Business Plan Reversing Aging Through Telomere Lengthening - defytime
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Business Plan Reversing Aging Through Telomere Lengthening
Contents
Business Summary . . . . . . . . . . . . . . . 3 TAM Clinical Studies . . . . . . . . . . . . . 13 Road Map Expectation . . . . . . . . . . . 24
Company . . . . . . . . . . . . . . . . . . . . 4 Defytime Bill Andrews Requested Investment . . . . . . . . . . . . 25
Aging Care Capsules . . . . . . . . . . . . 14
Our Team . . . . . . . . . . . . . . . . . . . . 5 Cosmeceutical Estimated Sales . . . . . . 26
Defytime Aging Care Cream . . . . . . . . 15
Telomeres . . . . . . . . . . . . . . . . . . . . 6 Non-medicated Item Estimated Sales . . . 27
Defytime Eye Serum . . . . . . . . . . . . . 16
Telomerase . . . . . . . . . . . . . . . . . . . 7 Cash Flow Analysis Assumptions . . . . . . 28
Defytime Deep Skin Express . . . . . . . . . 17
What is Aging? . . . . . . . . . . . . . . . . . 8 VVIP Medical Tour Estimated Sales . . . . . 29
Defytime Aqua Oil Drops . . . . . . . . . . 18
Causes & Treatment of Aging . . . . . . . . . 9 Company & Brand Structure . . . . . . . . 30
Defytime TAM Spray . . . . . . . . . . . . . 19
Telomerase Induction Proposed Summary Terms . . . . . . . . . . 31
- Anti Aging Therapeutic . . . . . . . . . . 10 Proposed South Pacific Clinic . . . . . . . . 20
Company Structure . . . . . . . . . . . . . 32
Telomerase Induction Inner Beauty NZ . . . . . . . . . . . . . . . 21
Contracts . . . . . . . . . . . . . . . . . . . 33
- Hybrid Vector Solution . . . . . . . . . . . 11
Brand Marketing Strategy . . . . . . . . . . 22
TAM CO314818 . . . . . . . . . . . . . . . . 12
SWOT Analysis . . . . . . . . . . . . . . . . 23
Business Plan 2
Business Summary
We have developed a genuine Our objectives are:
anti aging solution called TAM. • To create products with TAM (Telomerase Activating Molecule) as an active ingredient.
We now have a range of anti aging • To launch non-medicated and skin care products to introduce to the cosmetic market.
products: mask patch, nasal spray
• VVIP medical tour business.
and dermal products.
• To create telomere lengthening dermal products for anti aging and aging cure, and sell TAM
products through sales channels.
• To develop further premium anti aging products with TAM and non-medicated products.
• South Pacific Clinic could provide genuine anti aging services to VVIP medical tour groups.
Business Plan 3
Company
Defytime Ltd is headquartered in Auckland
New Zealand, with labs co-located in The University
of Auckland and research and development in Reno,
Nevada USA. Our first anti-aging clinic is located
in Vanuatu.
Our goal is to reverse the human aging process and cure diseases linked
to aging by activating telomerase and thus extending telomeres, leading
the cells to return to a state of youthful gene expression and function.
This cutting edge research is led by director Dr. Bill Andrews. Dr. Andrews
has worked in the biotech industry for over 35 years, focusing the last 20
years on finding ways to extend human lifespan through the intervention
of telomere shortening in human cells.
Business Plan 4
Our Team
Dr. Bill Andrews Laura A. Briggs, Ph.D.
Founder & President Vice President of Research & Discovery
Dr. Andrews is the founder and President of Sierra Science Laura Briggs received her B.S. degree in Nutrition in 1993 and
LLC, a biotech company in Reno, Nevada focused exclusively her Ph.D. in Environmental Science and Health in 2000 from
on finding drugs that will transiently induce the expression of the University of Nevada, Reno. After a one year post-doctoral
endogenous telomerase in human cells. position at UNR she joined Sierra Sciences, known as Andrews
Inc in 2001. In addition to coordinating research and development at
Dr. Andrews earned his Ph.D. in Molecular and Population Genetics at
Sierra Sciences, Dr. Briggs is also serving as the Biology Lab Coordinator
the University of Georgia in 1981. He was a Senior Scientist at Armos Corp
for Truckee Meadows Community College (TMCC) and has collaborated
and Codon Corp, Director of Molecular Biology at Codon and at Geron
on research projects at the V.A. Medical Center in Reno, Nevada.
Corp, and Director of Technology Development at EOS Biosciences.
While Director of Molecular Biology at Geron Corp from 1992 to 1997, Lancer Brown, M.S.
Dr. Andrews was one of the principal discoverers of both the RNA and
protein components of human telomerase and was awarded 2nd place Program Director of Screening
as "National Inventor of the Year" in 1997 for this work.
Lancer Brown received his B.S. and M.S. degrees in
He is named inventor on 45 US issued telomerase patents. Dr. Andrews Biotechnology in 2003 from the University of Nevada, Reno
is highly respected and widely known for his expertise and passion and was one of three students in the inaugural advanced BS/
for curing aging and TEDS. He has been a featured expert in many MS Biotechnology Program. He distinguished himself as the
documentaries and is a frequent guest speaker at prestigious events. first student to complete the program. Lancer came to Sierra Sciences as
Dr. Andrews is also an ultra marathon runner whose ultimate goal is an intern while completing his degree. Following graduation, he joined
to run a 7-minute mile at the age of 130. Sierra Sciences full-time where he has proven to have remarkable ability
to engineer genes and DNA. He has recently been promoted to Program
Director of Screening.
Business Plan 5
Telomeres Cell
Chromosome
Telomere
Telomeres are an essential part of human cells that
affect how our cells age.
DNA
Cell division plays a critical role in normal growth, maintenance and
repair of all human tissues, including skin.
Telomeres are repeated sequences of DNA at the ends of each Telomere
chromosome and are key genetic elements involved with the regulation
of cell division. Telomeres shorten every time a cell divides, and once
telomeres reach a critically short length, the cell either dies by apoptosis
or stops dividing and senesces.
Telomeres are the caps at the end of each strand of DNA that protect
our chromosomes, like the plastic tips at the end of shoelaces. Without
the coating, shoelaces become frayed until they can no longer do their
job, just as without telomeres, DNA strands become damaged and our
cells can’t do their job.
Telomeres are shortened as we age, but telomeres can also be
shortened by stress, smoking, obesity, lack of exercise and a poor diet.
As cells divide over time telomeres shorten,
and eventually cell division stops.
Business Plan 6
Telomerase
Telomerase is a naturally occurring enzyme that
maintains telomeres and prevents them from Telomerase
shortening during cell division.
Telomerase, also called telomere terminal transferase, is a
ribonucleoprotein that adds the polynucleotide “TTAGGG” to the 3’end
of telomeres, at the ends of eukaryotic chromosomes.
C
Telomerase is a reverse transcriptase enzyme that carries its own RNA RNA template C C A A
U
molecule (with the pattern of ”CCCAAUCCC” in vertebrates), which is A G
T T
G G A
used as a template for adding new bases onto the ends of telomeres.
DNA
Nucleotide
Business Plan 7
What is Aging?
Ageing (British English) or aging (American English)
is just the process of becoming older.
The term is used to refer to biological aging of human beings, animals
and other organisms, but can also refer to individual cells within an
organism (cellular aging) or to the population of a species
(population aging).
In humans, aging is an accumulation of changes over time,
encompassing physical, psychological, and social change. Reaction
time may slow with age, while knowledge and wisdom may expand.
Aging is one of the greatest contributing risk factors for most human
diseases, and of the roughly 150,000 people who die each day across
the globe, about two thirds die from age-related causes.
Business Plan 8
Causes & Treatment of Aging The activation of telomerase in aged mice rejuvenates the entire body
Telomerase Induction
The causes of aging can be ascribed to damage, whereby the
accumulation of externally induced damage (such as DNA point
mutations) may cause biological systems to fail, or to programmed
aging, whereby internal processes (such as DNA telomere shortening)
may cause aging.
Telomere-shortening can be seen as a programmed aging ‘disease’, and
could be cured by lengthening telomeres via Telomerase Induction.
Defytime proposes 2 different Telomerase
Induction methods:
• Anti Aging Therapeutic used in creams, supplements, and drugs
• Hybrid Vector Solution (injection of a virus), available in our clinic in With telomerase aging is reversed Without telomerase aging continues
Vanuatu for VVIP patients.
The next 2 pages explain how these processes work.
Business Plan 9
Anti Aging Therapeutic Repressor
Protein no Telomerase production
Chromosome
Telomerase Induction Method 1 Regulator Site Telomerase Gene
Telomerase can be naturally produced by your cells to repair telomeres,
but this function is shut off by a repressor protein binding to a regulator
site or ‘switch’ on the chromosome.
• Defytime introduces a therapeutic element that binds to the Repressor
repressor protein. Protein
Telomerase production activated
Anti-aging
• This prevents the repressor protein from binding to the regulator site, Therapeutic
allowing telomerase production to be activated.
Chromosome
• The telomerase produced by your cells can then repair the portions of
the telomeres lost in cell division. Regulator Site Telomerase Gene
Business Plan 10Hybrid Vector Solution + =
Cloning Activated Adeno-Associated Virus
Human Telomerase Gene (AAV) Viral Vector Hybrid Vector
Telomerase Induction Method 2
In Defytime Telomere Lengthening Therapy, a hybrid vector combining
the activated human telomerase gene with an adeno associated virus
(AAV) is made and cultured.
• The adeno associated virus does not cause disease, and has a very
mild immune response.
• The AAV transfers the hybrid vector (section of DNA) into your cells,
where it can produce telomerase.
• The telomerase produced by your cells can then repair the portions of
the telomeres lost in cell division.
Transfers into cells and onto Hybrid vector solution
genomic DNA to produce telomerase. injected into the bloodstream
Business Plan 11TAM CO314818
Telomerase Activating Molecule
Developed by Bill Andrews, Ph. D. (Sierra Sciences, LLC.)
in 2014, TAM CO314818 is a state of the art Telomerase
Activating Molecule (TAM) that counteracts and suppresses
the fundamental cause of aging: telomere shortening.
By interfering with the action of telomerase inhibiting substances TAM
CO314818 induces telomerase to function normally and to cause cell
division to become more active leading to younger and healthier cells.
TAM is the most effective anti-aging compound available, being 300
times more effective than TA65 - currently the strongest telomerase
inducer in the market.
The TAM compound is mixed with other ingredients for oral and dermal
products. All Defytime products feature the TAM logo to indicate they
contain the TAM compound.
Business Plan 12TAM Clinical Studies
Excellent improvement of skin condition over 30 days
Clinical trials in vivo in Italy (Abich Labs in cooperation with San Raffaele
Hospital) proved the strong anti-aging properties of our TAM products.
• 100 women tested, 36-65 years old
• Applied twice daily, 20ug/ml TAM
• Tested on day 0, 15, 30
Day 0 Day 15 Day 30
Business Plan 13Defytime Bill Andrews
Aging Care Capsules
With Telomerase Activation
• Defytime Dr. Bill Andrews anti-aging dietary supplement
with TAM improves biological health (skin, vessels, brain, bone).
• Made in New Zealand from quality ingredients.
• TAM targets telomeres in cells, leading to younger and
healthier cells.
• TAM is the most effective anti-aging compound available.
Business Plan 14Defytime Aging Care Cream
With Telomerase Activation
• Defytime Aging Care Cream with TAM counteracts and suppresses
the fundamental cause of skin aging: telomere shortening. Skin cells
are rejuvenated, youthful elasticity is restored, fine lines and wrinkles
disappear.
• A state of the art natural micro-emulsion optimized to deliver TAM to
achieve maximum results.
• Made in New Zealand from quality ingredients.
• TAM targets telomeres within skin tissue, leading to younger and
healthier skin cells.
• TAM is the most effective anti-aging compound available.
Business Plan 15Defytime Eye Serum
With Telomerase Activation
• Defytime Eye Serum with Jojoba Oil and Macadamia Seed Oil Esters
along with TAM acts to prevent premature aging of the skin.
• Made in New Zealand from quality ingredients.
• TAM targets telomeres within skin tissue, leading to younger and
healthier skin cells.
• TAM is the most effective anti-aging compound available.
Business Plan 16Defytime Deep Skin Express
Rejuvenating Eye Patch with Telomerase Activation
• Defytime Deep Skin Express rapidly delivers active ingredients into the
deep dermal layer of the skin for lasting effects.
• Convenient and fast application (1 minute).
• Over 1.5mm absorption into the dermal layer after 50 minutes.
• Made in New Zealand from 100% natural and sustainable ingredients.
• Dermal tested and hypoallergenic.
• TAM targets telomeres within skin tissue, leading to younger and
healthier skin cells, and is the most effective anti-aging compound
available.
Business Plan 17Defytime Aqua Oil Drops
With Telomerase Activation
• Defytime Aqua Oil Drops with Rosehip Oil, Macadamia Oil and
Astaxanthin Oil along with TAM offers a wide range of skin health
benefits when used regularly.
• Made in New Zealand from quality ingredients.
• TAM targets telomeres within skin tissue, leading to younger and
healthier skin cells.
• TAM is the most effective anti-aging compound available.
Business Plan 18Defytime TAM Spray
With Telomerase Activation
• Defytime TAM Spray with Aqueous Propolis helps to improve biological
health, while preventing dry mouth, tooth decay and gum disease
naturally.
• Made in New Zealand from natural ingredients and free of sugar and
preservatives.
• Promotes production of saliva as well as providing active
anti-bacterial properties against tooth decay, gingivitis and
bad breath.
• TAM targets telomeres in cells, leading to younger and healthier cells,
and is the most effective anti-aging compound available.
Business Plan 19South Pacific Clinic
Business Plan 20Inner Beauty NZ Drink
Anti Aging Care Water
In the South Pacific we can host
an Anti Aging Center for clinical
treatment of VVIP.
Defytime Nasal Spray can deliver TAM
efficacy as a key inner beauty item, along Care
with other treatments.
Anti Aging Dermal Products & Nasal Spray
Eat
Anti Aging Capsules
Business Plan 21Brand Bill’s Give lectures
Introduce Bill
name as top and create
and his work
Telomere supporters
through internet
lengthening through social
and mass media
Scientist networks
Prove the
Keep updating
Marketing mechanism
evidence and
Strategy with third party
proof
tests
Brand
Marketing
Strategy Products
connected with
Create sales
channels for
Produce and
introduce new
Bill’s name mass sales products
Business Plan 22SWOT Analysis
Strength Opportunity SWOT
Genuine anti aging and cure Unlimited market • As a new idea it may take time for
consumers to understand the mechanism,
aging solution but when consumers accept the idea it will
create a huge market for the long term.
Threat • So, we need to spend time and money on
Weakness Similar products could create
marketing and branding Bill’s name as the
leading telomere expert. We also need to
find the right channels to sell.
New mechanism confusion for consumers
Business Plan 23Road Map Expectation
Aug 30, 2019 Sep 30, 2019 Mar 30, 2020 Jun 30, 2020
Business Plan Aug 20 - 30 2019 (restructure web sites)
Market Research ~Aug 20, 2019 (market testing already completed)
Complete Contract Completed 28th September, Reno USA
Set Up Company Completed July 10, 2019 (Defytime Singapore - expecting initial fund)
Invest Fund August 30, 2019 (invest actual fund)
Order the Machines Sep 15 (1st machine with initial fund)
Produce Samples March 15 - Aug 30, 2019 (by Defytime, NZ)
Test Production February - Aug 2019
Viral Injection Sales Only for VVIP 2020 by booking / 3 clinical tests
Mass Production & Sales
Business Plan 24Requested Investment
Total: US$19Million
Details Amount (US$) Notes
License fee 3 Million
NZ clinic center (South Pacific) 5 Million Includes property cost
Viral clinic tests 2 Million 3 persons
Viral manufacturing factory setup costs 1 Million
New drug development costs 2 Million Until clinic phase 2/A
Marketing costs for dermal and oral 3 Million Branding, PR
Manufacturing costs for cosmetics 2 Million Mask patch, serum, cream, oral & nasal spray, capsules, oil
Operation costs 1 Million Yearly
Total 19 Million
Business Plan 25Cosmeceutical Estimated Sales
Financial Years Ending March 31 2019 2020 2021 2022
Serum Unit Price (US$) 250 250 250 250
Volume Growth N/A 7.5% 10% 30%
Sales Volume (units) 50,000 53,750 59,125 76,863
Total Direct Sales Revenue $12,500,000.00 $13,437,500.00 $14,781,250.00 $19,215,750.00
High-end anti aging products in the U.S., Prevage retails for about $175, and StriVectin for about $185.
Japan and China: Based on the current pricing of Prevage and StriVectin, the company
plans to price at more than $250.00
In 2018, the Freedonia Group estimated global cosmeceutical sales at
about $5.8 billion and predicted a 7.4% average annual growth in
the U.S. through 2020.
Business Plan 26Non-medicated Item Estimated Sales
Financial Years Ending March 31 2019 2020 2021 2022
Capsule Unit Price (US$) 800 800 800 800
Volume Growth N/A 7.5% 10% 30%
Sales Volume (units) 50,000 53,750 59,125 76,863
Total Direct Sales Revenue $40,000,000.00 $43,000,000.00 $47,300,000.00 $61,490,400.00
Business Plan 27Cash Flow Analysis Assumptions
Fiscal Years Ending March 31 2019 2020 2021 2022
Total Revenue 1 $12,500,000.00 $13,437,500.00 $14,781,250.00 $19,215,750.00
2 $40,000,000.00 $43,000,000.00 $47,300,000.00 $61,490,400.00
Sub Total $52,500,000.00 $56,437,500.00 $62,081,250.00 $80,706,150.00
Cost of Sales (20% of Sales) 10500000 11287500 12416250 16141230
Marketing Expenses (2% of Sales) 1050000 1128750 1241625 1614123
Operating Expenses (4% of Sales) 2100000 2257500 2483250 3228246
Working Capital (10% of Sales) 5250000 5643750 6208125 8070615
Net Profit (24% of Sales) $12,600,000 $13,545,000 $14,899,500 $19,369,476
Business Plan 28VVIP Medical Tour Estimated Sales
Fiscal Years Ending March 31 2019 2020 2021 2022
Unit Price (US$) $2,000,000.00 $2,000,000.00 $2,000,000.00 $2,000,000.00
Volume Growth N/A 10% 20% 30%
Sales Volume (Units) 100 110 132 172
Total Sales Revenue $200,000,000.00 $220,000,000.00 $264,000,000.00 $344,000,000.00
Cost of Sales (20% of Sales) $40,000,000.00 $44,000,000.00 $52,800,000.00 $68,800,000.00
Working Capital Tax / Operation Cost / $120,000,000.00 $132,000,000.00 $158,400,000.00 $206,400,000.00
Marketing Cost (60% of Sales)
Net Profit (20% of Sales) $40,000,000.00 $44,000,000.00 $52,800,000.00 $68,800,000.00
Business Plan 29Company & Defytime Singapore
Brand Structure
Equity Major Share Holder Equity Equity
Pay License Fee
Investment 51% Investment Investment
DefyAging
New Zealand New Zealand
Defytime Science Alternatif NZ Ltd
New Zealand (DDC) Dermal Base PL
Local Sales
R&D Center Clinic Center Corporation
(Joint Venture)
Japan China USA
Business Plan 30Proposed Summary Terms Investment: 19 Million USD
Summary Terms Description
Target Investors from overseas 19 million USD
The terms for the investment include receiving 30% of Defytime Singapore
The entire business will operate with Defytime NZ capital of 19 million USD by purchasing or investing for the corporations shown in the
Company & Brand Structure diagram. The business model for R&D and IPO will commence with the primary investment.
Defytime Singapore HQ Shareholders Bill Andrews 20%
Jonathan Greenwood 40%
Investors 30%
Others 10%
Defytime Singapore A company targeted to be listed in the stock market (the target company for value maximization)
Backdoor listing by securing the capital, or direct listing after 3~5 years
If backdoor listing possible share premium realization through continuous R&D
If direct listing: attracts large scale funds (attracting institutional and general investment when IPO)
Sierra Sciences LLC Know how and patient management under the supervision of Dr. Bill
Materials research and drug development, strategic management of intellectual property
Deftime Science Drug Design Company
Promotes new drug development based on Sierra Sciences’ findings
Development of new drugs and health foods
Defytime NZ Dermal related new product development and sales company management
(Defytime Holdings’ subsidiary)
Performs the role of a cash-cow
Alternatif NZ Ltd Dermal Production Base
Defytime Japan Regional sales or marketing subsidiary corporations
Defytime China Attract investors with marketing skills and financing capacity in their region
Defytime Korea (Joint Venture established)
Management and control through sales licenses
Business Plan 31Company Structure
Name of Company Defytime Limited (HQ)
CEO Jonathan Greenwood
Capital $500,000.00
Sale $500,000.00
Products Defytime Facial Serum, Mask Patch, Nasal Spray
Employees 8
Place New Zealand, Singapore, Hong Kong
Email biotechnz@gmail.com, jonathan@defytime.com
Website www.defytime.com
Name of Company Share Holder Relationship Number of Shares
Defytime Holdings Limited Jonathan Greenwood CEO 70
Business Plan 32Contracts
Business Plan 33Thank you www.defytime.com
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