Journal of Family Practice Oncology

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Journal of Family Practice Oncology
Journal of
                                                 Family Practice Oncology
    Provincial Health Services Authority                                                      Issue Number 40, Spring 2023                      |   www.fpon.ca

    Education                               B.C.’s 10-year cancer action plan
    Update                                  By Dr. Kim Chi, Chief Medical Officer, and
                                            Heather Findlay, Chief Operating Officer,
    By Dr. Sian Shuel,                      BC Cancer
    Medical Education Lead, FPON            B.C.’s 10-year cancer plan was officially
                                            announced in February at a special event                CANCER CARE YOU CAN COUNT ON
    The Family Practice Oncology                                                                    Multi-year policy framework to deliver cancer care in B.C.
    Network (FPON), BC Cancer Primary       with Premier David Eby, Minister of Health,
    Care Program's educational arm,         Adrian Dix, leaders from BC Cancer,
    continues offering accredited, free-    Provincial Health Services Authority and
    of-charge, oncology-based education     representatives from our clinical teams.
    to help meet educational needs and      More than a BC Cancer plan, this is an action
    requirements, provide resources,        plan for the people of British Columbia that
    and support the cancer care system.     includes investments in people, technology
    Here are some recent and upcoming       and innovation across our province. It
    highlights.                             details short-term priorities to better
    Partnering with UBC Continuing          prevent, detect, and treat cancers along with
    Professional Development, FPON’s        actionable steps to deliver improved care for
    first educational offering of the       people now while preparing for the growing
    year was a webcast for primary care     needs of the future.
    entitled 'Precancerous Lesions of the                                                    patients who must travel for care from rural
                                            The announcement included an initial
    Vulva – What you Need to Know.' This                                                     communities.
                                            $440-million investment over three years.
    webcast, which included identifying     This funding will be used to expand cancer-      We’re building capacity across our
    lesions of the vulva that have a risk   care teams and service hours, introduce          organization to deliver on these immediate
    of malignant transformation and         revised pay structures to ensure B.C. is         steps and longer-term change. Thanks to
                      continued on page 2   attractive and competitive for oncologists       additions to BC Cancer’s care funding in
                                            and cancer-care professionals, improve           2021-2022 and 2022-2023 totalling $66M
                                            cancer screening programs, continuing to         we’ve been able to recruit 400 new clinical
                                            expand the Hereditary Cancer Program,            and support roles across our centres. To
                                            and increase Indigenous patient support          date, we’ve filled 85% of these roles, adding
                                            positions. Within this investment is a $170      more than 55 new physicians and 283
    BEST PRACTICE                           million grant to the BC Cancer Foundation        new nurses, allied health professionals and
    CANCER CARE GEMS                        to support cancer research, genomic testing,     support staff.
                                            increase access to clinical trials and support                                      continued on page 2
1    New 10-year cancer action plan for
     B.C.
3 Precancerous lesions of the Vulva
5 Treatment of Liver Malignancies
6 Breast Cancer Screening Update
7 Nutrition and Cancer: What's the
  Evidence?
7 Febrile Neutropenia Update
8 BC’s 10-year Cancer Action Plan
  & Primary Care Connection: HPV
  Vaccination
10 Mental Health Medication Choice
   and the Impact on Cancer
   Treatments
Journal of Family Practice Oncology
Education Update                                 Understanding Prognosis in our Patients.'        opportunity to your area.
       continued from page 1                            Find details on future conferences at fpon.
                                                                                                         Lastly, FPON’s twice-yearly ‘General
       answers to common patient questions, is          ca. Alternatively, sign up here to be notified
                                                                                                         Practitioner in Oncology (GPO) Education
       part of the recurring series of webcasts         of our upcoming educational opportunities.
                                                                                                         Program,' is an educational requirement
       for primary care. So far, 2023 has also          The BC Cancer Primary Care Lung Cancer           involving a 2-week didactic and 6-week
       offered 'Psychosocial Perspective on             learning session will be available starting      clinical rotation for family physicians
       Cancer-Related Fatigue - What is it, and         April 16 as part of a series of interactive      newly hired as GPOs in BC and the
       what can we do about it?', 'Lung Cancer          online learning sessions to help primary         Yukon (both within community cancer
       Screening and Suspected Lung Cancer              care providers better support their patients     clinics and at BC Cancer Centres). In the
       in Primary Care' and 'Pancreatic Cancer          with cancer. (See the link in the Learning       spirit of inclusion and to align with the
       .'This webcast series, which runs the            Session Update) Developed in partnership         BCMQI Clinical Practitioner in Oncology
       third Thursday of most months from 8-9           with the UBC Division of Continuing              Privileging Dictionary, after consultation
       am, includes didactic and interactive            Professional Development, this accredited        with stakeholders, the name of the 2-week
       teaching with polling questions and              module will review lung cancer prevention        didactic portion attended by GPOs, BC
       Q and A. Accreditation application is            and screening (including BC Cancer’s Lung        Cancer nurse practitioners and palliative
       underway for the upcoming 2023/2024              Screening Program details), diagnosis,           medicine residents was changed to
       year with planned webcasts, chosen by            treatment and survivorship care. Point-          Clinical Practitioner in Oncology (CPO)
       our representative planning committee            of-care resources will be embedded               Education. Palliative Care Residents
       on 'Things you can do in clinic today to         throughout the module. To access the             continue to have hands-on clinical
       prevent ovarian cancer,' 'Management             new lung cancer learning session once            teaching specific to their education. The
       of Treatment-Related Side Effects of             available, go to the Continuing Medical          6-week clinical rotation specifically for
       Androgen Deprivation Therapy,' 'Female           Education tab at fpon.ca. The newly              GPs in Oncology remains unchanged, as
       Sexual Health & Cancer Survivorship’ and         updated Breast Cancer and the Prostate           does the 6-week BC Cancer NP clinical
       more. Recordings of previous webcasts            Cancer and Colorectal Cancer sessions are        rotation requirement. As a result of
       and registration links for upcoming              also found there.                                ongoing evaluation and improvement
       webcasts can be found at fpon.ca                                                                  implementation, the 2023 spring intake of
                                                        On a related note, small group learning
       We kicked off this year’s Cancer Awareness                                                        the 2-week didactic CPO Education saw
                                                        sessions based on the online Breast
       Month with our April 1 'Practical Cancer                                                          the addition of talks focused on Hodgkin
                                                        Cancer learning module have occurred in
       Care for Primary Point of Care Providers.'                                                        Lymphoma and Hepatocellular Cancer.
                                                        the East Kootenays and West Kootenays.
       Topics selected by our primary care              Each session saw family physicians, a local      As we aim to help meet the oncology
       conference working group included                GPO, and a medical oncologist from the           learning needs of primary care
       'Practical Hematology for Primary Care,'         Regional Cancer Centre meet virtually to         practitioners, GPOs and NPs, we
       'This Child May have Cancer: What to             discuss the module, network and review           continuously seek feedback from our
       do and what not to do for a child with a         issues relevant to the region. Feedback          readers and participants. Please email
       suspected malignancy,' 'Managing Late            has been positive, and plans for additional      FPON’s Medical Education Lead at
       Effects of Childhood Cancer,' and 'Lung          networking sessions are well underway.           sian.shuel@bccancer.bc.ca with any
       Cancer – Current Management and                  Please reach out if you want to bring this       suggestions.

    B.C.’s 10-year cancer action plan                  Team-based care puts the patient at the            questions. Now that we have the framework
    continued from page 1                              heart of a dedicated, multidisciplinary health     for the plan and the initial investment,
                                                       care team, improving continuity of care,           our priority at this time is to build out our
    These significant recruitment efforts support
                                                       experience and outcomes. This collaborative        engagement plan with our regional health
    our ongoing work to implement a new
                                                       model of care will also boost the experience       authority partners, First Nations Health
    model of care throughout our centres.
                                                       and satisfaction of staff and physicians by        Authority, primary care and others.
                                                       enabling them to work to the full scope of
                                                                                                          As we move forward with this work, we look
       BC Cancer provides specialized cancer           their practice.
                                                                                                          forward to sharing more information on our
       care services to communities across
                                                       To date, 51 teams are active across our            priorities and next steps. In the meantime,
       British Columbia, the territories of many
                                                       centres. These teams support tumour group          we encourage you to review the full action
       distinct First Nations. We are grateful
       to all the First Nations who have cared         based care and are tailored to each centre’s       plan www.bccancer.bc.ca/cancerplan.
       for and nurtured this land for all time,        staffing capacity and patient needs. Teams
                                                                                                          Contact Dr. Kim Chi at kchi@bccancer.bc.ca
       including the xʷməθkwəy̓ əm (Musqueam),         could include a patient care aide, clerk,
                                                                                                          and Heather Findlay at heather.findlay@
       Sḵwx̱ wú7mesh Úxwumixw (Squamish), and          licensed practical nurse, registered nurse,
                                                                                                          bccancer.bc.ca.
             ̓ ̓ ətaɬ (Tsleil-Waututh) First Nations
       səlil w                                         nurse practitioner, GPO and oncologist.
       on whose unceded and ancestral                                                                     Learn more about B.C.’s 10-year cancer
                                                       B.C.’s 10-year cancer action plan has been
       territory our head office is located.                                                              action plan at www.bccancer.bc.ca/
                                                       met with enthusiasm, support and many
                                                                                                          cancerplan

2   FAMILY PRACTICE ONCOLOGY NETWORK JOURNAL / SPRING 2023
Journal of Family Practice Oncology
Precancerous lesions of the vulva: What you need to know
By Dr. Melanie Altas, Obstetrics & Gynaecology,   papilloma virus (HPV) subtypes, such as         erosion, smooth or with an irregular surface.
University of British Columbia                    HPV 6 and 11. They are not precancerous         A high index of suspicion is necessary,
                                                  and therefore do not require treatment to       particularly those with risk factors (see Table 2).4
Vulvar squamous cell cancer makes up 5%
                                                  prevent progression to malignancy. LSIL
of gynecologic malignancies. High-grade
                                                  should be treated as condyloma.2                When to Biopsy
vulvar intraepithelial neoplasias (VIN) are the
precursor lesions to vulvar                                    High grade lesions are divided     • Chronic ulcers or erosions
cancer. While the incidence                                    into high grade squamous           • Lesion with atypical features (irregular
of cancer remains stable,                                      epithelial lesions (HSIL) and        surface, differing pigmentation,
high grade VIN is increasing,                                  differentiated VIN (dVIN).           asymmetrical)
particularly amongst younger                                   These lesions develop via          • Skin conditions not improving with
women.1 Diagnosing                                             two distinct pathways. HSIL is       treatment (dermatoses such as lichen
premalignant lesions can be                                    HPV dependant and caused             sclerosus, condyloma).
a challenge for physicians                                     by high-risk subtypes, such as     • First episode of “genital warts” over age
as they often present with                                     HPV 16 and 18. On the other          forty.
subtle signs and symptoms                                      hand, the etiology of dVIN is
that can be easily overlooked                                  less well understood but is        Clinical Behavior
or misdiagnosed. Early                                         known to develop independent
                                         Dr. Melanie Altas                                        HSIL has been found to be linked to 20%
identification is important as                                 of HPV infection.2
                                                                                                  of vulvar squamous cell cancers, whereas
treatment of VIN can prevent
                                                   Clinical Presentation                          dVIN is associated with 80%. Therefore,
the progression to cancer.
                                                                                                  most vulvar cancers are not caused by HPV.
                                                  Approximately 40% of high grade lesions are     Patients diagnosed with high grade lesions
Classification & Etiology                         asymptomatic.3 Lesions may be found during      will commonly inquire about the risk of
Precancerous lesions of the vulva were            self-examination or during routine pelvic       malignancy. The cancer risk is contingent on
first reported in 19222 and have since been       examinations. The most common symptom           the type of lesion identified.
described using evolving classification           is vulvar pruritus, although patients may
                                                                                                                         continued on page 4
systems. Currently, the International Society     experience pain, dysuria and dyspareunia.
for the Study of Vulvovaginal Disease (ISSVD)
                                                  Diagnosing HSIL or dVIN during an
employs a system that differentiates lesions
                                                  examination can be challenging owing to
based on etiology and malignant potential
                                                  their varied appearance. Lesions may exhibit
(see Table 1).2
                                                  different colours such as brown, white, red,
Low grade squamous intraepithelial lesions        or flesh coloured (Image 1). Additionally,
(LSIL) are associated with low-risk human         lesions may present as flat, raised or an

   Table 1: Classification of VIN
   Year of Publication 1986 ISSVD                     2004 ISSVD          2015 ISSVD
   Terminology           VIN 1 (mild dysplasia)       Condyloma           LSIL
                         VIN 2 (moderate dysplasia)   Usual type VIN      HSIL
                         VIN 3 (severe dysplasia
                         or carcinoma in situ)
                         Differentiated VIN           Differentiated VIN Differentiated VIN

   Table 2: Risk factors for the development of high-grade vulvar lesions4
   HSIL                                           dVIN
   HPV infection                                  Poorly controlled vulvar dermatoses
                                                  (lichen sclerosus, lichen planus)
   Smoking
   > 2 sexual partners                                                                            Image 1: a) Brown HSIL on perineum b)
   Immunosuppression                                                                              White HSIL in left lower labia majora Photos
                                                                                                  courtesy of BC Centre for Vulvar Health

                                                                                           FAMILY PRACTICE ONCOLOGY NETWORK JOURNAL / SPRING 2023        3
Journal of Family Practice Oncology
Precancerous lesions of the vulva                 in younger women, as well as a high risk              Apr 1;26(2):140-146.
    continued from page 3                             of recurrence laser ablation is appealing          5. McAlpine JN, Kim SY, Akbari A et
                                                      as repeat surgical excision can lead to               al. HPV-independent differentiated
    HSIL has a lower malignant potential.1,3
                                                      unsatisfactory cosmetic and functional                vulvar intraepithelial neoplasia (dVIN)
    • 10% risk of progression to cancer
                                                      results.6                                             is associated with an aggressive
    • 1.2% chance of regression, particularly in
                                                      Topical imiquimod 5% is applied by the                clinical course. Int J of Gynecol Path.
      young women or pregnancy
                                                      patient in a thin layer two to three times per        2017;36:507-516
    • Longer time to progress to cancer (50-72
                                                      week for up to sixteen weeks. For both laser       6. Preti, Mario; Joura, Elmar; Vieira-Baptista,
      months)
                                                      ablation and imiquimod, invasive disease              Pedro; Van Beurden, Marc et al. The
    DVIN is less common but has a higher              must be ruled out. Current research suggests          European Society of Gynaecological
    malignant potential.1,5                           there is no difference in outcomes between            Oncology (ESGO), the International
    • Accounts for less than 10% of high-grade        surgical excision, laser ablation and topical         Society for the Study of Vulvovaginal
      lesions                                         imiquimod.8                                           Disease (ISSVD), the European College for
                                                                                                            the Study of Vulval Disease (ECSVD) and
    • 33% risk of progression to cancer
                                                      Follow-Up                                             the European Federation for Colposcopy
    • Shorter time to progress to cancer (13-23
                                                      Following treatment, close clinical                   (EFC) Consensus Statements on Pre-
      months)
                                                      surveillance is warranted.6 The risk of               invasive Vulvar Lesions. Journal of Lower
                                                      recurrence is high, up to 25% with a quarter          Genital Tract Disease 26(3):p 229-244,
    Treatment
                                                      of those being late recurrences.9 At the BC           July 2022.
    The goals of treatment involve preventing                                                            7. Jamieson A, Tse SS, Proctor L, Sadownik
                                                      Centre for Vulvar Health, we follow patients
    progression to malignancy and symptom                                                                   LA. A Scoping Review of Treatment
                                                      every six months for two years then annually
    relief while preserving vulvar anatomy and                                                              Outcome Measures for Vulvar
                                                      for those who received surgical excision
    function.                                                                                               Intraepithelial Neoplasia. J Low Genit
                                                      or laser ablation. For patients using topical
    Once the diagnosis of a high-grade lesion         imiquimod, closer follow-up is warranted              Tract Dis. 2022 Oct 1;26(4):328-338.
    is made, a referral should be initiated to        both during and shortly after the sixteen-         8. Lawrie T, Nordin A, Chakrabarti M, et
    a gynecologist comfortable discussing             week treatment. Follow-up appointments                al. Medical and surgical interventions
    treatment options. In British Columbia,           include an examination of the entire lower            for the treatment of usual-type vulval
    referrals can be made to the BC Centre for        genital tract, including vulva, perianal area,        intraepithelial neoplasia. Cochrane
    Vulvar Health where patients have access to       vagina and cervix. Risk factors modification          Database Syst Rev.2016 Jan 5;(1)
    gynecologists, gynecologic oncologists as         can also be reviewed, including smoking            9. Satmary W, Holschneider CH, Brunette
    well as psychological support.                    cessation, HPV vaccination or optimizing              LL, Natarajan S. Vulvar intraepithelial
    Given the risk of invasive disease, patients      control of chronic dermatoses.                        neoplasia: Risk factors for recurrence.
    with dVIN should undergo surgical excision                                                              Gynecol Oncol. 2018 Jan;148(1):126-131.
                                                      References
    with wide margins.6
                                                      1. Thuijs, NB, van Beurden, M, Bruggink, AH,
    For patients with HSIL, various treatment
                                                         Steenbergen, RDM, Berkhof, J, Bleeker,
    options are available, including surgical
                                                         MCG. Vulvar intraepithelial neoplasia:
    excision, CO2 laser ablation and topical
                                                         Incidence and long-term risk of vulvar
    therapy.6,7 The choice of treatment option
                                                         squamous cell carcinoma. Int. J. Cancer.
    depends on patient and lesion specific
                                                         2021; 148: 90– 98.
                                                                                                               Educational
    factors as well as provider preference.                                                                    opportunities provided
                                                      2. Bornstein J, Bogliatto F, Haefner H,
    Currently, there is no high-quality evidence
                                                         Stockdale C, Preti M et al. The 2015
                                                                                                               by BC Cancer’s Family
    to guide management decision making.7
                                                         International Society for the Study of                Practice Oncology
    There is also a lack of literature on quality-                                                             Network
                                                         Vulvovaginal Disease (ISSVD) Terminology
    of-life outcomes.
                                                         of Vulvar Squamous Intraepithelial
    CO2 laser ablation is commonly performed             Lesions. Obstet & Gynecol 2016 127(2):p               made possible in part
    in a hospital ambulatory clinic setting              264-268                                               thanks to the support
    using local anesthetic. This is preferred for
                                                      3. van Seters M, van Beurden M, de Craen                 of the BC Cancer
    multifocal disease, larger lesions as well as
    lesions near the clitoris and perianal area.
                                                         AJ. Is the assumed natural history of                 Foundation
                                                         vulvar intraepithelial neoplasia III based on
    Given that there is rising incidence of HSIL
                                                         enough evidence? A systematic review of
                                                         3322 published patients. Gynecol Oncol.
                                                         2005 May;97(2):645-51.
       BC Centre for Vulvar Health
                                                      4. Jamieson A, Tse SS, Brar H, Sadownik LA,
        referral information can be                      Proctor L. A Systematic Review of Risk                                      /BCCancerFoundation
                                                                                                                                             @bccancerfdn
                                                         Factors for Development, Recurrence,
         found at bcvulvarhealth.ca                                                                                                bccancerfoundation.com
                                                         and Progression of Vulvar Intraepithelial
                                                         Neoplasia. J Low Genit Tract Dis. 2022

4   FAMILY PRACTICE ONCOLOGY NETWORK JOURNAL / SPRING 2023
Journal of Family Practice Oncology
Treatment of liver malignancies: An overview of
Yttrium-90 TransArterial RadioEmbolization (TARE)
By Jasper Yoo, Medical Student,                     the mapping procedure confirms that hepatic       Neuroendocrine tumours (NETs)
University of British Columbia                      arterial anatomy is amenable to safe delivery
                                                                                                      Many patients with neuroendocrine tumour
                                                    of Y-90 radioembolics to the liver without
Dr. Pedro Lourenço, Dr. Jun Wang,                                                                     present with multifocal disease and are
                                                    non-target embolization or extrahepatic
Dr. Behrang Homayoon, Interventional                                                                  not surgical candidates.10 Under the GIYTT
                                                    radiation toxicity. This procedure is shorter
Radiologists, Surrey Memorial Hospital                                                                protocol, Y-90 radioembolization is used for
                                                    compared to the mapping procedure
                                                                                                      metastatic NETs with liver-dominant disease
                                                    and involves targeted delivery of Y-90
                                                                                                      and low-volume extrahepatic disease.4 In a
                                                    radioembolic particles into the liver.
                                                                                                      retrospective population-based cohort study
                                                                                                      conducted in British Columbia, TARE was
                                                    Applications of TARE
                                                                                                      well tolerated in metastatic liver-dominant
                                                                                                      NETs, and 86% of patients achieved partial
                                                    Early or intermediate-stage hepato-
                                                                                                      response or stable disease.11 In unresectable
                                                    cellular carcinoma
                                                                                                      metastatic NETs, TARE has a lower incidence
                                                    In the setting of hepatocellular carcinoma        of side effects and a higher disease control
                                                    (HCC), Y-90 radioembolization is performed        rate than TACE.10
      Jasper Yoo      Dr. Behrang Homayoon          mainly in those who are not candidates for
                                                    surgical resection at time of presentation.       Cholangiocarcinoma and
                                                    Treatment goals include downstaging               gallbladder carcinoma
Overview of yttrium-90 transarterial                to resection or transplant, bridging to
radioembolization                                                                                     Under the BC Cancer GIBYTT protocol,
                                                    transplant, or palliation. TARE is an important
                                                                                                      TARE is now indicated for locally advanced
Transarterial radioembolization (TARE)              alternative catheter-based treatment
                                                                                                      cholangiocarcinoma or gallbladder
is a minimally invasive catheter-directed           strategy for patients with contraindications
                                                                                                      carcinoma not amenable for surgical
brachytherapy technique performed by                to transarterial chemoembolization (TACE),
                                                                                                      resection at time of presentation.4 In
interventional radiology to treat primary           particularly those with portal venous
                                                                                                      comparison to chemotherapy only,
or metastatic liver malignancies. TARE              thrombosis.5
                                                                                                      TARE has been shown to prolong
involves the selective intraarterial delivery of    More recently, there are emerging data            survival in cholangiocarcinoma,12 and
microspheres loaded with the radioisotope           supporting the use of Y-90 radiation              TARE has also been used to downstage
yttrium-90 (90Y or Y-90) through the                segmentectomy and radiation lobectomy             previously unresectable intrahepatic
hepatic vasculature, directly targeted at           in well-selected patients with HCC. Y-90          cholangiocarcinoma (ICC) to resectable
tumours. In BC, under the GIYTT protocol,           radiation segmentectomy is a targeted             ICC.13 In addition, radiation segmentectomy
TARE is used to treat early to intermediate-        form of TARE typically delivered to one           and radiation lobectomy techniques have
stage hepatocellular carcinoma (HCC), and           or two hepatic segments. It allows high,          been safely used in unresectable ICC.14
it is also used as cytoreductive therapy for        ablative doses of radiation to be delivered
hepatic metastatic neuroendocrine tumours           to tumours while minimizing damage to             Conclusion
(NETs).1-3 More recently, in February, the          liver parenchyma and has been shown to be
GIBYTT protocol was activated. Under                                                                  TARE is an important modality in the
                                                    equivalent to other curative-intent treatment
this protocol, the eligibility criteria for                                                           management of early to intermediate stage
                                                    strategies in well-selected patients.6-7
Y-90 radioembolization expanded to                                                                    HCC, hepatic metastatic NETs, and locally
                                                    Ablative TARE has been shown to improve
include patients with locally advanced                                                                advanced unresectable ICC and gallbladder
                                                    survival when compared to conventional
cholangiocarcinoma or gallbladder carcinoma                                                           carcinoma. Access to Y-90 radioembolization
                                                    TARE in select patients with HCC and portal
not amenable to surgical resection.4                                                                  is available at various sites across British
                                                    vein thrombosis.8
                                                                                                      Columbia for patients who have undergone
Y-90 radioembolization is typically a two-          Radiation lobectomy involves lobar delivery       evaluation by an interventional radiologist
stage procedure. The first session is a             of Y-90 radioembolic microspheres that            after multidisciplinary discussion at a liver
pre-treatment mapping procedure that                targets HCC localized to one hepatic lobe,        tumour conference.
involves detailed interrogation of hepatic          but also results in ipsilateral hepatic lobar
and mesenteric arterial anatomy with                atrophy and contralateral lobar hypertrophy.      References
angiography. This is followed by injection of       Radiation lobectomy candidates often have         1. BC Cancer. Neuroendocrine Tumors
technetium-99m MAA into the liver for both          well-preserved liver function and smaller            [Internet]. 2022 [cited 2022 May 30].
dosimetric considerations and to assess the         tumour burden, and radiation lobectomy               Available from: www.bccancer.bc.ca/
potential for extrahepatic toxicity prior to Y-90   is often performed as a bridge to surgical           health-professionals/clinical-resources/
radioembolic administration. The second             resection. It can also be performed for              cancer-management-manual/
session is typically performed two weeks after      larger tumours as an alternative to radiation        gastrointestinal/neuroendocrine-tumors
the mapping procedure. It is undertaken if          segmentectomy.9                                                           continued on page 6

                                                                                               FAMILY PRACTICE ONCOLOGY NETWORK JOURNAL / SPRING 2023   5
Journal of Family Practice Oncology
BC Cancer Breast Screening update
    As evidence evolves, BC Cancer Breast             services to facilitate breast cancer               as part of the BC Cancer Breast Screening
    Screening has revised its policy for breast       surveillance for individuals at increased risk,    Program facilitates annual mammography
    cancer risk stratification and is expanding       specifically due to a prior tissue diagnosis of:   for those with a history of ADH/ALH/LCIS.
                                                      • Atypical Ductal Hyperplasia (ADH)                The Screening Program retains the patient
                                                                                                         in the database and sends annual referrals to
                                                      • Atypical Lobular Hyperplasia (ALH)
                                                                                                         diagnostic services to schedule this follow-
                                                      • Classical Lobular Carcinoma In Situ (LCIS)
                                                                                                         up mammogram similar to the screening
                                                      BC Cancer Breast Screening now                     program process for lower risk patients.
                                                      recommends surveillance with annual
                                                                                                         www.bccancer.bc.ca/screening/
                                                      mammography through diagnostic imaging
                                                                                                         Documents/Breast-Higher-Risk.pdf
                                                      given the typically more complicated history
                                                      of biopsy and possibly surgery. The new            For those who prefer a visual depiction of
                                                      service will facilitate and formalize this         the screening referral process, check out
                                                      surveillance through:                              the Breast Screening Algorithm for risk
                                                                                                         categorization and consequent screening
                                                      • Patient and Provider notifications
                                                                                                         regimen within our Program:
                                                      • Direct referrals to diagnostic imaging for
                                                         annual mammography                              www.bccancer.bc.ca/screening/Documents/
                                                                                                         Breast-Screening-Referral-Algorithm.pdf
                                                      For more details check out the BC Cancer
                                                      website Health Care Provider fact sheet for        This service has been endorsed by BC Family
                                                      the Higher Risk Surveillance program. The          Doctors, and the provincial Medical Imaging
                 www.bccancer.bc.ca/screening         incorporation of this surveillance extension       Advisory Committee.

    Treatment of liver malignancies                      [Internet]. 2022. Available from: www.             A systematic review. Eur J Radiol.
    continued from page 5                                bccancer.bc.ca/books/liver/5-treatment-            2018;100(September 2017):23-29.
                                                         modalities-in-hcc                                  doi:10.1016/j.ejrad.2018.01.012
       www.bccancer.bc.ca/health-
                                                      6. Lewandowski RJ, Gabr A, Abouchaleh              11. Tsang ES, Loree JM, Davies JM, et
       professionals/clinical-resources/cancer-
                                                         N, Ali R, Al Asadi A, Mora RA, et al.               al. Efficacy and prognostic factors
       management-manual/gastrointestinal/
                                                         Radiation segmentectomy: Potential                  for Y-90 radioembolization (Y-
       neuroendocrine-tumors
                                                         curative therapy for early hepatocellular           90) in metastatic neuroendocrine
    2. BC Cancer. Treatment Options by Stage             carcinoma. Radiology. 2018;287(3):1050–8.           tumors with liver metastases. Can J
       [Internet]. 2022 [cited 2022 May 30].                                                                 Gastroenterol Hepatol. 2020;2020:8-12.
                                                      7. Kim E, Sher A, Abboud G, et al. Radiation
       Available from: www.bccancer.bc.ca/                                                                   doi:10.1155/2020/5104082
                                                         segmentectomy for curative intent of
       books/liver/6-treatment-options-by-stage
                                                         unresectable very early to early stage          12. Gangi A, Shah J, Hat N, et al. Intrahepatic
    3. BC Cancer. BC Cancer Protocol                     hepatocellular carcinoma (RASER): a                 Cholangiocarcinoma Treated with
       Summary of Yttrium-90 for                         single-centre, single-arm study. Lancet             Transarterial Yttrium-90 Glass
       Transarterial Radioembolisation                   Gastroenterol Hepatol. 2022;7(9):843-               Microsphere Radioembolization: Results
       (TARE) for Hepatocellular Cancer or               850. doi:10.1016/S2468-1253(22)00091-7              of a Single Institution Retrospective
       Neuroendocrine Tumours with Hepatic                                                                   Study. Published online 2018:1101-1108.
                                                      8. Cardarelli-Leite L, Chung J, Klass
       Disease [Internet]. 2023 [cited 2023                                                                  doi:10.1016/j.jvir.2018.04.001.
                                                         D, et al. Ablative Transarterial
       March 21]. Available from: www.bccancer.
                                                         Radioembolization Improves Survival in          13. Edeline J, Touchefeu Y, Guiu B,
       bc.ca/chemotherapy-protocols-site/
                                                         Patients with HCC and Portal Vein Tumor             et al. Radioembolization Plus
       Documents/Gastrointestinal/GIYTT_
                                                         Thrombus. Cardiovasc Intervent Radiol.              Chemotherapy for First-line Treatment
       Protocol.pdf
                                                         2020;43(3):411-422. doi:10.1007/s00270-             of Locally Advanced Intrahepatic
    4. BC Cancer. BC Cancer Protocol                     019-02404-5                                         Cholangiocarcinoma: A Phase 2 Clinical
       Summary of Yttrium-90 for Transarterial                                                               Trial. JAMA Oncol. 2020;6(1):51-59.
                                                      9. Malhotra A, Liu DM, Talenfeld AD.
       Radioembolisation (TARE) for Locally                                                                  doi:10.1001/jamaoncol.2019.3702
                                                         Radiation Segmentectomy and Radiation
       Advanced Cholangiocarcinoma or
                                                         Lobectomy: A Practical Review of                14. Kumar P, Mhaskar R, Kim R, et
       Gallbladder Carcinoma Not Amenable
                                                         Techniques. Tech Vasc Interv Radiol                 al. Unresectable Intrahepatic
       for Surgical Resection [Internet]. 2023
                                                         [Internet]. 2019;22(2):49–57. Available             Cholangiocarcinoma Treated with
       [cited 2023 March 21]. Available from:
                                                         from: https://doi.org/10.1053/j.                    Radiation Segmentectomy/Lobectomy
       www.bccancer.bc.ca/chemotherapy-
                                                         tvir.2019.02.003                                    Using Yttrium 90-labeled Glass
       protocols-site/Documents/
                                                      10. Jia Z, Wang W. Yttrium-90                          Microspheres. J Clin Exp Hepatol.
       Gastrointestinal/GIBYTT_Protocol.pdf
                                                          radioembolization for unresectable                 2022;12(5):1259-1263. doi:10.1016/j.
    5. BC Cancer. Treatment Modalities in HCC                                                                jceh.2022.03.008
                                                          metastatic neuroendocrine liver tumor:

6   FAMILY PRACTICE ONCOLOGY NETWORK JOURNAL / SPRING 2023
Journal of Family Practice Oncology
Nutrition and cancer: what’s the evidence?
                                                                                                www.bccancer.bc.ca/prevent/nutrition-exercise

                                                                About one-third of most cancers can be prevented through a healthy
                                                                diet, being physically active and maintaining a healthy weight.

   Check out the FPON website for the recording
   of the October 20, 2022 Webcast: “Nutrition
   and Cancer: What’s the evidence?” presented by
   Terry Lok, RD of the BC Cancer Nutrition Services
   Department.

   https://media.phsa.ca/home/iframe?url=BCCA/
   bccahealth%5cFPON_Oct_Webcast_20221108

   For more information, check out the following sites
   that were recommended during this webcast:
   World Cancer Research Fund:
   https://www.wcrf.org/diet-activity-and-cancer
   Cancer Risk Matrix:
   https://www.wcrf.org/diet-activity-and-can-
   cer-risk-matrix

Febrile neutropenia assessment and treatment update
The BC Cancer guidance document              and lymphoma has been updated. This                       – updated duration of antimicrobial
for febrile neutropenia assessment and       reference is available on the BC Cancer                     therapy
treatment for adults with solid tumour       website in the Supportive Care section of the             – updated vancomycin trough target
                                             Cancer Management Manual, under Febrile                     levels
                                             Neutropenia.
                                                                                                    • Updated low risk treatment
  Febrile neutropenia assessment
                                             Key updates:                                             recommendations:
  and treatment guidance updated
                                             • Consolidated assessment and treatment                   – consider omitting ciprofloxacin if
  December 2022                                recommendations of febrile neutropenia                    no previous infection history with
  Febrile neutropenia occurs when a          • Updated high risk treatment                               pseudomonas aeruginosa
  patient has a fever and a significant        recommendations:                                        – updated treatment alternatives for beta-
  reduction in their white blood cells           – updated treatment alternatives for beta-              lactam allergy
  (neutropenia) that are needed to fight           lactam allergy                                      – updated treatment alternative for
  infections.                                                                                            low risk patients who do not meet all
                                                 – clarified indications for antimicrobial
                                                   selection                                             outpatient criteria

www.bccancer.bc.ca/health-professionals/clinical-resources/cancer-management-manual/supportive-care/febrile-neutropenia

                                                                                             FAMILY PRACTICE ONCOLOGY NETWORK JOURNAL / SPRING 2023   7
Journal of Family Practice Oncology
BC’s 10-year Cancer Action Plan and some implications
    for Primary Care
    By Dr. Catherine Clelland                         Within the details of these areas of focus         commercial tobacco products and other
    Medical Director, Primary Care, BC Cancer         and targets are several priorities that have       related lifestyle behaviour.
                                                      strong linkage to community primary care.
    Disease prevention, screening, diagnosis and                                                         HPV, or the human papillomavirus, is the
                                                      In particular, the actions indicated under
    management, along with longitudinal follow-                                                          most common sexually transmitted infection
                                                      prevention and early detection that include
    up, are core tenants of primary healthcare.                                                          in the world today and can affect any man
                                                      enhancement of prevention strategies with
    Well-established evidence internationally                                                            or woman who is sexually active. Using
                                                                      emphasis on at risk populations
    of better patient outcomes                                                                           condoms may reduce the chances of getting
                                                                      focused on:
    and more cost-effective care                                                                         HPV, but it is highly contagious, and condoms
    when Primary Care is well                                       a. Implementation of health          do not provide full protection. Infection
    integrated into and involved                                    promotion activities with a          can occur with skin-to-skin or oral contact
    cross the healthcare care                                       specific focus on lung cancer        with the genital area, and without having
    continuum. This has formed                                      moving B.C. towards a lower          intercourse. While cervical cancer is the most
    the basis for the BC Ministry                                   smoking rate, in alignment with      common HPV related cancer, the reality is
    of Health Primary Care Policy                                   the Government of Canada’s           the risk is much broader. Mouth and throat
    papers that underpin the                                        Tobacco Strategy.                    cancer, anal cancer, vaginal and vulvar cancer
    shift to the “team-based”                                       b. Increasing the uptake of          and penile cancer are also on the list. More
    Patient Medical Home and                                        HPV vaccine achieving the            recently, there is some early data indicating
    development of Primary Care                                     National Advisory Committee          HPV related airways cancer, particularly in
                                          Dr. Cathy Clelland
    Networks. The cancer care                                       on Immunization (NACI)               health care providers providing care for HPV
    system is no exception, and                                     target of 90% HPV vaccination        related cancer services such as colposcopy.
    on February 24, 2023, the Minister of Health         coverage (two or more doses) of
                                                                                                         Human papillomavirus vaccines are
    announced the release of “BC’s 10-year               adolescents by 17 years of age, moving to
                                                                                                         immunizations that prevent infection by
    Cancer Action Plan”, outlining the 10-year           the elimination of cervical cancer in B.C.
                                                                                                         certain types of human papillomavirus.
    goals to:
                                                     Smoking cessation has long been part of             Available HPV vaccines protect against either
    1. Reduce the incidence of cancer in BC;         primary care practice and while BC has the          two, four, or nine types of HPV. All HPV
    2. Improve cancer survival, cure rates and       lowest commercial tobacco smoking rates in          vaccines protect against at least HPV types
        quality of life; and                         Canada, more can be done to reduce the risk         16 and 18, which cause the greatest risk of
    3. Ensure a strong system delivering             of cancer, cardiovascular and other smoking         cervical cancer. Details of HPV immunization
        modern, evidence-based province-wide         related conditions. While it is still the leading   recommendations and coverage in BC can
        cancer care                                  cause of lung cancer, nearly 30% of patients        be found on the Immunize BC website
                                                     diagnosed with lung cancer today are non-           https://immunizebc.ca/hpv In BC, children
    To achieve these goals, 3-year targets have
                                                     smokers. The risks of vaping, particularly          up to the age of 18 are eligible for funded
    been set within 4 areas of focus:
                                                     of nicotine containing products are only            vaccination. Those who get the vaccine
    1. Prevent cancer and find cancer earlier;       starting to become known, and more data is          in grade 6 need 2 doses at least 6 months
    2. Ensure timely access to cancer treatments;    needed to see the impact on cancer risk. A          apart, while those who start the HPV vaccine
    3. Optimize care through collaboration and       new approach that includes input from youth         series on or after their 15th birthday need
        partnership; and                             and others in the target population to design       3 doses over 6 months. Immunize BC has
                                                     effective strategies to increase awareness          developed a patient/parent handout to
    4. Revitalize our cancer care system through
                                                     and ultimately reduce risk from the use of          help dispel some of the misinformation
        essential enablers.
                                                                                                         that has been circulating and that can be
                                                                                                         downloaded from their website.
                                                                                                         According to Immunize BC, in addition to
                                                                                                         all children up to the age of 18, the HPV9
                                                                                                         vaccine is also recommended and free for:
                                                                                                         • HIV-positive people up to 26 years of age
                                                                                                         • Transgender people up to 26 years of age
                            FPON Communications &                                                        • Cisgender* males up to 26 years of age who:
                            Journal of Family Practice Oncology                                            – have sex with other men
                            have gone Digital                                                              – are not yet sexually active but are
                              To stay up to date with what’s happening,                                      questioning their sexual orientation
                                          sign up through this QR code!                                    – are street-involved
                                                                                                                              continued on page 11

8   FAMILY PRACTICE ONCOLOGY NETWORK JOURNAL / SPRING 2023
Journal of Family Practice Oncology
Protect your child from cancer
                       with the HPV vaccine.
Four things you need to know about the HPV vaccine:
  1.       The HPV vaccine is cancer prevention.
           The vaccine protects against HPV infections that can cause:
                        • Mouth and throat cancer
                        • Cervical cancer
                        • Anal cancer
                        • Vaginal and vulvar cancer               It also protects against infections
                        • Penile cancer                                that cause genital warts.

 2.        Age matters. Don’t wait to vaccinate.
           It is recommended that children get the HPV vaccine in grade 6. Here’s why:
              The vaccine works best when given at a young age because preteens produce more antibodies
              after HPV vaccination than older teens.
              For the vaccine to work best, people need to be vaccinated before they are sexually active and
              exposed to HPV.
           When you vaccinate your child on time, you give them the best protection from HPV cancers later
           in life.

 3.        The HPV vaccine is safe.

           200,000,000
           HPV Vaccine Doses Safely Given
                                                Over 15 years of vaccine safety monitoring has shown that
                                                the HPV vaccine is safe. More than 200 million doses of the
                                                vaccine have been safely given worldwide.

 4.        HPV vaccination works!
                           Studies in Canada and other countries with HPV vaccine programs have shown a
                           big decrease in HPV infections, cervical pre-cancers, and genital warts since the
                           HPV vaccine has been used.

       What is HPV?                                 •   About 3 out of 4 unvaccinated sexually active people
                                                        will get HPV at some point in their lives.
       •   HPV stands for human papillomavirus.     •   There are many different types of HPV. Most HPV
       •   It is the most common sexually               infections are harmless and go away on their own. But
           transmitted infection.                       some infections can lead to cancer or genital warts.
                                                                                                                          07/22

              For translations and more
              information, scan the QR code or
              visit immunizebc.ca/hpv

                                                                           FAMILY PRACTICE ONCOLOGY NETWORK JOURNAL / SPRING 2023   9
Journal of Family Practice Oncology
Managing psychiatric medications in patients with cancer
     By Dr. Alan Bates, MD, PhD, FRCPC                  due to their minimal 2D6 inhibition. An              Another setting where prescribing an SSRI
     Provincial Lead for Psychiatry and Acting          added bonus, that often makes these                  may seem foolhardy is in the context of
     Program Medical Director for Supportive            medications more attractive to patients              neuroendocrine tumor with risk of carcinoid
     Care at BC Cancer                                  reluctant to take a psychiatric medication, is       syndrome, but recent reviews suggest they
                                                        that both venlafaxine and mirtazapine can            are relatively safe.5-6
     Given the overall prevalence of anxiety
                                                        help with tamoxifen-induced hot flashes
     and depression, it’s not surprising that                                                                In patients where gabapentin or pregabalin
                                                        at night. Escitalopram and citalopram are
     mental health comorbidities are common                                                                  are not working adequately for neuropathic
                                                                        also relatively low risk. If a
     in people with cancer.                                                                                  pain, it’s worth remembering that SNRIs like
                                                                        patient is unable to achieve
     Substance use disorders are                                                                             duloxetine and tricyclic antidepressants like
                                                                        adequate results from weak
     a good example of mental                                                                                nortriptyline also have evidence for helping
                                                                        2D6-inhibitors, it might
     health syndromes that can                                                                               with neuropathic pain.
                                                                        be reasonable for them to
     increase risk of cancer.
                                                                        choose, in the context of            Small doses of as needed lorazepam can
     The increased prevalence
                                                                        education about this issue,          help certain patients get through some
     of depression in head and
                                                                        to continue a strong inhibitor       investigations and procedures. In addition
     neck cancer, compared to
                                                                        as some evidence suggests            to its effects on anxiety, lorazepam can
     most other forms of cancer,
                                                                        the clinical significance of         also help with anticipatory nausea. In
     is likely partially explained
                                                                        this interaction is overblown.2      addition to all the other well-known risks
     by premorbid depression
                                                                        However, there are studies           of benzodiazepines, the risk of respiratory
     associated with risk-elevating
                                               Dr. Alan Bates           that report clinically significant   depression is present to a much greater
     substance use. Cancer
                                                                        effects.3                            degree in patients taking opioids.
     treatments can also precipitate
     psychiatric symptoms. Steroid-induced              In addition to being helpful for hot flashes,        Stimulants from both the methylphenidate
     mood disturbances, for example, are a              mirtazapine has other secondary effects              and dextroamphetamine families can
     common challenge. Compared to the                  that tend to be beneficial in this population.       sometimes be helpful for brain fog or mental
     general population, the rate of diagnosis of       Promotion of sleep (at lower doses),                 fatigue. However, reduction in appetite
     psychiatric syndromes begins to increase           increased appetite, and reduction of nausea          caused by stimulants is often unwanted in this
     10 months before cancer diagnosis, peaks           all tend to be welcome side effects. Similarly,      setting. There is also anecdotal concern about
     sharply around time of diagnosis, and              olanzapine is often used by oncologists              seizure risk being increased by stimulants in
     then remains elevated for up to 10 years.1         for treatment-resistant nausea, even in the          patients with brain tumors, but the limited
     Therefore, primary care providers are              absence of any psychiatric symptoms.                 evidence available does not support that
     frequently managing psychiatric medications                                                             risk.7 Bupropion is another alternative for
                                                        In a setting where methadone, which
     in the context of cancer.                                                                               patients with depression characterized
                                                        can have a large effect on QT interval,
                                                                                                             by lack of motivation and mental energy,
     The best-known cancer- and mental health-          is commonly used for pain control, it’s
                                                                                                             but it is known to increase risk of seizure,
     related medication interaction is likely           worth being more vigilant about the risk
                                                                                                             particularly in the context of malnutrition and
     the risk of reducing the effectiveness of          of psychiatric medications prolonging QT.
                                                                                                             electrolyte abnormalities. Antipsychotics as a
     tamoxifen through strong cytochrome p450           Among SSRIs, escitalopram and citalopram
                                                                                                             class also lower seizure threshold.
     2D6 (CYP2D6)-inhibiting antidepressants            are the only two that show a convincing
     such as paroxetine, fluoxetine or bupropion.       dose-response effect on QT.4 With a few              Steroids such as prednisone and
     To mitigate that risk, venlafaxine and             possible exceptions, antipsychotics also have        dexamethasone given as part of chemotherapy
     mirtazapine are antidepressants of choice          risk for contributing to QT prolongation.            regimens can cause or exacerbate a wide
                                                                                                             variety of psychiatric symptoms. Patients with
                                                                                                             a history of bipolar disorder are particularly
                                                                                                             at risk for destabilization. Olanzapine can be
        Key Points                                                                                           used to address steroid-induced irritability,
        1. Antidepressants that are strong cytochrome p450 2D6 (CYP2D6) inhibitors                           hypomania, mania, or psychosis and can be
           (e.g. paroxetine, fluoxetine or bupropion) may decrease the effectiveness of                      given prophylactically in patients with a high
           some cancer medications such as Tamoxifen.                                                        level of risk. Olanzapine or other antipsychotics
        2. Be vigilant about the risk of psychiatric medications prolonging QT, particularly if              (depending on the patient and scenario) can
           a patient is on methadone for pain management as it can also contribute to this.                  also be helpful in minimizing immunotherapy-
                                                                                                             induced psychotic symptoms and might
        3. Steroids (e.g. prednisone and dexamethasone) given as part of chemotherapy
                                                                                                             allow a patient to continue a regimen that
           regimens can cause or exacerbate a wide variety of psychiatric symptoms.
                                                                                                             might otherwise have to be discontinued.
        4. Patients with severe and persistent mental illness may need dose reductions of
           longstanding medications in the context of acute medical illness and/or acute                     Patients with severe and persistent mental
           medical settings.                                                                                 illness such as schizophrenia or bipolar
                                                                                                                                    continued on page 11

10   FAMILY PRACTICE ONCOLOGY NETWORK JOURNAL / SPRING 2023
Expansion of FPON-UBC CPD self-directed online courses:
Lung Cancer available April 14, 2023
With the increasing prevalence of lung cancer, the BC Cancer Primary Care
Learning Sessions: Lung Cancer eLearning course offers valuable resources and
knowledge to support health professionals in their work. This online course is
designed to provide primary care providers with up-to-date information on the
diagnosis, treatment and management of lung cancer in primary care settings.
Explore the BC Cancer Primary Care Learning Sessions: Lung Cancer today
using the following link:
https://ubccpd.ca/learn/learning-activities/course?eventtemplate=477-bc-cancer-primary-care-learning-sessions-lung-cancer
Links to all modules in the BC Cancer Primary Care Learning Sessions are also available on our website FPON.ca
www.bccancer.bc.ca/health-professionals/networks/family-practice-oncology-network/continuing-medical-education#Primary--Care--
Learning--Sessions

Managing psychiatric medications                 2. Haque R, Shi J, Schottinger JE, Ahmed SA,       5. Isenberg-Grzeda E, MacGregor M, Bergel
continued from page 10                              Cheetham TC, Chung J, et al. Tamoxifen             A, Eagle S, Espi Forcen F, Mehta R, et al.
                                                    and Antidepressant Drug Interaction                Antidepressants appear safe in patients
disorder may need dose reductions of                in a Cohort of 16 887 Breast Cancer                with carcinoid tumor: Results of a
longstanding medications in the context of          Survivors. J Natl Cancer Inst. 2016                retrospective review. Eur J Surg Oncol J
acute medical illness and/or acute medical          Mar;108(3):djv337.                                 Eur Soc Surg Oncol Br Assoc Surg Oncol.
settings. A classic example of the latter is                                                           2018 Jun;44(6):744–9.
                                                 3. Kelly CM, Juurlink DN, Gomes T, Duong-
the need to consider reducing olanzapine or
                                                    Hua M, Pritchard KI, Austin PC, et al.          6. Isenberg-Grzeda E, MacGregor M,
clozapine in environments where patients
                                                    Selective serotonin reuptake inhibitors            Matsoukas K, Chow N, Reidy-Lagunes D,
can’t smoke as smoking induces CYP1A2 and
                                                    and breast cancer mortality in women               Alici Y. Must antidepressants be avoided
speeds up metabolism of those medications.
                                                    receiving tamoxifen: a population based            in patients with neuroendocrine tumors?
This short article cannot account for all the       cohort study. BMJ. 2010 Feb 8;340:c693.            Results of a systematic review. Palliat
individual differences between patients,         4. Castro VM, Clements CC, Murphy SN,                 Support Care. 2020 Oct;18(5):602–8.
settings, and scenarios, and the content            Gainer VS, Fava M, Weilburg JB, et al.          7. Meyers CA, Weitzner MA, Valentine
should be used along with other resources           QT interval and antidepressant use: a              AD, Levin VA. Methylphenidate therapy
and does not replace clinical judgment. Using       cross sectional study of electronic health         improves cognition, mood, and function
interaction-checking software and being             records. BMJ. 2013 Jan 29;346(jan29                of brain tumor patients. J Clin Oncol Off J
aware of kidney and liver dysfunction that          3):f288–f288.                                      Am Soc Clin Oncol. 1998 Jul;16(7):2522–7.
may affect metabolism and serum protein
and medication levels are always prudent
practices. Relatively rare syndromes such as
serotonin syndrome also become less rare         BC’s Cancer Action Plan and some implications      primary care and our partners will need to
with so many possible variables contributing.    for Primary Care continued from page 8             take a much broader approach to ensure
When in doubt, consult with a physician or                                                          awareness that HPV related cancers are not
                                                 • Cisgender males in youth custody services
pharmacist colleague. The RACE line www.                                                            just about cervical cancer prevention. We
                                                   centres or in the care of the Ministry of
raceconnect.ca can also be an excellent                                                             need to shift the dialogue to counter the
                                                   Children and Family Development (MCFD)
resource. When done judiciously, active                                                             misinformation that creates stigma around
management of psychiatric medications            • Two-Spirit, transgender, and non-binary
                                                                                                    HPV, advocate for broader coverage of
in people with cancer can improve quality          people up to 26 years of age
                                                                                                    immunization and improves prevention of all
of life, reduce side effects, and (through       Immunize BC also notes that the HPV9               HPV related cancers in addition to other HPV
improving tolerance of and ability to attend     vaccine is recommended, but not provided           related conditions. This is action that primary
treatments) lengthen survival.                   free (unless noted above), for:                    care, through the Patient Medical Homes
                                                 • Females 19 to 45 years of age                    and Primary Care Networks, in partnership
References                                                                                          with Public Health and BC Cancer can
                                                 • Males 19-26 years of age (unless noted
1. Lu D, Andersson TML, Fall K, Hultman CM,                                                         collaborate with other partners both at the
                                                   above)
   Czene K, Valdimarsdóttir U, et al. Clinical                                                      local, regional and provincial levels.
   Diagnosis of Mental Disorders Immediately     • Males 27 years of age and older who have
                                                   sex with men                                     We are planning on including pieces on all
   Before and After Cancer Diagnosis: A
                                                                                                    HPV related cancers in the Fall 2023 Journal,
   Nationwide Matched Cohort Study in            In our quest for improving care that is
                                                                                                    so stay tuned for more information.
   Sweden. JAMA Oncol. 2016 Sep 1;2(9):1188.     based on equity, diversity and inclusion,

                                                                                             FAMILY PRACTICE ONCOLOGY NETWORK JOURNAL / SPRING 2023   11
Opportunities for clinician input to inform programming
     for adolescents and young adults with cancer in BC

                                                                                                              Why It Matters
                                                                                                              • An AYA is diagnosed with
                                                                                                                cancer every 65 minutes in
                                                                                                                Canada – more than 20 AYAs
                                                                                                                every day.
                                                                                                              • Cancer in AYAs is unique from
                                                                                                                older adults and pediatric
                                                                                                                populations with distinct
                                                                                                                medical and psychosocial
                                                                                                                needs.
                                                                                                              • AYA specific cancer care in
                                                                                                                Canada is limited. In the UK and
                                                                                                                Australia young adult specific
                                                                                                                cancer care is standard practice.
                                                                                                              • Only 0.4% of cancer research
                                                                                                                funding in Canada is dedicated
                                                                                                                to AYAs.

                                                       In November at the BC Cancer Summit, the        “I want to be able to better support young
                                                       Anew Research Collaborative and BC Cancer       adults with cancer. I believe we can.”
                                                       hosted a session focused on cancer care         ~Clinician attending the BC Cancer Summit
                                                       needs and programing for AYAs. Attended         session focused on AYA care
                                                       by nearly 70 AYAs and clinicians, the session
     Do you care for adolescent and young              reinforced a gap in AYA specific cancer         Over the next few months, Dr. Jon Avery,
     adult (AYAs) patients (aged 15-39) with           care. Building from the Summit, we are now      will be interviewing clinicians across BC who
                                                       reaching out to clinicians who care for AYAs    care for AYAs with cancer and who wish to
     cancer? Do you have perspectives and
                                                       to understand their experiences, needs and      share their insights about AYA specific cancer
     ideas on how their diverse needs could be
                                                       priorities to improve cancer care for AYAs.     care. “This is an opportunity to reflect on the
     better met? Read on…
                                                                                                       unique needs of AYAs and identify tangible
                                                                                                       steps and priorities to improve cancer care
                                                                                                       for AYAs in BC,” noted Dr. Cheryl Heykoop,
                                                                                                       Anew Research Lead, Program Head of Royal
         FAMILY PHYSICIANS & GENERAL PRACTITIONERS                                                     Roads University MA Leadership Program
                                                                                                       (Health), and patient with lived experience of
         Is funding a barrier to you pursuing extra training                                           cancer as an AYA.

         in CANCER CARE?                                                                               Simultaneously, Anew is working on a
                                                                                                       research project, funded by CIHR, focused
         The Canadian Association of General Practitioners in Oncology (CAGPO) offers                  on understanding and addressing the cancer
         training scholarships of up to one month in duration for FPs/GPs interested in                care realities of racialized AYAs. In late spring/
         cancer care. Please email info@cagpo.ca for information about the scholarship                 early summer, we will be hosting
         program and application form.
                                                                                                       further conversations with clinicians and
         Drs. Lori Ann Hayward & Pamela Craigie                                                        care providers to reflect on the learnings
         Applications must be received by June 15, 2023.                                               from racialized AYAs and identify tangible
         Please join us for our annual 2023 CAGPO conference.                                          ways to improve cancer care for racialized
         Details at www.cagpo-annual-conference.ca                                                     AYAs in BC.
                                                                                                       To learn more about any of the above
                                                                                                       or to take part in the interviews and/or
                                                                                                       conversations, kindly send an expression of
                                                                                                       interest to hello@anewresearch.ca

12   FAMILY PRACTICE ONCOLOGY NETWORK JOURNAL / SPRING 2023
Virtual primary care learning session timely as Nelson's
community Oncology clinic transitions to general
practitioner in Oncology (GPO) care model
By Dr. Sian Shuel, medical                                                                                         module, learners came
education lead, primary care                                                                                       together with local experts,
program with Dr. Mike Vance,                                                                                       including their local GPO (Dr.
GPO Nelson, BC                                                                                                     Vance), a medical oncologist
                                                                                                                   from Kelowna and a family
The community of Nelson,
                                                                                                                   physician champion from
in BC’s Interior, recently
                                                                                                                   Nelson, to briefly review key
transitioned to a GPO model
                                                                                                                   learnings from the module.
from cancer care provided
                                                                                                                   This certified 1.5-hour
by Dr. Phillip Malpass, an
                                                                                                                   workshop was developed to
internist/geriatrician who
                                                                                                                   create an opportunity to build
received the Patient Care
                                                                                                                   connections and discuss
Championship BC Cancer
                                                                                                                   clinical and community-
Excellence Award in 2019 for
                                                                                                                   specific questions.
his work.
                                                                                                                    Feedback from the Learning
With change often comes
                                                                                                                    Session in Nelson was
opportunity, and earlier this
                                                                                                                    positive, reporting that
year, BC Cancer Primary Care
                                                                                                                    the workshop provided an
Program's Virtual Learning                      chemotherapy nurses, a charge nurse and a
                                                                                                   opportunity for an improved understanding
session provided a platform for community       clinic clerk.
                                                                                                   of the diagnostic, referral and treatment
physicians to connect with one of their new     During the one-year transition period from         process under the new GPO model.
community GPOs, Dr. Mike Vance, and an          internist to GPO care, GPOs from Trail went        The module also facilitated an increased
oncologist from their regional BC Cancer        above and beyond. Commuting to Nelson,             awareness of resources that patients in
Centre in Kelowna on community-specific         they covered the outpatient clinic, ensuring       Nelson could access through their linkage
questions.                                      patients could continue accessing care in          with BC Cancer in Kelowna. The resultant
Dr. Vance is familiar with the area, having     Nelson while the three new GPO trainees            understanding of, and confidence in, the
completed high school in Nelson. Upon           completed their education, including               system's process was vital for arming primary
finishing his medical education, he returned    rotations at BC Cancer in Kelowna.                 care practitioners to provide reassurance
to Nelson to practice family and emergency      During his clinical rotations, Dr. Vance heard     for their patients with a cancer diagnosis.
medicine, followed by hospitalist and           about the small group virtual BC Cancer            The Learning Session also created an
addictions medicine work. After completing      Primary Care Learning Session opportunity          opportunity to give feedback to the Regional
his clinical rotations in the spring of 2022,   from a medical oncologist who helped               Cancer Centre on their ongoing work
he added GPO to his clinical duties. As         facilitate a workshop in the east Kootenays.       toward equitable access to care and patient
a GPO, Dr. Vance assesses patients for          They agreed it would create an excellent           resources.
appropriateness of the next round of            opportunity to support the local transition to     If you're interested in bringing this
chemotherapy after receiving a Community        the community's GPO model of cancer care.          opportunity to your community,
Oncology Network Referral (CONRef) from
the medical oncologist at the regional centre   The virtual Learning Session in Nelson was         please get in touch with Dr. Sian Shuel at
and provides surveillance and follow-up         based on the online breast cancer module.          sian.shuel@bccancer.bc.ca
care.                                           After completing the accredited online

The community oncology clinic in Nelson is
situated inside the Kootenay Lake Hospital.       FOR MORE INFORMATION                                ISSN 2369-4165 (Print)
It helps provide cancer care for patients in                                                          ISSN 2369-4173 (Online)
                                                  To learn more about the Family Practice
a large geographical area from Kootenay           Oncology Network or become involved,                Key title:
Lake, 1.5 hours east, to Nakusp, 2 hours          please email FPON@bccancer.bc.ca                    Journal of family practice oncology
northwest. With Nelson being 4 hours east         or visit www.fpon.ca                                Publications Mail Agreement
of Kelowna, the community oncology clinic                                                             Number 41172510
                                                  The content of articles in this Journal
helps ensure patients can receive care closer     represent the views of the named                    Return all undeliverable Canadian
to home. The cancer care team in Nelson           authors and do not necessarily                      Addresses to
is currently supported by three part-time         represent the position of BC Cancer,                BC Cancer, 600 West 10th Ave,
GPOs, a dedicated dietician, a social worker,     PHSA or any other organization.                     Vancouver, BC V5Z 4E6
an indigenous patient navigator, three

                                                                                            FAMILY PRACTICE ONCOLOGY NETWORK JOURNAL / SPRING 2023   13
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