disorder Once fully developed, BN tends to be self-p diagnoses among adult outpatients in England may persist for years or even decades with • Anoressia nervosa on self-esteem, career and relationships. It sufferers to delay seeking help due to the s • Bulimia nervosa BED with binge eating,11 and it is easy for them BED AN problem secret as their weight is generally AN • Altri disturbi dell’alimentazione (ADA) 3.4 Other eating disorders • Disturbo da binge-eating (BED) Most OEDs are very similar to AN and BN.12 same over-concern about eating, shape an • (ARFID) ADA OEDs same tendency to engage in persistent and BN BN and other forms of weight-control behavio OEDs are mixed states in which the feature are combined in such a way that it is not p either diagnosis. Body weight may be low i restriction is marked. Many people with an OED have a history o Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford both, reflecting the diagnostic migration th among the eating disorders9,14 (see Figure 4 Fairburn and Harrison15).The OEDs are as im 3.2 Anorexia nervosa the level of eating disorder features is the s AN typically starts in early to mid-adolescence with a period duration and their impact on everyday func of dieting that gets out of control and becomes persistent, inflexible and extreme.3 Progressive weight loss results and is One small subgroup also merits mentioning accompanied by over-concern about body shape and weight, specialising in the treatment of young child although this may not be acknowledged and may be absent adolescents with eating problems see some at the outset. There is a fear of weight gain and fatness, and restrict their eating but not in an attempt t this drives further dieting. The dieting may be accompanied shape or weight. These states vary in natur by other forms of weight-control behaviour including been well characterised. They have recently over-exercising, self-induced vomiting and laxative misuse. ‘avoidant/restrictive food intake disorder’.3 Typically, sufferers do not acknowledge having a problem; prevalence in specialist clinics for children r their low weight and extreme weight-control behaviour are 14%.16, 17 In our experience, they are rarely consistent with their desire to maintain strict control over their eating, shape and weight. 3 Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women
Chapter 4 C 3. Eating disorders and their The course of AN varies greatly. It may be s may require some form of intervention; or management treatment-resistant and persist for many ye Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale life-threatening. For those with longstandin becomes increasingly poor over time, altho 3.1 Clinical features still occur.10 In the early years, it is common Figure 4.1 shows the typical distribution of the four eating into BN or an OED. disorder diagnoses among adult outpatients.4 The OEDs are the most common diagnosis, followed by BN and then 3.3 Bulimia nervosa AN. Eating disorder services see relatively few cases of BED. BN generally starts in late adolescence or e Among adolescents, the diagnostic distribution differs (ie that It begins in much the same way as AN, but AN is more common than BN), but the OEDs remain the most months or years the dieting becomes punc common diagnosis.5 BED is not often seen in this age group.5 episodes of binge eating with the result tha AN, BN and the OEDs mainly affect girls or young women: lost tends to be regained. (‘Binges’ are epis about one in ten patients is male.3 In contrast, men constitute in which large amounts of food are consum Disturbi dell’alimentazione about a third of patients with BED. A typical distribution of the eating disorder diagnoses among adult outpatients6 is shown here (Figure 4.1). a sense of loss of control at the time.) The followed by self-induced vomiting or laxativ attempt to minimise the amount of food ab Figure 4.1 Typical distribution of the eating disorder Once fully developed, BN tends to be self-p diagnoses among adult outpatients in England may persist for years or even decades with • Anoressia nervosa on self-esteem, career and relationships. It sufferers to delay seeking help due to the s • Bulimia nervosa with binge eating,11 and it is easy for them BED BED AN AN problem secret as their weight is generally • Altri disturbi dell’alimentazione (ADA) 3.4 Other eating disorders • Disturbo da binge-eating (BED) Most OEDs are very similar to AN and BN.12 same over-concern about eating, shape an • (ARFID) ADA OEDs same tendency to engage in persistent and BN BN and other forms of weight-control behavio OEDs are mixed states in which the feature Anoressia nervosa are combined in such a way that it is not p either diagnosis. Body weight may be low i • Restrizione dietetica calorica persistente, restriction is marked. rigida ed estrema Many people with an OED have a history o • Basso peso Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford both, reflecting the diagnostic migration th among the eating disorders9,14 (see Figure 4 • Eccessiva valutazione del peso e della forma Chapter 4 Fairburn and Harrison15).The OEDs are as imC 3.2 Anorexia nervosa del corpo the level of eating disorder features is the s AN typically starts in early to mid-adolescence with a period duration and their impact on everyday func • Soprattutto adolescenti of dieting that gets out of control and becomes persistent, 3. Eating disorders and their inflexible and extreme.3 Progressive weight loss results and is accompanied by over-concern about body shape and weight, The One course may requirein specialising of AN varies small subgroup some alsogreatly. It may be s merits mentioning form of intervention; the treatment of young child or management although this may not be acknowledged and may be absent treatment-resistant adolescents with eating life-threatening. restrict and persist Forbut their eating problems those notwith for see many in anlongstandin attempt t ye some at the outset. There is a fear of weight gain and fatness, and this drives further dieting. The dieting may be accompanied becomes shape increasingly or weight. Thesepoor overvary states time, altho in natur 3.1other by Clinical forms features of weight-control behaviour including still occur. been 10 In the early years, well characterised. They ithave is common recently over-exercising, Figure 4.1 showsself-induced vomiting and the typical distribution oflaxative the fourmisuse. eating into BN or an OED. food intake disorder’.3 ‘avoidant/restrictive Typically, sufferers do disorder diagnoses not acknowledge among adult outpatients.having4 a problem; The OEDs prevalence in specialist clinics for children r theirthe are lowmost weight and extreme common diagnosis,weight-control followed by behaviour BN and then are 3.3 16, 14%. Bulimia 17 In our nervosa experience, they are rarely consistent AN. Eatingwith theirservices disorder desire toseemaintain relativelystrict fewcontrol cases of over BED. BN generally starts in late adolescence or e their eating, Among shape and adolescents, theweight. diagnostic distribution differs (ie that It begins in much the same way as AN, but AN is more common than BN), but the OEDs remain the most months or years the dieting becomes punc common diagnosis.5 BED is not often seen in this age group.5 episodes of binge eating with the result tha AN, BN and the OEDs mainly affect girls or young women: lost tends to be regained. (‘Binges’ are epis about one in ten patients is male.3 In contrast, men constitute in which large amounts of food are consum Disturbi dell’alimentazione about a third of patients with BED. A typical distribution of the eating disorder diagnoses among adult outpatients6 is Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women shown here (Figure 4.1). a sense of loss of control at the time.) The followed by self-induced vomiting or laxativ attempt to minimise the amount of food ab Figure 4.1 Typical distribution of the eating disorder Once fully developed, BN tends to be self-p diagnoses among adult outpatients in England may persist for years or even decades with • Anoressia nervosa on self-esteem, career and relationships. It sufferers to delay seeking help due to the s • Bulimia nervosa with binge eating,11 and it is easy for them BED BED AN AN problem secret as their weight is generally • Disturbo da binge-eating (BED) 3.4 Other eating disorders • Altri disturbi dell’alimentazione (ADA) Most OEDs are very similar to AN and BN.12 same over-concern about eating, shape an • (ARFID) ADA OEDs same tendency to engage in persistent and BN BN and other forms of weight-control behavio OEDs are mixed states in which the feature Bulimia nervosa are combined in such a way that it is not p either diagnosis. Body weight may be low i • Restrizione dietetica calorica persistente, restriction is marked. rigida ed estrema Many people with an OED have a history o • Episodi di abbuffate ricorrenti seguiti da Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford both, reflecting the diagnostic migration th among the eating disorders9,14 (see Figure 4 comportamenti di compenso Fairburn and Harrison15).The OEDs are as im 3.2 Anorexia nervosa • Non sottopeso the level of eating disorder features is the s AN typically starts in early to mid-adolescence with a period duration and their impact on everyday func • Eccessiva valutazione del peso e della forma of dieting that gets out of control and becomes persistent, One small subgroup also merits mentioning del corpo inflexible and extreme. Progressive weight loss results and is 3 accompanied by over-concern about body shape and weight, specialising in the treatment of young child • Soprattutto giovani donne although this may not be acknowledged and may be absent adolescents with eating problems see some at the outset. There is a fear of weight gain and fatness, and restrict their eating but not in an attempt t this drives further dieting. The dieting may be accompanied shape or weight. These states vary in natur by other forms of weight-control behaviour including been well characterised. They have recently over-exercising, self-induced vomiting and laxative misuse. ‘avoidant/restrictive food intake disorder’.3 Typically, sufferers do not acknowledge having a problem; prevalence in specialist clinics for children r their low weight and extreme weight-control behaviour are 14%.16, 17 In our experience, they are rarely consistent with their desire to maintain strict control over their eating, shape and weight. 4 Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women
Chapter 4 C 3. Eating disorders and their The course of AN varies greatly. It may be s may require some form of intervention; or management treatment-resistant and persist for many ye Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale life-threatening. For those with longstandin becomes increasingly poor over time, altho 3.1 Clinical features still occur.10 In the early years, it is common Figure 4.1 shows the typical distribution of the four eating into BN or an OED. disorder diagnoses among adult outpatients.4 The OEDs are the most common diagnosis, followed by BN and then 3.3 Bulimia nervosa AN. Eating disorder services see relatively few cases of BED. BN generally starts in late adolescence or e Among adolescents, the diagnostic distribution differs (ie that It begins in much the same way as AN, but AN is more common than BN), but the OEDs remain the most months or years the dieting becomes punc common diagnosis.5 BED is not often seen in this age group.5 episodes of binge eating with the result tha AN, BN and the OEDs mainly affect girls or young women: lost tends to be regained. (‘Binges’ are epis about one in ten patients is male.3 In contrast, men constitute in which large amounts of food are consum Disturbi dell’alimentazione about a third of patients with BED. A typical distribution of the eating disorder diagnoses among adult outpatients6 is shown here (Figure 4.1). a sense of loss of control at the time.) The followed by self-induced vomiting or laxativ attempt to minimise the amount of food ab Figure 4.1 Typical distribution of the eating disorder Once fully developed, BN tends to be self-p diagnoses among adult outpatients in England may persist for years or even decades with • Anoressia nervosa on self-esteem, career and relationships. It sufferers to delay seeking help due to the s • Bulimia nervosa with binge eating,11 and it is easy for them BED BED AN AN problem secret as their weight is generally • Altri disturbi dell’alimentazione (ADA) 3.4 Other eating disorders • Disturbo da binge-eating (BED) Most OEDs are very similar to AN and BN.12 same over-concern about eating, shape an • (ARFID) ADA OEDs same tendency to engage in persistent and BN BN and other forms of weight-control behavio OEDs are mixed states in which the feature Altri disturbi dell’alimentazione are combined in such a way that it is not p either diagnosis. Body weight may be low i • Soprattutto disturbi sottosoglia o misti restriction is marked. • La stessa psicopatologia dell’AN e BN Many people with an OED have a history o • Un sottogruppo sottopeso Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford both, reflecting the diagnostic migration th among the eating disorders9,14 (see Figure 4 • Soprattutto giovani donne Chapter 4 Fairburn and Harrison15).The OEDs are as imC 3.2 Anorexia nervosa the level of eating disorder features is the s AN typically starts in early to mid-adolescence with a period duration and their impact on everyday func of dieting that gets out of control and becomes persistent, 3. Eating disorders and their inflexible and extreme.3 Progressive weight loss results and is accompanied by over-concern about body shape and weight, The One course may requirein specialising of AN varies small subgroup some alsogreatly. It may be s merits mentioning form of intervention; the treatment of young child or management although this may not be acknowledged and may be absent treatment-resistant adolescents with eating life-threatening. restrict and persist Forbut their eating problems those notwith for see many in anlongstandin attempt t ye some at the outset. There is a fear of weight gain and fatness, and this drives further dieting. The dieting may be accompanied becomes shape increasingly or weight. Thesepoor overvary states time, altho in natur 3.1other by Clinical forms features of weight-control behaviour including still occur. been 10 In the early years, well characterised. They ithave is common recently over-exercising, Figure 4.1 showsself-induced vomiting and the typical distribution oflaxative the fourmisuse. eating into BN or an OED. food intake disorder’.3 ‘avoidant/restrictive Typically, sufferers do disorder diagnoses not acknowledge among adult outpatients.having4 a problem; The OEDs prevalence in specialist clinics for children r theirthe are lowmost weight and extreme common diagnosis,weight-control followed by behaviour BN and then are 3.3 16, 14%. Bulimia 17 In our nervosa experience, they are rarely consistent AN. Eatingwith theirservices disorder desire toseemaintain relativelystrict fewcontrol cases of over BED. BN generally starts in late adolescence or e their eating, Among shape and adolescents, theweight. diagnostic distribution differs (ie that It begins in much the same way as AN, but AN is more common than BN), but the OEDs remain the most months or years the dieting becomes punc common diagnosis.5 BED is not often seen in this age group.5 episodes of binge eating with the result tha AN, BN and the OEDs mainly affect girls or young women: lost tends to be regained. (‘Binges’ are epis about one in ten patients is male.3 In contrast, men constitute in which large amounts of food are consum Disturbi dell’alimentazione about a third of patients with BED. A typical distribution of the eating disorder diagnoses among adult outpatients6 is Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women shown here (Figure 4.1). a sense of loss of control at the time.) The followed by self-induced vomiting or laxativ attempt to minimise the amount of food ab Figure 4.1 Typical distribution of the eating disorder Once fully developed, BN tends to be self-p diagnoses among adult outpatients in England may persist for years or even decades with • Anoressia nervosa on self-esteem, career and relationships. It sufferers to delay seeking help due to the s • Bulimia nervosa with binge eating,11 and it is easy for them BED BED AN AN problem secret as their weight is generally • Altri disturbi dell’alimentazione (ADA) 3.4 Other eating disorders • Disturbo da binge-eating (BED) Most OEDs are very similar to AN and BN.12 same over-concern about eating, shape an • (ARFID) ADA OEDs same tendency to engage in persistent and BN BN and other forms of weight-control behavio OEDs are mixed states in which the feature Disturbo da binge-eating are combined in such a way that it is not p either diagnosis. Body weight may be low i • Episodi di abbuffata ricorrenti non seguiti da restriction is marked. comportamenti di compenso Many people with an OED have a history o • Tendenza generale a mangiare in eccesso Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford both, reflecting the diagnostic migration th among the eating disorders9,14 (see Figure 4 • Spesso coesiste con l’obesità Fairburn and Harrison15).The OEDs are as im • Ampia fascia di età, un terzo sono maschi3.2 Anorexia nervosa the level of eating disorder features is the s AN typically starts in early to mid-adolescence with a period duration and their impact on everyday func of dieting that gets out of control and becomes persistent, inflexible and extreme.3 Progressive weight loss results and is One small subgroup also merits mentioning accompanied by over-concern about body shape and weight, specialising in the treatment of young child although this may not be acknowledged and may be absent adolescents with eating problems see some at the outset. There is a fear of weight gain and fatness, and restrict their eating but not in an attempt t this drives further dieting. The dieting may be accompanied shape or weight. These states vary in natur by other forms of weight-control behaviour including been well characterised. They have recently over-exercising, self-induced vomiting and laxative misuse. ‘avoidant/restrictive food intake disorder’.3 Typically, sufferers do not acknowledge having a problem; prevalence in specialist clinics for children r their low weight and extreme weight-control behaviour are 14%.16, 17 In our experience, they are rarely consistent with their desire to maintain strict control over their eating, shape and weight. 5 Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women
Chapter 4 C 3. Eating disorders and their The course of AN varies greatly. It may be s may require some form of intervention; or management treatment-resistant and persist for many ye Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale life-threatening. For those with longstandin becomes increasingly poor over time, altho 3.1 Clinical features still occur.10 In the early years, it is common Figure 4.1 shows the typical distribution of the four eating into BN or an OED. disorder diagnoses among adult outpatients.4 The OEDs are the most common diagnosis, followed by BN and then 3.3 Bulimia nervosa AN. Eating disorder services see relatively few cases of BED. BN generally starts in late adolescence or e Among adolescents, the diagnostic distribution differs (ie that It begins in much the same way as AN, but AN is more common than BN), but the OEDs remain the most months or years the dieting becomes punc common diagnosis.5 BED is not often seen in this age group.5 episodes of binge eating with the result tha AN, BN and the OEDs mainly affect girls or young women: lost tends to be regained. (‘Binges’ are epis about one in ten patients is male.3 In contrast, men constitute in which large amounts of food are consum Disturbi dell’alimentazione about a third of patients with BED. A typical distribution of the eating disorder diagnoses among adult outpatients6 is shown here (Figure 4.1). a sense of loss of control at the time.) The followed by self-induced vomiting or laxativ attempt to minimise the amount of food ab Figure 4.1 Typical distribution of the eating disorder Once fully developed, BN tends to be self-p diagnoses among adult outpatients in England may persist for years or even decades with • Anoressia nervosa on self-esteem, career and relationships. It sufferers to delay seeking help due to the s • Bulimia nervosa with binge eating,11 and it is easy for them BED BED AN AN problem secret as their weight is generally • Altri disturbi dell’alimentazione (ADA) 3.4 Other eating disorders • Disturbo da binge-eating (BED) Most OEDs are very similar to AN and BN.12 same over-concern about eating, shape an • ARFID ADA OEDs same tendency to engage in persistent and BN BN and other forms of weight-control behavio OEDs are mixed states in which the feature ARFID are combined in such a way that it is not p either diagnosis. Body weight may be low i • Restrizione alimentare selettiva persistente restriction is marked. - apparente mancanza d’interesse per il mangiare Many people with an OED have a history o - evitamento basato sulle caratteristiche Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford both, reflecting the diagnostic migration th sensoriali del cibo among the eating disorders9,14 (see Figure 4 Chapter 4 Fairburn and Harrison15).The OEDs are as imC - preoccupazioni relativa alle conseguenze 3.2 Anorexia nervosa the level of eating disorder features is the s negative del mangiare AN typically starts in early to mid-adolescence with a period duration and their impact on everyday func of dieting that gets out of control and becomes persistent, • Malnutrizione 3. Eating disorders and their inflexible and extreme.3 Progressive weight loss results and is The One course of AN varies small subgroup alsogreatly. It may be s merits mentioning • Soprattutto nell’infanzia accompanied by over-concern about body shape and weight, may requirein specialising some form of intervention; the treatment of young child or management although this may not be acknowledged and may be absent treatment-resistant adolescents with eating life-threatening. restrict and persist Forbut their eating problems those notwith for see many in anlongstandin attempt t ye some at the outset. There is a fear of weight gain and fatness, and this drives further dieting. The dieting may be accompanied becomes shape increasingly or weight. Thesepoor overvary states time, altho in natur 3.1other by Clinical forms features of weight-control behaviour including still occur. been 10 In the early years, well characterised. They ithave is common recently over-exercising, Figure 4.1 showsself-induced vomiting and the typical distribution oflaxative the fourmisuse. eating into BN or an OED. food intake disorder’.3 ‘avoidant/restrictive Typically, sufferers do disorder diagnoses not acknowledge among adult outpatients.having4 a problem; The OEDs prevalence in specialist clinics for children r theirthe are lowmost weight and extreme common diagnosis,weight-control followed by behaviour BN and then are 3.3 16, 14%. Bulimia 17 In our nervosa experience, they are rarely consistent AN. Eatingwith theirservices disorder desire toseemaintain relativelystrict fewcontrol cases of over BED. BN generally starts in late adolescence or e their eating, Among shape and adolescents, theweight. diagnostic distribution differs (ie that It begins in much the same way as AN, but AN is more common than BN), but the OEDs remain the most months or years the dieting becomes punc common diagnosis.5 BED is not often seen in this age group.5 episodes of binge eating with the result tha AN, BN and the OEDs mainly affect girls or young women: lost tends to be regained. (‘Binges’ are epis about one in ten patients is male.3 In contrast, men constitute in which large amounts of food are consum Disturbi dell’alimentazione about a third of patients with BED. A typical distribution of the eating disorder diagnoses among adult outpatients6 is Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women shown here (Figure 4.1). a sense of loss of control at the time.) The followed by self-induced vomiting or laxativ attempt to minimise the amount of food ab Figure 4.1 Typical distribution of the eating disorder Once fully developed, BN tends to be self-p diagnoses among adult outpatients in England may persist for years or even decades with Disturbi tradizionali on self-esteem, career and relationships. It sufferers to delay seeking help due to the s • Anoressia nervosa with binge eating,11 and it is easy for them BED BED AN AN problem secret as their weight is generally • Bulimia nervosa 3.4 Other eating disorders • Altri disturbi dell’alimentazione Most OEDs are very similar to AN and BN.12 same over-concern about eating, shape an (sottosoglia o condizioni miste) ADA OEDs same tendency to engage in persistent and BN BN and other forms of weight-control behavio Altre condizioni OEDs are mixed states in which the feature are combined in such a way that it is not p • Disturbo da binge-eating (BED) either diagnosis. Body weight may be low i restriction is marked. • ARFID Many people with an OED have a history o Source Christopher G. Fairburn, Professor of Psychiatry, University of Oxford both, reflecting the diagnostic migration th among the eating disorders9,14 (see Figure 4 Fairburn and Harrison15).The OEDs are as im 3.2 Anorexia nervosa the level of eating disorder features is the s AN typically starts in early to mid-adolescence with a period duration and their impact on everyday func of dieting that gets out of control and becomes persistent, inflexible and extreme.3 Progressive weight loss results and is One small subgroup also merits mentioning accompanied by over-concern about body shape and weight, specialising in the treatment of young child although this may not be acknowledged and may be absent adolescents with eating problems see some at the outset. There is a fear of weight gain and fatness, and restrict their eating but not in an attempt t this drives further dieting. The dieting may be accompanied shape or weight. These states vary in natur by other forms of weight-control behaviour including been well characterised. They have recently over-exercising, self-induced vomiting and laxative misuse. ‘avoidant/restrictive food intake disorder’.3 Typically, sufferers do not acknowledge having a problem; prevalence in specialist clinics for children r their low weight and extreme weight-control behaviour are 14%.16, 17 In our experience, they are rarely consistent with their desire to maintain strict control over their eating, shape and weight. 6 Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale Argomenti Descrizione generale Decorso Distribuzione Cause Aree danneggiate Trattamento Decorso Anoressia nervosa • Inizia nell’adolescenza, spesso breve durata ed auto-limitata • Se persiste, frequentemente evolve nella BN o in ADA • La minoranza rimane come AN, il disturbo diventa grave di lunga durata. Bulimia nervosa • Inizia nella tarda adolescenza o nella giovane età adulta • Frequentemente preceduta da AN o condizioni simil-AN • Può persistere come BN o ADA Altri disturbi dell’alimentazione • Decorso non ben caratterizzato • Iniziano nell’adolescenza o nella giovane età adulta • Spesso preceduti da AN o BN 7
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale Decorso Migrazione diagnostica AN ADA BN Argomenti Descrizione generale Decorso Distribuzione Cause Aree danneggiate Trattamento 8
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale Distribuzione Punti generali • La distribuzione non è stabile – Modificazioni secolari • Emergenza della BN negli anni 70 (nord Europa e America, poi Italia del Nord) • Emergenza dei DA nei Paesi asiatici negli anni 90 • Distribuzione globale irregolare Distribuzione Anoressia nervosa Bulimia nervosa BED Distribuzione mondiale Società occidentali Società occidentali Non conosciuta Principalmente razza Principalmente razza Origine etnica Distribuzione irregolare bianca bianca Adolescenza (alcuni Giovani adulti (alcuni Età Età adulta giovani adulti) adolescenti) Sesso 90% femmine 90% femmine 2/3 femmine Prevalenza 0,1-0,5% 1,0-2.0% 3% Modificazioni secolari Possibile incremento Possibile incremento Non conosciuto 9
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale Argomenti Descrizione generale Decorso Distribuzione Cause Aree danneggiate Trattamento Cause Punti generali Le cause non sono conosciute Molte sfide metodologiche • I DA non sono comuni • I DA sono difficili da individuare • I campioni clinici non sono rappresentativi • I DA sono difficili da diagnosticare, sono usate delle definizioni inconsistenti • Non vi sono dei fenotipi ovvi da studiare – Per es. AN o AN persistente • Problema della comorbilità – Molto ignorata, anche se appare esista una relazione tra DA e depressione 10
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale Cause Punti generali (cont.) Familiarità indubbia • Rischio aumentato di 10 volte nei familiari di primo grado • Trasmissione crociata tra i DA tradizionali Gli studi sui gemelli suggeriscono un importante contributo genetico • I fattori genetici sembrano contribuire al 40-60% della predisposizione Cause Punti generali (cont.) Studi di associazione genome-wide (GWAS) • Risultati negativi nel primo studio (1000 partecipanti) • Studio con 3495 AN e 10982 controlli (Duncan et al, 2017) – Identificato un locus genome-wide significativo per l’anoressia nervosa sul cromosoma 12 • (index variant rs4622308, p=4.3x10-9) nella regione (chr12:56,372,585-56,482,185) che include 6 geni. – Correlazioni positive con schizofrenia, neuroticismo, livello di istruzione e HDL colesterolo – Correlazioni negative con alcuni fenotipi (BMI, insulina, glucosio e lipidi) • Un nuovo studio è in corso (obiettivo N = 25000) 11
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale Cause Punti generali (cont.) Le modificazioni secolari suggeriscono il contributo di processi sociali Alcuni fattori di rischio potenziali sono stati individuati AN BN BED Psych Esperienze avverse nell’infanzia ++ +++ ++ ++ Depressione nei genitori + ++ + + Abuso di sostanze nei genitori - ++ - - Fattori di vulnerabilità alla dieta + +++ + - - Obesità nell’infanzia - +++ + - - Obesità nei genitori - +++ - - Menarca precoce - ++ - - Perfezionismo +++ ++ - - Bassa autostima +++ +++ + ++ Argomenti Classificazione DSM-5 Distribuzione Decorso Cause Aree danneggiate Trattamento 12
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale Aree danneggiate Relazioni interpersonali • Trascurare le amicizie per perseguire il controllo del peso • Isolamento sociale e attività solitarie che richiedono consumo di energia • Riduzione degli interessi • Difficoltà nella relazione di coppia Profitto scolastico/lavorativo • Organizzazione della giornata secondo rituali precisi e stereotipati • Difficoltà di concentrazione, di attenzione e comprensione • Interruzione del lavoro/scuola • Eccessivo impegno scolastico Aree danneggiate Funzionamento psicologico • Ansia • Apatia • Senso di colpa • Prolungati episodi di irritabilità • Scoppi di rabbia • Depressione, demoralizzazione • Sbalzi d’umore • Bassa autostima e pensieri suicidari • Presenza di atti impulsivi abuso di alcool o di droghe, autolesionismo 13
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale Aree danneggiate Aree danneggiate (cont) Salute fisica Complicanze mediche Conseguenti a • Elettrolitiche • dieta ipocalorica • Cardiache • perdita di peso • Endocrine • vomito auto-indotto • Orali • uso improprio di lassativi, diuretici • Gastrointestinali • attività fisica eccessiva • Renali Il recupero del peso e la sospensione dei • Polmonari comportamenti non salutari di controllo • Neurologiche del peso risolve la gran parte delle • Ossee complicanze mediche • Cutanee • Ematologiche e immunologiche • Funzione mestruale e riproduttiva Argomenti Classificazione DSM-5 Distribuzione Decorso Cause Aree danneggiate Trattamento 14
Copyright dr. Riccardo Dalle Grave (2017). Solo per uso personale Terapie farmacologiche Anoressia nervosa Nessun trattamento farmacologico Bulimia nervosa Antidepressivi – effetto a breve termine sulla frequenza delle abbuffate Altri disturbi dell’alimentazione Nessuno studio Binge-eating disorder Lisdexamfetamina – effetto a breve termine sulla frequenza delle abbuffate Trattamenti psicologici evidence-based (NICE guideline May 2017 – NG69) Bulimia Binge Eating Anoressia OSFED Nervosa Disorder Nervosa Adulti GSH GSH CBT-E o “Mantra” Trattamento del Se inefficace Se inefficace o SSCM DA che più gli CBT-ED CBT-ED Se inefficace FPT assomiglia Adolescenti FT-BN GSH FT-AN Trattamento del Se inefficace Se inefficace Se inefficace DA che più gli CBT-ED CBT-ED CBT-ED o ANFT assomiglia AFP-AN = Adolescent- Focused Psychotherapy for Anorexia Nervosa; CBT-ED = Cognitive Behaviour Therapy for Eating Disorders; GSH = Guided Self-Help; FPT= Focal psychodynamic therapy: MANTRA = Maudsley Anorexia Nervosa Treatment for Adults; OSFED = other specied feeding and eating disorders; SSCN = Specialist Supportive Clinical Management N.B. La CBT-ED per gli adolescenti è stata sviluppata e valutata a Villa Garda in tre studi di coorte 15
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