Corona Virus: Overview and Dealing with it - Dr. Amine Marref March 17, 2020

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Corona Virus: Overview and
      Dealing with it

       Dr. Amine Marref
       amine@marref.org

        March 17, 2020
Roadmap

 1   Naming            6   Symptoms
 2   Origin of Virus   7   Contracting the
 3   Health Risk           Disease
 4   Transmission      8   Fatalities
                       9   Concluding
 5   Prevention
                           Remarks
Naming

  Scientific name for disease: CoronaVirus Disease
  (CoViD-19)1
  Scientific name for virus responsible for disease: Severe
  Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2)2
  The word Corona is the Latin of the English word Crown.
  The corona disease is caused by a crown virus which is called
  so because apparently the first person to discover this group
  of viruses thought they look like little crowns.

   1
       World Health Organization (WHO): www.who.int
   2
       World Health Organization (WHO): www.who.int
Naming

  An electron-microscope picture of SARS-CoV-23

   3
       Rocky Mountain Laboratories (RML): www.niaid.nih.gov
Origin of Virus
There are quite a few hypotheses that explain the origin of the
disease.
      The virus was created in labs to be used as a biological
      weapon.
           The virus was created in US labs and was launched in
           China.
           The virus was created in Chinese labs and was launched
           by mistake in China.
           There are at least two books published in the past and
           that discuss strikingly similar events.
             End of Days by Sylvia Browne, 2008 which identifies 2020 as
           the year where a virus outbreak occurs that causes a severe
           pneumonia-like disease worldwide.
             The Eyes of Darkness by Dean Koontz, 1981 which discusses a
           virus called Wuhan-400 (at least in later prints) that also takes
           the world by surprise and no prizes for noticing it: it originates in
           Wuhan, China!
Origin of Virus

   The virus is caused by bats when bitten by them, eating
   them, or eating something bitten by them.
        Bats are the source of previous viruses such as EboV,
        SARS-CoV, and MERS-CoV4 .
        It has been reported that people in Wuhan – the place
        where the virus was first discovered – consume exotic
        animals such as bats.

    4
        www.who.int
Health Risk

   According to Johns Hopkins University5 , the number of
   fatalities caused by the Covid-19 according to the latest
   update while writing these lines (2020-03-17-14:00) is 3.96%
   which corresponds to 7,330 deaths out of 185,067 case
   worldwide.
   According to the same source6 , the number of fatalities from
   seasonal flu is from 291,000 to 646,000 out of a billion case
   worldwide annually which corresponds to a fatality rate of
   0.06%.

    5
        Johns Hopkins University: coronavirus.jhu.edu/map.html
    6
        Johns Hopkins University: coronavirus.jhu.edu/map.html
Health Risk

   According to the World Health Organization7 , since
   MERS-CoV was discovered it infected 2494 persons of which
   it killed 858 i.e. with fatality rate of 34.4%.
   According to National Health Service8 , since SARS-CoV was
   discovered, it infected 8098 persons of which 774 died i.e.
   with fatality rate of 9.5%.

    7
        World Health Organization: who.int
    8
        National Health Service: nhs.uk
Health Risk

    The following table summarizes the previous statistics.
    Notice that there is an inversly-proportional relationship
    between the spreading force of the virus quantified by the
    number of cases worldwide, and the deadliness of the virus
    quantified by the number of fatalities it causes.
    So far, it seems that the virus has a large spreading force
    with relatively small deadliness.
  Virus Name      Outbreak       Cases          Fatalities     Ratio
   SARS-CoV        2003          8,098             774          9.5%
   MERS-CoV        2012          2,494             858         34.4%
  SARS-CoV-2       2019         185,067           7,330        3.96%
 InfluenzaVirus      -       1,000,000,000   291,000-646,000   0.06%
Health Risk

   The virus is reported to infect pretty much anybody, but it is
   most deadly for certain classes of people.
        Old people.
        People with chronic diseases such as cardiovascular
        disease, diabetes, chronic respiratory disease,
        hypertension, and cancer. 9

    9
        Centers for Disease Control and Prevention (CDC): cdc.gov
Health Risk

   When the virus penetrates the host’s body cells, it starts
   making copies of itself and spread until it sometimes reaches
   the alveoli in the lungs and causes an inflammation that
   makes it hard for them to do their job of exchanging oxygen
   and carbon dioxide which eventually causes breathing
   difficulties. 10 11
   The virus can spread to the digestive system and other
   organs such as the heart, liver, and kidneys which could
   result in a very strong immune-system response that causes
   inflammations which make things a lot worse.

    10
       Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19)
  pneumonia in two patients with lung cancer, February 2020
    11
      Chest CT Findings in Coronavirus Disease-19 (COVID-19): Relationship to
  Duration of Infection, February 2020
Transmission

   The corona virus is contagious, and transmission between
   humans occurs primarily through coughing and sneezing.
        It is possible for the droplets that come out from the
        mouth or nose while coughing or sneezing to travel as
        far as 10 meters.
        The droplets contain the virus in different quantities: a
        person that is showing symptoms will produce droplets
        that contain more quantities of the virus compared to a
        person who is asymptomatic.
Transmission

   The virus is transmitted secondarily via skin contact e.g.
   handshaking or touching a surface to which the virus has
   attached itself.
         The virus attaches itself to surfaces using hydrogen and
         hydrophilic bonds.
         A recent study12 shows that SARS-CoV-2 can stick for
         days to plastic and stainless steel surfaces, and for
         hours to copper and cardboard surfaces.

    12
     Aerosol and surface stability of HCoV-19 (SARS-CoV-2) compared to
  SARS-CoV-1, March 2020
Transmission

   A recent study13 discovered the virus in the human feces of
   infected people, but did not conclude whether or not the
   virus is viable – in that state – to infect people.
   There are ongoing studies 14 on whether or not recovered
   cases can become re-infected and spread the virus

    13
         Study: COVID-19 may spread in several different ways: cidrap.umn.edu
    14
         Positive RT-PCR Test Results in Patients Recovered From COVID-19, February
  2020
Prevention

World health organizations and institutions recommend the
following precautionary methods to avoid contracting the disease.
      Staying at home if possible, and limiting outside activity as
      much as possible except for the absolute necessities.
      Washing hands thoroughly with soap by rubbing it forcefully
      on the palms, the back of the hands, between fingers, and in
      the crevices of the nails. This should become a second
      nature: do it when you are home, before eating, after using
      the bathroom, after sneezing, when handling cash, etc.
      Avoid touching the face, nose, mouth, and eyes (probably
      the hardest!).
      Walking away from any person that coughs or sneezes.
Prevention

   Adopt a minimalist-greeting style: greeting people verbally
   (use telepathy if you can), and avoid handshakes, kissing,
   hugging, etc.
   Make sure to cover the toilet seat before flushing to avoid
   the volatile droplets (at least until it is confirmed whether or
   not the virus is transmitted this way).
   Avoid using public loos.
Humane Prevention

It is easy for people to lose their humanity in case of pandemics
and disasters.
       Walking away from a person who sneezes or coughs should
       be done tactfully e.g. pretending that you want to make a
       phone call.
             Do not walk away from people while looking at them
             with fright or contempt. They might have contracted
             the virus, you might too!
       Avoiding handshake should be done with a warm smile.
Humane Prevention

  Panic-buying will cause food to become scarce and therefore
  prices will go up.
        If the pandemic in your area does not recede within a
        couple of weeks or a month, you will run out of the
        food you hastily stockpiled. However this time, you
        might not find food to buy because the prices just went
        crazy.
        There are people who only earn enough to buy food for
        one day, do not add to their miseries.
Symptoms

  The corona disease shares many symptoms with seasonal flu:
  fever, dry cough, fatigue, and sputum production.
  The corona disease differs from the flu in that it causes
  shortness of breath in one out of five cases who have
  contracted the disease 15 (see next figure).

  15
       World Health Organization (WHO): who.int
Symptoms

                            Covid-19 Symptoms with Probability of Occurrence
                                        based on Previous Cases
                   Fever                                                           87.90%
              Dry Cough                                                   67.70%
                 Fatigue                                    38.10%
    Sputum Production                                   33.40%
    Shortness of Breath                        18.60%
 Musle Pain or Joint Pain                14.80%
            Sore Throat                 13.90%
              Headache                  13.60%
                   Chills             11.40%
    Nausea or Vomiting        5%
       Nasal Congestion       4.80%
                Diarrhea     3.70%
Symptoms

  The following table 16 compares the symptoms of Covid-19,
  seasonal flu, and common cold.
  As can be seen, it is difficult without proper medical testing
  to identify Covid-19 because of the similarity in symptoms
  between the three diseases.
  Fortunately, Covid-19 is distinguishable because it causes
  shortness of breath (blue cell).
  Unfortunately, shortness of breath shows that the disease can
  become dangerous for the infected person.

  16
       Deutsche Welle (DW): dw.com
Symptoms

       Symptoms        Covid-19 Influenza Common Cold
       Dry Cough        +++       +++             +
          Fever         +++       +++              -
    Nasal Congestion      -        ++           +++
      Sore Throat        ++        ++           +++
   Shortness of Breath   ++         --            --
        Headache         ++       +++              -
          Pain           ++       +++           +++
        Sneezing         --         --          +++
         Fatigue         ++       +++            ++
        Diarrhea          -        ++             --
+++: Frequently, ++: Sometimes, +: Occasionally, -: Rarely, - -:
Not Observable.
Contracting the Disease
If you ever contract the disease, it is best to not panic, and think
logically and scientifically.
      I have devised a flowchart (see next figure) that explains the
      optimal response a person that contract the disease might
      adopt.
      The devised response is not theoretically optimal, as this
      would imply rushing to a health center after you cough just
      once!
      However, the theoretically-optimal response will put a huge
      burden on health centers and their staff, which could lead to
      even more disastrous consequences.
            Instead of focusing on genuine cases and cases with
            high risks, health centers will be wasting their limited
            resources on cases that are otherwise perfectly fine.
Contracting the Disease
                                  You are showing some of the disease symptoms
                                       such as fever, dry cough, and fatigue.
                                            Perhaps you have the virus.

                             You belong to                                  You Belong to
                               Group A                                        Group B

            You are not in                     You are in                  There is a chance
            contact with a                   contact with a               you have the virus.
             person from                      person from                 Contact the nearest
               Group B                          Group B                      health center.

                                          Wait until you feel            Group A: People who are not
                                       better, and when you              old and who have no chronic
                                          are with a person              diseases
                                       from Group B, wear a
          Wait until you feel                mask and do                 Group B: People who are old
                better                 everything possible to            or who have chronic diseases
                                        not transmit the virus
                                         to them in case you
                                        have contracted the
                                               disease

                                            You are still
                                          sick and started
             You feel fine
                                         having difficulties
                                              breathing

                                      There is a good chance
          Maintain prevention           you have the virus.
              measures                 Contact the nearest
                                           health center
Contracting the Disease
   The previous response flowchart is based on the following.
          If you are not old and you are not suffering from
          chronic diseases, in case you contract Covid-19 you will
          recover with a 98% chance.
          The disease is most dangerous when the virus reaches
          alveoli in the lungs, and this is easily detectable by
          starting to have shortness of breath.
          Old people and those with chronic diseases should take
          no chance.
   It is possible to add more elements to the diagram, such as
   data about contact with people who might already be sick
   (e.g. they are coming from an infected area). These new
   elements can be integrated to give a more informed response
   when showing disease symptoms.
Fatalities

                                                                                            17
  The following table is taken from ”Our World in Data”
                                 Fatalities by Covid-19 by Age Group
                       0%         2%      4%      6%   8%        10%   12%   14%     16%

          0-9 years         0%
         10-19 years        0.20%
         20-29 years        0.20%
         30-39 years        0.20%
         40-49 years         0.40%
         50-59 years              1.30%
         60-69 years                      3.60%
         70-79 years                                        8%
   above 80 years                                                                  14.60%

    17
         Our World in Data: ourworldindata.org
Fatalities

                                                                           18
  The following table is taken from ”Our World in Data”
                   Fatalities by Covid-19 by Medical Condition

          Cardiovascular Dieases                                     11%
                       Diabetes                              7.30%
   Chronic Respiratory Disease                        6.30%
                   Hypertension                      6.00%

                         Cancer                    5.60%
             No Health Condition    0.90%

    18
         Our World in Data: ourworldindata.org
Concluding Remarks

  At the time of writing these lines, the number of people who
  recovered from Covid-19 is 80,236 out of 185,067 cases i.e.
  with a recovery rate of 43.3%. Whereas the number of
  deaths does not exceed 4% most of which target a
  statistically-known group of people.
  According to this, there is an unwarranted panic from people
  which could itself far exceed Covid-19 in its devastation.
  My advice to you is to focus on preventing yourself from
  contracting the disease without fearing it unless you are from
  a vulnerable group, or if the virus becomes more powerful in
  future.
  Mass panic and hysteria is what is sought by satanic
  organizations to dominate people and their wealth.
Concluding Remarks

  I am not a health professional, I actually have a Ph.D. in
  Computer Science in Real-Time Systems.
  This however does not stop me from reading about the
  development of this pandemic, especially statistical research.
  I have put enough references for the reader for further
  research, and in cases where I show my own opinion, I clearly
  say so.
Concluding Remarks

  Do not fight the disease as an independent
individual, fight it as a member of the society.
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