CTSA Program Webinar 2:00 PM - 3:00 PM ET - Wednesday, October 23, 2019
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CTSA Program Webinar
Wednesday, October 23, 2019
2:00 PM – 3:00 PM ET
Agenda
Time Topic Presenter
Welcome
2:00 PM Michael Kurilla, MD, PhD
NCATS and CTSA Program Updates
NIH Tribal Health Research Office David R Wilson, PhD
Kathryn Meurs, DVM, PhD
COHA (Clinical & Translational Science Award One
Lauren Trepanier, DVM, PhD
Health Alliance)
Tracy Webb, DVM, PhD
3:00 PM Adjourn
2
NCATS and CTSA Program Updates
Michael Kurilla
NCATS CTSA Program Input
Soliciting input on program objectives as well as Request For
Application (RFA) issues, from a variety of sources:
• Peer Reviewers
• Public & Consortium members
o Request for Information (RFI)
o Town Hall Q&A January 2020 (tentative)
• NCATS
4
NCATS CTSA Program RFI
• RFI: https://grants.nih.gov/grants/guide/notice-files/NOT-TR-19-
027.html
• Comments: https://grants.nih.gov/grants/rfi/rfi.cfm?ID=90
• Close Date: Oct 25, 2019
5
Transition to Enterprise Committees
• Transition Underway
• Working Group Applications: https://clic-ctsa.org/groups/working-
groups-proposal-information
6
Discussion Forum: Login Testing
Facilitation of the Discussion Forums is a joint effort of CLIC and NCATS.
Discussion Forums will require authentication through a secure login on a G Suite
Federated Enterprise platform hosted by NCATS.
An email will be sent in early November to the CTSA Program Administrators with a link
and instructions to test their institutions’ login.
Any new technology has technical challenges. Please help us with this testing so that we
can anticipate and fix IT issues in advance of the launch of the forums.
Anticipated launch date of the Discussion Forums is January 2, 2020.
7
Reminder: Serving on CTSA Program Review Panels
Q: Would NCATS allow PI’s or other CTSA personnel who are not conflicted to
serve on CTSA’s grant review study group? (Pod submission; NCATS’ responses
in the May 2019 SC Meeting and May 2019 CTSA Program Webinar)
A: NCATS analyses show:
o KL2 PIs, TL1 PIs, and other CTSA Key Personnel comprise greater than 65% of the CTSA
review panels
o Normal recruitment rates for reviewers (accepted/invited) hover around 20% due to
limitations of availability
• Shared with Steering Committee that NCATS welcomes willing reviewers;
names of individuals interested in serving in peer review may be conveyed to
program staff
8
How to Submit Reviewer Suggestions
Send the following information to your Program Official:
• Name, institution, expertise; and
• Person profile ID or eRA Commons ID or email
Additional Information:
• Suggestions will be placed in the eRA system for Review staff
• Selection not guaranteed that they will be selected to serve by NCATS Scientific Review Officer due to
conflicts and the suggested reviewer’s availability
• Key Personnel (as listed in an application or that are identified by the NCATS Scientific Review Officer as
having an NIH-defined “major professional role”) cannot serve on the panel that reviews any application
in which they are named
• UL1, KL2 and TL1 PIs can serve as reviewers, however, this is extremely challenging based on their
conflicts and availability (see previous slide stats)
• More information about NIH Conflict of Interest: https://grants.nih.gov/grants/peer/peer_coi.htm
Program Webinars
• November & December
• Cancelled due to holidays
• Call for 2020 Topics of Interest
• Submit to the CLIC Suggestion Box
10Reminders • Diversity/Re-entry Supplement Applications • Due Nov. 1 • Nominations for new Steering Committee members • Due Nov. 1 • Conference Grant (R13) Letter-to-request permission to submit • Due Nov. 1 for planned Dec. 12 receipt date • CCIA Applications • Due Nov. 8 11
Announcements & Opportunities
• NIGMS RFI: Strategies to Support Acquisition and Use of Biospecimens
for Research on Sepsis in Humans. Responses due Nov 15
• NIGMS is seeking input on strategies for acquiring and providing access to
biological materials from humans for use in mechanistic studies of sepsis
through this This RFI and a Notice of Information: NIGMS Sepsis Research
Priorities are part of the NIGMS response to recommendations from an
Advisory Council Working Group on sepsis.
• NINR RFA: Strategies to Improve Health Outcomes and to Reduce
Disparities in Rural Populations (R01 Clinical Trial Optional). Due Dec 13
12Un-Meeting
Save the Date
Lifespan and Life Course
Research: Integrating
Strategies
Monday, March 2, 2020
with a reception on Sunday, March 1, 2020
Northwestern University
Chicago, IL
Registration and travel award nomination information will be distributed in November
2019.
This work was funded in part by the University of Rochester Center for Leading Innovation and
Collaboration (CLIC), under Grant U24TR002260. CLIC is the coordinating center for the Clinical
and Translational Science Awards (CTSA) Program, funded by the National Center for Advancing
Translational Sciences (NCATS) at the National Institutes of Health (NIH). This work is solely the
responsibility of the authors and does not necessarily represent the official views of the NIH.NIH Tribal Health Research
Office
Introduction and Update
Clinical and Translational Science Awards
Program
October 23, 2019
David R. Wilson, Ph.D.
Director of the Tribal Health Research Office
Tribal Health Research OfficeAmerican Indian Reservations
Tribal Health Research OfficeFederal Trust Responsibility
• Since the formation of the Union, the United States (U.S.)
has recognized Indian Tribes as sovereign nations.
• Resulted in the transfer of land under treaties
• Federal programs and services that benefit American Indians
and Alaska Natives based upon concept of government-to-
government relationship
• American Indians are provided healthcare as outlined in
treaties
Tribal Health Research Office573* federally recognized tribes in the US with
total citizenship of about 4.5 million people.
Each Tribe is unique and has different:
• Histories
• Cultural traditions
• Languages
• Government structures
• Institutions and systems
• Only ethnic minority in the US to
have “Dual-Citizenship”
*Federal Register/ Vol. 83, No. 141, July 23,
2018Tribal Health Research Office
Tribal Health Research Office
Established in 2015, the Tribal Health Research Office is located in the Division of Program Coordination, Planning, and Strategic Initiatives in the Office of the Director (OD), NIH. The office was created in recognition of the importance of ensuring meaningful input from and collaboration with tribal Nations on NIH programs and policies. To also ensure the effective implementation of the HHS Tribal Consultation Policy
NIH Tribal Advisory Committee
Tribal Health Research OfficeTribal Health Research Coordinating Council THRCC THRCC serves as a catalyst for developing research, research training, and career development initiatives focused on American Indians and Alaska Natives (AI/AN). It provides a forum for discussing the diverse health issues and challenges facing AI/AN communities, and how NIH research can help address those needs.
Research Discussions
with Tribal Leaders
Tribal Health Research OfficeCommunity Engagement
Tribal Health Research OfficeMilestones
Strategic Goal 1:
Enhancing Communication and
Collaboration
Strategic Goal 2:
Building Research Capacity for Tribes,
Tribal Organizations,
and Tribal Colleges and Universities
Strategic Goal 3:
Expanding Research
Strategic Goal 4:
Enhancing Cultural Competency and
Community Engagement
Tribal Health Research OfficeNIH/IHS/SAMHSA Tribal Consultation / Listening
Session on the Opioid Crisis in Indian Country
Tribal Health Research OfficeTribal Consultations on Intellectual Property and Data Sharing and Management
Better Access to NIH Data
NATURE NEWS
07 MAY 2019
Navajo Nation and US health agency reach data-sharing agreement
Researchers funded by the National Institutes of Health will have access to health information from tribe members.
Sara Reardon
At Navajo
Nation
Head Start
Center
in Leupp, AZSummer Internship Students & Activities
Visit to Pacific
Northwest University
Roots to Wings
Program July 8, 2019Scientific Community
Engagement
• Substance use and mental health
challenges have been identified as major
public health concerns linked to decreased
quality of life and life expectancy across
America.
• These challenges disproportionately affect
some Indigenous communities, yet existing
data reveal high rates of abstinence and
recovery among Indigenous people.
• Using data from NIH funded studies, this
lecture will describe trajectories of early life
course substance use, mental health
challenges, and enduring mental health
among Indigenous people in North America.David R. Wilson, Ph.D. Juliana Blome, Ph.D. Edmund (Ted) Keane, MSPH Tori Mends-Cole, MA Maria Jamela R. Revilleza, Ph.D. Shawn M. Thomas, MPH
THRO Director Assistant Director Health Science Policy Analyst Health Science Policy Analyst Health Science Policy Analyst
Health Science Policy AnalystNext Steps • Meeting the Strategic Plan • 2018 Research Portfolio • NCATS: Can CTSAs play a role in expanding regional training hubs for AI/AN students • Getting a better understanding of what activities CTSAs are currently pursuing with Tribal nations
Clinical and Translational Science Award One Health Alliance
Agenda • Introduction to COHA (Kate Meurs) • Description of COHA Structure (Kate Meurs) • Clinician Scientist Training Subcommittee (Lauren Trepanier) • Communication & Collaboration Subcommittee (Tracy Webb) • Opportunities for Collaboration • Q &A
An Introduction to COHA 15 Veterinary Colleges that have partnered with Medical Colleges on a CTSA https://ctsaonehealthalliance.org/
Purdue
University of University of University Ohio State
Minnesota Wisconsin
University Tufts University
University of
California, Davis
Cornell
University
University of
Pennsylvania
North Carolina
Colorado State State University
University
University of
Kansas State Auburn University of
Missouri
University University Florida
University of
GeorgiaCOHA Mission
• Advance our understanding of diseases shared by
humans and animals
• Leverage the expertise of physicians, research
scientists, veterinarians, and other professionals to
find solutions for medical problems and to address
the well-being of humans, animals, and the
environmentCOHA Activities •Annual Pilot Grant Funding • Shared Resources Biorepository Clinical trial tools • Attendance at ACTS meeting
COHA Structure • Executive and Steering Committee • Subcommittees Clinical Studies Biorepository Clinician Scientist Training Communication and Collaboration
(Veterinary) Clinical Studies
• Provide Good Clinical Practice Training
• Adopt a Common Data Model for health records
• Engage with the OHDSI OMOP community and
expert human data partners to follow best practices
in conforming clinical data to the CDMBiorepository
Clinician Scientist Training • COHA CTSA Innovation Award • U01TR002953-01 • “Translational Workforce Training - Leveraging the Veterinary Specialist”
Clinician Scientist Training
• COHA CTSA Innovation Award
• U01TR002953-01
• “Translational Workforce Training - Leveraging
the Veterinary Specialist”
• Premise: Specialty trained veterinary clinicians
can enhance translational research teamsU01 Initiative 1
• Translational research fellowships for residency
trained veterinarians
Two-year non-degree research training
Interdisciplinary research teams at centers of
excellence across COHA institutionsU01 Initiative 1
• Translational research fellowships for residency-
trained veterinarians
https://beta.ctsaonehealthalliance.org/coha-
translational-research-fellowship-opportunity-
residency-trained-veterinariansTranslational research fellowships • Metrics of success: Peer reviewed publications of collaborative research that advances human health Transition to an academic faculty position with 50% or more effort to translational research (LRP- CR eligibility) Successful competition for a K-award
U01 Initiative 2 • Translational Research Immersion Program (TRIP) 3 day research “boot camp” for veterinary faculty in clinical and translational research Goal is to prepare veterinary faculty to conduct quality research and to forge collaborations with translational research groups
U01 Initiative 2 • Pilot TRIP held in Madison, WI in Sept 2019 Creating protected time, writing career development awards, grantsmanship, networking, lab management, mentoring… https://www.vetmed.wisc.edu/data/coha-trip/ Follow-up grant coaching
TRIP feedback 2019
• The diversity of the speakers was outstanding.
• I can definitely take away many tangible items that will help in my day-to-day work and
overall career planning
• The content was well-thought out, very applicable, and directly useful to me as a mid-
career faculty. I wish I had this when I started my position
• This course was very helpful and informative. It synthesized several other similar faculty
development/grantsmanship courses I have taken over the last year into a compact and
informative format
• The in-person networking with other veterinary faculty was amazing! It was great
learning how similar some of our issues/challenges are.TRIP follow-up • Programs scheduled for 2020, 2022, and 2024 • Success metrics: Grantsmanship Confidence Self-Assessment tool Number of attendees with federal or foundation grants within 2 years of TRIP Number of attendees on K- or R-series awards within 5 years of TRIP attendance
U01 initiative #3 • Translational Summits to bring DVMs, MDs, and PhDs together around a shared disease of interest About two thirds of veterinary schools lack allied health professional schools on the same campus Difficult for many veterinary faculty to network and contribute to translational research teams
Translational Summits
• DVM and MD co-hosts
• Educate physicians about spontaneous diseases in
veterinary patients
• Educate veterinarians about state of the art research
• Brainstorm about collaborative research
approaches
• Affiliated with national human health meetingsPilot Translational Summits • Calcium oxalate urolithiasis Madison WI, 2017 “This is an eye opener” • Inherited cardiomyopathies Orlando FL, 2018 “This is a genius idea”
Planned Translational Summits • Atopic skin disease • Retinal diseases • glomerular diseases • Multi-drug resistant infections • Chronic pain
Communication & Collaboration • Goal: develop priorities and an implementation plan to increase awareness of the capabilities of COHA and other veterinary schools to support collaborative translational research.
Communication & Collaboration • Members representing 8 COHA schools: Colorado State University Kansas State University North Carolina State University Purdue University Tufts University University of Minnesota University of Missouri University of Pennsylvania
Communication & Collaboration • 2017 & 2018 Pilot Grants • Enhancing Awareness of One Health: An Inter-Professional Student Collaboration Veterinary students attended AMSA conferences o Competitive selection
Communication & Collaboration • Enhancing Awareness of One Health: An Inter-Professional Student Collaboration Faculty presented lectures at AMSA Developed collaborations between professional students Developed teaching opportunities
Communication & Collaboration 2018 AMSA Exhibit Booth Therapy dogs
Communication & Collaboration 2019 AMSA Exhibit Booth Therapy dogs CPR demonstration
Communication & Collaboration • Outcomes Post-conference surveys
Communication & Collaboration • Outcomes Very aware Somewhat aware Not aware
Communication & Collaboration • Outcomes Very interested Somewhat interested Not interested
Communication & Collaboration • Outcomes SAVMA and AMSA leaders’ meeting and collaboration Planned AMSA webinars @One Health and veterinary medicine topics
Communication & Collaboration • 2019 Pilot Grant • Effective Branding of the One Health Campaign Develop One Health “story” with Story Lab Develop campaign to launch One Health “story” Develop target audience and pre- and post-surveys to measure success
Communication & Collaboration • COHA website development Success stories “One Health in a Minute” videos Slide decks Posters
Communication & Collaboration
Communication & Collaboration
Communication & Collaboration • “One Health in a Minute” videos Chronic Pain in Companion Animals Hypertrophic Cardiomyopathy: Collaborating for a Cure Knight’s Landing One Health Clinic
Opportunities for Collaboration • Meeting at ACTS in April 2020?
COHA Contact Information • https://ctsaonehealthalliance.org/ • Kate Meurs kmmeurs@ncsu.edu • Lauren Trepanier lauren.trepanier@wisc.edu • Tracy Webb tracy.webb@colostate.edu
CLIC/NCATS Communication Channels
Sharing Content: CLIC Website Twitter
News (Consortium News & WOW! Factor stories): NCATS: twitter.com/ncats_nih_gov
clic-ctsa.org/news CLIC: twitter.com/CLIC_CTSA
Events: clic-ctsa.org/events Hashtag: #CTSAProgram
Educational tools (Education Clearinghouse): clic-
ctsa.org/education
Funding opportunities (RFAs):
https://clic-ctsa.org/collaboration/clic-synergy- CLIC Contact Us
papers
Have a question and not sure where to direct it?:
https://clic-ctsa.org/collaboration/clic-un-
meetings clic-ctsa.org/contact
Career & training opportunities (Opportunities
Board): https://clic-ctsa.org/opportunities-board
Newsletters
CTSA Ansible: Subscribe Here
CLIC News Roundup: Subscribe Here
NCATS e-Newsletter: ncats.nih.gov/enewsCTSA Program Initiative Channels
ACT Network Recruitment Innovation Center (RIC)
Website: http://www.actnetwork.us/National Website:
Subscribe to newsletter: https://trialinnovationnetwork.org/recruitment-
https://bit.ly/2HQGsM5 innovation-center
Subscribe to newsletter:
https://bit.ly/2OpEDHc
IREx
Website: https://www.irbexchange.org SMART IRB
Subscribe to newsletter: https://bit.ly/2TtQG7b Website: https://smartirb.org
Subscribe to newsletter: https://bit.ly/2JFbiK3
National Center for Data to Health
(CD2H) Trial Innovation Network (TIN)
Website: http://www.actnetwork.us/National Website: https://trialinnovationnetwork.org
Subscribe to newsletter: Subscribe to newsletter:
https://bit.ly/2HQGsM5 https://bit.ly/2TXHQDZQuestions?
Reminders • November and December’s CTSA Program Webinars are CANCELLED. • The next scheduled webinar will be Wednesday, January 22nd, 2:00 PM – 3:00 PM Eastern Time. A new registration link will be issued late November or early December to include the new registration link for the 2020 Zoom webinars. • ctsa_program_webinar@clic-ctsa.org • https://clic-ctsa.org/groups/ctsa-program-group
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